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Conserved domains on  [gi|1958752849|ref|XP_038959124|]
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platelet-derived growth factor C isoform X1 [Rattus norvegicus]

Protein Classification

PDGF domain-containing protein( domain architecture ID 10065270)

PDGF domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 85-177 8.93e-26

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


:

Pssm-ID: 238079  Cd Length: 86  Bit Score: 94.36  E-value: 8.93e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752849  85 YSCTPRNFSVSIREELK-RTDTIFWPGCLLVKRCGGncaCClhNCNECQCVPRKVTKKYHEVLQLRPKIGVkglHKSLTD 163
Cdd:cd00135     1 SSCKPRETLVEISEELPdETNTIFKPPCVEVKRCGG---CC--NDESLECVPTETSNVTMQVLKISPKRKP---RSKLVE 72

                          90
                  ....*....|....
gi 1958752849 164 VALEHHEECDCVCR 177
Cdd:cd00135    73 ISFEEHTECECRPR 86
 
Name Accession Description Interval E-value
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 85-177 8.93e-26

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 94.36  E-value: 8.93e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752849  85 YSCTPRNFSVSIREELK-RTDTIFWPGCLLVKRCGGncaCClhNCNECQCVPRKVTKKYHEVLQLRPKIGVkglHKSLTD 163
Cdd:cd00135     1 SSCKPRETLVEISEELPdETNTIFKPPCVEVKRCGG---CC--NDESLECVPTETSNVTMQVLKISPKRKP---RSKLVE 72

                          90
                  ....*....|....
gi 1958752849 164 VALEHHEECDCVCR 177
Cdd:cd00135    73 ISFEEHTECECRPR 86
PDGF pfam00341
PDGF/VEGF domain;
87-174 1.25e-13

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 63.07  E-value: 1.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752849  87 CTPRNFSVSIREELK-RTDTIFWPGCLLVKRCGGncaCClhNCNECQCVPRKVTKKYHEVLQLRPKIGVKGlhKSLTDVA 165
Cdd:pfam00341   1 CKPRETLVEIRRELPdETNAFFKPSCVEVQRCSG---CC--NDEGLECVPTETHNVTMQVLKIEYAPRRPS--PELVEVS 73


                  ....*....
gi 1958752849 166 LEHHEECDC 174
Cdd:pfam00341  74 FEEHVQCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 87-174 4.41e-09

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 50.88  E-value: 4.41e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752849   87 CTPRNFSVSIREEL-KRTDTIFWPGCLLVKRCGGncaCClhNCNECQCVPRKVTKKYHEVLQLRPkigvkGLHKSLTDVA 165
Cdd:smart00141   3 CKPRETVVEVSREYpDETNFLFKPPCVTVKRCGG---CC--NDEGLECVPTETSNVTMQLLEISR-----PLSQHLVEVS 72


                   ....*....
gi 1958752849  166 LEHHEECDC 174
Cdd:smart00141  73 FEEHTKCEC 81
 
Name Accession Description Interval E-value
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 85-177 8.93e-26

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 94.36  E-value: 8.93e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752849  85 YSCTPRNFSVSIREELK-RTDTIFWPGCLLVKRCGGncaCClhNCNECQCVPRKVTKKYHEVLQLRPKIGVkglHKSLTD 163
Cdd:cd00135     1 SSCKPRETLVEISEELPdETNTIFKPPCVEVKRCGG---CC--NDESLECVPTETSNVTMQVLKISPKRKP---RSKLVE 72

                          90
                  ....*....|....
gi 1958752849 164 VALEHHEECDCVCR 177
Cdd:cd00135    73 ISFEEHTECECRPR 86
PDGF pfam00341
PDGF/VEGF domain;
87-174 1.25e-13

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 63.07  E-value: 1.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752849  87 CTPRNFSVSIREELK-RTDTIFWPGCLLVKRCGGncaCClhNCNECQCVPRKVTKKYHEVLQLRPKIGVKGlhKSLTDVA 165
Cdd:pfam00341   1 CKPRETLVEIRRELPdETNAFFKPSCVEVQRCSG---CC--NDEGLECVPTETHNVTMQVLKIEYAPRRPS--PELVEVS 73


                  ....*....
gi 1958752849 166 LEHHEECDC 174
Cdd:pfam00341  74 FEEHVQCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 87-174 4.41e-09

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 50.88  E-value: 4.41e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752849   87 CTPRNFSVSIREEL-KRTDTIFWPGCLLVKRCGGncaCClhNCNECQCVPRKVTKKYHEVLQLRPkigvkGLHKSLTDVA 165
Cdd:smart00141   3 CKPRETVVEVSREYpDETNFLFKPPCVTVKRCGG---CC--NDEGLECVPTETSNVTMQLLEISR-----PLSQHLVEVS 72


                   ....*....
gi 1958752849  166 LEHHEECDC 174
Cdd:smart00141  73 FEEHTKCEC 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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