DNA repair protein XRCC4 isoform X1 [Rattus norvegicus]
Protein Classification
HD_XRCC4_N domain-containing protein( domain architecture ID 10535161)
HD_XRCC4_N domain-containing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||
| XRCC4 | pfam06632 | DNA double-strand break repair and V(D)J recombination protein XRCC4; This family consists of ... |
2-334 | 0e+00 | ||||||
DNA double-strand break repair and V(D)J recombination protein XRCC4; This family consists of several eukaryotic DNA double-strand break repair and V(D)J recombination protein XRCC4 sequences. In the non-homologous end joining pathway of DNA double-strand break repair, the ligation step is catalyzed by a complex of XRCC4 and DNA ligase IV. It is thought that XRCC4 and ligase IV are essential for alignment-based gap filling, as well as for final ligation of the breaks. : Pssm-ID: 369011 [Multi-domain] Cd Length: 336 Bit Score: 506.56 E-value: 0e+00
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| Name | Accession | Description | Interval | E-value | ||||||
| XRCC4 | pfam06632 | DNA double-strand break repair and V(D)J recombination protein XRCC4; This family consists of ... |
2-334 | 0e+00 | ||||||
DNA double-strand break repair and V(D)J recombination protein XRCC4; This family consists of several eukaryotic DNA double-strand break repair and V(D)J recombination protein XRCC4 sequences. In the non-homologous end joining pathway of DNA double-strand break repair, the ligation step is catalyzed by a complex of XRCC4 and DNA ligase IV. It is thought that XRCC4 and ligase IV are essential for alignment-based gap filling, as well as for final ligation of the breaks. Pssm-ID: 369011 [Multi-domain] Cd Length: 336 Bit Score: 506.56 E-value: 0e+00
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| HD_XRCC4_N | cd22283 | N-terminal head domain found in X-ray repair cross-complementing protein 4 and similar ... |
2-127 | 1.12e-26 | ||||||
N-terminal head domain found in X-ray repair cross-complementing protein 4 and similar proteins; X-ray repair cross-complementing protein 4 (XRCC4) is a DNA repair protein involved in DNA non-homologous end-joining (NHEJ), which is required for double-strand break repair and V(D)J recombination. The DNA ligase IV (LIG4)- XRCC4 complex is responsible for the ligation step of NHEJ, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. XRCC4 monomers are comprised of an N-terminal globular head domain, a centrally located coiled-coil, and a C-terminal region. These monomers homodimerize through two dimerization domains, the N-terminal globular head domains and long extended alpha-helical coiled-coil regions. In addition, XRCC4 and XLF form symmetric heterodimers that interact through their globular head domains at the opposite end of the homodimer interface, and may form XLF-XRCC4 filaments. This model corresponds to the N-terminal head domain of XRCC4, which is structurally related to other XRCC4-superfamily members, PAXX, XLF, SAS6, and CCDC61. Pssm-ID: 409000 Cd Length: 117 Bit Score: 101.97 E-value: 1.12e-26
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| Name | Accession | Description | Interval | E-value | ||||||
| XRCC4 | pfam06632 | DNA double-strand break repair and V(D)J recombination protein XRCC4; This family consists of ... |
2-334 | 0e+00 | ||||||
DNA double-strand break repair and V(D)J recombination protein XRCC4; This family consists of several eukaryotic DNA double-strand break repair and V(D)J recombination protein XRCC4 sequences. In the non-homologous end joining pathway of DNA double-strand break repair, the ligation step is catalyzed by a complex of XRCC4 and DNA ligase IV. It is thought that XRCC4 and ligase IV are essential for alignment-based gap filling, as well as for final ligation of the breaks. Pssm-ID: 369011 [Multi-domain] Cd Length: 336 Bit Score: 506.56 E-value: 0e+00
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| HD_XRCC4_N | cd22283 | N-terminal head domain found in X-ray repair cross-complementing protein 4 and similar ... |
2-127 | 1.12e-26 | ||||||
N-terminal head domain found in X-ray repair cross-complementing protein 4 and similar proteins; X-ray repair cross-complementing protein 4 (XRCC4) is a DNA repair protein involved in DNA non-homologous end-joining (NHEJ), which is required for double-strand break repair and V(D)J recombination. The DNA ligase IV (LIG4)- XRCC4 complex is responsible for the ligation step of NHEJ, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. XRCC4 monomers are comprised of an N-terminal globular head domain, a centrally located coiled-coil, and a C-terminal region. These monomers homodimerize through two dimerization domains, the N-terminal globular head domains and long extended alpha-helical coiled-coil regions. In addition, XRCC4 and XLF form symmetric heterodimers that interact through their globular head domains at the opposite end of the homodimer interface, and may form XLF-XRCC4 filaments. This model corresponds to the N-terminal head domain of XRCC4, which is structurally related to other XRCC4-superfamily members, PAXX, XLF, SAS6, and CCDC61. Pssm-ID: 409000 Cd Length: 117 Bit Score: 101.97 E-value: 1.12e-26
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| HD_XRCC4-like_N | cd22210 | N-terminal head domain found in the XRCC4 superfamily of proteins; The XRCC4 superfamily ... |
4-127 | 1.45e-16 | ||||||
N-terminal head domain found in the XRCC4 superfamily of proteins; The XRCC4 superfamily includes five families: XRCC4, XLF, PAXX, SAS6 and CCDC61. XRCC4 (X-ray repair cross-complementing protein 4), XLF (XRCC4-like factor) and PAXX (paralog of XRCC4 and XLF) play crucial roles in the non-homologous end-joining (NHEJ) DNA repair pathway. SAS6 (spindle assembly abnormal protein 6) and CCDC61 (coiled-coil domain-containing protein 61) have a centrosomal/centriolar function. Members of this superfamily have an N-terminal globular head domain, a centrally located coiled-coil, and a C-terminal low-complexity region. They form homodimers through two homodimerization domains: an N-terminal globular head domain and a parallel coiled-coil domain. In addition, some members such as XRCC4 and XLF form symmetric heterodimers that interact through their globular head domains at the opposite end of the homodimer interface, and may form XLF-XRCC4 filaments. This model corresponds to the N-terminal head domain of XRCC4 superfamily proteins. Pssm-ID: 408999 Cd Length: 115 Bit Score: 74.50 E-value: 1.45e-16
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