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Conserved domains on  [gi|1958751301|ref|XP_038958498|]
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ankyrin repeat domain-containing protein 55 isoform X9 [Rattus norvegicus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
22-194 1.96e-27

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 111.20  E-value: 1.96e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  22 INHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHrqGPsIINYDDESGKTC 101
Cdd:COG0666   113 VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA--GA-DVNARDNDGETP 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301 102 VHIAAASGFGDIIHDL----AkvpecNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGH 177
Cdd:COG0666   190 LHLAAENGHLEIVKLLleagA-----DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGA 264

                         170
                  ....*....|....*..
gi 1958751301 178 TACVRLLSREGRAEPAR 194
Cdd:COG0666   265 ALIVKLLLLALLLLAAA 281
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
22-194 1.96e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 111.20  E-value: 1.96e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  22 INHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHrqGPsIINYDDESGKTC 101
Cdd:COG0666   113 VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA--GA-DVNARDNDGETP 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301 102 VHIAAASGFGDIIHDL----AkvpecNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGH 177
Cdd:COG0666   190 LHLAAENGHLEIVKLLleagA-----DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGA 264

                         170
                  ....*....|....*..
gi 1958751301 178 TACVRLLSREGRAEPAR 194
Cdd:COG0666   265 ALIVKLLLLALLLLAAA 281
Ank_2 pfam12796
Ankyrin repeats (3 copies);
103-184 7.14e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 7.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301 103 HIAAASGFGDIIHDLAKvPECNLQALDVDDRTPLHWAAAAGKAECVQSLLDlGMDSNLRDiNESTPLAYALYCGHTACVR 182
Cdd:pfam12796   2 HLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ..
gi 1958751301 183 LL 184
Cdd:pfam12796  79 LL 80
PHA03095 PHA03095
ankyrin-like protein; Provisional
 22-184 1.63e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 63.12  E-value: 1.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  22 INHQDTEGMTPLH--WAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN------RILCsiilshRQGPSIINY 93
Cdd:PHA03095  110 VNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanvellRLLI------DAGADVYAV 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  94 DDEsGKTCVHIAAAS--GFGDIIHDLAkVPECNLQALDVDDRTPLHWAAAAG--KAECVQSLLDLGMDSNLRDINESTPL 169
Cdd:PHA03095  184 DDR-FRSLLHHHLQSfkPRARIVRELI-RAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGISINARNRYGQTPL 261

                         170
                  ....*....|....*.
gi 1958751301 170 AYA-LYCGHTACVRLL 184
Cdd:PHA03095  262 HYAaVFNNPRACRRLI 277
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 28-57 1.08e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.11  E-value: 1.08e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958751301   28 EGMTPLHWAAFHNRPQHTQMLLKKGADPTL 57
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
22-194 1.96e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 111.20  E-value: 1.96e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  22 INHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHrqGPsIINYDDESGKTC 101
Cdd:COG0666   113 VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA--GA-DVNARDNDGETP 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301 102 VHIAAASGFGDIIHDL----AkvpecNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGH 177
Cdd:COG0666   190 LHLAAENGHLEIVKLLleagA-----DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGA 264

                         170
                  ....*....|....*..
gi 1958751301 178 TACVRLLSREGRAEPAR 194
Cdd:COG0666   265 ALIVKLLLLALLLLAAA 281
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
22-169 3.08e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 96.56  E-value: 3.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  22 INHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgpSIINYDDESGKTC 101
Cdd:COG0666   146 VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAG---ADVNAKDNDGKTA 222

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958751301 102 VHIAAASGFGDIIHDLAKVPEcNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPL 169
Cdd:COG0666   223 LDLAAENGNLEIVKLLLEAGA-DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
9-184 1.47e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 88.86  E-value: 1.47e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301   9 LLIVLLQQSSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRIlcsIILSHRQGP 88
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLL---VALLLLAAG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  89 SIINYDDESGKTCVHIAAASGFGDIIHDLAKVPEcNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTP 168
Cdd:COG0666    78 ADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTP 156

                         170
                  ....*....|....*.
gi 1958751301 169 LAYALYCGHTACVRLL 184
Cdd:COG0666   157 LHLAAANGNLEIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
103-184 7.14e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 7.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301 103 HIAAASGFGDIIHDLAKvPECNLQALDVDDRTPLHWAAAAGKAECVQSLLDlGMDSNLRDiNESTPLAYALYCGHTACVR 182
Cdd:pfam12796   2 HLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ..
gi 1958751301 183 LL 184
Cdd:pfam12796  79 LL 80
Ank_2 pfam12796
Ankyrin repeats (3 copies);
66-162 7.88e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 7.88e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  66 LHWAVQSGNRILCSIILSHRQGPsiiNYDDESGKTCVHIAAASGFGDIIHDLAKVPECNLQaldVDDRTPLHWAAAAGKA 145
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADA---NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHL 74

                          90
                  ....*....|....*..
gi 1958751301 146 ECVQSLLDLGMDSNLRD 162
Cdd:pfam12796  75 EIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
136-184 1.45e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 57.82  E-value: 1.45e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958751301 136 LHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLL 184
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLL 49
PHA03095 PHA03095
ankyrin-like protein; Provisional
 22-184 1.63e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 63.12  E-value: 1.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  22 INHQDTEGMTPLH--WAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN------RILCsiilshRQGPSIINY 93
Cdd:PHA03095  110 VNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanvellRLLI------DAGADVYAV 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  94 DDEsGKTCVHIAAAS--GFGDIIHDLAkVPECNLQALDVDDRTPLHWAAAAG--KAECVQSLLDLGMDSNLRDINESTPL 169
Cdd:PHA03095  184 DDR-FRSLLHHHLQSfkPRARIVRELI-RAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGISINARNRYGQTPL 261

                         170
                  ....*....|....*.
gi 1958751301 170 AYA-LYCGHTACVRLL 184
Cdd:PHA03095  262 HYAaVFNNPRACRRLI 277
Ank_4 pfam13637
Ankyrin repeats (many copies);
133-184 4.93e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.97  E-value: 4.93e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958751301 133 RTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLL 184
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PHA03095 PHA03095
ankyrin-like protein; Provisional
 22-182 8.23e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 60.81  E-value: 8.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  22 INHQDTEGMTPLH-WAAFHNRPQHT-QMLLKKGADPTLVDKDFKTALHWAVQS---GNRILCSIIlSHRQGPSIINyddE 96
Cdd:PHA03095  145 VNALDLYGMTPLAvLLKSRNANVELlRLLIDAGADVYAVDDRFRSLLHHHLQSfkpRARIVRELI-RAGCDPAATD---M 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  97 SGKTCVHIAAASGFGDIIHdLAKVPECNLQ--ALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALY 174
Cdd:PHA03095  221 LGNTPLHSMATGSSCKRSL-VLPLLIAGISinARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVR 299


                  ....*...
gi 1958751301 175 CGHTACVR 182
Cdd:PHA03095  300 NNNGRAVR 307
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 9-169 2.26e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 56.61  E-value: 2.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301   9 LLIVLLQQSSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgp 88
Cdd:PHA02876  158 LLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNR--- 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  89 SIINYDDESGKTCVH--------IAAASGFgdiihdlakvpecNLQALDVDDRTPLHWAAAAGK-AECVQSLLDLGMDSN 159
Cdd:PHA02876  235 SNINKNDLSLLKAIRnedletslLLYDAGF-------------SVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVN 301

                         170
                  ....*....|
gi 1958751301 160 LRDINESTPL 169
Cdd:PHA02876  302 AKNIKGETPL 311
Ank_5 pfam13857
Ankyrin repeats (many copies);
123-172 2.52e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 50.04  E-value: 2.52e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958751301 123 CNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYA 172
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
29-74 4.41e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.58  E-value: 4.41e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958751301  29 GMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN 74
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGN 46
Ank_2 pfam12796
Ankyrin repeats (3 copies);
20-84 6.07e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.11  E-value: 6.07e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958751301  20 SEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKgADPTLVDKDfKTALHWAVQSGNRILCSIILSH 84
Cdd:pfam12796  21 ADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEIVKLLLEK 83
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 6-188 8.01e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 54.29  E-value: 8.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301   6 TIWLLIVLLQQsslseINHQDTEGMTPLHWAAfHNRPQHTQM---LLKKGADPTLVDKDFKTALHWAVQSGNRIL--CSI 80
Cdd:PHA03100   88 IVKLLLEYGAN-----VNAPDNNGITPLLYAI-SKKSNSYSIveyLLDNGANVNIKNSDGENLLHLYLESNKIDLkiLKL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  81 ILSHrqgpsIINYDdesGKTCVHIAAASGfgdiihdlakvpeCNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNL 160
Cdd:PHA03100  162 LIDK-----GVDIN---AKNRVNYLLSYG-------------VPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNL 220

                         170       180
                  ....*....|....*....|....*...
gi 1958751301 161 RDINESTPLAYALYCGHTACVRLLSREG 188
Cdd:PHA03100  221 VNKYGDTPLHIAILNNNKEIFKLLLNNG 248
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 12-86 1.42e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.13  E-value: 1.42e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958751301  12 VLLqqSSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQ 86
Cdd:PTZ00322  100 ILL--TGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQ 172
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 22-90 2.16e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.13  E-value: 2.16e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958751301  22 INHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHrqGPSI 90
Cdd:PHA03100  185 INIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNN--GPSI 251
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 20-173 2.17e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 53.04  E-value: 2.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  20 SEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHrqGPSIINyDDESGK 99
Cdd:PHA02874  148 ADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDH--GNHIMN-KCKNGF 224

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958751301 100 TCVHIAaasgfgdIIHDLAKVP----ECNLQALDVDDRTPLHWA-AAAGKAECVQSLLDLGMDSNLRDINESTPLAYAL 173
Cdd:PHA02874  225 TPLHNA-------IIHNRSAIEllinNASINDQDIDGSTPLHHAiNPPCDIDIIDILLYHKADISIKDNKGENPIDTAF 296
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 11-185 2.34e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.96  E-value: 2.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  11 IVLLQQSSLSEINHQDTE-GMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILshRQGPS 89
Cdd:PHA02878  149 ITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILL--ENGAS 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  90 iINYDDESGKTCVHIAAASGFG-DIIHDLAKVPEC-NLQAlDVDDRTPLHwaAAAGKAECVQSLLDLGMDSNLRDINEST 167
Cdd:PHA02878  227 -TDARDKCGNTPLHISVGYCKDyDILKLLLEHGVDvNAKS-YILGLTALH--SSIKSERKLKLLLEYGADINSLNSYKLT 302

                         170       180
                  ....*....|....*....|
gi 1958751301 168 PLAYAL--YCGHTACVRLLS 185
Cdd:PHA02878  303 PLSSAVkqYLCINIGRILIS 322
Ank_5 pfam13857
Ankyrin repeats (many copies);
13-69 6.16e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.19  E-value: 6.16e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958751301  13 LLQQSSLSeINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWA 69
Cdd:pfam13857   1 LLEHGPID-LNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 23-188 6.91e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 51.53  E-value: 6.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  23 NHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQGPSIINYDDesGKTCV 102
Cdd:PHA02875   29 NFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKD--GMTPL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301 103 HIAAASGFGDIIHDLAKVpECNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVR 182
Cdd:PHA02875  107 HLATILKKLDIMKLLIAR-GADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICK 185


                  ....*.
gi 1958751301 183 LLSREG 188
Cdd:PHA02875  186 MLLDSG 191
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 28-160 1.06e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 50.76  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  28 EGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgpSIINYDDESGKTCVHIAAA 107
Cdd:PHA02875  101 DGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHK---ACLDIEDCCGCTPLIIAMA 177

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958751301 108 SGFGDI---IHDLAKVPECNLQALDVddrTPLHWAAAAGKAECVQSLLDLGMDSNL 160
Cdd:PHA02875  178 KGDIAIckmLLDSGANIDYFGKNGCV---AALCYAIENNKIDIVRLFIKRGADCNI 230
PHA02946 PHA02946
ankyin-like protein; Provisional
 23-169 3.43e-06

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 49.28  E-value: 3.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  23 NHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQGPSIINYDDESGktCV 102
Cdd:PHA02946   66 NETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEVIERINLLVQYGAKINNSVDEEG--CG 143

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958751301 103 HIAAASGFGDIIhdLAKVPECNLQALDVD----DRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPL 169
Cdd:PHA02946  144 PLLACTDPSERV--FKKIMSIGFEARIVDkfgkNHIHRHLMSDNPKASTISWMMKLGISPSKPDHDGNTPL 212
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 30-188 4.36e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 48.89  E-value: 4.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  30 MTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILC-----SIILSHrqGPSIINYDDEsGKTCVHI 104
Cdd:PHA03100   36 VLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLTDvkeivKLLLEY--GANVNAPDNN-GITPLLY 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301 105 AAASGFGD--IIHDLAKVpECNLQALDVDDRTPLHWAAAAGKAEC------------------VQSLLDLGMDSNLRDIN 164
Cdd:PHA03100  113 AISKKSNSysIVEYLLDN-GANVNIKNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYLLSYGVPINIKDVY 191

                         170       180
                  ....*....|....*....|....
gi 1958751301 165 ESTPLAYALYCGHTACVRLLSREG 188
Cdd:PHA03100  192 GFTPLHYAVYNNNPEFVKYLLDLG 215
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 94-184 1.12e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.94  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  94 DDESGKTCVHIAAASGFGDIIHDLAKVpecNLQAlDVDD---RTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLA 170
Cdd:PLN03192  521 DDPNMASNLLTVASTGNAALLEELLKA---KLDP-DIGDskgRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALW 596

                          90
                  ....*....|....
gi 1958751301 171 YALYCGHTACVRLL 184
Cdd:PLN03192  597 NAISAKHHKIFRIL 610
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 20-188 2.18e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.98  E-value: 2.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  20 SEINHQDTEGMTPLHWAAFHNRPQHTQM-LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHrqGPSIINYDDESG 98
Cdd:PHA02876  332 ADVNAADRLYITPLHQASTLDRNKDIVItLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDY--GADIEALSQKIG 409

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  99 kTCVHIAAasgFGDIIHDLAKV---PECNLQALDVDDRTPLHWAAAAG-KAECVQSLLDLGMDSNLRDINESTPLAYALy 174
Cdd:PHA02876  410 -TALHFAL---CGTNPYMSVKTlidRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIAL- 484

                         170
                  ....*....|....
gi 1958751301 175 cGHTACVRLLSREG 188
Cdd:PHA02876  485 -EYHGIVNILLHYG 497
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 21-172 2.38e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.98  E-value: 2.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  21 EINHQDTEGMTPLHWAAFHN-RPQHTQMLLKKGADPTLVDKDFKTALHWAvQSGNRILCSIILSHRQGPSIiNYDDESGK 99
Cdd:PHA02876  299 DVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQA-STLDRNKDIVITLLELGANV-NARDYCDK 376

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958751301 100 TCVHIAAASGFGDIIHDLAKVpECNLQALDVDDRTPLHWA-AAAGKAECVQSLLDLGMDSNLRDINESTPLAYA 172
Cdd:PHA02876  377 TPIHYAAVRNNVVIINTLLDY-GADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYA 449
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 28-60 2.56e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.12  E-value: 2.56e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1958751301  28 EGMTPLHWAAFH-NRPQHTQMLLKKGADPTLVDK 60
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
Ank_2 pfam12796
Ankyrin repeats (3 copies);
26-59 3.75e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.41  E-value: 3.75e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1958751301  26 DTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVD 59
Cdd:pfam12796  58 KDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 21-173 4.90e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 45.72  E-value: 4.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  21 EINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILshrQGPSIINYDDESGKT 100
Cdd:PHA02874  116 DVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLL---EKGAYANVKDNNGES 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301 101 CVHIAAAsgFGD-------IIHDLAKVPECNlqaldvDDRTPLHWAAAAGKAecVQSLLDLGMDSNLRDINESTPLAYAL 173
Cdd:PHA02874  193 PLHNAAE--YGDyacikllIDHGNHIMNKCK------NGFTPLHNAIIHNRS--AIELLINNASINDQDIDGSTPLHHAI 262
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 48-184 7.58e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.95  E-value: 7.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  48 LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgpSIINYDDESGKTCVHIAAASGFGDIIhdlakvpecnlqa 127
Cdd:PHA02874  110 ILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYG---ADVNIEDDNGCYPIHIAIKHNFFDII------------- 173

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958751301 128 ldvddrtplhwaaaagkaecvQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLL 184
Cdd:PHA02874  174 ---------------------KLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLL 209
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 28-55 8.49e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 39.55  E-value: 8.49e-05
                          10        20
                  ....*....|....*....|....*...
gi 1958751301  28 EGMTPLHWAAFHNRPQHTQMLLKKGADP 55
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADI 28
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 129-186 1.01e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.89  E-value: 1.01e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958751301 129 DVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLLSR 186
Cdd:PTZ00322  112 DYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 28-57 1.08e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.11  E-value: 1.08e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958751301   28 EGMTPLHWAAFHNRPQHTQMLLKKGADPTL 57
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 131-162 1.18e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.19  E-value: 1.18e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1958751301 131 DDRTPLHWAAA-AGKAECVQSLLDLGMDSNLRD 162
Cdd:pfam00023   1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
PHA03095 PHA03095
ankyrin-like protein; Provisional
 22-90 1.19e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 44.63  E-value: 1.19e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958751301  22 INHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgPSI 90
Cdd:PHA03095  250 INARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKN--PSA 316
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 48-188 1.22e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.86  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  48 LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQGpsiINYDDESGKTCVHIAAASGFG---DIIHDLAKVPECN 124
Cdd:PLN03192  544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACN---VHIRDANGNTALWNAISAKHHkifRILYHFASISDPH 620

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958751301 125 LqALDVddrtpLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLLSREG 188
Cdd:PLN03192  621 A-AGDL-----LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNG 678
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 46-127 2.00e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.12  E-value: 2.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  46 QMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQGPSIInydDESGKTCVHIAAASGFGDIIHDLAKVPECNL 125
Cdd:PTZ00322   99 RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLL---DKDGKTPLELAEENGFREVVQLLSRHSQCHF 175


                  ..
gi 1958751301 126 QA 127
Cdd:PTZ00322  176 EL 177
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 12-174 3.32e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 43.13  E-value: 3.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  12 VLLQQSSLSeINHQDTEGMTPLHWAAfhNRPQHTQM---LLKKGADPTLVDKDFKTALHWAVQSG---NRILCSIILShr 85
Cdd:PHA02876  257 LLLYDAGFS-VNSIDDCKNTPLHHAS--QAPSLSRLvpkLLERGADVNAKNIKGETPLYLMAKNGydtENIRTLIMLG-- 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  86 qgpSIINYDDESGKTCVHIAAA-SGFGDIIHDLAKVpECNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDIN 164
Cdd:PHA02876  332 ---ADVNAADRLYITPLHQASTlDRNKDIVITLLEL-GANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQK 407

                         170
                  ....*....|
gi 1958751301 165 ESTPLAYALY 174
Cdd:PHA02876  408 IGTALHFALC 417
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 131-160 3.62e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.57  E-value: 3.62e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958751301  131 DDRTPLHWAAAAGKAECVQSLLDLGMDSNL 160
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
103-188 9.27e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.09  E-value: 9.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301 103 HIAAASGFGDIIHDLAKVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVR 182
Cdd:COG0666    25 LLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVK 104


                  ....*.
gi 1958751301 183 LLSREG 188
Cdd:COG0666   105 LLLEAG 110
Ank_4 pfam13637
Ankyrin repeats (many copies);
21-49 1.42e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 1.42e-03
                          10        20
                  ....*....|....*....|....*....
gi 1958751301  21 EINHQDTEGMTPLHWAAFHNRPQHTQMLL 49
Cdd:pfam13637  26 DINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
64-117 1.45e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 1.45e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958751301  64 TALHWAVQSGNRILCSIILSHRQgpsIINYDDESGKTCVHIAAASGFGDIIHDL 117
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGA---DINAVDGNGETALHFAASNGNVEVLKLL 53
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 78-173 2.19e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.43  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751301  78 CSIILSHRQGPSIINyDDESGKTCVHIAAASGFGDIIH--------------------DLAKVPE------CNLQALDVD 131
Cdd:PHA02876   99 CDIILDIKYASIILN-KHKLDEACIHILKEAISGNDIHydkinesieymklikeriqqDELLIAEmlleggADVNAKDIY 177

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1958751301 132 DRTPLHWAAAAGKAECVQSLLDLGMDSNLRDINESTPLAYAL 173
Cdd:PHA02876  178 CITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAV 219
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 116-184 2.46e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.27  E-value: 2.46e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958751301 116 DLAKVPECNLQALDVDDRTPLHWA-------AAAGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLL 184
Cdd:PTZ00322   59 NKDATPDHNLTTEEVIDPVVAHMLtvelcqlAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVL 134
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 131-159 5.47e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.54  E-value: 5.47e-03
                          10        20
                  ....*....|....*....|....*....
gi 1958751301 131 DDRTPLHWAAAAGKAECVQSLLDLGMDSN 159
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
Ank_4 pfam13637
Ankyrin repeats (many copies);
100-152 5.60e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.94  E-value: 5.60e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958751301 100 TCVHIAAASGFGDIIHDLAKVPeCNLQALDVDDRTPLHWAAAAGKAECVQSLL 152
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKG-ADINAVDGNGETALHFAASNGNVEVLKLLL 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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