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Conserved domains on  [gi|1958751293|ref|XP_038958494|]
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ankyrin repeat domain-containing protein 55 isoform X5 [Rattus norvegicus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11430360)

ankyrin repeat (ANK) domain-containing protein mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

CATH:  1.25.40.20
Gene Ontology:  GO:0005515
PubMed:  33435370|15152081|17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
29-238 5.75e-40

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 146.64  E-value: 5.75e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  29 DSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAE 108
Cdd:COG0666    84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 109 PDVRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSH 188
Cdd:COG0666   164 GNLEIVKLLLEAGA--DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA 241

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958751293 189 RqgpSIINYDDESGKTCVHIAAASGFGDIIHDLAKVPECNLQALDVDDRT 238
Cdd:COG0666   242 G---ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
Ank_2 pfam12796
Ankyrin repeats (3 copies);
207-288 1.75e-14

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 1.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 207 HIAAASGFGDIIHDLAKvPECNLQALDVDDRTPLHWAAAAGKAECVQSLLDlGMDSNLRDiNESTPLAYALYCGHTACVR 286
Cdd:pfam12796   2 HLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ..
gi 1958751293 287 LL 288
Cdd:pfam12796  79 LL 80
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
29-238 5.75e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 146.64  E-value: 5.75e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  29 DSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAE 108
Cdd:COG0666    84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 109 PDVRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSH 188
Cdd:COG0666   164 GNLEIVKLLLEAGA--DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA 241

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958751293 189 RqgpSIINYDDESGKTCVHIAAASGFGDIIHDLAKVPECNLQALDVDDRT 238
Cdd:COG0666   242 G---ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
PHA03095 PHA03095
ankyrin-like protein; Provisional
 3-286 6.60e-23

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 101.64  E-value: 6.60e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293   3 YQAASNGDVNSLTAVIREDPSIlECCDSEGCTPL---MHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLE 79
Cdd:PHA03095   19 LLNASNVTVEEVRRLLAAGADV-NFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  80 GCVSLL-RNGAKHNIPDKNGRLPLHA-----ATAEPDVRLLIVLLqqsslSEINHQDTEGMTPLH-WAAFHNRPQHT-QM 151
Cdd:PHA03095   98 DVIKLLiKAGADVNAKDKVGRTPLHVylsgfNINPKVIRLLLRKG-----ADVNALDLYGMTPLAvLLKSRNANVELlRL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 152 LLKKGADPTLVDKDFKTALHWAVQS---GNRILCSIIlSHRQGPSIINyddESGKTCVHIAAASGFGDIIHdLAKVPECN 228
Cdd:PHA03095  173 LIDAGADVYAVDDRFRSLLHHHLQSfkpRARIVRELI-RAGCDPAATD---MLGNTPLHSMATGSSCKRSL-VLPLLIAG 247

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 229 LQ--ALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVR 286
Cdd:PHA03095  248 ISinARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVR 307
Ank_2 pfam12796
Ankyrin repeats (3 copies);
36-163 8.34e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 8.34e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  36 LMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEgCVSLLrngAKHNIPDKngrlplhaataepdvrlli 115
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLE-IVKLL---LEHADVNL------------------- 57

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1958751293 116 vllqqsslseinhqDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVD 163
Cdd:pfam12796  58 --------------KDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
207-288 1.75e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 1.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 207 HIAAASGFGDIIHDLAKvPECNLQALDVDDRTPLHWAAAAGKAECVQSLLDlGMDSNLRDiNESTPLAYALYCGHTACVR 286
Cdd:pfam12796   2 HLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ..
gi 1958751293 287 LL 288
Cdd:pfam12796  79 LL 80
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 31-59 1.29e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 41.80  E-value: 1.29e-05
                           10        20
                   ....*....|....*....|....*....
gi 1958751293   31 EGCTPLMHAVSGRQVDTVKLLLKMGANIN 59
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 198-288 1.32e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.94  E-value: 1.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 198 DDESGKTCVHIAAASGFGDIIHDLAKVpecNLQAlDVDD---RTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLA 274
Cdd:PLN03192  521 DDPNMASNLLTVASTGNAALLEELLKA---KLDP-DIGDskgRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALW 596

                          90
                  ....*....|....
gi 1958751293 275 YALYCGHTACVRLL 288
Cdd:PLN03192  597 NAISAKHHKIFRIL 610
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 235-264 5.71e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 5.71e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958751293  235 DDRTPLHWAAAAGKAECVQSLLDLGMDSNL 264
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 5-155 2.16e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 40.77  E-value: 2.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293   5 AASNGDVNSLTAVIREDPS-ILECCDSE---GCTPLMHAVSGRQVDTVKLLLKMGANINTQDA--------------YGR 66
Cdd:cd22192    58 AALYDNLEAAVVLMEAAPElVNEPMTSDlyqGETALHIAVVNQNLNLVRELIARGADVVSPRAtgtffrpgpknliyYGE 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  67 TSLCLATYLGwLEGCVSLL-RNGAKHNIPDKNGRLPLHAATAEPDVRL------LIV----LLQQSSLSEI-NHQdteGM 134
Cdd:cd22192   138 HPLSFAACVG-NEEIVRLLiEHGADIRAQDSLGNTVLHILVLQPNKTFacqmydLILsydkEDDLQPLDLVpNNQ---GL 213

                         170       180
                  ....*....|....*....|.
gi 1958751293 135 TPLHWAAFHNRPQHTQMLLKK 155
Cdd:cd22192   214 TPFKLAAKEGNIVMFQHLVQK 234
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
29-238 5.75e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 146.64  E-value: 5.75e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  29 DSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAE 108
Cdd:COG0666    84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 109 PDVRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSH 188
Cdd:COG0666   164 GNLEIVKLLLEAGA--DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA 241

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958751293 189 RqgpSIINYDDESGKTCVHIAAASGFGDIIHDLAKVPECNLQALDVDDRT 238
Cdd:COG0666   242 G---ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
29-273 3.48e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 138.93  E-value: 3.48e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  29 DSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAE 108
Cdd:COG0666    51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 109 PDVRLLIVLLQQSslSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSH 188
Cdd:COG0666   131 GNLEIVKLLLEAG--ADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 189 RqgpSIINYDDESGKTCVHIAAASGFGDIIHDLAKVPEcNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDIN 268
Cdd:COG0666   209 G---ADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA-DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLD 284


                  ....*
gi 1958751293 269 ESTPL 273
Cdd:COG0666   285 LLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-298 8.30e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 129.69  E-value: 8.30e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  34 TPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRL 113
Cdd:COG0666    23 LLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEI 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 114 LIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgps 193
Cdd:COG0666   103 VKLLLEAGA--DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAG---- 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 194 iinyddesgktcvhiaaasgfgdiihdlakvpeCNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPL 273
Cdd:COG0666   177 ---------------------------------ADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223

                         250       260
                  ....*....|....*....|....*
gi 1958751293 274 AYALYCGHTACVRLLSREGRAEPAR 298
Cdd:COG0666   224 DLAAENGNLEIVKLLLEAGADLNAK 248
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
48-288 6.50e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 107.35  E-value: 6.50e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  48 VKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAepDVRLLIVLLQQSSLSEIN 127
Cdd:COG0666     4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAAL--AGDLLVALLLLAAGADIN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 128 HQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHrqgpsiinyddesgktcvh 207
Cdd:COG0666    82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA------------------- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 208 iaaasgfgdiihdlakvpECNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRL 287
Cdd:COG0666   143 ------------------GADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKL 204


                  .
gi 1958751293 288 L 288
Cdd:COG0666   205 L 205
PHA03095 PHA03095
ankyrin-like protein; Provisional
 3-286 6.60e-23

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 101.64  E-value: 6.60e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293   3 YQAASNGDVNSLTAVIREDPSIlECCDSEGCTPL---MHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLE 79
Cdd:PHA03095   19 LLNASNVTVEEVRRLLAAGADV-NFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  80 GCVSLL-RNGAKHNIPDKNGRLPLHA-----ATAEPDVRLLIVLLqqsslSEINHQDTEGMTPLH-WAAFHNRPQHT-QM 151
Cdd:PHA03095   98 DVIKLLiKAGADVNAKDKVGRTPLHVylsgfNINPKVIRLLLRKG-----ADVNALDLYGMTPLAvLLKSRNANVELlRL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 152 LLKKGADPTLVDKDFKTALHWAVQS---GNRILCSIIlSHRQGPSIINyddESGKTCVHIAAASGFGDIIHdLAKVPECN 228
Cdd:PHA03095  173 LIDAGADVYAVDDRFRSLLHHHLQSfkpRARIVRELI-RAGCDPAATD---MLGNTPLHSMATGSSCKRSL-VLPLLIAG 247

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 229 LQ--ALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVR 286
Cdd:PHA03095  248 ISinARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVR 307
PHA03095 PHA03095
ankyrin-like protein; Provisional
 45-288 1.56e-22

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 100.48  E-value: 1.56e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  45 VDTVKLLLKMGANINTQDAYGRTSLC--LATYLGWLEGCVS-LLRNGAKHNIPDKNGRLPLHA----ATAEPDVRLLIvl 117
Cdd:PHA03095   27 VEEVRRLLAAGADVNFRGEYGKTPLHlyLHYSSEKVKDIVRlLLEAGADVNAPERCGFTPLHLylynATTLDVIKLLI-- 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 118 lqqSSLSEINHQDTEGMTPLH--WAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN------RILCsiilshR 189
Cdd:PHA03095  105 ---KAGADVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanvellRLLI------D 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 190 QGPSIINYDDEsGKTCVHIAAAS--GFGDIIHDLAkVPECNLQALDVDDRTPLHWAAAAG--KAECVQSLLDLGMDSNLR 265
Cdd:PHA03095  176 AGADVYAVDDR-FRSLLHHHLQSfkPRARIVRELI-RAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGISINAR 253

                         250       260
                  ....*....|....*....|....
gi 1958751293 266 DINESTPLAYA-LYCGHTACVRLL 288
Cdd:PHA03095  254 NRYGQTPLHYAaVFNNPRACRRLI 277
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 39-194 1.64e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 81.64  E-value: 1.64e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  39 AVSGRQVDTVKLLLKMGANINTQDAYGRTSL--CLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIV 116
Cdd:PHA03100   80 YNLTDVKEIVKLLLEYGANVNAPDNNGITPLlyAISKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKIL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 117 --LLQQ--------------SSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRI 180
Cdd:PHA03100  160 klLIDKgvdinaknrvnyllSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKE 239

                         170
                  ....*....|....
gi 1958751293 181 LCSIILSHrqGPSI 194
Cdd:PHA03100  240 IFKLLLNN--GPSI 251
Ank_2 pfam12796
Ankyrin repeats (3 copies);
36-163 8.34e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 8.34e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  36 LMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEgCVSLLrngAKHNIPDKngrlplhaataepdvrlli 115
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLE-IVKLL---LEHADVNL------------------- 57

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1958751293 116 vllqqsslseinhqDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVD 163
Cdd:pfam12796  58 --------------KDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
207-288 1.75e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 1.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 207 HIAAASGFGDIIHDLAKvPECNLQALDVDDRTPLHWAAAAGKAECVQSLLDlGMDSNLRDiNESTPLAYALYCGHTACVR 286
Cdd:pfam12796   2 HLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ..
gi 1958751293 287 LL 288
Cdd:pfam12796  79 LL 80
Ank_2 pfam12796
Ankyrin repeats (3 copies);
170-266 1.78e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 1.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 170 LHWAVQSGNRILCSIILSHRQGPsiiNYDDESGKTCVHIAAASGFGDIIHDLAKVPECNLQaldVDDRTPLHWAAAAGKA 249
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADA---NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHL 74

                          90
                  ....*....|....*..
gi 1958751293 250 ECVQSLLDLGMDSNLRD 266
Cdd:pfam12796  75 EIVKLLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-292 9.00e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 73.16  E-value: 9.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  33 CTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLclatylgwlegcvSLLRNgAKHNIPDkngrlplhaataepDVR 112
Cdd:PHA03100   36 VLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPL-------------HYLSN-IKYNLTD--------------VKE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 113 LLIVLLQQSSLseINHQDTEGMTPLHWAAfHNRPQHTQM---LLKKGADPTLVDKDFKTALHWAVQSGNRIL--CSIILS 187
Cdd:PHA03100   88 IVKLLLEYGAN--VNAPDNNGITPLLYAI-SKKSNSYSIveyLLDNGANVNIKNSDGENLLHLYLESNKIDLkiLKLLID 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 188 HrqgpsIINYDdesGKTCVHIAAASGfgdiihdlakvpeCNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDI 267
Cdd:PHA03100  165 K-----GVDIN---AKNRVNYLLSYG-------------VPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNK 223

                         250       260
                  ....*....|....*....|....*
gi 1958751293 268 NESTPLAYALYCGHTACVRLLSREG 292
Cdd:PHA03100  224 YGDTPLHIAILNNNKEIFKLLLNNG 248
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 23-209 2.22e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 72.30  E-value: 2.22e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  23 SILECC------DSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDK 96
Cdd:PHA02874  109 TILDCGidvnikDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDN 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  97 NGRLPLHAATAEPDVRLLIVLLQQSslSEINHQDTEGMTPLHWAAFHNRPqhTQMLLKKGADPTLVDKDFKTALHWAVQS 176
Cdd:PHA02874  189 NGESPLHNAAEYGDYACIKLLIDHG--NHIMNKCKNGFTPLHNAIIHNRS--AIELLINNASINDQDIDGSTPLHHAINP 264

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1958751293 177 GNRI-LCSIILSHRQGPSIinyDDESGKTCVHIA 209
Cdd:PHA02874  265 PCDIdIIDILLYHKADISI---KDNKGENPIDTA 295
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 8-277 2.43e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 71.92  E-value: 2.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293   8 NGDVNSLTAVIREDPSILECCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLG-------WLEG 80
Cdd:PHA02874   11 SGDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGahdiiklLIDN 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  81 CV----------------SLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLQQSslSEINHQDTEGMTPLHWAAFHN 144
Cdd:PHA02874   91 GVdtsilpipciekdmikTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYG--ADVNIEDDNGCYPIHIAIKHN 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 145 RPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHrqGPSIINyDDESGKTCVHIAaasgfgdIIHDLAKV 224
Cdd:PHA02874  169 FFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDH--GNHIMN-KCKNGFTPLHNA-------IIHNRSAI 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958751293 225 P----ECNLQALDVDDRTPLHWA-AAAGKAECVQSLLDLGMDSNLRDINESTPLAYAL 277
Cdd:PHA02874  239 EllinNASINDQDIDGSTPLHHAiNPPCDIDIIDILLYHKADISIKDNKGENPIDTAF 296
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 9-276 3.61e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 72.02  E-value: 3.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293   9 GDVNSLTAvirEDPSILECcdsegctplmhAVSGRQVDTVKLLLKMGANINTQDaygrTSLCLATYLGWLEGCVSLLRNG 88
Cdd:PHA02876  202 ADVNIIAL---DDLSVLEC-----------AVDSKNIDTIKAIIDNRSNINKND----LSLLKAIRNEDLETSLLLYDAG 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  89 AKHNIPDKNGRLPLHAATAEPDV-RLLIVLLQQSslSEINHQDTEGMTPLHWAAFHN-RPQHTQMLLKKGADPTLVDKDF 166
Cdd:PHA02876  264 FSVNSIDDCKNTPLHHASQAPSLsRLVPKLLERG--ADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLY 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 167 KTALHWAvQSGNRILCSIILSHRQGPSiINYDDESGKTCVHIAAASGFGDIIHDLAKVpECNLQALDVDDRTPLHWA-AA 245
Cdd:PHA02876  342 ITPLHQA-STLDRNKDIVITLLELGAN-VNARDYCDKTPIHYAAVRNNVVIINTLLDY-GADIEALSQKIGTALHFAlCG 418

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1958751293 246 AGKAECVQSLLDLGMDSNLRDINESTPLAYA 276
Cdd:PHA02876  419 TNPYMSVKTLIDRGANVNSKNKDLSTPLHYA 449
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 34-292 4.77e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 71.63  E-value: 4.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  34 TPLMHAVSGRQVDT-VKLLLKMGANINTQDAYGRTSLCLATYLGW-LEGCVSLLRNGAKHNIPDKNGRLPLH-AATAEPD 110
Cdd:PHA02876  275 TPLHHASQAPSLSRlVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHqASTLDRN 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 111 VRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILcsiilshrq 190
Cdd:PHA02876  355 KDIVITLLELGA--NVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPYM--------- 423

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 191 gpsiinyddeSGKTCVHIAAasgfgdiihdlakvpecNLQALDVDDRTPLHWAAAAG-KAECVQSLLDLGMDSNLRDINE 269
Cdd:PHA02876  424 ----------SVKTLIDRGA-----------------NVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQN 476

                         250       260
                  ....*....|....*....|...
gi 1958751293 270 STPLAYALycGHTACVRLLSREG 292
Cdd:PHA02876  477 QYPLLIAL--EYHGIVNILLHYG 497
PHA03095 PHA03095
ankyrin-like protein; Provisional
 28-194 6.43e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 70.82  E-value: 6.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  28 CDSEGCTPLMHAVSGRQVD--TVKLLLKMGANINTQDAYGRTSL-CLATYLGWLEGCVS-LLRNGAKHNIPDKNGRLPLH 103
Cdd:PHA03095  148 LDLYGMTPLAVLLKSRNANveLLRLLIDAGADVYAVDDRFRSLLhHHLQSFKPRARIVReLIRAGCDPAATDMLGNTPLH 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 104 -AATAEPDVRLLIVLLQQSSLSeINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILC 182
Cdd:PHA03095  228 sMATGSSCKRSLVLPLLIAGIS-INARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAV 306

                         170
                  ....*....|..
gi 1958751293 183 SIILSHRqgPSI 194
Cdd:PHA03095  307 RAALAKN--PSA 316
Ank_2 pfam12796
Ankyrin repeats (3 copies);
4-95 2.83e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.83  E-value: 2.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293   4 QAASNGDVNSLTAVIREDPSIlECCDSEGCTPLMHAVSGRQVDTVKLLLKmGANINTQDaYGRTSLCLATYLGWLEGCVS 83
Cdd:pfam12796   3 LAAKNGNLELVKLLLENGADA-NLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 1958751293  84 LLRNGAKHNIPD 95
Cdd:pfam12796  80 LLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 36-264 4.24e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 68.09  E-value: 4.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  36 LMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLI 115
Cdd:PHA02875    6 LCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 116 VLLQQSS-LSEINHQDteGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgpSI 194
Cdd:PHA02875   86 ELLDLGKfADDVFYKD--GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHK---AC 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958751293 195 INYDDESGKTCVHIAAASGFGDI---IHDLAKVPECNLQALDVddrTPLHWAAAAGKAECVQSLLDLGMDSNL 264
Cdd:PHA02875  161 LDIEDCCGCTPLIIAMAKGDIAIckmLLDSGANIDYFGKNGCV---AALCYAIENNKIDIVRLFIKRGADCNI 230
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 32-196 2.52e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 65.67  E-value: 2.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  32 GCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAE-PD 110
Cdd:PHA02878  168 GNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKD 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 111 VRLLIVLLQQSslSEINHQDT-EGMTPLHwAAFHNrPQHTQMLLKKGADPTLVDKDFKTALHWAVQS------GNRILCS 183
Cdd:PHA02878  248 YDILKLLLEHG--VDVNAKSYiLGLTALH-SSIKS-ERKLKLLLEYGADINSLNSYKLTPLSSAVKQylciniGRILISN 323

                         170
                  ....*....|...
gi 1958751293 184 IILSHRQGPSIIN 196
Cdd:PHA02878  324 ICLLKRIKPDIKN 336
Ank_2 pfam12796
Ankyrin repeats (3 copies);
240-288 2.66e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 57.05  E-value: 2.66e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958751293 240 LHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLL 288
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLL 49
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 2-162 5.23e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 61.55  E-value: 5.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293   2 VYQAASNGDVNSLTAVIREDPSILECCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGC 81
Cdd:PHA02875   72 LHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGI 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  82 VSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLqqSSLSEINHQDTEG-MTPLHWAAFHNRPQHTQMLLKKGADPT 160
Cdd:PHA02875  152 ELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLL--DSGANIDYFGKNGcVAALCYAIENNKIDIVRLFIKRGADCN 229


                  ..
gi 1958751293 161 LV 162
Cdd:PHA02875  230 IM 231
Ank_2 pfam12796
Ankyrin repeats (3 copies);
102-188 7.94e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.89  E-value: 7.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 102 LHAATAEPDVRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKgADPTLVDKDfKTALHWAVQSGNRIL 181
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGA--DANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEI 76


                  ....*..
gi 1958751293 182 CSIILSH 188
Cdd:pfam12796  77 VKLLLEK 83
Ank_4 pfam13637
Ankyrin repeats (many copies);
237-288 1.40e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 53.82  E-value: 1.40e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958751293 237 RTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLL 288
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 33-289 1.41e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 60.28  E-value: 1.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  33 CTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSL---CLA--------------------TYLGWLEGC-------- 81
Cdd:PHA02878   38 FIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLhiiCKEpnklgmkemirsinkcsvfyTLVAIKDAFnnrnveif 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  82 VSLLRNGAKHN--IPDKNgrlpLHAATAEPDVRLLIVLLQQSSLSEINHQDTE-GMTPLHWAAFHNRPQHTQMLLKKGAD 158
Cdd:PHA02878  118 KIILTNRYKNIqtIDLVY----IDKKSKDDIIEAEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGAN 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 159 PTLVDKDFKTALHWAVQSGNRILCSIILshRQGPSiINYDDESGKTCVHIAAASGFG-DIIHDLAKVPEC-NLQAlDVDD 236
Cdd:PHA02878  194 VNIPDKTNNSPLHHAVKHYNKPIVHILL--ENGAS-TDARDKCGNTPLHISVGYCKDyDILKLLLEHGVDvNAKS-YILG 269

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958751293 237 RTPLHwaAAAGKAECVQSLLDLGMDSNLRDINESTPLAYAL--YCGHTACVRLLS 289
Cdd:PHA02878  270 LTALH--SSIKSERKLKLLLEYGADINSLNSYKLTPLSSAVkqYLCINIGRILIS 322
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 49-276 2.55e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 59.69  E-value: 2.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  49 KLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLQQSslSEINH 128
Cdd:PHA02876  162 EMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNR--SNINK 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 129 QDTEGMTplhwaAFHNRPQHTQMLL-KKGADPTLVDKDFKTALHWAVQSGNriLCSIILSHRQGPSIINYDDESGKTCVH 207
Cdd:PHA02876  240 NDLSLLK-----AIRNEDLETSLLLyDAGFSVNSIDDCKNTPLHHASQAPS--LSRLVPKLLERGADVNAKNIKGETPLY 312

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958751293 208 IAAASGFgdiihDLAKVPECNLQALDVD--DR---TPLHWAAAAGK-AECVQSLLDLGMDSNLRDINESTPLAYA 276
Cdd:PHA02876  313 LMAKNGY-----DTENIRTLIMLGADVNaaDRlyiTPLHQASTLDRnKDIVITLLELGANVNARDYCDKTPIHYA 382
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 66-292 1.77e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 56.54  E-value: 1.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  66 RTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLQQSSLSEINHQDTEgmTPLHWAAFHNR 145
Cdd:PHA02875    3 QVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIE--SELHDAVEEGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 146 PQHTQMLLKKGadpTLVD----KDFKTALHWAVQSGNRILCSIILSHRQGPSIINYDDesgKTCVHIAAASGFGDIIHDL 221
Cdd:PHA02875   81 VKAVEELLDLG---KFADdvfyKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDK---FSPLHLAVMMGDIKGIELL 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958751293 222 AKVPECnlqaLDVDD---RTPLHWAAAAGKAECVQSLLDLGMDSNLRDIN-ESTPLAYALYCGHTACVRLLSREG 292
Cdd:PHA02875  155 IDHKAC----LDIEDccgCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRG 225
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 113-273 3.12e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 56.23  E-value: 3.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 113 LLIVLLQQSSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgp 192
Cdd:PHA02876  158 LLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNR--- 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 193 SIINYDDESGKTCVH--------IAAASGFgdiihdlakvpecNLQALDVDDRTPLHWAAAAGK-AECVQSLLDLGMDSN 263
Cdd:PHA02876  235 SNINKNDLSLLKAIRnedletslLLYDAGF-------------SVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVN 301

                         170
                  ....*....|
gi 1958751293 264 LRDINESTPL 273
Cdd:PHA02876  302 AKNIKGETPL 311
Ank_5 pfam13857
Ankyrin repeats (many copies);
227-276 7.46e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 48.88  E-value: 7.46e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958751293 227 CNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYA 276
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 111-190 9.49e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.90  E-value: 9.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 111 VRLLIvllqqSSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQ 190
Cdd:PTZ00322   98 ARILL-----TGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQ 172
Ank_4 pfam13637
Ankyrin repeats (many copies);
133-178 1.13e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.42  E-value: 1.13e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958751293 133 GMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN 178
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGN 46
Ank_2 pfam12796
Ankyrin repeats (3 copies);
3-62 4.30e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.80  E-value: 4.30e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293   3 YQAASNGDVNSLTAVIREDPSileCCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQD 62
Cdd:pfam12796  35 HLAAKNGHLEIVKLLLEHADV---NLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_5 pfam13857
Ankyrin repeats (many copies);
118-173 1.84e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.03  E-value: 1.84e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958751293 118 LQQSSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWA 173
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02946 PHA02946
ankyin-like protein; Provisional
 127-273 4.96e-06

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 48.90  E-value: 4.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 127 NHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQGPSIINYDDESGktCV 206
Cdd:PHA02946   66 NETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEVIERINLLVQYGAKINNSVDEEG--CG 143

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958751293 207 HIAAASGFGDIIhdLAKVPECNLQALDVD----DRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPL 273
Cdd:PHA02946  144 PLLACTDPSERV--FKKIMSIGFEARIVDkfgkNHIHRHLMSDNPKASTISWMMKLGISPSKPDHDGNTPL 212
Ank_4 pfam13637
Ankyrin repeats (many copies);
98-153 8.60e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.03  E-value: 8.60e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958751293  98 GRLPLHAATAEPDVRLLIVLLQqsSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLL 153
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLE--KGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
18-72 1.01e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.10  E-value: 1.01e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958751293  18 IREDPSILECCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLA 72
Cdd:pfam13857   2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 31-59 1.29e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 41.80  E-value: 1.29e-05
                           10        20
                   ....*....|....*....|....*....
gi 1958751293   31 EGCTPLMHAVSGRQVDTVKLLLKMGANIN 59
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 198-288 1.32e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.94  E-value: 1.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 198 DDESGKTCVHIAAASGFGDIIHDLAKVpecNLQAlDVDD---RTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLA 274
Cdd:PLN03192  521 DDPNMASNLLTVASTGNAALLEELLKA---KLDP-DIGDskgRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALW 596

                          90
                  ....*....|....
gi 1958751293 275 YALYCGHTACVRLL 288
Cdd:PLN03192  597 NAISAKHHKIFRIL 610
PHA02798 PHA02798
ankyrin-like protein; Provisional
 45-185 3.80e-05

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 46.37  E-value: 3.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  45 VDTVKLLLKMGANINTQDAYGRTSLC-----LATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAataepdvrllivLLQ 119
Cdd:PHA02798   51 TDIVKLFINLGANVNGLDNEYSTPLCtilsnIKDYKHMLDIVKILIENGADINKKNSDGETPLYC------------LLS 118

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958751293 120 QSSLseinhqdtegmtplhwaafhNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSII 185
Cdd:PHA02798  119 NGYI--------------------NNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNHHIDIEII 164
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 31-62 7.86e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 7.86e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1958751293  31 EGCTPLMHAV-SGRQVDTVKLLLKMGANINTQD 62
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 132-164 8.42e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.58  E-value: 8.42e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1958751293 132 EGMTPLHWAAFH-NRPQHTQMLLKKGADPTLVDK 164
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 132-159 1.06e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 39.55  E-value: 1.06e-04
                          10        20
                  ....*....|....*....|....*...
gi 1958751293 132 EGMTPLHWAAFHNRPQHTQMLLKKGADP 159
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADI 28
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 233-290 1.16e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.89  E-value: 1.16e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958751293 233 DVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLLSR 290
Cdd:PTZ00322  112 DYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 21-127 1.62e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.50  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  21 DPSILECCDSEGCTplmHAVSGRQVDtVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRL 100
Cdd:PTZ00322   75 DPVVAHMLTVELCQ---LAASGDAVG-ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKT 150

                          90       100
                  ....*....|....*....|....*..
gi 1958751293 101 PLHAAtAEPDVRLLIVLLQQSSLSEIN 127
Cdd:PTZ00322  151 PLELA-EENGFREVVQLLSRHSQCHFE 176
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 132-161 1.79e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 1.79e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958751293  132 EGMTPLHWAAFHNRPQHTQMLLKKGADPTL 161
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
34-85 1.79e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 1.79e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958751293  34 TPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEgCVSLL 85
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVE-VLKLL 53
PHA02791 PHA02791
ankyrin-like protein; Provisional
 95-178 1.95e-04

ankyrin-like protein; Provisional


Pssm-ID: 165154 [Multi-domain]  Cd Length: 284  Bit Score: 43.49  E-value: 1.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  95 DKNGRLPLHAATAEPDVRLLIVLLQQSSLSEInhqdTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAV 174
Cdd:PHA02791   27 DVHGHSALYYAIADNNVRLVCTLLNAGALKNL----LENEFPLHQAATLEDTKIVKILLFSGMDDSQFDDKGNTALYYAV 102


                  ....
gi 1958751293 175 QSGN 178
Cdd:PHA02791  103 DSGN 106
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 150-231 2.32e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.12  E-value: 2.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 150 QMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQGPSIInydDESGKTCVHIAAASGFGDIIHDLAKVPECNL 229
Cdd:PTZ00322   99 RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLL---DKDGKTPLELAEENGFREVVQLLSRHSQCHF 175


                  ..
gi 1958751293 230 QA 231
Cdd:PTZ00322  176 EL 177
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 2-165 3.31e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 43.70  E-value: 3.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293   2 VYQAASNGDVNSLTAVIR--EDPSIlecCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLE 79
Cdd:PLN03192  529 LLTVASTGNAALLEELLKakLDPDI---GDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHK 605

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  80 gCVSLLRNGAKHNIPDKNGRLpLHAATAEPDVRLLIVLLQQSslSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADP 159
Cdd:PLN03192  606 -IFRILYHFASISDPHAAGDL-LCTAAKRNDLTAMKELLKQG--LNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681


                  ....*.
gi 1958751293 160 TLVDKD 165
Cdd:PLN03192  682 DKANTD 687
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 31-60 3.60e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.01  E-value: 3.60e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1958751293  31 EGCTPLMHAVSGRQVDTVKLLLKMGANINT 60
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 235-266 3.68e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.04  E-value: 3.68e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1958751293 235 DDRTPLHWAAA-AGKAECVQSLLDLGMDSNLRD 266
Cdd:pfam00023   1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 235-264 5.71e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 5.71e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958751293  235 DDRTPLHWAAAAGKAECVQSLLDLGMDSNL 264
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02798 PHA02798
ankyrin-like protein; Provisional
 29-138 1.74e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 40.97  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  29 DSEGCTPLMHAVSG-----RQVDTVKLLLKMGANINTQDAYGRTSLCLA---TYLGWLEGCVSLLRNGAKHNIPDKNGRL 100
Cdd:PHA02798   68 DNEYSTPLCTILSNikdykHMLDIVKILIENGADINKKNSDGETPLYCLlsnGYINNLEILLFMIENGADTTLLDKDGFT 147

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1958751293 101 PLHA---ATAEPDVRLLIVLLQQSslSEIN-HQDTEGMTPLH 138
Cdd:PHA02798  148 MLQVylqSNHHIDIEIIKLLLEKG--VDINtHNNKEKYDTLH 187
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 5-155 2.16e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 40.77  E-value: 2.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293   5 AASNGDVNSLTAVIREDPS-ILECCDSE---GCTPLMHAVSGRQVDTVKLLLKMGANINTQDA--------------YGR 66
Cdd:cd22192    58 AALYDNLEAAVVLMEAAPElVNEPMTSDlyqGETALHIAVVNQNLNLVRELIARGADVVSPRAtgtffrpgpknliyYGE 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  67 TSLCLATYLGwLEGCVSLL-RNGAKHNIPDKNGRLPLHAATAEPDVRL------LIV----LLQQSSLSEI-NHQdteGM 134
Cdd:cd22192   138 HPLSFAACVG-NEEIVRLLiEHGADIRAQDSLGNTVLHILVLQPNKTFacqmydLILsydkEDDLQPLDLVpNNQ---GL 213

                         170       180
                  ....*....|....*....|.
gi 1958751293 135 TPLHWAAFHNRPQHTQMLLKK 155
Cdd:cd22192   214 TPFKLAAKEGNIVMFQHLVQK 234
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 182-277 2.83e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.43  E-value: 2.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 182 CSIILSHRQGPSIINyDDESGKTCVHIAAASGFGDIIH--------------------DLAKVPE------CNLQALDVD 235
Cdd:PHA02876   99 CDIILDIKYASIILN-KHKLDEACIHILKEAISGNDIHydkinesieymklikeriqqDELLIAEmlleggADVNAKDIY 177

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1958751293 236 DRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYAL 277
Cdd:PHA02876  178 CITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAV 219
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 220-288 2.85e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.27  E-value: 2.85e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958751293 220 DLAKVPECNLQALDVDDRTPLHWA-------AAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLL 288
Cdd:PTZ00322   59 NKDATPDHNLTTEEVIDPVVAHMLtvelcqlAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVL 134
Ank_4 pfam13637
Ankyrin repeats (many copies);
168-221 3.15e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 3.15e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958751293 168 TALHWAVQSGNRILCSIILSHRQgpsIINYDDESGKTCVHIAAASGFGDIIHDL 221
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGA---DINAVDGNGETALHFAASNGNVEVLKLL 53
PHA02946 PHA02946
ankyin-like protein; Provisional
 23-230 3.92e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 39.65  E-value: 3.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293  23 SILECCDSEGCTPLMHA---VSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGR 99
Cdd:PHA02946   27 NMLQAIEPSGNYHILHAycgIKGLDERFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHK 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 100 LPLHAATAEPD-VRLLIVLLQQSSLSEINHQDTEGMTPLhWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN 178
Cdd:PHA02946  107 TPLYYLSGTDDeVIERINLLVQYGAKINNSVDEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIHRHLMSDN 185

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958751293 179 RILCSIILSHRQGPSiINYDDESGKTCVHIAAASGFG--DIIHDLAKVPECNLQ 230
Cdd:PHA02946  186 PKASTISWMMKLGIS-PSKPDHDGNTPLHIVCSKTVKnvDIINLLLPSTDVNKQ 238
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 235-263 6.55e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.16  E-value: 6.55e-03
                          10        20
                  ....*....|....*....|....*....
gi 1958751293 235 DDRTPLHWAAAAGKAECVQSLLDLGMDSN 263
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
Ank_4 pfam13637
Ankyrin repeats (many copies);
65-118 6.93e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.94  E-value: 6.93e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958751293  65 GRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLL 118
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 100-178 7.14e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.23  E-value: 7.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751293 100 LPLHAATAEPDVRLLIVLLQQSSlSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKkgADPTLVDK----DF---KTALHW 172
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLLKCPS-CDLFQRGALGETALHVAALYDNLEAAVVLME--AAPELVNEpmtsDLyqgETALHI 95


                  ....*.
gi 1958751293 173 AVQSGN 178
Cdd:cd22192    96 AVVNQN 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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