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Conserved domains on  [gi|1958641461|ref|XP_038957394|]
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dynein axonemal assembly factor 3 isoform X1 [Rattus norvegicus]

Protein Classification

molybdopterin molybdotransferase MoeA; ribosomal eL19 family protein( domain architecture ID 13864566)

molybdopterin molybdotransferase MoeA mediates molybdenum ligation to molybdopterin| ribosomal eL19 family protein similar to Trypanosoma cruzi ribosomal protein L19-like protein that is part of the ribosome

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4471 pfam14740
Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and ...
 219-499 1.31e-148

Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916. This domain is more C-terminal in many members to DUF4470, pfam14737.


:

Pssm-ID: 464292  Cd Length: 303  Bit Score: 435.16  E-value: 1.31e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 219 LSLRPLKFRERDALEAVFRFWSGGEkgPEVFPMSRLWDSRLRHYLGSRYDARRGVADWDLRMKLHDRGAQVIHFHEFRRW 298
Cdd:pfam14740   1 LDLSLLKFKERDQLEAIFKFWRRPE--SHPFDIEKYWDQRLRQYLGTRYDSRKGVFDWDLHMKLHDRGANVIHSQEYRRW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 299 RDTGVAFELRDlSAYHVPNRTMASGRLLSHRGERVAARGYWGDIATGPFVAFGIEADDKSLLRTSNGQPVKTASEITQHN 378
Cdd:pfam14740  79 RETGVAFEFRE-GEYQVPNKTLASGRVGNHKGEKVAHRGYWGDIVTGPYISFGIETEDESLLKTSNGQHVKTATDVSERN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 379 VTELFRDVAAWRGPRA--------------IKGNVEETKSPEPDAPAQ---------EPFTIHFLPLDSSQTLHHKTCYR 435
Cdd:pfam14740 158 LLALFHELQTREPYEHdstdsarygsvqllMTELLPEGEDSEEENTADddksdlitlPGVKVHFLPLDSLRKLPHKSKYR 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958641461 436 GRFQLLYVSCGMIHLLSPELGACVAPGGNLVVELARYLVDLRPKELKAFSDRVVEIAQAAGFAP 499
Cdd:pfam14740 238 NFFDIIFVSASMVHFLKPELFQILAPGAVLVVETAKYLVDLRKEQLQEFAEKVKELAKEAGFKP 301
DUF4470 pfam14737
Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and ...
 60-187 3.48e-26

Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916.


:

Pssm-ID: 464289  Cd Length: 97  Bit Score: 102.99  E-value: 3.48e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461  60 WWGLSPALDLQAESPPVDPDsqsktehkipELDALLLGSVDGRHMLRTLARAMLWPLRRFNFYVLENNLEAVARHMLIFS 139
Cdd:pfam14737   1 PWGNTPALDLLQLLPKNEGE----------DLNILLLGSGDLRNVLKTIASLPETYSGKLHITLNDRDPEVVARNILLLL 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1958641461 140 LALEEPEKMGLQgpelvqfakspsmfhpsylspERSETFLELWGNALL 187
Cdd:pfam14737  71 ILLEPDDNPGLD---------------------EAAELLLHLWYSAFL 97
PTZ00436 super family cl33183
60S ribosomal protein L19-like protein; Provisional
 533-657 1.10e-08

60S ribosomal protein L19-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00436:

Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 57.65  E-value: 1.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 533 PSKVLAPTPESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLE 612
Cdd:PTZ00436  222 PAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAAPAK 301

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1958641461 613 LMSPPQTDQTLPLEEMSPP-QAGQSPSLELMSPTRADQTPSLEAIS 657
Cdd:PTZ00436  302 AAAAPAKAAAAPAKAAAPPaKAAAPPAKAATPPAKAAAPPAKAAAA 347
 
Name Accession Description Interval E-value
DUF4471 pfam14740
Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and ...
 219-499 1.31e-148

Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916. This domain is more C-terminal in many members to DUF4470, pfam14737.


Pssm-ID: 464292  Cd Length: 303  Bit Score: 435.16  E-value: 1.31e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 219 LSLRPLKFRERDALEAVFRFWSGGEkgPEVFPMSRLWDSRLRHYLGSRYDARRGVADWDLRMKLHDRGAQVIHFHEFRRW 298
Cdd:pfam14740   1 LDLSLLKFKERDQLEAIFKFWRRPE--SHPFDIEKYWDQRLRQYLGTRYDSRKGVFDWDLHMKLHDRGANVIHSQEYRRW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 299 RDTGVAFELRDlSAYHVPNRTMASGRLLSHRGERVAARGYWGDIATGPFVAFGIEADDKSLLRTSNGQPVKTASEITQHN 378
Cdd:pfam14740  79 RETGVAFEFRE-GEYQVPNKTLASGRVGNHKGEKVAHRGYWGDIVTGPYISFGIETEDESLLKTSNGQHVKTATDVSERN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 379 VTELFRDVAAWRGPRA--------------IKGNVEETKSPEPDAPAQ---------EPFTIHFLPLDSSQTLHHKTCYR 435
Cdd:pfam14740 158 LLALFHELQTREPYEHdstdsarygsvqllMTELLPEGEDSEEENTADddksdlitlPGVKVHFLPLDSLRKLPHKSKYR 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958641461 436 GRFQLLYVSCGMIHLLSPELGACVAPGGNLVVELARYLVDLRPKELKAFSDRVVEIAQAAGFAP 499
Cdd:pfam14740 238 NFFDIIFVSASMVHFLKPELFQILAPGAVLVVETAKYLVDLRKEQLQEFAEKVKELAKEAGFKP 301
DUF4470 pfam14737
Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and ...
 60-187 3.48e-26

Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916.


Pssm-ID: 464289  Cd Length: 97  Bit Score: 102.99  E-value: 3.48e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461  60 WWGLSPALDLQAESPPVDPDsqsktehkipELDALLLGSVDGRHMLRTLARAMLWPLRRFNFYVLENNLEAVARHMLIFS 139
Cdd:pfam14737   1 PWGNTPALDLLQLLPKNEGE----------DLNILLLGSGDLRNVLKTIASLPETYSGKLHITLNDRDPEVVARNILLLL 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1958641461 140 LALEEPEKMGLQgpelvqfakspsmfhpsylspERSETFLELWGNALL 187
Cdd:pfam14737  71 ILLEPDDNPGLD---------------------EAAELLLHLWYSAFL 97
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 533-657 1.10e-08

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 57.65  E-value: 1.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 533 PSKVLAPTPESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLE 612
Cdd:PTZ00436  222 PAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAAPAK 301

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1958641461 613 LMSPPQTDQTLPLEEMSPP-QAGQSPSLELMSPTRADQTPSLEAIS 657
Cdd:PTZ00436  302 AAAAPAKAAAAPAKAAAPPaKAAAPPAKAATPPAKAAAPPAKAAAA 347
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 496-674 1.31e-07

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 55.31  E-value: 1.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 496 GFA-PHTGTK-PSETFARFYKLGDSTRGGGDSAVE-SGPVPSKV------LAPTPESINPPQADQAPslEVMSPPKVDQT 566
Cdd:pfam05109 438 GFAaPNTTTGlPSSTHVPTNLTAPASTGPTVSTADvTSPTPAGTtsgaspVTPSPSPRDNGTESKAP--DMTSPTSAVTT 515

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 567 PPLEAMSPPEADQAPPLEAISPSQTDSAPPlEAMNPPQTDQTPSLELMSPPQTDQTLP-LEEMSPPQAGQSPSLELMSPT 645
Cdd:pfam05109 516 PTPNATSPTPAVTTPTPNATSPTLGKTSPT-SAVTTPTPNATSPTPAVTTPTPNATIPtLGKTSPTSAVTTPTPNATSPT 594

                         170       180
                  ....*....|....*....|....*....
gi 1958641461 646 RADQTPSLEAISLSQADQATSLEAMSPPR 674
Cdd:pfam05109 595 VGETSPQANTTNHTLGGTSSTPVVTSPPK 623
KLF18_N cd21575
N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like ...
 542-677 9.37e-07

N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like factor 18, is a product of a chromosomal neighbor of the KLF17 gene and is likely a product of its duplication. Phylogenetic analyses revealed that mammalian predicted KLF18 proteins and KLF17 proteins experienced elevated rates of evolution and are grouped with KLF1/KLF2/KLF4 and non-mammalian KLF17. KLF18 has been found in the human testis, though it was previously hypothesized to be a pseudogene in extant placental mammals. Mouse KLF18 expression data indicates that it may function in early embryonic development. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF18. Some KLF18 isoforms have duplicated N-terminal domains.


Pssm-ID: 410566 [Multi-domain]  Cd Length: 276  Bit Score: 51.23  E-value: 9.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 542 ESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQ 621
Cdd:cd21575    49 GQMTTPSGDQTLYGGQMTTPNGNQTLYGGQMTTSTGNQTLYGGQMTTSGSDQTLYGGQMTTSSGDQTLYGGQMTTSSGDQ 128

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958641461 622 TLPLEEMSPPQAGQSPSLELMSPTRADQTPSLEAISLSQADQATSLEAMSPPRADQ 677
Cdd:cd21575   129 TLYGGQMTTSTGDQTLYGGQMTTSTGDQTLYGGQMTTSSGDQTLYGGQMTTSTSNQ 184
 
Name Accession Description Interval E-value
DUF4471 pfam14740
Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and ...
 219-499 1.31e-148

Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916. This domain is more C-terminal in many members to DUF4470, pfam14737.


Pssm-ID: 464292  Cd Length: 303  Bit Score: 435.16  E-value: 1.31e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 219 LSLRPLKFRERDALEAVFRFWSGGEkgPEVFPMSRLWDSRLRHYLGSRYDARRGVADWDLRMKLHDRGAQVIHFHEFRRW 298
Cdd:pfam14740   1 LDLSLLKFKERDQLEAIFKFWRRPE--SHPFDIEKYWDQRLRQYLGTRYDSRKGVFDWDLHMKLHDRGANVIHSQEYRRW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 299 RDTGVAFELRDlSAYHVPNRTMASGRLLSHRGERVAARGYWGDIATGPFVAFGIEADDKSLLRTSNGQPVKTASEITQHN 378
Cdd:pfam14740  79 RETGVAFEFRE-GEYQVPNKTLASGRVGNHKGEKVAHRGYWGDIVTGPYISFGIETEDESLLKTSNGQHVKTATDVSERN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 379 VTELFRDVAAWRGPRA--------------IKGNVEETKSPEPDAPAQ---------EPFTIHFLPLDSSQTLHHKTCYR 435
Cdd:pfam14740 158 LLALFHELQTREPYEHdstdsarygsvqllMTELLPEGEDSEEENTADddksdlitlPGVKVHFLPLDSLRKLPHKSKYR 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958641461 436 GRFQLLYVSCGMIHLLSPELGACVAPGGNLVVELARYLVDLRPKELKAFSDRVVEIAQAAGFAP 499
Cdd:pfam14740 238 NFFDIIFVSASMVHFLKPELFQILAPGAVLVVETAKYLVDLRKEQLQEFAEKVKELAKEAGFKP 301
DUF4470 pfam14737
Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and ...
 60-187 3.48e-26

Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916.


Pssm-ID: 464289  Cd Length: 97  Bit Score: 102.99  E-value: 3.48e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461  60 WWGLSPALDLQAESPPVDPDsqsktehkipELDALLLGSVDGRHMLRTLARAMLWPLRRFNFYVLENNLEAVARHMLIFS 139
Cdd:pfam14737   1 PWGNTPALDLLQLLPKNEGE----------DLNILLLGSGDLRNVLKTIASLPETYSGKLHITLNDRDPEVVARNILLLL 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1958641461 140 LALEEPEKMGLQgpelvqfakspsmfhpsylspERSETFLELWGNALL 187
Cdd:pfam14737  71 ILLEPDDNPGLD---------------------EAAELLLHLWYSAFL 97
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 533-657 1.10e-08

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 57.65  E-value: 1.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 533 PSKVLAPTPESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLE 612
Cdd:PTZ00436  222 PAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAAPAK 301

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1958641461 613 LMSPPQTDQTLPLEEMSPP-QAGQSPSLELMSPTRADQTPSLEAIS 657
Cdd:PTZ00436  302 AAAAPAKAAAAPAKAAAPPaKAAAPPAKAATPPAKAAAPPAKAAAA 347
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 525-672 2.06e-08

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 56.88  E-value: 2.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 525 SAVESGPVPSKVLAPTPESINPPQAdqapslevMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQ 604
Cdd:PTZ00436  208 AAAPSGKKSAKAAAPAKAAAAPAKA--------AAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPA 279

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958641461 605 TDQTPSLELMSPPQTDQTLPLEEMSPP-QAGQSPSLELMSPTRADQTPSLEAISLSQADQATSLEAMSP 672
Cdd:PTZ00436  280 KAAAPPAKAAAPPAKAAAAPAKAAAAPaKAAAAPAKAAAPPAKAAAPPAKAATPPAKAAAPPAKAAAAP 348
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 496-674 1.31e-07

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 55.31  E-value: 1.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 496 GFA-PHTGTK-PSETFARFYKLGDSTRGGGDSAVE-SGPVPSKV------LAPTPESINPPQADQAPslEVMSPPKVDQT 566
Cdd:pfam05109 438 GFAaPNTTTGlPSSTHVPTNLTAPASTGPTVSTADvTSPTPAGTtsgaspVTPSPSPRDNGTESKAP--DMTSPTSAVTT 515

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 567 PPLEAMSPPEADQAPPLEAISPSQTDSAPPlEAMNPPQTDQTPSLELMSPPQTDQTLP-LEEMSPPQAGQSPSLELMSPT 645
Cdd:pfam05109 516 PTPNATSPTPAVTTPTPNATSPTLGKTSPT-SAVTTPTPNATSPTPAVTTPTPNATIPtLGKTSPTSAVTTPTPNATSPT 594

                         170       180
                  ....*....|....*....|....*....
gi 1958641461 646 RADQTPSLEAISLSQADQATSLEAMSPPR 674
Cdd:pfam05109 595 VGETSPQANTTNHTLGGTSSTPVVTSPPK 623
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 568-689 3.33e-07

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 53.03  E-value: 3.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 568 PLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQTLPLEEMSPP-QAGQSPSLELMSPTR 646
Cdd:PTZ00436  222 PAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPaKAAAPPAKAAAAPAK 301

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1958641461 647 ADQTPSLEAISLSQADQATSLEAMSPPRADQIPPLEAMSPLQA 689
Cdd:PTZ00436  302 AAAAPAKAAAAPAKAAAPPAKAAAPPAKAATPPAKAAAPPAKA 344
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 559-687 4.65e-07

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 52.64  E-value: 4.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 559 SPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQTLPLEEMSPP-QAGQSP 637
Cdd:PTZ00436  220 AAPAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPaKAAAAP 299

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958641461 638 SLELMSPTRADQTPSLEAISLSQADQATSLEAMSPPRADQIPPLEAMSPL 687
Cdd:PTZ00436  300 AKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAATPPAKAAAPPAKAAAAPV 349
KLF18_N cd21575
N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like ...
 542-677 9.37e-07

N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like factor 18, is a product of a chromosomal neighbor of the KLF17 gene and is likely a product of its duplication. Phylogenetic analyses revealed that mammalian predicted KLF18 proteins and KLF17 proteins experienced elevated rates of evolution and are grouped with KLF1/KLF2/KLF4 and non-mammalian KLF17. KLF18 has been found in the human testis, though it was previously hypothesized to be a pseudogene in extant placental mammals. Mouse KLF18 expression data indicates that it may function in early embryonic development. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF18. Some KLF18 isoforms have duplicated N-terminal domains.


Pssm-ID: 410566 [Multi-domain]  Cd Length: 276  Bit Score: 51.23  E-value: 9.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 542 ESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQ 621
Cdd:cd21575    49 GQMTTPSGDQTLYGGQMTTPNGNQTLYGGQMTTSTGNQTLYGGQMTTSGSDQTLYGGQMTTSSGDQTLYGGQMTTSSGDQ 128

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958641461 622 TLPLEEMSPPQAGQSPSLELMSPTRADQTPSLEAISLSQADQATSLEAMSPPRADQ 677
Cdd:cd21575   129 TLYGGQMTTSTGDQTLYGGQMTTSTGDQTLYGGQMTTSSGDQTLYGGQMTTSTSNQ 184
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 532-730 1.99e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 51.46  E-value: 1.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 532 VPSKVLAPTPESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSL 611
Cdd:pfam05109 448 LPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAV 527

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 612 ELMSPPQTDQTLplEEMSPPQAGQSPSLELMSPTRADQTPSLEAislsqadQATSLEAMSPPRADQIPPLEAMSPLQAEV 691
Cdd:pfam05109 528 TTPTPNATSPTL--GKTSPTSAVTTPTPNATSPTPAVTTPTPNA-------TIPTLGKTSPTSAVTTPTPNATSPTVGET 598

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1958641461 692 VLPLEAISPPQADLAPPPEVISPVQEAlamSSAIAPLKH 730
Cdd:pfam05109 599 SPQANTTNHTLGGTSSTPVVTSPPKNA---TSAVTTGQH 634
PHA03247 PHA03247
large tegument protein UL36; Provisional
 491-727 2.29e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 2.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461  491 IAQAAGFA-PHTGTKPSETFARFYKLGDSTRGGGDSAVESGPVPSKVLAP--------TPESINPPQADQAPSLEVMS-P 560
Cdd:PHA03247  2692 VGSLTSLAdPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPpavpagpaTPGGPARPARPPTTAGPPAPaP 2771

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461  561 PKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQ----TDQTPSLELMSPPQTDQTLPLEEMSPPQA--- 633
Cdd:PHA03247  2772 PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAaalpPAASPAGPLPPPTSAQPTAPPPPPGPPPPslp 2851

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461  634 ----------------GQSPSLELMSPTRAdQTPSLEAISLSQADQATSLEAMSPPRADQIPPLEAMSPLQAEVVLPLEA 697
Cdd:PHA03247  2852 lggsvapggdvrrrppSRSPAAKPAAPARP-PVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQ 2930

                          250       260       270
                   ....*....|....*....|....*....|
gi 1958641461  698 ISPPQADLAPPPEVISPVQEALAMSSAIAP 727
Cdd:PHA03247  2931 PPPPPPPRPQPPLAPTTDPAGAGEPSGAVP 2960
KLF18_N cd21575
N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like ...
 558-677 3.03e-06

N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like factor 18, is a product of a chromosomal neighbor of the KLF17 gene and is likely a product of its duplication. Phylogenetic analyses revealed that mammalian predicted KLF18 proteins and KLF17 proteins experienced elevated rates of evolution and are grouped with KLF1/KLF2/KLF4 and non-mammalian KLF17. KLF18 has been found in the human testis, though it was previously hypothesized to be a pseudogene in extant placental mammals. Mouse KLF18 expression data indicates that it may function in early embryonic development. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF18. Some KLF18 isoforms have duplicated N-terminal domains.


Pssm-ID: 410566 [Multi-domain]  Cd Length: 276  Bit Score: 49.69  E-value: 3.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 558 MSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQTLPLEEMSPPQAGQSP 637
Cdd:cd21575     9 MTTSSGDQTLYGGQMTTPSGDQTLYGGQMTTSFSEQTLYGGQMTTPSGDQTLYGGQMTTPNGNQTLYGGQMTTSTGNQTL 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1958641461 638 SLELMSPTRADQTPSLEAISLSQADQATSLEAMSPPRADQ 677
Cdd:cd21575    89 YGGQMTTSGSDQTLYGGQMTTSSGDQTLYGGQMTTSSGDQ 128
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 505-625 4.70e-06

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 49.56  E-value: 4.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 505 PSETFARFYKLGDSTRGGGDSAVESGPVPSKVLAPTPESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLE 584
Cdd:PTZ00436  229 PAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAAPAKAAAAPAK 308

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1958641461 585 AISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQTLPL 625
Cdd:PTZ00436  309 AAAAPAKAAAPPAKAAAPPAKAATPPAKAAAPPAKAAAAPV 349
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 485-617 6.07e-06

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 49.18  E-value: 6.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 485 SDRVVEIAQAAGFAPHTGTKPSETFARFYKLGDSTRGGGDSAVESGPVPSKVLAPTPESINPPQADQAPSLEVMSPPKVD 564
Cdd:PTZ00436  216 SAKAAAPAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKA 295

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958641461 565 QTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPP 617
Cdd:PTZ00436  296 AAAPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAATPPAKAAAPPAKAAAAP 348
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 533-713 8.44e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.38  E-value: 8.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 533 PSKVLAPTPESIN-----PPQADQAPSLEVMSPPKVdQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQ 607
Cdd:pfam03154 375 PPHLSGPSPFQMNsnlppPPALKPLSSLSTHHPPSA-HPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGL 453

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 608 TPSLELMSPPQ----TDQTLPLEEMSPPQAGQSPSLELMSPtradqtPSLEAISLSQADQATSLEAMSPPRADQIPPLEA 683
Cdd:pfam03154 454 HQVPSQSPFPQhpfvPGGPPPITPPSGPPTSTSSAMPGIQP------PSSASVSSSGPVPAAVSCPLPPVQIKEEALDEA 527

                         170       180       190
                  ....*....|....*....|....*....|
gi 1958641461 684 MSPlqaevvlplEAISPPQADLAPPPEVIS 713
Cdd:pfam03154 528 EEP---------ESPPPPPRSPSPEPTVVN 548
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 577-707 9.16e-06

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 48.41  E-value: 9.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 577 ADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQTLPLEEMSPP-QAGQSPSLELMSPTRADQTPSLEA 655
Cdd:PTZ00436  217 AKAAAPAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPaKAAAPPAKAAAPPAKAAAPPAKAA 296

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958641461 656 ISLSQADQATSLEAMSPPRADQIPPLEAMSPLQAEVVLPLEAISPPQADLAP 707
Cdd:PTZ00436  297 AAPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAATPPAKAAAPPAKAAAAP 348
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 492-631 1.22e-05

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 48.02  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 492 AQAAGFAPHTGTKPSETFARFYKLGDSTRGGGDSAVESGPVPSKVLAPTPESINPPQADQAPSLEVMSPPKVDQTPPLEA 571
Cdd:PTZ00436  209 AAPSGKKSAKAAAPAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKA 288

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 572 MSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQTLPLEEMSPP 631
Cdd:PTZ00436  289 AAPPAKAAAAPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAATPPAKAAAPPAKAAAAP 348
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 570-701 1.62e-05

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 47.64  E-value: 1.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 570 EAMSPPEADQAPPLEAISPSQTdSAPPLEAMNPPQTDQTPSLELMSPPQTDQTLPLEEMSPP-QAGQSPSLELMSPTRAD 648
Cdd:PTZ00436  218 KAAAPAKAAAAPAKAAAPPAKA-AAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPaKAAAPPAKAAAPPAKAA 296

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958641461 649 QTPSLEAISLSQADQATSlEAMSPPRADQIPPLEAMSPLQAEVVLPLEAISPP 701
Cdd:PTZ00436  297 AAPAKAAAAPAKAAAAPA-KAAAPPAKAAAPPAKAATPPAKAAAPPAKAAAAP 348
PTZ00249 PTZ00249
variable surface protein Vir28; Provisional
 530-700 9.07e-05

variable surface protein Vir28; Provisional


Pssm-ID: 140276 [Multi-domain]  Cd Length: 516  Bit Score: 45.79  E-value: 9.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 530 GPVPSKVLAPTPESINPPQADQAPSLEVMSPP-------KVDQTPPLEAMSPPE----ADQAPPLE---AISPSQTDSAP 595
Cdd:PTZ00249  252 GRPPVETRPPNPVSVSSPQAHGRHPGETHTPPlvtvpssKAHDRNPVQTPTPTSvsgySSQAKGLEkqaGGESERTSSVP 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 596 PLEAMNP-PQTDQTPSLELMSPPQTDQTlplEEMSPPQAGQSPSLELMSPTRADQTPSLEAIS--LSQADQATSLEAMSP 672
Cdd:PTZ00249  332 SEQFPLPlPVLLPLGQSGPLESSESEET---DEYAGPKGLPEPELELVELQEEDQRHGLKHDVdtFREDEEDTFLQEGDQ 408

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1958641461 673 PRADQIPPLEA---MSPLQAEVVLPLEAISP 700
Cdd:PTZ00249  409 PAGSMQSTFDTgtiMGTIKGAVSNVLEAVEP 439
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 521-727 1.24e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.36  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 521 GGGDSAVESGPVPSKVLAPTPESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAM 600
Cdd:PRK07764  590 PAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGW 669

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 601 NPPQTDQTPSLELMSPPQTDQTLPLEEmSPPQAGQSPSLELMSPTRADQ--TPSLEAISLSQADQATSLEAMSPPRADQI 678
Cdd:PRK07764  670 PAKAGGAAPAAPPPAPAPAAPAAPAGA-APAQPAPAPAATPPAGQADDPaaQPPQAAQGASAPSPAADDPVPLPPEPDDP 748

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1958641461 679 PpleamSPLQAEVVLPLEAISPPQADLAPPPEVISPVQEALAMSSAIAP 727
Cdd:PRK07764  749 P-----DPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPS 792
PHA03247 PHA03247
large tegument protein UL36; Provisional
 522-728 1.26e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 1.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461  522 GGDSAVESGPVPSKVLAPTPESINPPQADQAPSLEVMSPPKVDQTPPLEAmspPEADQAPPLEAISPSQTDSAPPLEAMN 601
Cdd:PHA03247  2602 VDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPER---PRDDPAPGRVSRPRRARRLGRAAQASS 2678

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461  602 PPQTDQTPSL--------ELMSPPQTDQT-------------LPLEEMSPPQAGQSPSLELMSPTRADQTPSLEAISLSQ 660
Cdd:PHA03247  2679 PPQRPRRRAArptvgsltSLADPPPPPPTpepaphalvsatpLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA 2758

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958641461  661 ADQATS-LEAMSPPRADQIPPLEAMSPLQAEVVLPLEAISPPQADLAPPPEVISPVQEALAMSSAIAPL 728
Cdd:PHA03247  2759 RPPTTAgPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP 2827
PHA03247 PHA03247
large tegument protein UL36; Provisional
 525-722 1.30e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 1.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461  525 SAVESGPVPSKVLAPTPESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEAD---QAPPLEAISPSQTDSAPPLEAMN 601
Cdd:PHA03247  2808 PAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDvrrRPPSRSPAAKPAAPARPPVRRLA 2887

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461  602 PPQTDQTPSlELMSPPQTDQTLPLEEMSPPQAGQSPSLELMSPTRADQTPSLEAISLsqADQATSLEAMSPPRADQIPPL 681
Cdd:PHA03247  2888 RPAVSRSTE-SFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPL--APTTDPAGAGEPSGAVPQPWL 2964

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1958641461  682 EAMSPLQAEVVLPLeaiSPPQADLAPPPEVISPVQEALAMS 722
Cdd:PHA03247  2965 GALVPGRVAVPRFR---VPQPAPSREAPASSTPPLTGHSLS 3002
KLF18_N cd21575
N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like ...
 544-677 2.02e-04

N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like factor 18, is a product of a chromosomal neighbor of the KLF17 gene and is likely a product of its duplication. Phylogenetic analyses revealed that mammalian predicted KLF18 proteins and KLF17 proteins experienced elevated rates of evolution and are grouped with KLF1/KLF2/KLF4 and non-mammalian KLF17. KLF18 has been found in the human testis, though it was previously hypothesized to be a pseudogene in extant placental mammals. Mouse KLF18 expression data indicates that it may function in early embryonic development. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF18. Some KLF18 isoforms have duplicated N-terminal domains.


Pssm-ID: 410566 [Multi-domain]  Cd Length: 276  Bit Score: 43.91  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 544 INPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQTL 623
Cdd:cd21575     9 MTTSSGDQTLYGGQMTTPSGDQTLYGGQMTTSFSEQTLYGGQMTTPSGDQTLYGGQMTTPNGNQTLYGGQMTTSTGNQTL 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958641461 624 PLEEMSPPQAGQSPSLELMSPTRADQTPSLEAISLSQADQATSLEAMSPPRADQ 677
Cdd:cd21575    89 YGGQMTTSGSDQTLYGGQMTTSSGDQTLYGGQMTTSSGDQTLYGGQMTTSTGDQ 142
KLF18_N cd21575
N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like ...
 544-677 2.17e-04

N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like factor 18, is a product of a chromosomal neighbor of the KLF17 gene and is likely a product of its duplication. Phylogenetic analyses revealed that mammalian predicted KLF18 proteins and KLF17 proteins experienced elevated rates of evolution and are grouped with KLF1/KLF2/KLF4 and non-mammalian KLF17. KLF18 has been found in the human testis, though it was previously hypothesized to be a pseudogene in extant placental mammals. Mouse KLF18 expression data indicates that it may function in early embryonic development. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF18. Some KLF18 isoforms have duplicated N-terminal domains.


Pssm-ID: 410566 [Multi-domain]  Cd Length: 276  Bit Score: 43.91  E-value: 2.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 544 INPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQTL 623
Cdd:cd21575    65 MTTPNGNQTLYGGQMTTSTGNQTLYGGQMTTSGSDQTLYGGQMTTSSGDQTLYGGQMTTSSGDQTLYGGQMTTSTGDQTL 144

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958641461 624 PLEEMSPPQAGQSPSLELMSPTRADQTPSLEAISLSQADQATSLEAMSPPRADQ 677
Cdd:cd21575   145 YGGQMTTSTGDQTLYGGQMTTSSGDQTLYGGQMTTSTSNQTLYGGQMTTSSGNQ 198
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
525-720 4.57e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 4.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 525 SAVESGPVPSKVLAPTPESINPPQADQAPSLEVMSP-----PKVDQTPPLEAMSPPEADQAP---PLEAISPSQTDSAPP 596
Cdd:PRK12323  393 AAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPapealAAARQASARGPGGAPAPAPAPaaaPAAAARPAAAGPRPV 472

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 597 LEAMNPPQTDQTPSLElmSPPQTDQTLPLEEMSPPQAgqSPSLELMSPTRADqtpsleAISLSQADQATSLEamSPPRAD 676
Cdd:PRK12323  473 AAAAAAAPARAAPAAA--PAPADDDPPPWEELPPEFA--SPAPAQPDAAPAG------WVAESIPDPATADP--DDAFET 540

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1958641461 677 QIP-PLEAMSPLQAEVVLPLEAISPPQADLAPPPEVISPVQEALA 720
Cdd:PRK12323  541 LAPaPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALA 585
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
521-709 4.93e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.33  E-value: 4.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 521 GGGDSA---VESGPVPSKVLAPTPESINPPQADQAPSLEVMSPPKVDQTPPL----EAMSP-----PEADQAPPLEAISP 588
Cdd:PRK12323  368 SGGGAGpatAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVaaapARRSPapealAAARQASARGPGGA 447

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 589 SQTDSAPpleAMNPPQTDQTPSLELMSPPQTDQTLPLEEMSPPQAGQSPSlelMSPTRADQTPSLEAISLSQAD----QA 664
Cdd:PRK12323  448 PAPAPAP---AAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADD---DPPPWEELPPEFASPAPAQPDaapaGW 521

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1958641461 665 TSLEAMSPPRADQIPPLEAMSPLQAEVVLPLEAISPPQADLAPPP 709
Cdd:PRK12323  522 VAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPP 566
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 534-690 7.73e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 7.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 534 SKVLAPTPESINPPQAdqapsleVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLEL 613
Cdd:pfam05109 511 SAVTTPTPNATSPTPA-------VTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAV 583

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 614 MSPPQTDQTLPLEEMSPPQAGQSPSLELMSPTRADQTPSLEAIS---------LSQADQATSL------EAMSPPRAD-- 676
Cdd:pfam05109 584 TTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSavttgqhniTSSSTSSMSLrpssisETLSPSTSDns 663

                         170
                  ....*....|....*.
gi 1958641461 677 --QIPPLEAMSPLQAE 690
Cdd:pfam05109 664 tsHMPLLTSAHPTGGE 679
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 524-724 8.13e-04

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 42.61  E-value: 8.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 524 DSAVESGPVPSKVLAPTPESinpPQADQAPslevmSPPKVDQTPPLeamSPPEA--DQAPPLEAI---SPSQTDSAPPLE 598
Cdd:PLN03209  334 DAADGPKPVPTKPVTPEAPS---PPIEEEP-----PQPKAVVPRPL---SPYTAyeDLKPPTSPIptpPSSSPASSKSVD 402

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 599 AMNPPQT-DQTPSLELMS--------PPQTDQTLPL------EEMSPPQAgQSPSLELMSPTRADQTPSLEAISLSQADQ 663
Cdd:PLN03209  403 AVAKPAEpDVVPSPGSASnvpevepaQVEAKKTRPLspyaryEDLKPPTS-PSPTAPTGVSPSVSSTSSVPAVPDTAPAT 481

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958641461 664 A-TSLEAMSPPRADQIPPLEAMSPLQAEVVlPLEAISPPQADLAPPPEVISPVQEALAMSSA 724
Cdd:PLN03209  482 AaTDAAAPPPANMRPLSPYAVYDDLKPPTS-PSPAAPVGKVAPSSTNEVVKVGNSAPPTALA 542
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 492-730 1.41e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.08  E-value: 1.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461  492 AQAAGFAPHTGTKPSET-----FARFYKLGDSTRGGGDSAVESG----PVPSKVLAPTPESINPPQADQAPSLEVMSPPK 562
Cdd:PHA03307    15 AEGGEFFPRPPATPGDAaddllSGSQGQLVSDSAELAAVTVVAGaaacDRFEPPTGPPPGPGTEAPANESRSTPTWSLST 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461  563 VDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPleamnppqtdqTPSLELMSPPQTDQTLPLEEMSPPQAGQSPSlelm 642
Cdd:PHA03307    95 LAPASPAREGSPTPPGPSSPDPPPPTPPPASPPP-----------SPAPDLSEMLRPVGSPGPPPAASPPAAGASP---- 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461  643 SPTRADQTPSLEAISLSQADQATSlEAMSPPRADQippleamsplqaevvlpleAISPPQADLAPPPEVISPVQEALAMS 722
Cdd:PHA03307   160 AAVASDAASSRQAALPLSSPEETA-RAPSSPPAEP-------------------PPSTPPAAASPRPPRRSSPISASASS 219


                   ....*...
gi 1958641461  723 SAIAPLKH 730
Cdd:PHA03307   220 PAPAPGRS 227
PLN03131 PLN03131
hypothetical protein; Provisional
 557-701 1.55e-03

hypothetical protein; Provisional


Pssm-ID: 178677 [Multi-domain]  Cd Length: 705  Bit Score: 42.07  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 557 VMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQTL-PLEEMSP----P 631
Cdd:PLN03131  350 VAPEAAAPMAPPIDLFQLPATSPAPPVDLFEIPPLDPAPAINAYQPPQTSLPSSIDLFGGITQQQSInSLDEKSPelsiP 429

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958641461 632 QAGQSPSLELMSPTRADQTP-SLEAISLSQADQATSleamsppRADQIPPLEA---MSPLQAEVVLPLEAISPP 701
Cdd:PLN03131  430 KNEGWATFDGIQPIASTPGNeNLTPFSIGPSMAGSA-------NFDQVPSLDKgmqWPPFQNSSDEESASGPAP 496
PHA03378 PHA03378
EBNA-3B; Provisional
 529-711 1.66e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.98  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 529 SGPVPSKVLAPTPESinpPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQT 608
Cdd:PHA03378  606 PEPPTTQSHIPETSA---PRQWPMPLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTGAN 682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 609 PSLELMSPPQTDQTLPLE--EMSPPQAGQSPslelMSPTRADQTPSLEAISLSQADQATSlEAMSPPRADQIPPLEAMSP 686
Cdd:PHA03378  683 TMLPIQWAPGTMQPPPRAptPMRPPAAPPGR----AQRPAAATGRARPPAAAPGRARPPA-AAPGRARPPAAAPGRARPP 757

                         170       180
                  ....*....|....*....|....*
gi 1958641461 687 LQAEVVLPLEAISPPQADLAPPPEV 711
Cdd:PHA03378  758 AAAPGRARPPAAAPGAPTPQPPPQA 782
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 539-727 1.81e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 539 PTPESINPPQADQAPSLEVMSPP---KVDQTPPLeaMSPPEADQAPPLEAISpSQTDSAPPLEAMNPPQTDQTPSLELMS 615
Cdd:pfam03154 255 PPPPSQVSPQPLPQPSLHGQMPPmphSLQTGPSH--MQHPVPPQPFPLTPQS-SQSQVPPGPSPAAPGQSQQRIHTPPSQ 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 616 PPQTDQTLPLEEMSPPQAGQSPSLELMSPTRADQTPSLEAislsqADQATSLEAMSPPRAD-QIPPLEAMSPLQAevvlp 694
Cdd:pfam03154 332 SQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQS-----HKHPPHLSGPSPFQMNsNLPPPPALKPLSS----- 401

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1958641461 695 LEAISPPQADlaPPPEVISPVQEALAMSSAIAP 727
Cdd:pfam03154 402 LSTHHPPSAH--PPPLQLMPQSQQLPPPPAQPP 432
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 492-711 1.94e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 1.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 492 AQAAGFAPHTGTKPSETFARFYKLGDSTRGGG--DSAVESGPVPSKVLAPTPESINPPQADQAPSLEVMSPP-KVDQTPP 568
Cdd:PRK07764  592 PGAAGGEGPPAPASSGPPEEAARPAAPAAPAApaAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASdGGDGWPA 671

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 569 LEAMSPPEADQAPPLEAISPSQTDSAPPLEAmnpPQTDQTPSLELMSPPQTDQTLPLEEMSPPQAGQSPSLELMSPTRAD 648
Cdd:PRK07764  672 KAGGAAPAAPPPAPAPAAPAAPAGAAPAQPA---PAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDP 748

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958641461 649 QTPSLEAISLSQADQAtsleamsPPRADQIPPLEAMSPLQAEVVLPLEAISPPQADLAPPPEV 711
Cdd:PRK07764  749 PDPAGAPAQPPPPPAP-------APAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEV 804
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 524-732 1.99e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.61  E-value: 1.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461  524 DSAVESGPVPSKVLAP--------------TPESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPS 589
Cdd:PRK10263   338 EPVTQTPPVASVDVPPaqptvawqpvpgpqTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQ 417

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461  590 QTDSAPPLEAmNPPQTDQTPSLELMSPPQTDQTLPLEEMSPPQAGQSPSLELMSPTRAD----QTPSLEAISLSQADQAt 665
Cdd:PRK10263   418 QPYYAPAPEQ-PAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEplyqQPQPVEQQPVVEPEPV- 495

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461  666 sLEAMSPPRadqiPPL--------------EAMSPLQAEVVLPLEAISPPQADLAPP-PEVISPVQEALAMSSAIAPLKH 730
Cdd:PRK10263   496 -VEETKPAR----PPLyyfeeveekrarerEQLAAWYQPIPEPVKEPEPIKSSLKAPsVAAVPPVEAAAAVSPLASGVKK 570


                   ..
gi 1958641461  731 VT 732
Cdd:PRK10263   571 AT 572
PHA03247 PHA03247
large tegument protein UL36; Provisional
 518-727 2.20e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 2.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461  518 STRGGGDSAVESGPVPSKVLAPTPESINPPQADQAPS--LEVMSPPKVDQTPPLEAMSPPEADQA-----PPLEAISPSQ 590
Cdd:PHA03247  2635 ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGraAQASSPPQRPRRRAARPTVGSLTSLAdppppPPTPEPAPHA 2714

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461  591 TDSAPPLEAMNPPQTDQTPSLELMS---PPQTDQTLPLEEMSPPQAGQSPSLELMSPTRADQT-PSLEAISLSQADQATS 666
Cdd:PHA03247  2715 LVSATPLPPGPAAARQASPALPAAPappAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAgPPRRLTRPAVASLSES 2794

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958641461  667 LEAMSPPRADQIPPLEAMSPLQAE--VVLPLEAISPPQADL-APPPEVISPVQEALAMSSAIAP 727
Cdd:PHA03247  2795 RESLPSPWDPADPPAAVLAPAAALppAASPAGPLPPPTSAQpTAPPPPPGPPPPSLPLGGSVAP 2858
KLF18_N cd21575
N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like ...
 544-650 2.25e-03

N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like factor 18, is a product of a chromosomal neighbor of the KLF17 gene and is likely a product of its duplication. Phylogenetic analyses revealed that mammalian predicted KLF18 proteins and KLF17 proteins experienced elevated rates of evolution and are grouped with KLF1/KLF2/KLF4 and non-mammalian KLF17. KLF18 has been found in the human testis, though it was previously hypothesized to be a pseudogene in extant placental mammals. Mouse KLF18 expression data indicates that it may function in early embryonic development. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF18. Some KLF18 isoforms have duplicated N-terminal domains.


Pssm-ID: 410566 [Multi-domain]  Cd Length: 276  Bit Score: 40.44  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 544 INPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQT-------PSLELMSP 616
Cdd:cd21575   135 MTTSTGDQTLYGGQMTTSTGDQTLYGGQMTTSSGDQTLYGGQMTTSTSNQTLYGGQMTTSSGNQTlyggqmtTPITLSGG 214

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1958641461 617 PQT----DQTLPLEEMSPPQAGQSPSLELMSPTRADQT 650
Cdd:cd21575   215 QMTtstgDQTLYGGQMTSHQSSSLPYPGQLTFSSSHLI 252
KLF18_N cd21575
N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like ...
 544-688 2.77e-03

N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like factor 18, is a product of a chromosomal neighbor of the KLF17 gene and is likely a product of its duplication. Phylogenetic analyses revealed that mammalian predicted KLF18 proteins and KLF17 proteins experienced elevated rates of evolution and are grouped with KLF1/KLF2/KLF4 and non-mammalian KLF17. KLF18 has been found in the human testis, though it was previously hypothesized to be a pseudogene in extant placental mammals. Mouse KLF18 expression data indicates that it may function in early embryonic development. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF18. Some KLF18 isoforms have duplicated N-terminal domains.


Pssm-ID: 410566 [Multi-domain]  Cd Length: 276  Bit Score: 40.44  E-value: 2.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 544 INPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQTL 623
Cdd:cd21575    79 MTTSTGNQTLYGGQMTTSGSDQTLYGGQMTTSSGDQTLYGGQMTTSSGDQTLYGGQMTTSTGDQTLYGGQMTTSTGDQTL 158

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958641461 624 PLEEMSPPQAGQSPSLELMSPTRADQTPSLEAISLSQADQAT-----------SLEAMSPPRADQIPPLEAMSPLQ 688
Cdd:cd21575   159 YGGQMTTSSGDQTLYGGQMTTSTSNQTLYGGQMTTSSGNQTLyggqmttpitlSGGQMTTSTGDQTLYGGQMTSHQ 234
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 525-708 3.25e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 3.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 525 SAVESGPVPSKVLAPTPESINPPQADQAPSlevmsPPK--VDQTPPLEAMSPPEADqaPPLEAISPsqtdsaPPLEAMNP 602
Cdd:pfam03154 196 TAGPTPSAPSVPPQGSPATSQPPNQTQSTA-----APHtlIQQTPTLHPQRLPSPH--PPLQPMTQ------PPPPSQVS 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 603 PQTDQTPSLELMSPP--QTDQTLPLEEMSPPQAGQSPSLELMSPTRADQTPSLEAISLSQADQAT-----SLEAMSPPRA 675
Cdd:pfam03154 263 PQPLPQPSLHGQMPPmpHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTppsqsQLQSQQPPRE 342

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1958641461 676 DQIPPLE-AMSPLQAEVVLPLEAISPPQADLAPP 708
Cdd:pfam03154 343 QPLPPAPlSMPHIKPPPTTPIPQLPNPQSHKHPP 376
PHA03247 PHA03247
large tegument protein UL36; Provisional
 498-701 5.27e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 5.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461  498 APHTGTKPSETFARFYKLGDSTRGGGDSAVEsgpvpskvlAPTPESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEA 577
Cdd:PHA03247  2835 QPTAPPPPPGPPPPSLPLGGSVAPGGDVRRR---------PPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP 2905

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461  578 DQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDqtlpleemspPQAGQSPSLELMSPTRADQTPSLEAIS 657
Cdd:PHA03247  2906 ERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD----------PAGAGEPSGAVPQPWLGALVPGRVAVP 2975

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1958641461  658 LSQADQ-ATSLEA-MSPPRADQIPPLEAMSPLQAEVVLPLEAISPP 701
Cdd:PHA03247  2976 RFRVPQpAPSREApASSTPPLTGHSLSRVSSWASSLALHEETDPPP 3021
PHA03247 PHA03247
large tegument protein UL36; Provisional
 538-727 5.27e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 5.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461  538 APTPESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPqtdqtpslelmsPP 617
Cdd:PHA03247  2495 APDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEPVHPRMLTWIRGLEELASDDAGDPPPPLPPAAP------------PA 2562

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461  618 QTDQTLPLEEMSPPQAGQSPSLELMSPTRADQTPSLEAISLSQADQATSLEAMSPPRADQIPPLEAMSP----LQAEVVL 693
Cdd:PHA03247  2563 APDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPspaaNEPDPHP 2642

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1958641461  694 PLEAISPPQADLAPPPEVISPVQEALAMSSAIAP 727
Cdd:PHA03247  2643 PPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQA 2676
PRK12495 PRK12495
hypothetical protein; Provisional
 549-675 8.59e-03

hypothetical protein; Provisional


Pssm-ID: 183558 [Multi-domain]  Cd Length: 226  Bit Score: 38.31  E-value: 8.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641461 549 ADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPplEAMNPPQTDQ--------TPSLELMSPPQTD 620
Cdd:PRK12495   78 AGDGAEATAPSDAGSQASPDDDAQPAAEAEAADQSAPPEASSTSATD--EAATDPPATAaardgptpDPTAQPATPDERR 155

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958641461 621 QTLPLEEMSPPQAGQSPSLELMSPTRADQTPSLEAISLSQADQATslEAMSPPRA 675
Cdd:PRK12495  156 SPRQRPPVSGEPPTPSTPDAHVAGTLQAARESLVETLARFARRAA--ATDDPRRA 208
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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