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Conserved domains on  [gi|1958641464|ref|XP_038957452|]
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dynein axonemal assembly factor 3 isoform X3 [Rattus norvegicus]

Protein Classification

molybdopterin molybdotransferase MoeA; ribosomal eL19 family protein( domain architecture ID 13864566)

molybdopterin molybdotransferase MoeA mediates molybdenum ligation to molybdopterin| ribosomal eL19 family protein similar to Trypanosoma cruzi ribosomal protein L19-like protein that is part of the ribosome

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4471 pfam14740
Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and ...
 175-455 3.44e-149

Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916. This domain is more C-terminal in many members to DUF4470, pfam14737.


:

Pssm-ID: 464292  Cd Length: 303  Bit Score: 435.16  E-value: 3.44e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 175 LSLRPLKFRERDALEAVFRFWSGGEkgPEVFPMSRLWDSRLRHYLGSRYDARRGVADWDLRMKLHDRGAQVIHFHEFRRW 254
Cdd:pfam14740   1 LDLSLLKFKERDQLEAIFKFWRRPE--SHPFDIEKYWDQRLRQYLGTRYDSRKGVFDWDLHMKLHDRGANVIHSQEYRRW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 255 RDTGVAFELRDlSAYHVPNRTMASGRLLSHRGERVAARGYWGDIATGPFVAFGIEADDKSLLRTSNGQPVKTASEITQHN 334
Cdd:pfam14740  79 RETGVAFEFRE-GEYQVPNKTLASGRVGNHKGEKVAHRGYWGDIVTGPYISFGIETEDESLLKTSNGQHVKTATDVSERN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 335 VTELFRDVAAWRGPRA--------------IKGNVEETKSPEPDAPAQ---------EPFTIHFLPLDSSQTLHHKTCYR 391
Cdd:pfam14740 158 LLALFHELQTREPYEHdstdsarygsvqllMTELLPEGEDSEEENTADddksdlitlPGVKVHFLPLDSLRKLPHKSKYR 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958641464 392 GRFQLLYVSCGMIHLLSPELGACVAPGGNLVVELARYLVDLRPKELKAFSDRVVEIAQAAGFAP 455
Cdd:pfam14740 238 NFFDIIFVSASMVHFLKPELFQILAPGAVLVVETAKYLVDLRKEQLQEFAEKVKELAKEAGFKP 301
DUF4470 pfam14737
Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and ...
 16-143 3.24e-26

Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916.


:

Pssm-ID: 464289  Cd Length: 97  Bit Score: 102.99  E-value: 3.24e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464  16 WWGLSPALDLQAESPPVDPDsqsktehkipELDALLLGSVDGRHMLRTLARAMLWPLRRFNFYVLENNLEAVARHMLIFS 95
Cdd:pfam14737   1 PWGNTPALDLLQLLPKNEGE----------DLNILLLGSGDLRNVLKTIASLPETYSGKLHITLNDRDPEVVARNILLLL 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1958641464  96 LALEEPEKMGLQgpelvqfakspsmfhpsylspERSETFLELWGNALL 143
Cdd:pfam14737  71 ILLEPDDNPGLD---------------------EAAELLLHLWYSAFL 97
PTZ00436 super family cl33183
60S ribosomal protein L19-like protein; Provisional
 489-611 1.50e-08

60S ribosomal protein L19-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00436:

Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 57.27  E-value: 1.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 489 PSKVLAPTPESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLE 568
Cdd:PTZ00436  222 PAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAAPAK 301

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1958641464 569 LMSPPQTDQTLPLEEMSPP-QAGQSPSLELMSPTRADQTPSLEA 611
Cdd:PTZ00436  302 AAAAPAKAAAAPAKAAAPPaKAAAPPAKAATPPAKAAAPPAKAA 345
 
Name Accession Description Interval E-value
DUF4471 pfam14740
Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and ...
 175-455 3.44e-149

Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916. This domain is more C-terminal in many members to DUF4470, pfam14737.


Pssm-ID: 464292  Cd Length: 303  Bit Score: 435.16  E-value: 3.44e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 175 LSLRPLKFRERDALEAVFRFWSGGEkgPEVFPMSRLWDSRLRHYLGSRYDARRGVADWDLRMKLHDRGAQVIHFHEFRRW 254
Cdd:pfam14740   1 LDLSLLKFKERDQLEAIFKFWRRPE--SHPFDIEKYWDQRLRQYLGTRYDSRKGVFDWDLHMKLHDRGANVIHSQEYRRW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 255 RDTGVAFELRDlSAYHVPNRTMASGRLLSHRGERVAARGYWGDIATGPFVAFGIEADDKSLLRTSNGQPVKTASEITQHN 334
Cdd:pfam14740  79 RETGVAFEFRE-GEYQVPNKTLASGRVGNHKGEKVAHRGYWGDIVTGPYISFGIETEDESLLKTSNGQHVKTATDVSERN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 335 VTELFRDVAAWRGPRA--------------IKGNVEETKSPEPDAPAQ---------EPFTIHFLPLDSSQTLHHKTCYR 391
Cdd:pfam14740 158 LLALFHELQTREPYEHdstdsarygsvqllMTELLPEGEDSEEENTADddksdlitlPGVKVHFLPLDSLRKLPHKSKYR 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958641464 392 GRFQLLYVSCGMIHLLSPELGACVAPGGNLVVELARYLVDLRPKELKAFSDRVVEIAQAAGFAP 455
Cdd:pfam14740 238 NFFDIIFVSASMVHFLKPELFQILAPGAVLVVETAKYLVDLRKEQLQEFAEKVKELAKEAGFKP 301
DUF4470 pfam14737
Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and ...
 16-143 3.24e-26

Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916.


Pssm-ID: 464289  Cd Length: 97  Bit Score: 102.99  E-value: 3.24e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464  16 WWGLSPALDLQAESPPVDPDsqsktehkipELDALLLGSVDGRHMLRTLARAMLWPLRRFNFYVLENNLEAVARHMLIFS 95
Cdd:pfam14737   1 PWGNTPALDLLQLLPKNEGE----------DLNILLLGSGDLRNVLKTIASLPETYSGKLHITLNDRDPEVVARNILLLL 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1958641464  96 LALEEPEKMGLQgpelvqfakspsmfhpsylspERSETFLELWGNALL 143
Cdd:pfam14737  71 ILLEPDDNPGLD---------------------EAAELLLHLWYSAFL 97
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 489-611 1.50e-08

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 57.27  E-value: 1.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 489 PSKVLAPTPESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLE 568
Cdd:PTZ00436  222 PAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAAPAK 301

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1958641464 569 LMSPPQTDQTLPLEEMSPP-QAGQSPSLELMSPTRADQTPSLEA 611
Cdd:PTZ00436  302 AAAAPAKAAAAPAKAAAPPaKAAAPPAKAATPPAKAAAPPAKAA 345
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 452-630 1.49e-07

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 54.92  E-value: 1.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 452 GFA-PHTGTK-PSETFARFYKLGDSTRGGGDSAVE-SGPVPSKV------LAPTPESINPPQADQAPslEVMSPPKVDQT 522
Cdd:pfam05109 438 GFAaPNTTTGlPSSTHVPTNLTAPASTGPTVSTADvTSPTPAGTtsgaspVTPSPSPRDNGTESKAP--DMTSPTSAVTT 515

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 523 PPLEAMSPPEADQAPPLEAISPSQTDSAPPlEAMNPPQTDQTPSLELMSPPQTDQTLP-LEEMSPPQAGQSPSLELMSPT 601
Cdd:pfam05109 516 PTPNATSPTPAVTTPTPNATSPTLGKTSPT-SAVTTPTPNATSPTPAVTTPTPNATIPtLGKTSPTSAVTTPTPNATSPT 594

                         170       180
                  ....*....|....*....|....*....
gi 1958641464 602 RADQTPSLEAISLSQADQATSLEAMSPPR 630
Cdd:pfam05109 595 VGETSPQANTTNHTLGGTSSTPVVTSPPK 623
KLF18_N cd21575
N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like ...
 498-633 8.66e-07

N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like factor 18, is a product of a chromosomal neighbor of the KLF17 gene and is likely a product of its duplication. Phylogenetic analyses revealed that mammalian predicted KLF18 proteins and KLF17 proteins experienced elevated rates of evolution and are grouped with KLF1/KLF2/KLF4 and non-mammalian KLF17. KLF18 has been found in the human testis, though it was previously hypothesized to be a pseudogene in extant placental mammals. Mouse KLF18 expression data indicates that it may function in early embryonic development. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF18. Some KLF18 isoforms have duplicated N-terminal domains.


Pssm-ID: 410566 [Multi-domain]  Cd Length: 276  Bit Score: 51.23  E-value: 8.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 498 ESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQ 577
Cdd:cd21575    49 GQMTTPSGDQTLYGGQMTTPNGNQTLYGGQMTTSTGNQTLYGGQMTTSGSDQTLYGGQMTTSSGDQTLYGGQMTTSSGDQ 128

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958641464 578 TLPLEEMSPPQAGQSPSLELMSPTRADQTPSLEAISLSQADQATSLEAMSPPRADQ 633
Cdd:cd21575   129 TLYGGQMTTSTGDQTLYGGQMTTSTGDQTLYGGQMTTSSGDQTLYGGQMTTSTSNQ 184
 
Name Accession Description Interval E-value
DUF4471 pfam14740
Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and ...
 175-455 3.44e-149

Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916. This domain is more C-terminal in many members to DUF4470, pfam14737.


Pssm-ID: 464292  Cd Length: 303  Bit Score: 435.16  E-value: 3.44e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 175 LSLRPLKFRERDALEAVFRFWSGGEkgPEVFPMSRLWDSRLRHYLGSRYDARRGVADWDLRMKLHDRGAQVIHFHEFRRW 254
Cdd:pfam14740   1 LDLSLLKFKERDQLEAIFKFWRRPE--SHPFDIEKYWDQRLRQYLGTRYDSRKGVFDWDLHMKLHDRGANVIHSQEYRRW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 255 RDTGVAFELRDlSAYHVPNRTMASGRLLSHRGERVAARGYWGDIATGPFVAFGIEADDKSLLRTSNGQPVKTASEITQHN 334
Cdd:pfam14740  79 RETGVAFEFRE-GEYQVPNKTLASGRVGNHKGEKVAHRGYWGDIVTGPYISFGIETEDESLLKTSNGQHVKTATDVSERN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 335 VTELFRDVAAWRGPRA--------------IKGNVEETKSPEPDAPAQ---------EPFTIHFLPLDSSQTLHHKTCYR 391
Cdd:pfam14740 158 LLALFHELQTREPYEHdstdsarygsvqllMTELLPEGEDSEEENTADddksdlitlPGVKVHFLPLDSLRKLPHKSKYR 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958641464 392 GRFQLLYVSCGMIHLLSPELGACVAPGGNLVVELARYLVDLRPKELKAFSDRVVEIAQAAGFAP 455
Cdd:pfam14740 238 NFFDIIFVSASMVHFLKPELFQILAPGAVLVVETAKYLVDLRKEQLQEFAEKVKELAKEAGFKP 301
DUF4470 pfam14737
Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and ...
 16-143 3.24e-26

Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916.


Pssm-ID: 464289  Cd Length: 97  Bit Score: 102.99  E-value: 3.24e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464  16 WWGLSPALDLQAESPPVDPDsqsktehkipELDALLLGSVDGRHMLRTLARAMLWPLRRFNFYVLENNLEAVARHMLIFS 95
Cdd:pfam14737   1 PWGNTPALDLLQLLPKNEGE----------DLNILLLGSGDLRNVLKTIASLPETYSGKLHITLNDRDPEVVARNILLLL 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1958641464  96 LALEEPEKMGLQgpelvqfakspsmfhpsylspERSETFLELWGNALL 143
Cdd:pfam14737  71 ILLEPDDNPGLD---------------------EAAELLLHLWYSAFL 97
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 489-611 1.50e-08

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 57.27  E-value: 1.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 489 PSKVLAPTPESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLE 568
Cdd:PTZ00436  222 PAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAAPAK 301

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1958641464 569 LMSPPQTDQTLPLEEMSPP-QAGQSPSLELMSPTRADQTPSLEA 611
Cdd:PTZ00436  302 AAAAPAKAAAAPAKAAAPPaKAAAPPAKAATPPAKAAAPPAKAA 345
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 481-628 2.86e-08

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 56.11  E-value: 2.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 481 SAVESGPVPSKVLAPTPESINPPQAdqapslevMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQ 560
Cdd:PTZ00436  208 AAAPSGKKSAKAAAPAKAAAAPAKA--------AAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPA 279

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958641464 561 TDQTPSLELMSPPQTDQTLPLEEMSPP-QAGQSPSLELMSPTRADQTPSLEAISLSQADQATSLEAMSP 628
Cdd:PTZ00436  280 KAAAPPAKAAAPPAKAAAAPAKAAAAPaKAAAAPAKAAAPPAKAAAPPAKAATPPAKAAAPPAKAAAAP 348
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 452-630 1.49e-07

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 54.92  E-value: 1.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 452 GFA-PHTGTK-PSETFARFYKLGDSTRGGGDSAVE-SGPVPSKV------LAPTPESINPPQADQAPslEVMSPPKVDQT 522
Cdd:pfam05109 438 GFAaPNTTTGlPSSTHVPTNLTAPASTGPTVSTADvTSPTPAGTtsgaspVTPSPSPRDNGTESKAP--DMTSPTSAVTT 515

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 523 PPLEAMSPPEADQAPPLEAISPSQTDSAPPlEAMNPPQTDQTPSLELMSPPQTDQTLP-LEEMSPPQAGQSPSLELMSPT 601
Cdd:pfam05109 516 PTPNATSPTPAVTTPTPNATSPTLGKTSPT-SAVTTPTPNATSPTPAVTTPTPNATIPtLGKTSPTSAVTTPTPNATSPT 594

                         170       180
                  ....*....|....*....|....*....
gi 1958641464 602 RADQTPSLEAISLSQADQATSLEAMSPPR 630
Cdd:pfam05109 595 VGETSPQANTTNHTLGGTSSTPVVTSPPK 623
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 524-645 4.43e-07

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 52.64  E-value: 4.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 524 PLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQTLPLEEMSPP-QAGQSPSLELMSPTR 602
Cdd:PTZ00436  222 PAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPaKAAAPPAKAAAAPAK 301

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1958641464 603 ADQTPSLEAISLSQADQATSLEAMSPPRADQIPPLEAMSPLQA 645
Cdd:PTZ00436  302 AAAAPAKAAAAPAKAAAPPAKAAAPPAKAATPPAKAAAPPAKA 344
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 515-643 5.98e-07

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 52.26  E-value: 5.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 515 SPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQTLPLEEMSPP-QAGQSP 593
Cdd:PTZ00436  220 AAPAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPaKAAAAP 299

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958641464 594 SLELMSPTRADQTPSLEAISLSQADQATSLEAMSPPRADQIPPLEAMSPL 643
Cdd:PTZ00436  300 AKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAATPPAKAAAPPAKAAAAPV 349
KLF18_N cd21575
N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like ...
 498-633 8.66e-07

N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like factor 18, is a product of a chromosomal neighbor of the KLF17 gene and is likely a product of its duplication. Phylogenetic analyses revealed that mammalian predicted KLF18 proteins and KLF17 proteins experienced elevated rates of evolution and are grouped with KLF1/KLF2/KLF4 and non-mammalian KLF17. KLF18 has been found in the human testis, though it was previously hypothesized to be a pseudogene in extant placental mammals. Mouse KLF18 expression data indicates that it may function in early embryonic development. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF18. Some KLF18 isoforms have duplicated N-terminal domains.


Pssm-ID: 410566 [Multi-domain]  Cd Length: 276  Bit Score: 51.23  E-value: 8.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 498 ESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQ 577
Cdd:cd21575    49 GQMTTPSGDQTLYGGQMTTPNGNQTLYGGQMTTSTGNQTLYGGQMTTSGSDQTLYGGQMTTSSGDQTLYGGQMTTSSGDQ 128

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958641464 578 TLPLEEMSPPQAGQSPSLELMSPTRADQTPSLEAISLSQADQATSLEAMSPPRADQ 633
Cdd:cd21575   129 TLYGGQMTTSTGDQTLYGGQMTTSTGDQTLYGGQMTTSSGDQTLYGGQMTTSTSNQ 184
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 488-686 2.22e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 51.07  E-value: 2.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 488 VPSKVLAPTPESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSL 567
Cdd:pfam05109 448 LPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAV 527

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 568 ELMSPPQTDQTLplEEMSPPQAGQSPSLELMSPTRADQTPSLEAislsqadQATSLEAMSPPRADQIPPLEAMSPLQAEV 647
Cdd:pfam05109 528 TTPTPNATSPTL--GKTSPTSAVTTPTPNATSPTPAVTTPTPNA-------TIPTLGKTSPTSAVTTPTPNATSPTVGET 598

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1958641464 648 VLPLEAISPPQADLAPPPEVISPVQEAlamSSAIAPLKH 686
Cdd:pfam05109 599 SPQANTTNHTLGGTSSTPVVTSPPKNA---TSAVTTGQH 634
KLF18_N cd21575
N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like ...
 514-633 2.80e-06

N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like factor 18, is a product of a chromosomal neighbor of the KLF17 gene and is likely a product of its duplication. Phylogenetic analyses revealed that mammalian predicted KLF18 proteins and KLF17 proteins experienced elevated rates of evolution and are grouped with KLF1/KLF2/KLF4 and non-mammalian KLF17. KLF18 has been found in the human testis, though it was previously hypothesized to be a pseudogene in extant placental mammals. Mouse KLF18 expression data indicates that it may function in early embryonic development. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF18. Some KLF18 isoforms have duplicated N-terminal domains.


Pssm-ID: 410566 [Multi-domain]  Cd Length: 276  Bit Score: 49.69  E-value: 2.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 514 MSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQTLPLEEMSPPQAGQSP 593
Cdd:cd21575     9 MTTSSGDQTLYGGQMTTPSGDQTLYGGQMTTSFSEQTLYGGQMTTPSGDQTLYGGQMTTPNGNQTLYGGQMTTSTGNQTL 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1958641464 594 SLELMSPTRADQTPSLEAISLSQADQATSLEAMSPPRADQ 633
Cdd:cd21575    89 YGGQMTTSGSDQTLYGGQMTTSSGDQTLYGGQMTTSSGDQ 128
PHA03247 PHA03247
large tegument protein UL36; Provisional
 455-683 3.34e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 3.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464  455 PHTGTKPSETFARFYKLGDSTRGGGDSAVESGPVPSKVLAP--------TPESINPPQADQAPSLEVMS-PPKVDQTPPL 525
Cdd:PHA03247  2701 PPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPpavpagpaTPGGPARPARPPTTAGPPAPaPPAAPAAGPP 2780

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464  526 EAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQ----TDQTPSLELMSPPQTDQTLPLEEMSPPQA------------ 589
Cdd:PHA03247  2781 RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAaalpPAASPAGPLPPPTSAQPTAPPPPPGPPPPslplggsvapgg 2860

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464  590 -------GQSPSLELMSPTRAdQTPSLEAISLSQADQATSLEAMSPPRADQIPPLEAMSPLQAEVVLPLEAISPPQADLA 662
Cdd:PHA03247  2861 dvrrrppSRSPAAKPAAPARP-PVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRP 2939

                          250       260
                   ....*....|....*....|.
gi 1958641464  663 PPPEVISPVQEALAMSSAIAP 683
Cdd:PHA03247  2940 QPPLAPTTDPAGAGEPSGAVP 2960
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 461-581 6.27e-06

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 48.79  E-value: 6.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 461 PSETFARFYKLGDSTRGGGDSAVESGPVPSKVLAPTPESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLE 540
Cdd:PTZ00436  229 PAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAAPAKAAAAPAK 308

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1958641464 541 AISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQTLPL 581
Cdd:PTZ00436  309 AAAAPAKAAAPPAKAAAPPAKAATPPAKAAAPPAKAAAAPV 349
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 441-573 8.02e-06

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 48.79  E-value: 8.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 441 SDRVVEIAQAAGFAPHTGTKPSETFARFYKLGDSTRGGGDSAVESGPVPSKVLAPTPESINPPQADQAPSLEVMSPPKVD 520
Cdd:PTZ00436  216 SAKAAAPAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKA 295

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958641464 521 QTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPP 573
Cdd:PTZ00436  296 AAAPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAATPPAKAAAPPAKAAAAP 348
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 533-663 1.19e-05

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 48.02  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 533 ADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQTLPLEEMSPP-QAGQSPSLELMSPTRADQTPSLEA 611
Cdd:PTZ00436  217 AKAAAPAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPaKAAAPPAKAAAPPAKAAAPPAKAA 296

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958641464 612 ISLSQADQATSLEAMSPPRADQIPPLEAMSPLQAEVVLPLEAISPPQADLAP 663
Cdd:PTZ00436  297 AAPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAATPPAKAAAPPAKAAAAP 348
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 489-669 1.28e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 48.61  E-value: 1.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 489 PSKVLAPTPESIN-----PPQADQAPSLEVMSPPKVdQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQ 563
Cdd:pfam03154 375 PPHLSGPSPFQMNsnlppPPALKPLSSLSTHHPPSA-HPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGL 453

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 564 TPSLELMSPPQ----TDQTLPLEEMSPPQAGQSPSLELMSPtradqtPSLEAISLSQADQATSLEAMSPPRADQIPPLEA 639
Cdd:pfam03154 454 HQVPSQSPFPQhpfvPGGPPPITPPSGPPTSTSSAMPGIQP------PSSASVSSSGPVPAAVSCPLPPVQIKEEALDEA 527

                         170       180       190
                  ....*....|....*....|....*....|
gi 1958641464 640 MSPlqaevvlplEAISPPQADLAPPPEVIS 669
Cdd:pfam03154 528 EEP---------ESPPPPPRSPSPEPTVVN 548
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 448-587 1.62e-05

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 47.64  E-value: 1.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 448 AQAAGFAPHTGTKPSETFARFYKLGDSTRGGGDSAVESGPVPSKVLAPTPESINPPQADQAPSLEVMSPPKVDQTPPLEA 527
Cdd:PTZ00436  209 AAPSGKKSAKAAAPAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKA 288

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 528 MSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQTLPLEEMSPP 587
Cdd:PTZ00436  289 AAPPAKAAAAPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAATPPAKAAAPPAKAAAAP 348
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 526-657 2.26e-05

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 47.25  E-value: 2.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 526 EAMSPPEADQAPPLEAISPSQTdSAPPLEAMNPPQTDQTPSLELMSPPQTDQTLPLEEMSPP-QAGQSPSLELMSPTRAD 604
Cdd:PTZ00436  218 KAAAPAKAAAAPAKAAAPPAKA-AAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPaKAAAPPAKAAAPPAKAA 296

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958641464 605 QTPSLEAISLSQADQATSlEAMSPPRADQIPPLEAMSPLQAEVVLPLEAISPP 657
Cdd:PTZ00436  297 AAPAKAAAAPAKAAAAPA-KAAAPPAKAAAPPAKAATPPAKAAAPPAKAAAAP 348
PTZ00249 PTZ00249
variable surface protein Vir28; Provisional
 486-656 1.17e-04

variable surface protein Vir28; Provisional


Pssm-ID: 140276 [Multi-domain]  Cd Length: 516  Bit Score: 45.41  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 486 GPVPSKVLAPTPESINPPQADQAPSLEVMSPP-------KVDQTPPLEAMSPPE----ADQAPPLE---AISPSQTDSAP 551
Cdd:PTZ00249  252 GRPPVETRPPNPVSVSSPQAHGRHPGETHTPPlvtvpssKAHDRNPVQTPTPTSvsgySSQAKGLEkqaGGESERTSSVP 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 552 PLEAMNP-PQTDQTPSLELMSPPQTDQTlplEEMSPPQAGQSPSLELMSPTRADQTPSLEAIS--LSQADQATSLEAMSP 628
Cdd:PTZ00249  332 SEQFPLPlPVLLPLGQSGPLESSESEET---DEYAGPKGLPEPELELVELQEEDQRHGLKHDVdtFREDEEDTFLQEGDQ 408

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1958641464 629 PRADQIPPLEA---MSPLQAEVVLPLEAISP 656
Cdd:PTZ00249  409 PAGSMQSTFDTgtiMGTIKGAVSNVLEAVEP 439
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 477-683 1.64e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.98  E-value: 1.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 477 GGGDSAVESGPVPSKVLAPTPESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAM 556
Cdd:PRK07764  590 PAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGW 669

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 557 NPPQTDQTPSLELMSPPQTDQTLPLEEmSPPQAGQSPSLELMSPTRADQ--TPSLEAISLSQADQATSLEAMSPPRADQI 634
Cdd:PRK07764  670 PAKAGGAAPAAPPPAPAPAAPAAPAGA-APAQPAPAPAATPPAGQADDPaaQPPQAAQGASAPSPAADDPVPLPPEPDDP 748

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1958641464 635 PpleamSPLQAEVVLPLEAISPPQADLAPPPEVISPVQEALAMSSAIAP 683
Cdd:PRK07764  749 P-----DPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPS 792
PHA03247 PHA03247
large tegument protein UL36; Provisional
 478-684 1.80e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 1.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464  478 GGDSAVESGPVPSKVLAPTPESINPPQADQAPSLEVMSPPKVDQTPPLEamsPPEADQAPPLEAISPSQTDSAPPLEAMN 557
Cdd:PHA03247  2602 VDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPE---RPRDDPAPGRVSRPRRARRLGRAAQASS 2678

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464  558 PPQTDQTPSL--------ELMSPPQTDQT-------------LPLEEMSPPQAGQSPSLELMSPTRADQTPSLEAISLSQ 616
Cdd:PHA03247  2679 PPQRPRRRAArptvgsltSLADPPPPPPTpepaphalvsatpLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA 2758

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958641464  617 ADQATS-LEAMSPPRADQIPPLEAMSPLQAEVVLPLEAISPPQADLAPPPEVISPVQEALAMSSAIAPL 684
Cdd:PHA03247  2759 RPPTTAgPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP 2827
PHA03247 PHA03247
large tegument protein UL36; Provisional
 481-678 1.82e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 1.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464  481 SAVESGPVPSKVLAPTPESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEAD---QAPPLEAISPSQTDSAPPLEAMN 557
Cdd:PHA03247  2808 PAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDvrrRPPSRSPAAKPAAPARPPVRRLA 2887

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464  558 PPQTDQTPSlELMSPPQTDQTLPLEEMSPPQAGQSPSLELMSPTRADQTPSLEAISLsqADQATSLEAMSPPRADQIPPL 637
Cdd:PHA03247  2888 RPAVSRSTE-SFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPL--APTTDPAGAGEPSGAVPQPWL 2964

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1958641464  638 EAMSPLQAEVVLPLeaiSPPQADLAPPPEVISPVQEALAMS 678
Cdd:PHA03247  2965 GALVPGRVAVPRFR---VPQPAPSREAPASSTPPLTGHSLS 3002
KLF18_N cd21575
N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like ...
 500-633 1.87e-04

N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like factor 18, is a product of a chromosomal neighbor of the KLF17 gene and is likely a product of its duplication. Phylogenetic analyses revealed that mammalian predicted KLF18 proteins and KLF17 proteins experienced elevated rates of evolution and are grouped with KLF1/KLF2/KLF4 and non-mammalian KLF17. KLF18 has been found in the human testis, though it was previously hypothesized to be a pseudogene in extant placental mammals. Mouse KLF18 expression data indicates that it may function in early embryonic development. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF18. Some KLF18 isoforms have duplicated N-terminal domains.


Pssm-ID: 410566 [Multi-domain]  Cd Length: 276  Bit Score: 43.91  E-value: 1.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 500 INPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQTL 579
Cdd:cd21575     9 MTTSSGDQTLYGGQMTTPSGDQTLYGGQMTTSFSEQTLYGGQMTTPSGDQTLYGGQMTTPNGNQTLYGGQMTTSTGNQTL 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958641464 580 PLEEMSPPQAGQSPSLELMSPTRADQTPSLEAISLSQADQATSLEAMSPPRADQ 633
Cdd:cd21575    89 YGGQMTTSGSDQTLYGGQMTTSSGDQTLYGGQMTTSSGDQTLYGGQMTTSTGDQ 142
KLF18_N cd21575
N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like ...
 500-633 2.01e-04

N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like factor 18, is a product of a chromosomal neighbor of the KLF17 gene and is likely a product of its duplication. Phylogenetic analyses revealed that mammalian predicted KLF18 proteins and KLF17 proteins experienced elevated rates of evolution and are grouped with KLF1/KLF2/KLF4 and non-mammalian KLF17. KLF18 has been found in the human testis, though it was previously hypothesized to be a pseudogene in extant placental mammals. Mouse KLF18 expression data indicates that it may function in early embryonic development. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF18. Some KLF18 isoforms have duplicated N-terminal domains.


Pssm-ID: 410566 [Multi-domain]  Cd Length: 276  Bit Score: 43.91  E-value: 2.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 500 INPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQTL 579
Cdd:cd21575    65 MTTPNGNQTLYGGQMTTSTGNQTLYGGQMTTSGSDQTLYGGQMTTSSGDQTLYGGQMTTSSGDQTLYGGQMTTSTGDQTL 144

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958641464 580 PLEEMSPPQAGQSPSLELMSPTRADQTPSLEAISLSQADQATSLEAMSPPRADQ 633
Cdd:cd21575   145 YGGQMTTSTGDQTLYGGQMTTSSGDQTLYGGQMTTSTSNQTLYGGQMTTSSGNQ 198
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
481-676 5.84e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.33  E-value: 5.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 481 SAVESGPVPSKVLAPTPESINPPQADQAPSLEVMSP-----PKVDQTPPLEAMSPPEADQAP---PLEAISPSQTDSAPP 552
Cdd:PRK12323  393 AAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPapealAAARQASARGPGGAPAPAPAPaaaPAAAARPAAAGPRPV 472

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 553 LEAMNPPQTDQTPSLElmSPPQTDQTLPLEEMspPQAGQSPSLELMSPTRADqtpsleAISLSQADQATSLEamSPPRAD 632
Cdd:PRK12323  473 AAAAAAAPARAAPAAA--PAPADDDPPPWEEL--PPEFASPAPAQPDAAPAG------WVAESIPDPATADP--DDAFET 540

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1958641464 633 QIP-PLEAMSPLQAEVVLPLEAISPPQADLAPPPEVISPVQEALA 676
Cdd:PRK12323  541 LAPaPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALA 585
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
477-665 6.69e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.94  E-value: 6.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 477 GGGDSA---VESGPVPSKVLAPTPESINPPQADQAPSLEVMSPPKVDQTPPL----EAMSP-----PEADQAPPLEAISP 544
Cdd:PRK12323  368 SGGGAGpatAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVaaapARRSPapealAAARQASARGPGGA 447

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 545 SQTDSAPpleAMNPPQTDQTPSLELMSPPQTDQTLPLEEMSPPQAGQSPSlelMSPTRADQTPSLEAISLSQAD----QA 620
Cdd:PRK12323  448 PAPAPAP---AAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADD---DPPPWEELPPEFASPAPAQPDaapaGW 521

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1958641464 621 TSLEAMSPPRADQIPPLEAMSPLQAEVVLPLEAISPPQADLAPPP 665
Cdd:PRK12323  522 VAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPP 566
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 490-646 9.06e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.60  E-value: 9.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 490 SKVLAPTPESINPPQAdqapsleVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLEL 569
Cdd:pfam05109 511 SAVTTPTPNATSPTPA-------VTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAV 583

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 570 MSPPQTDQTLPLEEMSPPQAGQSPSLELMSPTRADQTPSLEAIS---------LSQADQATSL------EAMSPPRAD-- 632
Cdd:pfam05109 584 TTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSavttgqhniTSSSTSSMSLrpssisETLSPSTSDns 663

                         170
                  ....*....|....*.
gi 1958641464 633 --QIPPLEAMSPLQAE 646
Cdd:pfam05109 664 tsHMPLLTSAHPTGGE 679
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 480-680 1.20e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 42.22  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 480 DSAVESGPVPSKVLAPTPESinpPQADQAPslevmSPPKVDQTPPLeamSPPEA--DQAPPLEAI---SPSQTDSAPPLE 554
Cdd:PLN03209  334 DAADGPKPVPTKPVTPEAPS---PPIEEEP-----PQPKAVVPRPL---SPYTAyeDLKPPTSPIptpPSSSPASSKSVD 402

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 555 AMNPPQT-DQTPSLELMS--------PPQTDQTLPL------EEMSPPQAgQSPSLELMSPTRADQTPSLEAISLSQADQ 619
Cdd:PLN03209  403 AVAKPAEpDVVPSPGSASnvpevepaQVEAKKTRPLspyaryEDLKPPTS-PSPTAPTGVSPSVSSTSSVPAVPDTAPAT 481

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958641464 620 A-TSLEAMSPPRADQIPPLEAMSPLQAEVVlPLEAISPPQADLAPPPEVISPVQEALAMSSA 680
Cdd:PLN03209  482 AaTDAAAPPPANMRPLSPYAVYDDLKPPTS-PSPAAPVGKVAPSSTNEVVKVGNSAPPTALA 542
PLN03131 PLN03131
hypothetical protein; Provisional
 513-638 1.69e-03

hypothetical protein; Provisional


Pssm-ID: 178677 [Multi-domain]  Cd Length: 705  Bit Score: 41.69  E-value: 1.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 513 VMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQTL-PLEEMSP----P 587
Cdd:PLN03131  350 VAPEAAAPMAPPIDLFQLPATSPAPPVDLFEIPPLDPAPAINAYQPPQTSLPSSIDLFGGITQQQSInSLDEKSPelsiP 429

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958641464 588 QAGQSPSLELMSPTRADQTP---SLEAISLSQADQATSLEAMSPPRADQIPPLE 638
Cdd:PLN03131  430 KNEGWATFDGIQPIASTPGNenlTPFSIGPSMAGSANFDQVPSLDKGMQWPPFQ 483
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 448-686 2.02e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.70  E-value: 2.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464  448 AQAAGFAPHTGTKPSET-----FARFYKLGDSTRGGGDSAVESG----PVPSKVLAPTPESINPPQADQAPSLEVMSPPK 518
Cdd:PHA03307    15 AEGGEFFPRPPATPGDAaddllSGSQGQLVSDSAELAAVTVVAGaaacDRFEPPTGPPPGPGTEAPANESRSTPTWSLST 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464  519 VDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPleamnppqtdqTPSLELMSPPQTDQTLPLEEMSPPQAGQSPSlelm 598
Cdd:PHA03307    95 LAPASPAREGSPTPPGPSSPDPPPPTPPPASPPP-----------SPAPDLSEMLRPVGSPGPPPAASPPAAGASP---- 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464  599 SPTRADQTPSLEAISLSQADQATSlEAMSPPRADQippleamsplqaevvlpleAISPPQADLAPPPEVISPVQEALAMS 678
Cdd:PHA03307   160 AAVASDAASSRQAALPLSSPEETA-RAPSSPPAEP-------------------PPSTPPAAASPRPPRRSSPISASASS 219


                   ....*...
gi 1958641464  679 SAIAPLKH 686
Cdd:PHA03307   220 PAPAPGRS 227
KLF18_N cd21575
N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like ...
 500-606 2.09e-03

N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like factor 18, is a product of a chromosomal neighbor of the KLF17 gene and is likely a product of its duplication. Phylogenetic analyses revealed that mammalian predicted KLF18 proteins and KLF17 proteins experienced elevated rates of evolution and are grouped with KLF1/KLF2/KLF4 and non-mammalian KLF17. KLF18 has been found in the human testis, though it was previously hypothesized to be a pseudogene in extant placental mammals. Mouse KLF18 expression data indicates that it may function in early embryonic development. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF18. Some KLF18 isoforms have duplicated N-terminal domains.


Pssm-ID: 410566 [Multi-domain]  Cd Length: 276  Bit Score: 40.44  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 500 INPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQT-------PSLELMSP 572
Cdd:cd21575   135 MTTSTGDQTLYGGQMTTSTGDQTLYGGQMTTSSGDQTLYGGQMTTSTSNQTLYGGQMTTSSGNQTlyggqmtTPITLSGG 214

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1958641464 573 PQT----DQTLPLEEMSPPQAGQSPSLELMSPTRADQT 606
Cdd:cd21575   215 QMTtstgDQTLYGGQMTSHQSSSLPYPGQLTFSSSHLI 252
PHA03378 PHA03378
EBNA-3B; Provisional
 485-667 2.17e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.59  E-value: 2.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 485 SGPVPSKVLAPTPESinpPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQT 564
Cdd:PHA03378  606 PEPPTTQSHIPETSA---PRQWPMPLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTGAN 682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 565 PSLELMSPPQTDQTLPLE--EMSPPQAGQSPslelMSPTRADQTPSLEAISLSQADQATSlEAMSPPRADQIPPLEAMSP 642
Cdd:PHA03378  683 TMLPIQWAPGTMQPPPRAptPMRPPAAPPGR----AQRPAAATGRARPPAAAPGRARPPA-AAPGRARPPAAAPGRARPP 757

                         170       180
                  ....*....|....*....|....*
gi 1958641464 643 LQAEVVLPLEAISPPQADLAPPPEV 667
Cdd:PHA03378  758 AAAPGRARPPAAAPGAPTPQPPPQA 782
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 448-667 2.40e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.12  E-value: 2.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 448 AQAAGFAPHTGTKPSETFARFYKLGDSTRGGG--DSAVESGPVPSKVLAPTPESINPPQADQAPSLEVMSPP-KVDQTPP 524
Cdd:PRK07764  592 PGAAGGEGPPAPASSGPPEEAARPAAPAAPAApaAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASdGGDGWPA 671

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 525 LEAMSPPEADQAPPLEAISPSQTDSAPPLEAmnpPQTDQTPSLELMSPPQTDQTLPLEEMSPPQAGQSPSLELMSPTRAD 604
Cdd:PRK07764  672 KAGGAAPAAPPPAPAPAAPAAPAGAAPAQPA---PAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDP 748

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958641464 605 QTPSLEAISLSQADQAtsleamsPPRADQIPPLEAMSPLQAEVVLPLEAISPPQADLAPPPEV 667
Cdd:PRK07764  749 PDPAGAPAQPPPPPAP-------APAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEV 804
KLF18_N cd21575
N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like ...
 500-644 2.56e-03

N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like factor 18, is a product of a chromosomal neighbor of the KLF17 gene and is likely a product of its duplication. Phylogenetic analyses revealed that mammalian predicted KLF18 proteins and KLF17 proteins experienced elevated rates of evolution and are grouped with KLF1/KLF2/KLF4 and non-mammalian KLF17. KLF18 has been found in the human testis, though it was previously hypothesized to be a pseudogene in extant placental mammals. Mouse KLF18 expression data indicates that it may function in early embryonic development. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF18. Some KLF18 isoforms have duplicated N-terminal domains.


Pssm-ID: 410566 [Multi-domain]  Cd Length: 276  Bit Score: 40.44  E-value: 2.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 500 INPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDQTL 579
Cdd:cd21575    79 MTTSTGNQTLYGGQMTTSGSDQTLYGGQMTTSSGDQTLYGGQMTTSSGDQTLYGGQMTTSTGDQTLYGGQMTTSTGDQTL 158

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958641464 580 PLEEMSPPQAGQSPSLELMSPTRADQTPSLEAISLSQADQAT-----------SLEAMSPPRADQIPPLEAMSPLQ 644
Cdd:cd21575   159 YGGQMTTSSGDQTLYGGQMTTSTSNQTLYGGQMTTSSGNQTLyggqmttpitlSGGQMTTSTGDQTLYGGQMTSHQ 234
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 480-688 2.60e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.22  E-value: 2.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464  480 DSAVESGPVPSKVLAP--------------TPESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPS 545
Cdd:PRK10263   338 EPVTQTPPVASVDVPPaqptvawqpvpgpqTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQ 417

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464  546 QTDSAPPLEAmNPPQTDQTPSLELMSPPQTDQTLPLEEMSPPQAGQSPSLELMSPTRAD----QTPSLEAISLSQADQAt 621
Cdd:PRK10263   418 QPYYAPAPEQ-PAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEplyqQPQPVEQQPVVEPEPV- 495

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464  622 sLEAMSPPRadqiPPL--------------EAMSPLQAEVVLPLEAISPPQADLAPP-PEVISPVQEALAMSSAIAPLKH 686
Cdd:PRK10263   496 -VEETKPAR----PPLyyfeeveekrarerEQLAAWYQPIPEPVKEPEPIKSSLKAPsVAAVPPVEAAAAVSPLASGVKK 570


                   ..
gi 1958641464  687 VT 688
Cdd:PRK10263   571 AT 572
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 495-683 2.88e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 2.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 495 PTPESINPPQADQAPSLEVMSPP---KVDQTPPLeaMSPPEADQAPPLEAISpSQTDSAPPLEAMNPPQTDQTPSLELMS 571
Cdd:pfam03154 255 PPPPSQVSPQPLPQPSLHGQMPPmphSLQTGPSH--MQHPVPPQPFPLTPQS-SQSQVPPGPSPAAPGQSQQRIHTPPSQ 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 572 PPQTDQTLPLEEMSPPQAGQSPSLELMSPTRADQTPSLEAislsqADQATSLEAMSPPRAD-QIPPLEAMSPLQAevvlp 650
Cdd:pfam03154 332 SQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQS-----HKHPPHLSGPSPFQMNsNLPPPPALKPLSS----- 401

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1958641464 651 LEAISPPQADlaPPPEVISPVQEALAMSSAIAP 683
Cdd:pfam03154 402 LSTHHPPSAH--PPPLQLMPQSQQLPPPPAQPP 432
PHA03247 PHA03247
large tegument protein UL36; Provisional
 474-683 3.03e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 3.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464  474 STRGGGDSAVESGPVPSKVLAPTPESINPPQADQAPS--LEVMSPPKVDQTPPLEAMSPPEADQA-----PPLEAISPSQ 546
Cdd:PHA03247  2635 ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGraAQASSPPQRPRRRAARPTVGSLTSLAdppppPPTPEPAPHA 2714

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464  547 TDSAPPLEAMNPPQTDQTPSLELMS---PPQTDQTLPLEEMSPPQAGQSPSLELMSPTRAD-QTPSLEAISLSQADQATS 622
Cdd:PHA03247  2715 LVSATPLPPGPAAARQASPALPAAPappAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPaAGPPRRLTRPAVASLSES 2794

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958641464  623 LEAMSPPRADQIPPLEAMSPLQAE--VVLPLEAISPPQADL-APPPEVISPVQEALAMSSAIAP 683
Cdd:PHA03247  2795 RESLPSPWDPADPPAAVLAPAAALppAASPAGPLPPPTSAQpTAPPPPPGPPPPSLPLGGSVAP 2858
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 481-664 5.14e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 5.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 481 SAVESGPVPSKVLAPTPESINPPQADQAPSlevmsPPK--VDQTPPLEAMSPPEADqaPPLEAISPsqtdsaPPLEAMNP 558
Cdd:pfam03154 196 TAGPTPSAPSVPPQGSPATSQPPNQTQSTA-----APHtlIQQTPTLHPQRLPSPH--PPLQPMTQ------PPPPSQVS 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464 559 PQTDQTPSLELMSPP--QTDQTLPLEEMSPPQAGQSPSLELMSPTRADQTPSLEAISLSQADQAT-----SLEAMSPPRA 631
Cdd:pfam03154 263 PQPLPQPSLHGQMPPmpHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTppsqsQLQSQQPPRE 342

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1958641464 632 DQIPPLE-AMSPLQAEVVLPLEAISPPQADLAPP 664
Cdd:pfam03154 343 QPLPPAPlSMPHIKPPPTTPIPQLPNPQSHKHPP 376
PHA03247 PHA03247
large tegument protein UL36; Provisional
 454-657 7.01e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 7.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464  454 APHTGTKPSETFARFYKLGDSTRGGGDSAVEsgpvpskvlAPTPESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEA 533
Cdd:PHA03247  2835 QPTAPPPPPGPPPPSLPLGGSVAPGGDVRRR---------PPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP 2905

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464  534 DQAPPLEAISPSQTDSAPPLEAMNPPQTDQTPSLELMSPPQTDqtlpleemspPQAGQSPSLELMSPTRADQTPSLEAIS 613
Cdd:PHA03247  2906 ERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD----------PAGAGEPSGAVPQPWLGALVPGRVAVP 2975

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1958641464  614 LSQADQ-ATSLEA-MSPPRADQIPPLEAMSPLQAEVVLPLEAISPP 657
Cdd:PHA03247  2976 RFRVPQpAPSREApASSTPPLTGHSLSRVSSWASSLALHEETDPPP 3021
PHA03247 PHA03247
large tegument protein UL36; Provisional
 494-683 7.07e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 7.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464  494 APTPESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAISPSQTDSAPPLEAMNPPqtdqtpslelmsPP 573
Cdd:PHA03247  2495 APDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEPVHPRMLTWIRGLEELASDDAGDPPPPLPPAAP------------PA 2562

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958641464  574 QTDQTLPLEEMSPPQAGQSPSLELMSPTRADQTPSLEAISLSQADQATSLEAMSPPRADQIPPLEAMSP----LQAEVVL 649
Cdd:PHA03247  2563 APDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPspaaNEPDPHP 2642

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1958641464  650 PLEAISPPQADLAPPPEVISPVQEALAMSSAIAP 683
Cdd:PHA03247  2643 PPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQA 2676
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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