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Conserved domains on  [gi|1958751700|ref|XP_038958650|]
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GTPase IMAP family member GIMD1 isoform X1 [Rattus norvegicus]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 9-175 1.13e-24

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd01852:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 201  Bit Score: 96.07  E-value: 1.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751700   9 INLAVLGKTQSGKSSAGNVLLGSADFYSRFAPGSVTKDCSLGRSchihgfmRRGGHEISlqiqVLDTPGYPHSKLSTRCV 88
Cdd:cd01852     1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESA-------VWDGRRVN----VIDTPGLFDTSVSPEQL 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751700  89 KQEVKKALEHHFgqEGLHLALLVHRADMpfFGQEASDSVQLIQELLGDSWKNYTAILFTHAEKIkeAGLSEEEYLCEASD 168
Cdd:cd01852    70 SKEIIRCLSLSA--PGPHAFLLVVPLGR--FTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDL--EGGSLEDYLEDSCE 143


                  ....*..
gi 1958751700 169 ALLTLLN 175
Cdd:cd01852   144 ALKRLLE 150
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 9-175 1.13e-24

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 96.07  E-value: 1.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751700   9 INLAVLGKTQSGKSSAGNVLLGSADFYSRFAPGSVTKDCSLGRSchihgfmRRGGHEISlqiqVLDTPGYPHSKLSTRCV 88
Cdd:cd01852     1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESA-------VWDGRRVN----VIDTPGLFDTSVSPEQL 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751700  89 KQEVKKALEHHFgqEGLHLALLVHRADMpfFGQEASDSVQLIQELLGDSWKNYTAILFTHAEKIkeAGLSEEEYLCEASD 168
Cdd:cd01852    70 SKEIIRCLSLSA--PGPHAFLLVVPLGR--FTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDL--EGGSLEDYLEDSCE 143


                  ....*..
gi 1958751700 169 ALLTLLN 175
Cdd:cd01852   144 ALKRLLE 150
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 10-174 2.41e-21

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 87.28  E-value: 2.41e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751700  10 NLAVLGKTQSGKSSAGNVLLGSADFYSRFAPGSVTKDCSLGRSchihgfmRRGGHEISlqiqVLDTPGYPHSKLSTRCVK 89
Cdd:pfam04548   2 RIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSR-------TWDGRIIN----VIDTPGLFDLSVSNDFIS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751700  90 QEVKKALehHFGQEGLHLALLVhrADMPFFGQEASDSVQLIQELLGDSWKNYTAILFTHAEKIKEAGLseEEYLCEAS-D 168
Cdd:pfam04548  71 KEIIRCL--LLAEPGPHAVLLV--LSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSL--DDYLSDGCpE 144


                  ....*.
gi 1958751700 169 ALLTLL 174
Cdd:pfam04548 145 FLKEVL 150
YeeP COG3596
Predicted GTPase [General function prediction only];
10-152 3.30e-07

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 49.76  E-value: 3.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751700  10 NLAVLGKTQSGKSSAGNVLLGsadfySRFAPGSVTKDCSlgRSCHIHGFMRRGGHEISLqiqvLDTPGYPHSKLSTRCVK 89
Cdd:COG3596    41 VIALVGKTGAGKSSLINALFG-----AEVAEVGVGRPCT--REIQRYRLESDGLPGLVL----LDTPGLGEVNERDREYR 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958751700  90 QeVKKALEHhfgqegLHLALLVHRADMPFFgqeASDsVQLIQELLGDSWKNYTAILFTHAEKI 152
Cdd:COG3596   110 E-LRELLPE------ADLILWVVKADDRAL---ATD-EEFLQALRAQYPDPPVLVVLTQVDRL 161
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 9-175 1.13e-24

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 96.07  E-value: 1.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751700   9 INLAVLGKTQSGKSSAGNVLLGSADFYSRFAPGSVTKDCSLGRSchihgfmRRGGHEISlqiqVLDTPGYPHSKLSTRCV 88
Cdd:cd01852     1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESA-------VWDGRRVN----VIDTPGLFDTSVSPEQL 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751700  89 KQEVKKALEHHFgqEGLHLALLVHRADMpfFGQEASDSVQLIQELLGDSWKNYTAILFTHAEKIkeAGLSEEEYLCEASD 168
Cdd:cd01852    70 SKEIIRCLSLSA--PGPHAFLLVVPLGR--FTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDL--EGGSLEDYLEDSCE 143


                  ....*..
gi 1958751700 169 ALLTLLN 175
Cdd:cd01852   144 ALKRLLE 150
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 10-174 2.41e-21

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 87.28  E-value: 2.41e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751700  10 NLAVLGKTQSGKSSAGNVLLGSADFYSRFAPGSVTKDCSLGRSchihgfmRRGGHEISlqiqVLDTPGYPHSKLSTRCVK 89
Cdd:pfam04548   2 RIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSR-------TWDGRIIN----VIDTPGLFDLSVSNDFIS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751700  90 QEVKKALehHFGQEGLHLALLVhrADMPFFGQEASDSVQLIQELLGDSWKNYTAILFTHAEKIKEAGLseEEYLCEAS-D 168
Cdd:pfam04548  71 KEIIRCL--LLAEPGPHAVLLV--LSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSL--DDYLSDGCpE 144


                  ....*.
gi 1958751700 169 ALLTLL 174
Cdd:pfam04548 145 FLKEVL 150
YeeP COG3596
Predicted GTPase [General function prediction only];
10-152 3.30e-07

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 49.76  E-value: 3.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751700  10 NLAVLGKTQSGKSSAGNVLLGsadfySRFAPGSVTKDCSlgRSCHIHGFMRRGGHEISLqiqvLDTPGYPHSKLSTRCVK 89
Cdd:COG3596    41 VIALVGKTGAGKSSLINALFG-----AEVAEVGVGRPCT--REIQRYRLESDGLPGLVL----LDTPGLGEVNERDREYR 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958751700  90 QeVKKALEHhfgqegLHLALLVHRADMPFFgqeASDsVQLIQELLGDSWKNYTAILFTHAEKI 152
Cdd:COG3596   110 E-LRELLPE------ADLILWVVKADDRAL---ATD-EEFLQALRAQYPDPPVLVVLTQVDRL 161
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
 9-182 2.03e-03

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 38.07  E-value: 2.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751700   9 INLAVLGKTQSGKSSAGNVLLG------SAdFYS---RFAPGSVTKDcslgrschihGFmrrggheislQIQVLDTPGY- 78
Cdd:cd01853    32 LTILVLGKTGVGKSSTINSIFGerkvsvSA-FQSetlRPREVSRTVD----------GF----------KLNIIDTPGLl 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751700  79 PHSK-------LSTrcVKQEVKKalehhfgqEGLHLALLVHRADMPFFGQEASDSVQLIQELLGDS-WKNyTAILFTHAE 150
Cdd:cd01853    91 ESQDqrvnrkiLSI--IKRFLKK--------KTIDVVLYVDRLDMYRVDNLDVPLLRAITDSFGPSiWRN-AIVVLTHAQ 159

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1958751700 151 KIKEAGLSEEEYLCEASDALLTllnSVQHRHI 182
Cdd:cd01853   160 SSPPDGPNGTPFSYDRFVAQRK---HIVQQAI 188
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 12-97 5.10e-03

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 35.67  E-value: 5.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958751700  12 AVLGKTQSGKSSAGNVLLGS----ADFysrfaPGsVTKDCslgrschIHGFMRRGGHeislQIQVLDTPGYPHSKLSTRC 87
Cdd:pfam01926   3 ALVGRPNVGKSTLINALTGAkaivSDY-----PG-TTRDP-------NEGRLELKGK----QIILVDTPGLIEGASEGEG 65

                          90
                  ....*....|
gi 1958751700  88 VKQEVKKALE 97
Cdd:pfam01926  66 LGRAFLAIIE 75
FtsK_SpoIIIE pfam01580
FtsK/SpoIIIE family; FtsK has extensive sequence similarity to wide variety of proteins from ...
 3-44 5.82e-03

FtsK/SpoIIIE family; FtsK has extensive sequence similarity to wide variety of proteins from prokaryotes and plasmids, termed the FtsK/SpoIIIE family. This domain contains a putative ATP binding P-loop motif. It is found in the FtsK cell division protein from E. coli and the stage III sporulation protein E SpoIIIE, which has roles in regulation of prespore specific gene expression in B. subtilis. A mutation in FtsK causes a temperature sensitive block in cell division and it is involved in peptidoglycan synthesis or modification. The SpoIIIE protein is implicated in intercellular chromosomal DNA transfer.


Pssm-ID: 279863 [Multi-domain]  Cd Length: 219  Bit Score: 36.59  E-value: 5.82e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1958751700   3 DANKMIINLAVLGKTQSGKSSAGNVLLGSADFYSrfAPGSVT 44
Cdd:pfam01580  33 DLKKMPVHLLIAGATGSGKSVALNTLILSLAYMH--TPEEVQ 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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