NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958751299|ref|XP_038958497|]
View 

ankyrin repeat domain-containing protein 55 isoform X8 [Rattus norvegicus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
10-200 1.31e-31

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.14  E-value: 1.31e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  10 INPKRLLIVLLQQSSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILS 89
Cdd:COG0666    62 ALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLE 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  90 HrqGPSiINYDDESGKTCVHIAAASGFGDIIHDLAKVPeCNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDI 169
Cdd:COG0666   142 A--GAD-VNAQDNDGNTPLHLAAANGNLEIVKLLLEAG-ADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDN 217

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1958751299 170 NESTPLAYALYCGHTACVRLLSREGRAEPAR 200
Cdd:COG0666   218 DGKTALDLAAENGNLEIVKLLLEAGADLNAK 248
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
10-200 1.31e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.14  E-value: 1.31e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  10 INPKRLLIVLLQQSSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILS 89
Cdd:COG0666    62 ALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLE 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  90 HrqGPSiINYDDESGKTCVHIAAASGFGDIIHDLAKVPeCNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDI 169
Cdd:COG0666   142 A--GAD-VNAQDNDGNTPLHLAAANGNLEIVKLLLEAG-ADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDN 217

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1958751299 170 NESTPLAYALYCGHTACVRLLSREGRAEPAR 200
Cdd:COG0666   218 DGKTALDLAAENGNLEIVKLLLEAGADLNAK 248
Ank_2 pfam12796
Ankyrin repeats (3 copies);
109-190 7.25e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 7.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299 109 HIAAASGFGDIIHDLAKvPECNLQALDVDDRTPLHWAAAAGKAECVQSLLDlGMDSNLRDiNESTPLAYALYCGHTACVR 188
Cdd:pfam12796   2 HLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ..
gi 1958751299 189 LL 190
Cdd:pfam12796  79 LL 80
PHA03095 PHA03095
ankyrin-like protein; Provisional
 28-190 1.67e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 63.12  E-value: 1.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  28 INHQDTEGMTPLH--WAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN------RILCsiilshRQGPSIINY 99
Cdd:PHA03095  110 VNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanvellRLLI------DAGADVYAV 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299 100 DDEsGKTCVHIAAAS--GFGDIIHDLAkVPECNLQALDVDDRTPLHWAAAAG--KAECVQSLLDLGMDSNLRDINESTPL 175
Cdd:PHA03095  184 DDR-FRSLLHHHLQSfkPRARIVRELI-RAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGISINARNRYGQTPL 261

                         170
                  ....*....|....*.
gi 1958751299 176 AYA-LYCGHTACVRLL 190
Cdd:PHA03095  262 HYAaVFNNPRACRRLI 277
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 34-63 1.10e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.11  E-value: 1.10e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958751299   34 EGMTPLHWAAFHNRPQHTQMLLKKGADPTL 63
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
10-200 1.31e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.14  E-value: 1.31e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  10 INPKRLLIVLLQQSSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILS 89
Cdd:COG0666    62 ALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLE 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  90 HrqGPSiINYDDESGKTCVHIAAASGFGDIIHDLAKVPeCNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDI 169
Cdd:COG0666   142 A--GAD-VNAQDNDGNTPLHLAAANGNLEIVKLLLEAG-ADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDN 217

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1958751299 170 NESTPLAYALYCGHTACVRLLSREGRAEPAR 200
Cdd:COG0666   218 DGKTALDLAAENGNLEIVKLLLEAGADLNAK 248
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
28-200 2.07e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 111.20  E-value: 2.07e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  28 INHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHrqGPsIINYDDESGKTC 107
Cdd:COG0666   113 VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA--GA-DVNARDNDGETP 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299 108 VHIAAASGFGDIIHDL----AkvpecNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGH 183
Cdd:COG0666   190 LHLAAENGHLEIVKLLleagA-----DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGA 264

                         170
                  ....*....|....*..
gi 1958751299 184 TACVRLLSREGRAEPAR 200
Cdd:COG0666   265 ALIVKLLLLALLLLAAA 281
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
13-190 1.82e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 103.11  E-value: 1.82e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  13 KRLLIVLLQQSSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHrq 92
Cdd:COG0666    32 LLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEA-- 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  93 GPSiINYDDESGKTCVHIAAASGFGDIIHDL----AKVpecNLQalDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRD 168
Cdd:COG0666   110 GAD-VNARDKDGETPLHLAAYNGNLEIVKLLleagADV---NAQ--DNDGNTPLHLAAANGNLEIVKLLLEAGADVNARD 183

                         170       180
                  ....*....|....*....|..
gi 1958751299 169 INESTPLAYALYCGHTACVRLL 190
Cdd:COG0666   184 NDGETPLHLAAENGHLEIVKLL 205
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
28-175 3.20e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 96.56  E-value: 3.20e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  28 INHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgpSIINYDDESGKTC 107
Cdd:COG0666   146 VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAG---ADVNAKDNDGKTA 222

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958751299 108 VHIAAASGFGDIIHDLAKVPEcNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPL 175
Cdd:COG0666   223 LDLAAENGNLEIVKLLLEAGA-DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
15-190 1.51e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 88.86  E-value: 1.51e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  15 LLIVLLQQSSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRIlcsIILSHRQGP 94
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLL---VALLLLAAG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  95 SIINYDDESGKTCVHIAAASGFGDIIHDLAKVPEcNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTP 174
Cdd:COG0666    78 ADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTP 156

                         170
                  ....*....|....*.
gi 1958751299 175 LAYALYCGHTACVRLL 190
Cdd:COG0666   157 LHLAAANGNLEIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
109-190 7.25e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 7.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299 109 HIAAASGFGDIIHDLAKvPECNLQALDVDDRTPLHWAAAAGKAECVQSLLDlGMDSNLRDiNESTPLAYALYCGHTACVR 188
Cdd:pfam12796   2 HLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ..
gi 1958751299 189 LL 190
Cdd:pfam12796  79 LL 80
Ank_2 pfam12796
Ankyrin repeats (3 copies);
72-168 7.99e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 7.99e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  72 LHWAVQSGNRILCSIILSHRQGPsiiNYDDESGKTCVHIAAASGFGDIIHDLAKVPECNLQaldVDDRTPLHWAAAAGKA 151
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADA---NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHL 74

                          90
                  ....*....|....*..
gi 1958751299 152 ECVQSLLDLGMDSNLRD 168
Cdd:pfam12796  75 EIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
142-190 1.47e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 57.82  E-value: 1.47e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958751299 142 LHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLL 190
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLL 49
PHA03095 PHA03095
ankyrin-like protein; Provisional
 28-190 1.67e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 63.12  E-value: 1.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  28 INHQDTEGMTPLH--WAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN------RILCsiilshRQGPSIINY 99
Cdd:PHA03095  110 VNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanvellRLLI------DAGADVYAV 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299 100 DDEsGKTCVHIAAAS--GFGDIIHDLAkVPECNLQALDVDDRTPLHWAAAAG--KAECVQSLLDLGMDSNLRDINESTPL 175
Cdd:PHA03095  184 DDR-FRSLLHHHLQSfkPRARIVRELI-RAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGISINARNRYGQTPL 261

                         170
                  ....*....|....*.
gi 1958751299 176 AYA-LYCGHTACVRLL 190
Cdd:PHA03095  262 HYAaVFNNPRACRRLI 277
Ank_4 pfam13637
Ankyrin repeats (many copies);
139-190 4.99e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.97  E-value: 4.99e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958751299 139 RTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLL 190
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PHA03095 PHA03095
ankyrin-like protein; Provisional
 6-188 5.38e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 61.58  E-value: 5.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299   6 SSDEINPKRLLIVLLQQSSlseINHQDTEGMTPLH-WAAFHNRPQHT-QMLLKKGADPTLVDKDFKTALHWAVQS---GN 80
Cdd:PHA03095  126 SGFNINPKVIRLLLRKGAD---VNALDLYGMTPLAvLLKSRNANVELlRLLIDAGADVYAVDDRFRSLLHHHLQSfkpRA 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  81 RILCSIIlSHRQGPSIINyddESGKTCVHIAAASGFGDIIHdLAKVPECNLQ--ALDVDDRTPLHWAAAAGKAECVQSLL 158
Cdd:PHA03095  203 RIVRELI-RAGCDPAATD---MLGNTPLHSMATGSSCKRSL-VLPLLIAGISinARNRYGQTPLHYAAVFNNPRACRRLI 277

                         170       180       190
                  ....*....|....*....|....*....|
gi 1958751299 159 DLGMDSNLRDINESTPLAYALYCGHTACVR 188
Cdd:PHA03095  278 ALGADINAVSSDGNTPLSLMVRNNNGRAVR 307
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 8-175 9.21e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 57.77  E-value: 9.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299   8 DEINPKRLLIVLLQQSSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSII 87
Cdd:PHA02876  151 ERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAI 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  88 LSHRqgpSIINYDDESGKTCVH--------IAAASGFgdiihdlakvpecNLQALDVDDRTPLHWAAAAGK-AECVQSLL 158
Cdd:PHA02876  231 IDNR---SNINKNDLSLLKAIRnedletslLLYDAGF-------------SVNSIDDCKNTPLHHASQAPSlSRLVPKLL 294

                         170
                  ....*....|....*..
gi 1958751299 159 DLGMDSNLRDINESTPL 175
Cdd:PHA02876  295 ERGADVNAKNIKGETPL 311
Ank_5 pfam13857
Ankyrin repeats (many copies);
129-178 2.55e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 50.04  E-value: 2.55e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958751299 129 CNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYA 178
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
35-80 4.46e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.58  E-value: 4.46e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958751299  35 GMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN 80
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGN 46
Ank_2 pfam12796
Ankyrin repeats (3 copies);
26-90 6.16e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.11  E-value: 6.16e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958751299  26 SEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKgADPTLVDKDfKTALHWAVQSGNRILCSIILSH 90
Cdd:pfam12796  21 ADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEIVKLLLEK 83
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 28-194 1.10e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.90  E-value: 1.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  28 INHQDTEGMTPLHWAAfHNRPQHTQM---LLKKGADPTLVDKDFKTALHWAVQSGNRIL--CSIILSHrqgpsIINYDde 102
Cdd:PHA03100   99 VNAPDNNGITPLLYAI-SKKSNSYSIveyLLDNGANVNIKNSDGENLLHLYLESNKIDLkiLKLLIDK-----GVDIN-- 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299 103 sGKTCVHIAAASGfgdiihdlakvpeCNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCG 182
Cdd:PHA03100  171 -AKNRVNYLLSYG-------------VPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNN 236

                         170
                  ....*....|..
gi 1958751299 183 HTACVRLLSREG 194
Cdd:PHA03100  237 NKEIFKLLLNNG 248
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 6-92 1.43e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.13  E-value: 1.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299   6 SSDEINPKRLLivllqqSSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCS 85
Cdd:PTZ00322   92 SGDAVGARILL------TGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165


                  ....*..
gi 1958751299  86 IILSHRQ 92
Cdd:PTZ00322  166 LLSRHSQ 172
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 28-96 2.21e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.13  E-value: 2.21e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958751299  28 INHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHrqGPSI 96
Cdd:PHA03100  185 INIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNN--GPSI 251
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 26-179 2.21e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 53.04  E-value: 2.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  26 SEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHrqGPSIINyDDESGK 105
Cdd:PHA02874  148 ADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDH--GNHIMN-KCKNGF 224

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958751299 106 TCVHIAaasgfgdIIHDLAKVP----ECNLQALDVDDRTPLHWA-AAAGKAECVQSLLDLGMDSNLRDINESTPLAYAL 179
Cdd:PHA02874  225 TPLHNA-------IIHNRSAIEllinNASINDQDIDGSTPLHHAiNPPCDIDIIDILLYHKADISIKDNKGENPIDTAF 296
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 17-191 2.39e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.96  E-value: 2.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  17 IVLLQQSSLSEINHQDTE-GMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILshRQGPS 95
Cdd:PHA02878  149 ITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILL--ENGAS 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  96 iINYDDESGKTCVHIAAASGFG-DIIHDLAKVPEC-NLQAlDVDDRTPLHwaAAAGKAECVQSLLDLGMDSNLRDINEST 173
Cdd:PHA02878  227 -TDARDKCGNTPLHISVGYCKDyDILKLLLEHGVDvNAKS-YILGLTALH--SSIKSERKLKLLLEYGADINSLNSYKLT 302

                         170       180
                  ....*....|....*....|
gi 1958751299 174 PLAYAL--YCGHTACVRLLS 191
Cdd:PHA02878  303 PLSSAVkqYLCINIGRILIS 322
Ank_5 pfam13857
Ankyrin repeats (many copies);
19-75 6.23e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.19  E-value: 6.23e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958751299  19 LLQQSSLSeINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWA 75
Cdd:pfam13857   1 LLEHGPID-LNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 29-194 7.05e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 51.53  E-value: 7.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  29 NHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQGPSIINYDDesGKTCV 108
Cdd:PHA02875   29 NFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKD--GMTPL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299 109 HIAAASGFGDIIHDLAKVpECNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVR 188
Cdd:PHA02875  107 HLATILKKLDIMKLLIAR-GADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICK 185


                  ....*.
gi 1958751299 189 LLSREG 194
Cdd:PHA02875  186 MLLDSG 191
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 34-166 1.08e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 50.76  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  34 EGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgpSIINYDDESGKTCVHIAAA 113
Cdd:PHA02875  101 DGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHK---ACLDIEDCCGCTPLIIAMA 177

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958751299 114 SGFGDI---IHDLAKVPECNLQALDVddrTPLHWAAAAGKAECVQSLLDLGMDSNL 166
Cdd:PHA02875  178 KGDIAIckmLLDSGANIDYFGKNGCV---AALCYAIENNKIDIVRLFIKRGADCNI 230
PHA02946 PHA02946
ankyin-like protein; Provisional
 29-175 4.10e-06

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 49.28  E-value: 4.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  29 NHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQGPSIINYDDESGktCV 108
Cdd:PHA02946   66 NETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEVIERINLLVQYGAKINNSVDEEG--CG 143

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958751299 109 HIAAASGFGDIIhdLAKVPECNLQALDVD----DRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPL 175
Cdd:PHA02946  144 PLLACTDPSERV--FKKIMSIGFEARIVDkfgkNHIHRHLMSDNPKASTISWMMKLGISPSKPDHDGNTPL 212
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 36-194 4.44e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 48.89  E-value: 4.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  36 MTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILC-----SIILSHrqGPSIINYDDEsGKTCVHI 110
Cdd:PHA03100   36 VLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLTDvkeivKLLLEY--GANVNAPDNN-GITPLLY 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299 111 AAASGFGD--IIHDLAKVpECNLQALDVDDRTPLHWAAAAGKAEC------------------VQSLLDLGMDSNLRDIN 170
Cdd:PHA03100  113 AISKKSNSysIVEYLLDN-GANVNIKNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYLLSYGVPINIKDVY 191

                         170       180
                  ....*....|....*....|....
gi 1958751299 171 ESTPLAYALYCGHTACVRLLSREG 194
Cdd:PHA03100  192 GFTPLHYAVYNNNPEFVKYLLDLG 215
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 14-178 8.67e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 48.52  E-value: 8.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  14 RLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHN-RPQHTQMLLKKGADPTLVDKDFKTALHWAvQSGNRILCSIILSHRQ 92
Cdd:PHA02876  288 RLVPKLLERGA--DVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQA-STLDRNKDIVITLLEL 364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  93 GPSIiNYDDESGKTCVHIAAASGFGDIIHDLAKVpECNLQALDVDDRTPLHWA-AAAGKAECVQSLLDLGMDSNLRDINE 171
Cdd:PHA02876  365 GANV-NARDYCDKTPIHYAAVRNNVVIINTLLDY-GADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKDL 442


                  ....*..
gi 1958751299 172 STPLAYA 178
Cdd:PHA02876  443 STPLHYA 449
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 100-190 1.15e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.94  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299 100 DDESGKTCVHIAAASGFGDIIHDLAKVpecNLQAlDVDD---RTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLA 176
Cdd:PLN03192  521 DDPNMASNLLTVASTGNAALLEELLKA---KLDP-DIGDskgRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALW 596

                          90
                  ....*....|....
gi 1958751299 177 YALYCGHTACVRLL 190
Cdd:PLN03192  597 NAISAKHHKIFRIL 610
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 26-194 2.22e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.98  E-value: 2.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  26 SEINHQDTEGMTPLHWAAFHNRPQHTQM-LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHrqGPSIINYDDESG 104
Cdd:PHA02876  332 ADVNAADRLYITPLHQASTLDRNKDIVItLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDY--GADIEALSQKIG 409

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299 105 kTCVHIAAasgFGDIIHDLAKV---PECNLQALDVDDRTPLHWAAAAG-KAECVQSLLDLGMDSNLRDINESTPLAYALy 180
Cdd:PHA02876  410 -TALHFAL---CGTNPYMSVKTlidRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIAL- 484

                         170
                  ....*....|....
gi 1958751299 181 cGHTACVRLLSREG 194
Cdd:PHA02876  485 -EYHGIVNILLHYG 497
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 34-66 2.26e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.12  E-value: 2.26e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1958751299  34 EGMTPLHWAAFH-NRPQHTQMLLKKGADPTLVDK 66
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
Ank_2 pfam12796
Ankyrin repeats (3 copies);
32-65 3.80e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.41  E-value: 3.80e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1958751299  32 DTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVD 65
Cdd:pfam12796  58 KDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 54-190 7.72e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.95  E-value: 7.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  54 LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgpSIINYDDESGKTCVHIAAASGFGDIIhdlakvpecnlqa 133
Cdd:PHA02874  110 ILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYG---ADVNIEDDNGCYPIHIAIKHNFFDII------------- 173

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958751299 134 ldvddrtplhwaaaagkaecvQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLL 190
Cdd:PHA02874  174 ---------------------KLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLL 209
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 34-61 8.59e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 39.55  E-value: 8.59e-05
                          10        20
                  ....*....|....*....|....*...
gi 1958751299  34 EGMTPLHWAAFHNRPQHTQMLLKKGADP 61
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADI 28
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 137-168 1.03e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.58  E-value: 1.03e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1958751299 137 DDRTPLHWAAA-AGKAECVQSLLDLGMDSNLRD 168
Cdd:pfam00023   1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 135-192 1.08e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.89  E-value: 1.08e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958751299 135 DVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLLSR 192
Cdd:PTZ00322  112 DYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 34-63 1.10e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.11  E-value: 1.10e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958751299   34 EGMTPLHWAAFHNRPQHTQMLLKKGADPTL 63
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA03095 PHA03095
ankyrin-like protein; Provisional
 28-96 1.22e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 44.63  E-value: 1.22e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958751299  28 INHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgPSI 96
Cdd:PHA03095  250 INARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKN--PSA 316
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 54-194 1.25e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.86  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  54 LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQGpsiINYDDESGKTCVHIAAASGFG---DIIHDLAKVPECN 130
Cdd:PLN03192  544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACN---VHIRDANGNTALWNAISAKHHkifRILYHFASISDPH 620

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958751299 131 LqALDVddrtpLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLLSREG 194
Cdd:PLN03192  621 A-AGDL-----LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNG 678
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 52-133 2.14e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.73  E-value: 2.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  52 QMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQGPSIInydDESGKTCVHIAAASGFGDIIHDLAKVPECNL 131
Cdd:PTZ00322   99 RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLL---DKDGKTPLELAEENGFREVVQLLSRHSQCHF 175


                  ..
gi 1958751299 132 QA 133
Cdd:PTZ00322  176 EL 177
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 18-180 3.38e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 43.13  E-value: 3.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  18 VLLQQSSLSeINHQDTEGMTPLHWAAfhNRPQHTQM---LLKKGADPTLVDKDFKTALHWAVQSG---NRILCSIILShr 91
Cdd:PHA02876  257 LLLYDAGFS-VNSIDDCKNTPLHHAS--QAPSLSRLvpkLLERGADVNAKNIKGETPLYLMAKNGydtENIRTLIMLG-- 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  92 qgpSIINYDDESGKTCVHIAAA-SGFGDIIHDLAKVpECNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDIN 170
Cdd:PHA02876  332 ---ADVNAADRLYITPLHQASTlDRNKDIVITLLEL-GANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQK 407

                         170
                  ....*....|
gi 1958751299 171 ESTPLAYALY 180
Cdd:PHA02876  408 IGTALHFALC 417
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 137-166 3.67e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.57  E-value: 3.67e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958751299  137 DDRTPLHWAAAAGKAECVQSLLDLGMDSNL 166
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
109-194 9.43e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.09  E-value: 9.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299 109 HIAAASGFGDIIHDLAKVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVR 188
Cdd:COG0666    25 LLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVK 104


                  ....*.
gi 1958751299 189 LLSREG 194
Cdd:COG0666   105 LLLEAG 110
Ank_4 pfam13637
Ankyrin repeats (many copies);
27-55 1.44e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 1.44e-03
                          10        20
                  ....*....|....*....|....*....
gi 1958751299  27 EINHQDTEGMTPLHWAAFHNRPQHTQMLL 55
Cdd:pfam13637  26 DINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
70-123 1.47e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 1.47e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958751299  70 TALHWAVQSGNRILCSIILSHRQgpsIINYDDESGKTCVHIAAASGFGDIIHDL 123
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGA---DINAVDGNGETALHFAASNGNVEVLKLL 53
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 84-179 2.23e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.43  E-value: 2.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751299  84 CSIILSHRQGPSIINyDDESGKTCVHIAAASGFGDIIH--------------------DLAKVPE------CNLQALDVD 137
Cdd:PHA02876   99 CDIILDIKYASIILN-KHKLDEACIHILKEAISGNDIHydkinesieymklikeriqqDELLIAEmlleggADVNAKDIY 177

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1958751299 138 DRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYAL 179
Cdd:PHA02876  178 CITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAV 219
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 122-190 2.78e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.27  E-value: 2.78e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958751299 122 DLAKVPECNLQALDVDDRTPLHWA-------AAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLL 190
Cdd:PTZ00322   59 NKDATPDHNLTTEEVIDPVVAHMLtvelcqlAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVL 134
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 137-165 5.54e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.54  E-value: 5.54e-03
                          10        20
                  ....*....|....*....|....*....
gi 1958751299 137 DDRTPLHWAAAAGKAECVQSLLDLGMDSN 165
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
Ank_4 pfam13637
Ankyrin repeats (many copies);
106-158 5.67e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.94  E-value: 5.67e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958751299 106 TCVHIAAASGFGDIIHDLAKVPeCNLQALDVDDRTPLHWAAAAGKAECVQSLL 158
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKG-ADINAVDGNGETALHFAASNGNVEVLKLLL 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH