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Conserved domains on  [gi|1958752035|ref|XP_038958781|]
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zinc finger protein 458 isoform X1 [Rattus norvegicus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003677|GO:0008270|GO:0005515|GO:0001217|GO:0003700
PubMed:  8183940|22803940|2023909|8183939|8183940|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-63 3.69e-27

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 104.60  E-value: 3.69e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958752035    5 LSFRDVAIDFSAEELEYLGPAQWSLYRDVMLENYSNLVFLGLASSKPYLITLLEQIKEP 63
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
107-520 3.77e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.79  E-value: 3.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 107 KPYKCEECGKSFHFPSLLSAHKRNHTGEKLYNC--EICCKAFHASSLLSLHKRIHTGQKPHESENYSKDFHYPSLLSQNK 184
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 185 VVHTGE-KSYQCEDHGKTFHYPSTFSKHKKIHTGEKPHKCEVC-GKAFDYPSRLSNHKRIHTGEKpykcevCDRAFHDPS 262
Cdd:COG5048   112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL------SKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 263 KLSQHKIIHTGEKPYKCDVCGKAFHYPSILSKHKIIHTEENLcKCDICGKAFHYPLLLSQHKIVHTGEKPYKCEDCGKAF 342
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSL-PLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 343 YYPSRLSRHKKIHTGE-------KPYKCEVCGKAFHYLSILSKHK--IVHTEEN--PYKC--EVCGKAFDYPSRLSNHKK 409
Cdd:COG5048   265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGESlkPFSCpySLCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 410 IHTEEKPYKC--EVCGNAF------CFSSSLRKHKIIHTgEKPYKCEV--CGKAFGSPSRLSKHKKIHTEEKP--YKCEV 477
Cdd:COG5048   345 LHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKN-DKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPP 423

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1958752035 478 CGKAFHFPSLLSVHKRIHTGEKPYKCEICGKAFYCASTLSVHK 520
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 497-576 2.80e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 2.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 497 GEKPYKCEI--CGKAFYCASTLSVHkRIHTGENNykcevcgKAFHCPSTLSvHRRIHTQEKPYKCEVCGQAFHVSSKLSY 574
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQ-------KLHENPSPEK-MNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1958752035 575 HK 576
Cdd:COG5189   417 HR 418
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 582-661 1.31e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 582 EKPYKCEI--CGKAFYYPSRLSKHKIvhmgekryHGQACGKALDYPSRhSKHKKLNPGEKPHKCEICGKAFHFPSLLSIH 659
Cdd:COG5189   347 GKPYKCPVegCNKKYKNQNGLKYHML--------HGHQNQKLHENPSP-EKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                  ..
gi 1958752035 660 KK 661
Cdd:COG5189   418 RK 419
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
629-727 4.67e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 4.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 629 SKHKKLNPGEKPHKCEICGKAFHFPSLLSIHKKIHTGEKTCKCEVCGKDFHY--PSRLSNHKKIHTEGKAYKCDICDKTF 706
Cdd:COG5048    22 STLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrPLELSRHLRTHHNNPSDLNSKSLPLS 101

                          90       100
                  ....*....|....*....|.
gi 1958752035 707 NYKSLLSKHkIGHTVENTYHS 727
Cdd:COG5048   102 NSKASSSSL-SSSSSNSNDNN 121
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-63 3.69e-27

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 104.60  E-value: 3.69e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958752035    5 LSFRDVAIDFSAEELEYLGPAQWSLYRDVMLENYSNLVFLGLASSKPYLITLLEQIKEP 63
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-45 7.14e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.21  E-value: 7.14e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1958752035   5 LSFRDVAIDFSAEELEYLGPAQWSLYRDVMLENYSNLVFLG 45
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 5-44 2.29e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 70.27  E-value: 2.29e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1958752035   5 LSFRDVAIDFSAEELEYLGPAQWSLYRDVMLENYSNLVFL 44
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
107-520 3.77e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.79  E-value: 3.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 107 KPYKCEECGKSFHFPSLLSAHKRNHTGEKLYNC--EICCKAFHASSLLSLHKRIHTGQKPHESENYSKDFHYPSLLSQNK 184
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 185 VVHTGE-KSYQCEDHGKTFHYPSTFSKHKKIHTGEKPHKCEVC-GKAFDYPSRLSNHKRIHTGEKpykcevCDRAFHDPS 262
Cdd:COG5048   112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL------SKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 263 KLSQHKIIHTGEKPYKCDVCGKAFHYPSILSKHKIIHTEENLcKCDICGKAFHYPLLLSQHKIVHTGEKPYKCEDCGKAF 342
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSL-PLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 343 YYPSRLSRHKKIHTGE-------KPYKCEVCGKAFHYLSILSKHK--IVHTEEN--PYKC--EVCGKAFDYPSRLSNHKK 409
Cdd:COG5048   265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGESlkPFSCpySLCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 410 IHTEEKPYKC--EVCGNAF------CFSSSLRKHKIIHTgEKPYKCEV--CGKAFGSPSRLSKHKKIHTEEKP--YKCEV 477
Cdd:COG5048   345 LHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKN-DKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPP 423

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1958752035 478 CGKAFHFPSLLSVHKRIHTGEKPYKCEICGKAFYCASTLSVHK 520
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 497-576 2.80e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 2.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 497 GEKPYKCEI--CGKAFYCASTLSVHkRIHTGENNykcevcgKAFHCPSTLSvHRRIHTQEKPYKCEVCGQAFHVSSKLSY 574
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQ-------KLHENPSPEK-MNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1958752035 575 HK 576
Cdd:COG5189   417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 582-661 1.31e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 582 EKPYKCEI--CGKAFYYPSRLSKHKIvhmgekryHGQACGKALDYPSRhSKHKKLNPGEKPHKCEICGKAFHFPSLLSIH 659
Cdd:COG5189   347 GKPYKCPVegCNKKYKNQNGLKYHML--------HGHQNQKLHENPSP-EKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                  ..
gi 1958752035 660 KK 661
Cdd:COG5189   418 RK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
347-370 1.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|....
gi 1958752035 347 RLSRHKKIHTGEKPYKCEVCGKAF 370
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
629-727 4.67e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 4.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 629 SKHKKLNPGEKPHKCEICGKAFHFPSLLSIHKKIHTGEKTCKCEVCGKDFHY--PSRLSNHKKIHTEGKAYKCDICDKTF 706
Cdd:COG5048    22 STLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrPLELSRHLRTHHNNPSDLNSKSLPLS 101

                          90       100
                  ....*....|....*....|.
gi 1958752035 707 NYKSLLSKHkIGHTVENTYHS 727
Cdd:COG5048   102 NSKASSSSL-SSSSSNSNDNN 121
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-63 3.69e-27

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 104.60  E-value: 3.69e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958752035    5 LSFRDVAIDFSAEELEYLGPAQWSLYRDVMLENYSNLVFLGLASSKPYLITLLEQIKEP 63
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-45 7.14e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.21  E-value: 7.14e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1958752035   5 LSFRDVAIDFSAEELEYLGPAQWSLYRDVMLENYSNLVFLG 45
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 5-44 2.29e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 70.27  E-value: 2.29e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1958752035   5 LSFRDVAIDFSAEELEYLGPAQWSLYRDVMLENYSNLVFL 44
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
107-520 3.77e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.79  E-value: 3.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 107 KPYKCEECGKSFHFPSLLSAHKRNHTGEKLYNC--EICCKAFHASSLLSLHKRIHTGQKPHESENYSKDFHYPSLLSQNK 184
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 185 VVHTGE-KSYQCEDHGKTFHYPSTFSKHKKIHTGEKPHKCEVC-GKAFDYPSRLSNHKRIHTGEKpykcevCDRAFHDPS 262
Cdd:COG5048   112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL------SKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 263 KLSQHKIIHTGEKPYKCDVCGKAFHYPSILSKHKIIHTEENLcKCDICGKAFHYPLLLSQHKIVHTGEKPYKCEDCGKAF 342
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSL-PLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 343 YYPSRLSRHKKIHTGE-------KPYKCEVCGKAFHYLSILSKHK--IVHTEEN--PYKC--EVCGKAFDYPSRLSNHKK 409
Cdd:COG5048   265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGESlkPFSCpySLCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 410 IHTEEKPYKC--EVCGNAF------CFSSSLRKHKIIHTgEKPYKCEV--CGKAFGSPSRLSKHKKIHTEEKP--YKCEV 477
Cdd:COG5048   345 LHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKN-DKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPP 423

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1958752035 478 CGKAFHFPSLLSVHKRIHTGEKPYKCEICGKAFYCASTLSVHK 520
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
247-607 1.07e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 1.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 247 KPYKCEVCDRAFHDPSKLSQHKIIHTGEKPYKCDV--CGKAFHYPSILSKHKIIHTEENL----------------CKCD 308
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSdlnskslplsnskassSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 309 ICGKAFHYPLLLSQHKIVHTGEKPYKCEDCGKAFYYPSRLSRHKKIHTGEKPYKC--------EVCGKAFHYLSILSKHK 380
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 381 IVHTEENPYKCEVCGKAFDYPSRLSNHKKIHTEEkPYKCEVCGNAFCFSSSLRKH-KIIHTGEKPYKCEVCGKAFGSPSR 459
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 460 LSKHKKIHTEEK------PYKCEVCGKAFHFPSLLSVHKR--IHTGE--KPYKC--EICGKAFYCASTLSVHKRIHTGEN 527
Cdd:COG5048   271 QSSSPNESDSSSekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 528 NYKC--EVCGKAF-----HCPSTLSVHRRIHTQEKPYKCEV--CGQAFHVSSKLSYHKRIHTAEKP--YKCEICGKAFYY 596
Cdd:COG5048   351 PAKEklLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                         410
                  ....*....|.
gi 1958752035 597 PSRLSKHKIVH 607
Cdd:COG5048   431 HYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
306-735 5.41e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 5.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 306 KCDICGKAFHYPLLLSQHKIVHTGEKPYKCED--CGKAFYYPSRLSRHKKIHTGEKPYKCEVCGKAFHYLSILSKHKIVH 383
Cdd:COG5048    35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSS 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 384 TEEN-PYKCEVCGKAFDYPSRLSNHKKIHTEEKPYKCEVCGNAFC-FSSSLRKHKIIHTGEKpykcevCGKAFGSPSRLS 461
Cdd:COG5048   115 SNSNdNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVnTPQSNSLHPPLPANSL------SKDPSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 462 KHKKIHTEEKPYKCEVCGKAFHFPSLLSVHKRIHTgEKPYKCEICGKAFYCASTLSVHKRIHTGENNYKCEVCGKAFHCP 541
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 542 STLSVHRRIHT-------QEKPYKCEVCGQAFHVSSKLSYHKR--IHTAE--KPYKC--EICGKAFYYPSRLSKHKIVHM 608
Cdd:COG5048   268 ASSQSSSPNESdsssekgFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 609 GEKRYHgqacgkaLDYPSRHSKHKKLNPGEKPhkceicgkAFHFPSLLSIHKKIHTGEKTCKCEVCGKDfhYPSRLSNHK 688
Cdd:COG5048   348 SISPAK-------EKLLNSSSKFSPLLNNEPP--------QSLQQYKDLKNDKKSETLSNSCIRNFKRD--SNLSLHIIT 410

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 1958752035 689 KIHTEGKAYKCDICDKTFNYKSLLSKHKIGHTVENTYHSEVCGKAFG 735
Cdd:COG5048   411 HLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
162-577 2.25e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 2.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 162 QKPHESENYSKDFHYPSLLSQNKVVHTGEKSYQCED--HGKTFHYPSTFSKHKKIHTGEKPHKCevCGKAFDYPSRLSNH 239
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 240 KRIHTGEKPYKCEVCD-RAFHDPSKLSQHKIIHTGEKPYKC---DVCGKAFHYPSILSKHKIIHTEENlckcdiCGKAFH 315
Cdd:COG5048   109 SLSSSSSNSNDNNLLSsHSLPPSSRDPQLPDLLSISNLRNNplpGNNSSSVNTPQSNSLHPPLPANSL------SKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 316 YPLLLSQHKIVHTGEKPYKCEDCGKAFYYPSRLSRHKKIHTgEKPYKCEVCGKAFHYLSILSKH-KIVHTEENPYKCEVC 394
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 395 GKAFDYPSR-LSNHKKIHTEE-----KPYKCEVCGNAFCFSSSLRKHK--IIHTGE--KPYKC--EVCGKAFGSPSRLSK 462
Cdd:COG5048   262 RSSLPTASSqSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 463 HKKIHTEEKPYKC--EVCGKAFHFPS-----LLSVHKRIHTGEKPYKCE--ICGKAFYCASTLSVHKRIHTGEN--NYKC 531
Cdd:COG5048   342 HILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRpyNCKN 421

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 1958752035 532 EVCGKAFHCPSTLSVHRRIHTQEKPYKCEVCGqAFHVSSKLSYHKR 577
Cdd:COG5048   422 PPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK-SFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 497-576 2.80e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 2.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 497 GEKPYKCEI--CGKAFYCASTLSVHkRIHTGENNykcevcgKAFHCPSTLSvHRRIHTQEKPYKCEVCGQAFHVSSKLSY 574
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQ-------KLHENPSPEK-MNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1958752035 575 HK 576
Cdd:COG5189   417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 385-465 3.00e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 3.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 385 EENPYKCEV--CGKAFDYPSRLSNHKKiHTEEKPYKCEvcgnafcfSSSLRKHKIIHTGEKPYKCEVCGKAFGSPSRLSK 462
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHML-HGHQNQKLHE--------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1958752035 463 HKK 465
Cdd:COG5189   417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 399-482 3.24e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 3.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 399 DYPSRLSNHKkihtEEKPYKCEV--CGNAFCFSSSLRKHKIiHTGEKPykcevcgKAFGSPSRlSKHKKIHTEEKPYKCE 476
Cdd:COG5189   336 DTPSRMLKVK----DGKPYKCPVegCNKKYKNQNGLKYHML-HGHQNQ-------KLHENPSP-EKMNIFSAKDKPYRCE 402


                  ....*.
gi 1958752035 477 VCGKAF 482
Cdd:COG5189   403 VCDKRY 408
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
219-717 9.64e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 9.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 219 KPHKCEVCGKAFDYPSRLSNHKRIHTGEKPYKCEV--CDRAFHDPSKLSQHKIIHTGEKPYKCDVCGKAFHYPSILSKHK 296
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 297 IIHTEENL-CKCDICGKAFHYPLllSQHKIVHTGEKPYKCEDCGKAFYYPSRLSRHKKIHTGEKPykcEVCGKAFHYLSI 375
Cdd:COG5048   112 SSSSNSNDnNLLSSHSLPPSSRD--PQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN---SLSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 376 LSKHKIVHTEENPYKCEVCGKAFDYPSRLSNHKKIHTEEkPYKCEVCGNAFCFSSSLRKH-KIIHTGEKPYKCEVCGKAF 454
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 455 GSPSRLSKHkkihteekpykcevcgkafHFPSLLSVHKRIHTgekPYKCEICGKAFYCASTLSVHKR--IHTGENNykce 532
Cdd:COG5048   266 PTASSQSSS-------------------PNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGESL---- 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 533 vcgKAFHCPSTLsvhrrihtqekpykcevCGQAFHVSSKLSYHKRIHTAEKPYKCeicgkafyyPSRLSKHKIVHMGEKR 612
Cdd:COG5048   320 ---KPFSCPYSL-----------------CGKLFSRNDALKRHILLHTSISPAKE---------KLLNSSSKFSPLLNNE 370

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 613 YHGQACgkalDYPSRHSKHKKLNPgekPHKCEICGKAFHFPSLLSIHKKIHTGEKtCKCEVCGKDFHYPSRLSNHKKIHT 692
Cdd:COG5048   371 PPQSLQ----QYKDLKNDKKSETL---SNSCIRNFKRDSNLSLHIITHLSFRPYN-CKNPPCSKSFNRHYNLIPHKKIHT 442

                         490       500
                  ....*....|....*....|....*
gi 1958752035 693 EGKAYKCDICdKTFNYKSLLSKHKI 717
Cdd:COG5048   443 NHAPLLCSIL-KSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 582-661 1.31e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 582 EKPYKCEI--CGKAFYYPSRLSKHKIvhmgekryHGQACGKALDYPSRhSKHKKLNPGEKPHKCEICGKAFHFPSLLSIH 659
Cdd:COG5189   347 GKPYKCPVegCNKKYKNQNGLKYHML--------HGHQNQKLHENPSP-EKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                  ..
gi 1958752035 660 KK 661
Cdd:COG5189   418 RK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 329-409 1.39e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 329 GEKPYKCE--DCGKAFYYPSRLSRHKKihTGEkpykcevCGKAFHYLSILSKHKIVHTEENPYKCEVCGKAFDYPSRLSN 406
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML--HGH-------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1958752035 407 HKK 409
Cdd:COG5189   417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
347-370 1.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|....
gi 1958752035 347 RLSRHKKIHTGEKPYKCEVCGKAF 370
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 231-286 1.71e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.71e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958752035 231 DYPSRLSNHKrihtGEKPYKCEV--CDRAFHDPSKLSQHK-------------------IIHTGEKPYKCDVCGKAF 286
Cdd:COG5189   336 DTPSRMLKVK----DGKPYKCPVegCNKKYKNQNGLKYHMlhghqnqklhenpspekmnIFSAKDKPYRCEVCDKRY 408
zf-H2C2_2 pfam13465
Zinc-finger double domain;
431-454 2.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.84e-03
                          10        20
                  ....*....|....*....|....
gi 1958752035 431 SLRKHKIIHTGEKPYKCEVCGKAF 454
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
629-727 4.67e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 4.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 629 SKHKKLNPGEKPHKCEICGKAFHFPSLLSIHKKIHTGEKTCKCEVCGKDFHY--PSRLSNHKKIHTEGKAYKCDICDKTF 706
Cdd:COG5048    22 STLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrPLELSRHLRTHHNNPSDLNSKSLPLS 101

                          90       100
                  ....*....|....*....|.
gi 1958752035 707 NYKSLLSKHkIGHTVENTYHS 727
Cdd:COG5048   102 NSKASSSSL-SSSSSNSNDNN 121
zf-H2C2_2 pfam13465
Zinc-finger double domain;
488-512 5.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.66e-03
                          10        20
                  ....*....|....*....|....*
gi 1958752035 488 LSVHKRIHTGEKPYKCEICGKAFYC 512
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
264-286 6.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.12e-03
                          10        20
                  ....*....|....*....|...
gi 1958752035 264 LSQHKIIHTGEKPYKCDVCGKAF 286
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 622-720 6.47e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 6.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752035 622 LDYPSRHSKHKklnpGEKPHKCEI--CGKAFHFPSLLSIHKKI-HTGEKTCKcevcgkdfhYPSRLSnHKKIHTEGKAYK 698
Cdd:COG5189   335 IDTPSRMLKVK----DGKPYKCPVegCNKKYKNQNGLKYHMLHgHQNQKLHE---------NPSPEK-MNIFSAKDKPYR 400

                          90       100
                  ....*....|....*....|...
gi 1958752035 699 CDICDKtfNYKSLLS-KHKIGHT 720
Cdd:COG5189   401 CEVCDK--RYKNLNGlKYHRKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
210-232 8.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.47e-03
                          10        20
                  ....*....|....*....|...
gi 1958752035 210 KHKKIHTGEKPHKCEVCGKAFDY 232
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 554-594 8.68e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 8.68e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958752035 554 EKPYKCEV--CGQAFHVSSKLSYHKR-------------------IHTAEKPYKCEICGKAF 594
Cdd:COG5189   347 GKPYKCPVegCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRY 408
zf-H2C2_2 pfam13465
Zinc-finger double domain;
235-258 8.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.89e-03
                          10        20
                  ....*....|....*....|....
gi 1958752035 235 RLSNHKRIHTGEKPYKCEVCDRAF 258
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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