alpha/beta hydrolase family protein may catalyze the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad
alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, ...
1-288
7.70e-101
alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine, and often the mechanism involves a nucleophilic attack on a carbonyl carbon atom.
The actual alignment was detected with superfamily member pfam09752:
Pssm-ID: 473884 [Multi-domain] Cd Length: 352 Bit Score: 299.35 E-value: 7.70e-101
Alpha/beta hydrolase domain containing 18; This entry represents alpha/beta hydrolase domain-containing protein 18 (ABHD18). Its function is not clear.
Pssm-ID: 370661 [Multi-domain] Cd Length: 352 Bit Score: 299.35 E-value: 7.70e-101
Alpha/beta hydrolase domain containing 18; This entry represents alpha/beta hydrolase domain-containing protein 18 (ABHD18). Its function is not clear.
Pssm-ID: 370661 [Multi-domain] Cd Length: 352 Bit Score: 299.35 E-value: 7.70e-101
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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