NCBI Conserved Domain Search

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 210.30 E-value: 2.41e-63

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  262 GTVTEFKHPGHFYVQLYSSEVLEYMNQLSASLKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVEGVDVLQKKAHV 341
Cdd:cd20408      1 GTVTEFKNPGEFYIQIYTLEVLESLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVDVQQKKAGV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958643055  342 LYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAGEWTEDCV 391
Cdd:cd20408     81 FYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEECI 130

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 197.67 E-value: 4.50e-59

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  800 ANVLEIISPTLFYAIPSEMPENQEKLCVLTAELLEHCNAQKGQPPYRPRTGEACCAKYTNDDFWYRAIVLEASDSDVKVL 879
Cdd:cd20411      1 ALVLEVISPDLFYALPKTGQVNVEKLKALMTELAEYCSKQSVPQQFRPRIGDACCARFTGDKNWYRAVVLETSDSEVKVL 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958643055  880 YADYGNVERLPFSRVQPITASHLQLPFRIIRCSLEG 915
Cdd:cd20411     81 YADYGNTETLPLSRILPITKSHLELPFQIIRCSLAG 116

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 127.86 E-value: 1.87e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  571 ETVDVMVCMMHSPGEFYCHclKDDALKKLDDLNKSLADYCAQKPPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSGNV 650
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQ--PKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLV 78

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1958643055  651 KVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWL 687
Cdd:pfam00567   79 EVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQL 115

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 114.75 E-value: 1.24e-30

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958643055  618 FKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFL 676
Cdd:cd20410      1 FKPIVGEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 113.22 E-value: 1.96e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  258 MEIKGTVTEFKHPGHFYVQlySSEVLEYMNQLSASLKETYANMVPEdGYLPVKGEVCVAKYTVDQTWNRAVVEgVDVLQK 337
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQ--PKSDSKKLEKLTEELQEYYASKPPE-SLPPAVGDGCVAAFSEDGKWYRAKIT-ESLDDG 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1958643055  338 KAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSG 378
Cdd:pfam00567   77 LVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 109.37 E-value: 5.35e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  796 KTVPANVLEIISPTLFYAIPSEmpeNQEKLCVLTAELLEHCNaQKGQPPYRPRTGEACCAKYTNDDFWYRAIVLE-ASDS 874
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKS---DSKKLEKLTEELQEYYA-SKPPESLPPAVGDGCVAAFSEDGKWYRAKITEsLDDG 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1958643055  875 DVKVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSLEG 915
Cdd:pfam00567   77 LVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 92.43 E-value: 5.36e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  802 VLEIISPTLFYAIPsEMPENQEKLCVLTAELLEHCNAQKGQPPYRPRTGEACCAKYTNDDFWYRAIV--LEASDSDVKVL 879
Cdd:cd20408      3 VTEFKNPGEFYIQI-YTLEVLESLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVqtVDVQQKKAGVF 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1958643055  880 YADYGNVERLPFSRVQPITASHLQLPFRIIRCSLEGLTELNGS 922
Cdd:cd20408     82 YIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGS 124

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 89.83 E-value: 3.79e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  271 GHFYVQLYSSEVLE-YMNQLSA-SLKETYAnmvPEDGYLPVKGEVCVAKYTVDQTWNRAVV-----EGVDVLQKKAHVLY 343
Cdd:cd20443      2 GRFYVQVVSDQRLSsIQQQLEGlSLKDKAN---PPGGFNPKKGELVLAQFSADNSWNRAMVvnaprQGTQSPKDEYEVFY 78

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1958643055  344 IDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGV-VP 381
Cdd:cd20443     79 IDYGNQETVPLSALRPLDPSVSSAPGLAQLCSLAHIkVP 117

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 87.12 E-value: 3.29e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  582 SPGEFYC-HCLKDDALKKLDDLNKSLADYC-AQKPPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSgNVKVHFVDYGN 659
Cdd:cd20411      8 SPDLFYAlPKTGQVNVEKLKALMTELAEYCsKQSVPQQFRPRIGDACCARFTGDKNWYRAVVLETSDS-EVKVLYADYGN 86

                           90       100
                   ....*....|....*....|....*...
gi 1958643055  660 VEEVTTDQLHAIAPQFLLLPFQGMQCWL 687
Cdd:cd20411     87 TETLPLSRILPITKSHLELPFQIIRCSL 114

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 83.57 E-value: 7.80e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  582 SPGEFYCHCLKDDALKKLDDLNKSLAD-YCAQKPPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSGN-VKVHFVDYGN 659
Cdd:cd20408      8 NPGEFYIQIYTLEVLESLVKLTSQLKKtYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVDVQQKkAGVFYIDYGN 87

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1958643055  660 VEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQPKNKHWTKEA 701
Cdd:cd20408     88 EETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEEC 129

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 81.19 E-value: 1.40e-18

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958643055  286 MNQLSaslKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVEGVDVlQKKAHVLYIDYGNEEIIPVDRIHQL 360
Cdd:cd20433      9 MEKLR---FEIASNPPLPGSYTPRKGDLCAAKFVEDGEWYRAKVEKVEG-DKKVHVLYIDYGNREVLPSTRLAAL 79

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 80.96 E-value: 1.61e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  823 EKLCVLTAELLEHCNAQKGQPPYRPRTGEACCAKYTNDDFWYRAIVLE-ASDSDVKVLYADYGNVERLPFSRVQPITASH 901
Cdd:cd20409      2 RQLAELQESLSAYCKVAPASSDFSPAVGEVCCAQFTEDNQWYRASVLAySSEDSVLVGYIDFGNSEEVALSRLRPIPPSL 81


                   .
gi 1958643055  902 L 902
Cdd:cd20409     82 L 82

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 75.41 E-value: 1.81e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  597 KKLDDLNKSLADYCAQKPPNGFKAE--VGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQ 674
Cdd:cd20412      4 LQLDKLVQEMTQYYESEENRHTLLTvqVGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRALRSD 83

                           90
                   ....*....|.
gi 1958643055  675 FLLLPFQGMQC 685
Cdd:cd20412     84 FLSLPFQAIEC 94

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 71.39 E-value: 1.65e-15

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958643055  622 VGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAI 671
Cdd:cd20379      1 VGDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 73.64 E-value: 2.22e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  575 VMVCMMHSPGEFYCHCLKDDALkkLDDLNKSLADYCAQKPPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHF 654
Cdd:cd20440     14 VYITHVYSPAKFYCQLDRNTEI--LEALMEKIAEISKLFNSQILDNCKTRLCLAKYFEDGQWYRALAHPVESSSHLSVYF 91

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958643055  655 VDYGNVEEVTTDQLHAI---APQFLLLPFQGMQCWL 687
Cdd:cd20440     92 VDYGNKQIVEKNEVLPIpdtAVDLLLTPMQAIKCCL 127

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 72.84 E-value: 3.61e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  569 VDETVDVMVCMMHSPGEFYCHCLKDDalKKLDDLNKSLADYCAQKppngfKAEVGRPC------CACFAGDGNWYRALVK 642
Cdd:cd20437      1 VGTTEKVKITAAVSPSKFYCQLLSWE--PELSKLTTQMTLHYESV-----SKELNPSCenfgllCAAKGKDGQWHRGFLQ 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1958643055  643 EILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWL 687
Cdd:cd20437     74 QLLPPSQVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 71.18 E-value: 5.11e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  598 KLDDLNKSLADYCAQKPPNG--FKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQF 675
Cdd:cd20433      4 QLEKLMEKLRFEIASNPPLPgsYTPRKGDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALPPAF 83

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 71.37 E-value: 1.24e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  567 FTVDETVDVMVCMMHSPGEFYCHCLKDdaLKKLDDLNKSLADYCAqkppngFKAEVGRPC-CACFA---GDGNWYRALVK 642
Cdd:cd20439      6 FKPGSVVDVKCSYVNSPGDFWCQLQTK--SSELKSLMKQIQSYYL------IHNDPYKHGqIACVAkysKDGKWYRAAVL 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1958643055  643 EILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDI 690
Cdd:cd20439     78 KQVSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 69.25 E-value: 2.43e-14

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958643055  841 GQPPYRPRTGEACCAKYTNDDFWYRAIVlEASDSD--VKVLYADYGNVERLPFSRVQPITAS 900
Cdd:cd20433     22 LPGSYTPRKGDLCAAKFVEDGEWYRAKV-EKVEGDkkVHVLYIDYGNREVLPSTRLAALPPA 82

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 69.85 E-value: 6.08e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  574 DVMVCMMHSPGEFYCHcLKDDALKkLDDLNKSLAD-YCAQKPPNGF--KAEVGRPCCACFAGDGnWYRALVKEILPSGnV 650
Cdd:cd20422      3 DAQVEFVKDPSEFWIR-LGEHAVP-FSKLMRSMTAfYSQASKLDGVvlKPQPGQLCCAKWKEDR-YYRAIVTAVKGKM-V 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958643055  651 KVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQPKNKHWTKEATARFQ 706
Cdd:cd20422     79 EVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFK 134

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 69.02 E-value: 6.87e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  573 VDVMVCMMHSPGEFYCHCLKDDALKKL--DDLN--KSLADYCAQKPPNgfkaeVGRPCCACFAGDGNWYRALVKEILPSG 648
Cdd:cd20425      2 TEVYVSHVNSPSDFYVQLAQDEDELSMisEKLNasKANDEEVECESLQ-----LGDLICAEYPEDGLWYRAVVKEKIPNN 76

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1958643055  649 NVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWL 687
Cdd:cd20425     77 LVSVQFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 68.24 E-value: 1.18e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  264 VTEFKHPGHFY-VQLYSSEVLEYMNQLSASLKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVegVDVLQKKAHVL 342
Cdd:cd20411      3 VLEVISPDLFYaLPKTGQVNVEKLKALMTELAEYCSKQSVPQQFRPRIGDACCARFTGDKNWYRAVV--LETSDSEVKVL 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958643055  343 YIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSG 378
Cdd:cd20411     81 YADYGNTETLPLSRILPITKSHLELPFQIIRCSLAG 116

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 69.04 E-value: 1.39e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  619 KAEVGRPCCACFAGDGNWYRALVKEILpSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQPKNKHWT 698
Cdd:cd20438     54 KPEPGLLCCARYSKDRHYYRAVITEVL-DLKVSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVWT 132


                   ....*...
gi 1958643055  699 KEATARFQ 706
Cdd:cd20438    133 KNANDFFK 140

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 67.10 E-value: 1.41e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  598 KLDDLNKSLADYCAQKPPN-GFKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFL 676
Cdd:cd20409      3 QLAELQESLSAYCKVAPASsDFSPAVGEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLRPIPPSLL 82

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 64.81 E-value: 7.51e-13

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958643055  622 VGRPCCACFAGDGNWYRALVKEI-LPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQP 692
Cdd:cd20423      5 PNPVCLAKYSEDGKWCRALIDNVyEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQ 76

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 63.69 E-value: 9.21e-13

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1958643055  850 GEACCAKYTNDDFWYRAIVLEASDSD-VKVLYADYGNVERLPFSRVQPI 897
Cdd:cd20379      2 GDLCAAKYEEDGKWYRARVLEVLSNDkVEVFFVDYGNTETVPLSDLRPL 50

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 66.37 E-value: 9.85e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  582 SPGEFYCHClkddALKKLDDLNKSLADYCAQKPPNGFKA---EVGRPCCACFAGDGNWYRALVKEIlPSGNVKVHFVDYG 658
Cdd:cd20426     10 SPEYFWCQF----ATEKIQCLAVKVQEAGEQVADRGNFIpsiYVGDPCIVKYSEDNHWYRALVTKI-NDNLVSVRFVDYG 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1958643055  659 NVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQPKNKHWTKEATARF 705
Cdd:cd20426     85 NEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEANDYF 131

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 64.04 E-value: 1.22e-12

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958643055  313 VCVAKYTVDQTWNRAVVEGVDVLQKKAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAG 384
Cdd:cd20423      8 VCLAKYSEDGKWCRALIDNVYEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPSG 79

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 63.30 E-value: 1.27e-12

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958643055  310 KGEVCVAKYTVDQTWNRAVVEGVDvLQKKAHVLYIDYGNEEIIPVDRIHQL 360
Cdd:cd20379      1 VGDLCAAKYEEDGKWYRARVLEVL-SNDKVEVFFVDYGNTETVPLSDLRPL 50

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 62.36 E-value: 3.11e-12

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958643055  845 YRPRTGEACCAKYTNDDFWYRAIVLEASDSD-VKVLYADYGNVERLPFSRVQPITASHL 902
Cdd:cd20410      1 FKPIVGEPCCAFFSGDGNWYRAMVKEILPGGaVKVHFVDYGNVEEVTLDKLRKITSTFL 59

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 64.37 E-value: 4.23e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  566 EFTVDETVDVMVCMMHSPGEFYCH--CLKddalKKLDDLNKSLADYCAQKPPNGFKA---EVGRPCCACfAGDGNWYRAL 640
Cdd:cd20421      6 QLQVGVTETVVVTEVTDPHRIFCQlrSLS----QELKRLSESMHQYYEGRVGSGYETrpeKLGSPCAAR-GSDGRWYRAV 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1958643055  641 VKEILPSGN-VKVHFVDYGNVEEVTTDQLHAIAPQFLLLP 679
Cdd:cd20421     81 LQQVFSANRvVEVLHVDYGRKEVVSVSNLRYLAPEYFRMP 120

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 62.50 E-value: 4.26e-12

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958643055  852 ACCAKYTNDDFWYRAIVLEASDS--DVKVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSLEGLTELNG 921
Cdd:cd20423      8 VCLAKYSEDGKWCRALIDNVYEPveMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPSG 79

MYND finger;

Pssm-ID: 460312 Cd Length: 39 Bit Score: 61.28 E-value: 4.47e-12

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958643055  162 CHRCGLFGS--LRCSQCKQTYYCSTACQRRDWSSHSTIC 198
Cdd:pfam01753    1 CAVCGKEALklLRCSRCKSVYYCSKECQKADWPYHKKEC 39

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 62.84 E-value: 7.61e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  582 SPGEFYCHCLKDDA--LKKLDDLNkSLADYCAQKPPNgfKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGN 659
Cdd:cd20441      1 SPSRFFIQLSEDEKviLQLAEELN-ETSEKSRENAAV--KLKVGDLVAAEYDEDLALYRAVITAVLPGKSFKVEFIDYGN 77

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1958643055  660 VEEVTTDQLHAIAPQFLLLPFQGMQCWLVDI 690
Cdd:cd20441     78 TAVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 61.07 E-value: 1.19e-11

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958643055  626 CCACFAGDGnWYRALVKEILPSGN-VKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQP 692
Cdd:cd20407     10 ICAAPVMNA-WYRAQVVGVFEETDeVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 62.48 E-value: 1.32e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  843 PPYRPRTGEACCAKYTNDDFWYRAIVLEA-------SDSDVKVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSLEG 915
Cdd:cd20443     34 GGFNPKKGELVLAQFSADNSWNRAMVVNAprqgtqsPKDEYEVFYIDYGNQETVPLSALRPLDPSVSSAPGLAQLCSLAH 113


                   .
gi 1958643055  916 L 916
Cdd:cd20443    114 I 114

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 61.32 E-value: 1.42e-11

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958643055  286 MNQLSASLKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVEGVdVLQKKAHVLYIDYGNEEIIPVDRI 357
Cdd:cd20409      4 LAELQESLSAYCKVAPASSDFSPAVGEVCCAQFTEDNQWYRASVLAY-SSEDSVLVGYIDFGNSEEVALSRL 74

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 62.90 E-value: 1.77e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  812 YAIPSEMPE---------NQEKLCVLTAELLEHcNAQKGQPPYRPRTGEACCAKYTNDDFWYRAIVLEASDSDVKVLYAD 882
Cdd:cd20426      4 YATAVDSPEyfwcqfateKIQCLAVKVQEAGEQ-VADRGNFIPSIYVGDPCIVKYSEDNHWYRALVTKINDNLVSVRFVD 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1958643055  883 YGNVERLPFSRVQPITASHLQLPFRIIRCSLEGLTELNGSSSQ 925
Cdd:cd20426     83 YGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSD 125

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 62.52 E-value: 1.84e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  574 DVMVCMMHSPGEFYCHCLKDDALkkLDDLNKSLADYCAQKPPNGFKAEVGRPCCACFAgDGNWYRALVKEILPsgNVKVH 653
Cdd:cd20424     15 EVYITYVNDPWTFYCQLARNAGV--LDQLASAISRLSSEIRKLELSVNPGTLCLAKYS-DQHWYRGIIITNKN--STEVF 89

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1958643055  654 FVDYGNVEEVTTDQLHAI---APQFLLLPFQGMQCWL 687
Cdd:cd20424     90 FVDYGNTEKVEKEDMLPIpsdAYELLLLPMQAIKCSL 126

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 59.00 E-value: 2.25e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  802 VLEIISPTLFYAIPSEmPENQEKLCVLTAELLEHCNAQKGQPPYRP-----RTGEACCAKYTNDDFWYRAIVLEASDSD- 875
Cdd:cd20419      2 VEYIESPSQFYVRFYS-KDTSEMLEDMMIEMRRCYSNEHVSERYVMpeafiQPGQVCCVRIPEDVWWYRVIIHQVLNKQe 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1958643055  876 VKVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSL 913
Cdd:cd20419     81 VEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 59.04 E-value: 2.43e-10

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958643055  844 PYRPrtGE-ACCAKYTNDDFWYRAIVL-EASDSDVKVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSLEGL 916
Cdd:cd20439     53 PYKH--GQiACVAKYSKDGKWYRAAVLkQVSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 56.51 E-value: 3.34e-10

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1958643055   621 EVGRPCCACFaGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQF 675
Cdd:smart00333    4 KVGDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPEEL 57

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 56.92 E-value: 3.68e-10

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958643055  605 SLADYCAQKPPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQF 675
Cdd:cd20430      4 ELAEVCPTAPPLFGTPDPNKIYGGKFSEDNCWYRCKVKSILSDEKCTVQYIDYGNTETVSRSSIVELPPDL 74

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 59.02 E-value: 4.09e-10

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958643055  846 RPRTGEACCAKYTNDDFWYRAIVLEASDSDVKVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSL 913
Cdd:cd20438     54 KPEPGLLCCARYSKDRHYYRAVITEVLDLKVSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSL 121

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 59.28 E-value: 4.42e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  261 KGTVTEFKHPGHFYVQLY-SSEVLEYMNQLSASLKETYANMVPEDgylPVKGEVCVAKYTVDQTWNRAVVEGVDVLQKKA 339
Cdd:cd20442      5 KGTLLSVSKNGTFYVRLLrNSEQLTDLESLIAKEAKKCKFVPVED---IKEGLECLAKSKKNLKWYRAVVEHLYPETEKM 81

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1958643055  340 HVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKC 374
Cdd:cd20442     82 LVFFVDHGITEVVSMGNIKQLSNDLLQIPRQAVLC 116

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 56.63 E-value: 8.72e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  804 EIISPTLFYAIpSEMPENQEKLCVLTAELlehcNAQKGQP-PYRPRTGEACCAKYTNDDF--WYRAIVLEASDSDVKVLY 880
Cdd:cd20431      2 EVVEVGHFWGY-RIDENSSEILQQLTAEI----NQRQLVPlTTKPVPNLLCLAPFTDADMkkYYRAKILYVSGSSAEVFF 76

                           90       100
                   ....*....|....*....|....*
gi 1958643055  881 ADYGNVERLPFSRVQPITASHLQLP 905
Cdd:cd20431     77 VDYGNTSQVPSSLLREIPETLLTLP 101

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 56.31 E-value: 1.93e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  270 PGHFYVQLYSSEVLeyMNQLSASLKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVEgvdvlQKKA----HVLYID 345
Cdd:cd20425     12 PSDFYVQLAQDEDE--LSMISEKLNASKANDEEVECESLQLGDLICAEYPEDGLWYRAVVK-----EKIPnnlvSVQFID 84

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1958643055  346 YGNEEIIPVDRIHQLSRSISLFPPSAIKCYV 376
Cdd:cd20425     85 YGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 56.74 E-value: 2.43e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  260 IKGTVTEFKHPGHFYVQLYSSEV--LEYMNQLSASLKETYANMVPEdgylPVKGEVCVAKYTVDQTWNRAVVEGVDvlQK 337
Cdd:cd20426      1 IEAYATAVDSPEYFWCQFATEKIqcLAVKVQEAGEQVADRGNFIPS----IYVGDPCIVKYSEDNHWYRALVTKIN--DN 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958643055  338 KAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAGEWTEDCV 391
Cdd:cd20426     75 LVSVRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEAN 128

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 55.92 E-value: 2.49e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  577 VCMMHSPGEFYCHCLKDDALKKLDDLNKSLADYCAQK------PPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSGNV 650
Cdd:cd20419      2 VEYIESPSQFYVRFYSKDTSEMLEDMMIEMRRCYSNEhvseryVMPEAFIQPGQVCCVRIPEDVWWYRVIIHQVLNKQEV 81

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1958643055  651 KVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWL 687
Cdd:cd20419     82 EVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 56.68 E-value: 2.83e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  574 DVMVCMMHSPGEFYCHcLKDDALKKLDDLNKSLADY--CAQKPPNGFkaeVGRPCCA--C-FAGDGNWYRALVKEILPSG 648
Cdd:cd20428      3 NVRVTNVCSDGTLYCQ-VPSKGLSKLNEILDKIEYYfhSRQMTSEYF---VSLPFCGkiClARYKGKWARVEITNVHSSR 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958643055  649 NVKVHFVDYGNVEEVTTDQLHAIAPQFL----LLPFQGMQCWLVDIQPKNKHWTKEA 701
Cdd:cd20428     79 ALDVHFLDTGTVASVKVSELREIPPPFLreliSIPPQALKCCLADLPLNIGMWTPDA 135

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 55.13 E-value: 3.55e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  807 SPTLFYAipsEMPENQEKLCVLTAELLEHCNAQKGQPPYRPRTGEACCAKYTNDDFWYRAIVLE-ASDSDVKVLYADYGN 885
Cdd:cd20441      1 SPSRFFI---QLSEDEKVILQLAEELNETSEKSRENAAVKLKVGDLVAAEYDEDLALYRAVITAvLPGKSFKVEFIDYGN 77

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1958643055  886 VERLPFSRVQPITASHLQLPFRIIRCSLEGL 916
Cdd:cd20441     78 TAVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 55.98 E-value: 3.87e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  261 KGTVTEFKHPGHFYVQLYSSEVleYMNQLSASLKETYANMVPEDGYL--PVKGEVCVAKYTvDQTWNRAVVegVDVLQKK 338
Cdd:cd20422      3 DAQVEFVKDPSEFWIRLGEHAV--PFSKLMRSMTAFYSQASKLDGVVlkPQPGQLCCAKWK-EDRYYRAIV--TAVKGKM 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958643055  339 AHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAGEWTEDCVVAVK 395
Cdd:cd20422     78 VEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFK 134

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 55.98 E-value: 4.35e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  846 RPRTGEACCAKYtNDDFWYRAIVLEASDSDVKVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSLEGLTELNGSSSQ 925
Cdd:cd20422     49 KPQPGQLCCAKW-KEDRYYRAIVTAVKGKMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSP 127


                   ...
gi 1958643055  926 PVM 928
Cdd:cd20422    128 EAI 130

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 54.61 E-value: 4.55e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  828 LTAELLEHCNAQKGQPPYR-PRTGEACCAKYTNDDFWYRAIVLEASDSD-VKVLYADYGNVERLPFSRVQPITASHLQLP 905
Cdd:cd20412      9 LVQEMTQYYESEENRHTLLtVQVGDIVAAPFRHDGSWYRARVLGFLENGnLDLYFVDYGDSGYVPLEDLRALRSDFLSLP 88


                   ....*..
gi 1958643055  906 FRIIRCS 912
Cdd:cd20412     89 FQAIECS 95

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 52.28 E-value: 9.31e-09

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1958643055   308 PVKGEVCVAKYTvDQTWNRAVVEGVDVlQKKAHVLYIDYGNEEIIPVDRIHQL 360
Cdd:smart00333    3 FKVGDKVAARWE-DGEWYRARIVKVDG-EQLYEVFFIDYGNEEVVPPSDLRQL 53

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 53.59 E-value: 1.13e-08

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958643055  622 VGRPCCACFAgDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQP 692
Cdd:cd20415     27 QGQACVALFE-DGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIEP 96

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410500 Cd Length: 91 Bit Score: 53.26 E-value: 1.24e-08

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958643055  633 DGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGM 683
Cdd:cd20429     41 ENNWYRVLVKGILTNGLVSVYELDYGKHELVSIRKVQPLIEKFRQLPFQAI 91

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 53.21 E-value: 1.70e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  270 PGHFYVQLYSSE-----VLEYMNQLSASLKETYANMvpedgylPVKGEVCVAKYTVDQTWNRAVVEgvDVL-QKKAHVLY 343
Cdd:cd20441      2 PSRFFIQLSEDEkvilqLAEELNETSEKSRENAAVK-------LKVGDLVAAEYDEDLALYRAVIT--AVLpGKSFKVEF 72

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958643055  344 IDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGV 379
Cdd:cd20441     73 IDYGNTAVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 53.58 E-value: 1.93e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  806 ISPTLFYAipsEMPENQEKLCVLTAELLEHCNA-QKGQPPYRPRTGEACCAKyTNDDFWYRAIVLEA-SDSDVKVLYADY 883
Cdd:cd20437     13 VSPSKFYC---QLLSWEPELSKLTTQMTLHYESvSKELNPSCENFGLLCAAK-GKDGQWHRGFLQQLlPPSQVKVWFIDY 88

                           90       100       110
                   ....*....|....*....|....*....|
gi 1958643055  884 GNVERLPFSRVQPITASHLQLPFRIIRCSL 913
Cdd:cd20437     89 GNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 53.23 E-value: 2.89e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  802 VLEIISPTLFYAIPSEMPENQEKLCVLTAELLEHCNAQKgqppYRPRTGEACCAKYTNDDFWYRAIVLEA-SDSDVKVLY 880
Cdd:cd20440     16 ITHVYSPAKFYCQLDRNTEILEALMEKIAEISKLFNSQI----LDNCKTRLCLAKYFEDGQWYRALAHPVeSSSHLSVYF 91

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958643055  881 ADYGNVERLPFSRVQPI--TASHLQL-PFRIIRCSL 913
Cdd:cd20440     92 VDYGNKQIVEKNEVLPIpdTAVDLLLtPMQAIKCCL 127

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 51.67 E-value: 4.48e-08

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  845 YRPRTGEACCAKYtNDDFWYRAIVLE-ASDSDVKVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSL 913
Cdd:cd20415     23 LCPVQGQACVALF-EDGAWYRARIIGlPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRL 91

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 52.64 E-value: 4.69e-08

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958643055  627 CACFAGDGNWYRALVKEILPSG------NVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQP--KNKHW 697
Cdd:cd20435     56 CAVEDENNLYHRVKVLEITEKDdktkprEVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVKPvdNDTEW 134

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 50.42 E-value: 5.73e-08

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958643055  306 YLPVKGEVCVAKYTVDQTWNRAVVEgvDVLQK-KAHVLYIDYGNEEIIPVDRIHQLS 361
Cdd:cd20410      1 FKPIVGEPCCAFFSGDGNWYRAMVK--EILPGgAVKVHFVDYGNVEEVTLDKLRKIT 55

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 52.48 E-value: 6.89e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  270 PGHFYVQlysseVLEYMNQLSASLK---ETYANMVPEDGYL--PVKGEVCVAKYTVDQTWNRAVVegVDVLQKKAHVLYI 344
Cdd:cd20438     17 PSNFWIR-----TDEYNNEFQALMKniaDIYNLCGNDEELLkkPEPGLLCCARYSKDRHYYRAVI--TEVLDLKVSVYFL 89

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1958643055  345 DYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAGEWTE 388
Cdd:cd20438     90 DFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVWTK 133

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 49.56 E-value: 8.15e-08

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958643055  311 GEVCVAKYTVDQTWNRAVVEGVDVLQKKAHVLYIDYGNEEIIPVDRIHQL 360
Cdd:cd21182      1 GDKCLAPYSDDGKYYEATIEEITEESDTATVVFDGYGNSEEVPLSDLKPL 50

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 51.30 E-value: 1.01e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  264 VTEFKHPGHFYVQLYSSEVLEYMNQLSASLKETYANMVPEDGY-LP----VKGEVCVAKYTVDQTWNRAVVegVDVL-QK 337
Cdd:cd20419      2 VEYIESPSQFYVRFYSKDTSEMLEDMMIEMRRCYSNEHVSERYvMPeafiQPGQVCCVRIPEDVWWYRVII--HQVLnKQ 79

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1958643055  338 KAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKC 374
Cdd:cd20419     80 EVEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPA 116

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 49.12 E-value: 1.16e-07

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1958643055  850 GEACCAKYTNDDFWYRAIVLEASDSD-VKVLYaDYGNVERLPFSRVQP 896
Cdd:cd04508      1 GDRVEAKWSDDGQWYPATVVAVNDDGkYTVLF-DDGNEEEVSEDDIRP 47

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 50.88 E-value: 1.55e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  262 GTVTEFK-----HPGHFYVQLYSSEV-LEYMNQLSASLKETYAN-MVPEDGYLpvkGEVCVAKYTvDQTWNRAVVEGVdV 334
Cdd:cd20437      2 GTTEKVKitaavSPSKFYCQLLSWEPeLSKLTTQMTLHYESVSKeLNPSCENF---GLLCAAKGK-DGQWHRGFLQQL-L 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1958643055  335 LQKKAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVS 377
Cdd:cd20437     77 PPSQVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSLS 119

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 50.54 E-value: 2.34e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  584 GEFYchcLKDDALKKLDDLNKSLADYCAQK---PPNGFKAEVGRPCCACFAGDGNWYRALVKE------ILPSGNVKVHF 654
Cdd:cd20443      2 GRFY---VQVVSDQRLSSIQQQLEGLSLKDkanPPGGFNPKKGELVLAQFSADNSWNRAMVVNaprqgtQSPKDEYEVFY 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1958643055  655 VDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQP 692
Cdd:cd20443     79 IDYGNQETVPLSALRPLDPSVSSAPGLAQLCSLAHIKV 116

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 49.33 E-value: 3.79e-07

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958643055  624 RPCCACFA--GDGNWYRALVKEILPSGNVK--VHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQPKN 694
Cdd:cd20418      5 RPEMPCLAeySDGKWYRAKLLSILEFNPVKilVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPPL 79

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 47.30 E-value: 5.36e-07

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958643055  308 PVKGEVCVAKYtvDQTWNRAVVEGVDVLQKKAHVLYIDYGNEEIIPVDRIHQLS 361
Cdd:cd20444      1 PTPGQMVIAKF--DGNHYRAIVLRVLNPDLKILVRFVDFGNVEVMKLENLYECP 52

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 48.56 E-value: 8.01e-07

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958643055  848 RTGEACCAKYtNDDFWYRAIVLEASD-SDVKVL--YADYGNVERLPFSRVQPITASHLQLPFRIIRCSLEGLTELNGSS 923
Cdd:cd20418      5 RPEMPCLAEY-SDGKWYRAKLLSILEfNPVKILvrHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPPLNDS 82

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 49.03 E-value: 9.10e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  262 GTVTEFK-----HPGHFYVQLY--SSEVLEYMNQLSaSLKETYANMvpedgYLPvkGEV-CVAKYTVDQTWNRAVVEGVd 333
Cdd:cd20439      9 GSVVDVKcsyvnSPGDFWCQLQtkSSELKSLMKQIQ-SYYLIHNDP-----YKH--GQIaCVAKYSKDGKWYRAAVLKQ- 79

                           90
                   ....*....|....*..
gi 1958643055  334 VLQKKAHVLYIDYGNEE 350
Cdd:cd20439     80 VSAKEVDVIFVDYGNQE 96

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 48.65 E-value: 1.06e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  264 VTEFKHPGHFYVQL-YSSEVLEYMNQLSASLKETYANMVpedgyLPVK-GEVCVAKYTvDQTWNRAVVegvDVLQKKAHV 341
Cdd:cd20424     18 ITYVNDPWTFYCQLaRNAGVLDQLASAISRLSSEIRKLE-----LSVNpGTLCLAKYS-DQHWYRGII---ITNKNSTEV 88

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958643055  342 LYIDYGNEEIIPVDRIHQL---SRSISLFPPSAIKC 374
Cdd:cd20424     89 FFVDYGNTEKVEKEDMLPIpsdAYELLLLPMQAIKC 124

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 47.29 E-value: 1.09e-06

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958643055  308 PVKGEVCVAKYTVDQTWNRAVVEGVDVlQKKAHVLYIDYGNEEIIPVDRIHQLS 361
Cdd:cd20430     19 PDPNKIYGGKFSEDNCWYRCKVKSILS-DEKCTVQYIDYGNTETVSRSSIVELP 71

Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar proteins; SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. Overexpression of SPF30 causes apoptosis. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410470 [Multi-domain] Cd Length: 55 Bit Score: 46.53 E-value: 1.21e-06

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1958643055  622 VGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQL 668
Cdd:cd20399      3 VGDKCMAVWSEDGQYYEATIEEISEDGTCTVTFDGYGNTEVTPLSQL 49

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 48.57 E-value: 1.22e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  263 TVTEFKHPGHFYVQL--YSSEVleymNQLSASLKETY-ANMVPEDGYLPVK-GEVCVAKyTVDQTWNRAVVEGVDVLQKK 338
Cdd:cd20421     16 VVTEVTDPHRIFCQLrsLSQEL----KRLSESMHQYYeGRVGSGYETRPEKlGSPCAAR-GSDGRWYRAVLQQVFSANRV 90

                           90       100
                   ....*....|....*....|...
gi 1958643055  339 AHVLYIDYGNEEIIPVDRIHQLS 361
Cdd:cd20421     91 VEVLHVDYGRKEVVSVSNLRYLA 113

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 46.09 E-value: 1.28e-06

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958643055  623 GRPCCACFAGDGNWYRALVKEILPSGN-VKVHFVDYGNVEEVTTDQLHAI 671
Cdd:cd21182      1 GDKCLAPYSDDGKYYEATIEEITEESDtATVVFDGYGNSEEVPLSDLKPL 50

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 48.27 E-value: 1.41e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  805 IISPTLFYAipsEMPENQEKLCVLTAELLEHCNA-QKGQPPYRPrtGEACCAKYTnDDFWYRAIVLEASDSdVKVLYADY 883
Cdd:cd20424     21 VNDPWTFYC---QLARNAGVLDQLASAISRLSSEiRKLELSVNP--GTLCLAKYS-DQHWYRGIIITNKNS-TEVFFVDY 93

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1958643055  884 GNVERLPFSRVQPITASH---LQLPFRIIRCSL 913
Cdd:cd20424     94 GNTEKVEKEDMLPIPSDAyelLLLPMQAIKCSL 126

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 47.42 E-value: 1.60e-06

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958643055  628 ACFAGDGNWYRALVKEIlPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQP 692
Cdd:cd20427     30 AVKAEEDAWLRAQVIEV-EEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQATKCKLAGLEP 93

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 47.45 E-value: 2.62e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  802 VLEIISPTLFYAipsEMPENQEKLCVLTAELlehcNAQKGQPPYRP----RTGEACCAKYTNDDFWYRAIVLEASDSD-V 876
Cdd:cd20425      6 VSHVNSPSDFYV---QLAQDEDELSMISEKL----NASKANDEEVEceslQLGDLICAEYPEDGLWYRAVVKEKIPNNlV 78

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1958643055  877 KVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSL 913
Cdd:cd20425     79 SVQFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 47.07 E-value: 4.43e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  264 VTEFKHPGHFYVQLYSSEvlEYMNQLSASLKEtYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVEGVDVLQkKAHVLY 343
Cdd:cd20440     16 ITHVYSPAKFYCQLDRNT--EILEALMEKIAE-ISKLFNSQILDNCKTRLCLAKYFEDGQWYRALAHPVESSS-HLSVYF 91

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1958643055  344 IDYGNEEIIPVDR---IHQLSRSISLFPPSAIKCY 375
Cdd:cd20440     92 VDYGNKQIVEKNEvlpIPDTAVDLLLTPMQAIKCC 126

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 46.86 E-value: 4.98e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  269 HPGHFYVQL-----YSSEVLEYMN----QLSASLKETYA---NMVPEDgyLPVKGEVCVAKYTvDQTWNRAVVEGV---- 332
Cdd:cd20435      1 DATHYSARIlehrsSDGEVTKSMSstylKLSMKLNMYYSdpsNRILHG--KVKVGDLCAVEDE-NNLYHRVKVLEItekd 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958643055  333 -DVLQKKAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVP 381
Cdd:cd20435     78 dKTKPREVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVKP 127

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 44.55 E-value: 5.32e-06

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958643055  850 GEACCAKYTNDDFWYRAIVLE--ASDSDVKVLYADYGNVERLPFSRVQPI 897
Cdd:cd21182      1 GDKCLAPYSDDGKYYEATIEEitEESDTATVVFDGYGNSEEVPLSDLKPL 50

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 44.57 E-value: 5.39e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1958643055   850 GEACCAKYtNDDFWYRAIVLEASDSD-VKVLYADYGNVERLPFSRVQPI 897
Cdd:smart00333    6 GDKVAARW-EDGEWYRARIVKVDGEQlYEVFFIDYGNEEVVPPSDLRQL 53

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 45.28 E-value: 5.45e-06

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958643055  852 ACCAKYTNDDfWYRAIVLEASDSD--VKVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSLEGLT 917
Cdd:cd20407      9 VICAAPVMNA-WYRAQVVGVFEETdeVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIE 75

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 46.26 E-value: 7.98e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  791 ELPVNKTVPANVLEIISPTLFYA-IPSEMPENQEklcvLTAELLEHCNAQKGQPPY-RPRTGEACCAKYTNDDFWYRAIV 868
Cdd:cd20421      6 QLQVGVTETVVVTEVTDPHRIFCqLRSLSQELKR----LSESMHQYYEGRVGSGYEtRPEKLGSPCAARGSDGRWYRAVL 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1958643055  869 LE--ASDSDVKVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSLEG 915
Cdd:cd20421     82 QQvfSANRVVEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 45.50 E-value: 8.22e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  831 ELLEHCNAQKGQPPYR-PRTGEACCAKyTNDDFWYRAIVLEASDSDVKVLYADYGNVERLPFSRVQPITASHLQLPFRII 909
Cdd:cd20427      6 EMKEFYSKSSTAMCLRsPSVGQLVAVK-AEEDAWLRAQVIEVEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQAT 84


                   ....*..
gi 1958643055  910 RCSLEGL 916
Cdd:cd20427     85 KCKLAGL 91

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 45.12 E-value: 1.04e-05

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958643055  306 YLPVKGEVCVAKYTvDQTWNRAVVEGVdVLQKKAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKC 374
Cdd:cd20415     23 LCPVQGQACVALFE-DGAWYRARIIGL-PGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKAREC 89

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 44.69 E-value: 1.37e-05

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958643055  614 PPNGFkaevgrpCCACFA-GDGN-WYRALVKEILPSgNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLP 679
Cdd:cd20431     42 VPNLL-------CLAPFTdADMKkYYRAKILYVSGS-SAEVFFVDYGNTSQVPSSLLREIPETLLTLP 101

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 42.96 E-value: 1.43e-05

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958643055  630 FAGDGNWYRALVKEILPSGNVKVHFvDYGNVEEVTTDQL 668
Cdd:cd04508      8 WSDDGQWYPATVVAVNDDGKYTVLF-DDGNEEEVSEDDI 45

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 43.10 E-value: 1.54e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1958643055  622 VGRPCCACFAGDGNWYRALVKEILPSGNVK-VHFVDYGNVEEV 663
Cdd:cd20413      3 PGDECLAKYWEDNKFYRAEVTAVHPSGKTAvVKFMEYGNYEEV 45

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410488 Cd Length: 68 Bit Score: 43.58 E-value: 1.69e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1958643055  850 GEACCAKYTnDDFWYRAIVLEASDSDVKVLYADYGNVERLPFSRVQPI 897
Cdd:cd20417      4 GEGCVVRGS-DTLWYRGKVLEVIGGMVRVQYVDQGYIEKIPQCHLYPM 50

Tudor domain found in Tudor domain-containing protein 10 (TDRD10) and similar proteins; TDRD10 is widely expressed and localized both to the nucleus and cytoplasm, and may play general roles like regulation of RNA metabolism. It contains a Tudor domain and an RNA recognition motif (RRM). The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410503 Cd Length: 139 Bit Score: 45.50 E-value: 2.02e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  246 FSDLRSLQLrkSMEIKGT----VTE-FKHPGHFYVQLYSSEVLEYMNQLSASLketyANMVPEDGYLP----VKGEVCVA 316
Cdd:cd20432      6 FGDLSWLAS--IMKVHGEvgllVTDtFPHTPYFWAILLTEESQQNMQQLFSTL----AEVESQQPFLAkedvHRGRRCLA 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1958643055  317 KYTVDQ---TWNRAVVegVDVLQKKAHVLYIDYGNEEIIPVDRIHQLS 361
Cdd:cd20432     80 ECPLGEeggAWNRCWV--LDVVEDFAVVFFVDFGSTANIPLPSLRSLD 125

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 44.32 E-value: 2.60e-05

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958643055  314 CVAKYTvDQTWNRAVVEGVDVLQK-KAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAGE 385
Cdd:cd20418     10 CLAEYS-DGKWYRAKLLSILEFNPvKILVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPPLND 81

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 45.10 E-value: 3.36e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  311 GEVCVAKYTVDQTWNRAVVegVDVLQKKAHVLYIDYGNEEIipVDRIHQLSRSISLF--PPSAIKCYVSGVVPAAGEWTE 388
Cdd:cd20436     50 GEFCLVEDTTSGEWYRGRV--LEKIDEKYEVFLIDRGEVLN--VHATNMASASGELFqlPPKAVCGIFANILPIGEKWSS 125

                           90
                   ....*....|....*
gi 1958643055  389 DCVVAVKALLFEQYC 403
Cdd:cd20436    126 TAVNYFSSLIGSQVK 140

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 43.15 E-value: 4.95e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  265 TEFKHPGHFYVQLYSSEVLEYMNQLSASLKE-TYANMVPEdgylPVKGEVCVAKYT--VDQTWNRAVVegVDVLQKKAHV 341
Cdd:cd20431      1 TEVVEVGHFWGYRIDENSSEILQQLTAEINQrQLVPLTTK----PVPNLLCLAPFTdaDMKKYYRAKI--LYVSGSSAEV 74

                           90
                   ....*....|...
gi 1958643055  342 LYIDYGNEEIIPV 354
Cdd:cd20431     75 FFVDYGNTSQVPS 87

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 41.56 E-value: 6.09e-05

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958643055  310 KGEVCVAKYTVDQTWNRAVVEGVDVLQKKAHVLYIDYGNEEIIPVDRIHQL 360
Cdd:cd20413      3 PGDECLAKYWEDNKFYRAEVTAVHPSGKTAVVKFMEYGNYEEVLLSDIKPI 53

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 41.89 E-value: 7.06e-05

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958643055  828 LTAELLEHCnaQKGQPPYR-PRTGEACCAKYTNDDFWYRAIVLEA-SDSDVKVLYADYGNVE 887
Cdd:cd20430      1 LSDELAEVC--PTAPPLFGtPDPNKIYGGKFSEDNCWYRCKVKSIlSDEKCTVQYIDYGNTE 60

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 44.26 E-value: 8.05e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  821 NQEKLCVLTAELLEHCNAQKGQPPYRPRTGEACCAKYTNDDFWYRAIVLEASDSDVK--VLYADYGNVERLPFSRVQPIT 898
Cdd:cd20442     24 NSEQLTDLESLIAKEAKKCKFVPVEDIKEGLECLAKSKKNLKWYRAVVEHLYPETEKmlVFFVDHGITEVVSMGNIKQLS 103

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1958643055  899 ASHLQLPFRIIRCSLEGLTELNGSSSqpvmELLRNAMLNQSVAL 942
Cdd:cd20442    104 NDLLQIPRQAVLCRWNWPESSKELSF----EILWKSLAGKEVKL 143

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410455 Cd Length: 55 Bit Score: 41.06 E-value: 8.46e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1958643055  627 CACFA--GDGNWYRALVKEILPSGNVKVHFVDYGNVEEVttdQLHAIAP 673
Cdd:cd20384      9 SRCLAkyDDGLWYPATVTDIDEDGKYTVKFDSYGEVAVV---ELDDILP 54

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 41.42 E-value: 1.06e-04

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958643055  311 GEVCVAkyTVDQTWNRAVVEGVDVLQKKAHVLYIDYGNEEIIPVDRIHQLsRSISL-FPPSAIKCYVSGVVP 381
Cdd:cd20407      8 GVICAA--PVMNAWYRAQVVGVFEETDEVEIKYLDYGGYERVPVDDLRQI-RSDFMtLPFQATECYLANIEP 76

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410516 Cd Length: 56 Bit Score: 40.87 E-value: 1.20e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1958643055  851 EACCAKYtnDDFWYRAIVLE-ASDSDVKVLYADYGNVERLPFSRVQPIT 898
Cdd:cd20445      3 ELCIAKY--MDKWYRAVCLEsVGDGRPTVLFCDYGNILMARLTDIRPFP 49

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 41.64 E-value: 1.64e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  288 QLSASLKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVegVDVLQKKAHVLYIDYGNEEIIPVDRIHQLSRSISLF 367
Cdd:cd20427      2 QMEDEMKEFYSKSSTAMCLRSPSVGQLVAVKAEEDAWLRAQV--IEVEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSL 79

                           90
                   ....*....|....
gi 1958643055  368 PPSAIKCYVSGVVP 381
Cdd:cd20427     80 PFQATKCKLAGLEP 93

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 42.41 E-value: 2.44e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  849 TGEACCAKYTNDDFWYRAIVLEASDSDVKVLYADYGNVERLPFSRVQPITASHLQLPFRIIRCSLEGLTELNGSSSQPVM 928
Cdd:cd20436     49 VGEFCLVEDTTSGEWYRGRVLEKIDEKYEVFLIDRGEVLNVHATNMASASGELFQLPPKAVCGIFANILPIGEKWSSTAV 128


                   ....*.
gi 1958643055  929 ELLRNA 934
Cdd:cd20436    129 NYFSSL 134

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410500 Cd Length: 91 Bit Score: 40.93 E-value: 2.54e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  824 KLCVLTAELLEHCNAQKGQPpYRPRTGEACCAKYTNDdfWYRAIVLEA-SDSDVKVLYADYGNVERLPFSRVQPITASHL 902
Cdd:cd20429      8 KLEVLMEEMILYYNKTEERP-VAIEKNKVYAAKIENN--WYRVLVKGIlTNGLVSVYELDYGKHELVSIRKVQPLIEKFR 84


                   ....*..
gi 1958643055  903 QLPFRII 909
Cdd:cd20429     85 QLPFQAI 91

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410516 Cd Length: 56 Bit Score: 39.33 E-value: 4.57e-04

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958643055  312 EVCVAKYtvDQTWNRAV-VEGVDvlQKKAHVLYIDYGNEEIIPVDrihqlsrSISLFPPSAIK 373
Cdd:cd20445      3 ELCIAKY--MDKWYRAVcLESVG--DGRPTVLFCDYGNILMARLT-------DIRPFPPTFAT 54

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410488 Cd Length: 68 Bit Score: 38.96 E-value: 7.88e-04

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  627 CACFAGDGNWYRALVKEILpSGNVKVHFVDYGNVEEVTTDQLHAIA-----PQFlLLPFQ 681
Cdd:cd20417      7 CVVRGSDTLWYRGKVLEVI-GGMVRVQYVDQGYIEKIPQCHLYPMVlypdiPQF-CIPCQ 64

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 38.44 E-value: 9.01e-04

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958643055  633 DGNWYRALVKEIL-PSGNVKVHFVDYGNVEEVTTDQL 668
Cdd:cd20444     12 DGNHYRAIVLRVLnPDLKILVRFVDFGNVEVMKLENL 48

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410455 Cd Length: 55 Bit Score: 37.59 E-value: 1.44e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1958643055  850 GEACCAKYTnDDFWYRAIVLEASDSD-VKVLYADYGNVERLPFSRVQPI 897
Cdd:cd20384      8 GSRCLAKYD-DGLWYPATVTDIDEDGkYTVKFDSYGEVAVVELDDILPL 55

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 37.71 E-value: 1.52e-03

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1958643055  848 RTGEACCAKYTNDDFWYRAIV--LEASDSDVKVLYADYGNVERLPFSRVQPI 897
Cdd:cd20413      2 KPGDECLAKYWEDNKFYRAEVtaVHPSGKTAVVKFMEYGNYEEVLLSDIKPI 53

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410516 Cd Length: 56 Bit Score: 37.79 E-value: 1.63e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1958643055  634 GNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLHAIAPQFLLLP 679
Cdd:cd20445     11 DKWYRAVCLESVGDGRPTVLFCDYGNILMARLTDIRPFPPTFATEP 56

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 36.80 E-value: 2.80e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1958643055  311 GEVCVAKYTVDQTWNRAVVEGVDvLQKKAHVLYiDYGNEEIIPVDRI 357
Cdd:cd04508      1 GDRVEAKWSDDGQWYPATVVAVN-DDGKYTVLF-DDGNEEEVSEDDI 45

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 38.05 E-value: 3.35e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  289 LSASLKETYANMVPEDGYLPVK-GEVCVAKYTVDQTWNRAVVEGVdVLQKKAHVLYIDYGNEEIIPVDRIHQLsRS--IS 365
Cdd:cd20412      9 LVQEMTQYYESEENRHTLLTVQvGDIVAAPFRHDGSWYRARVLGF-LENGNLDLYFVDYGDSGYVPLEDLRAL-RSdfLS 86


                   ....*....
gi 1958643055  366 LfPPSAIKC 374
Cdd:cd20412     87 L-PFQAIEC 94

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 37.81 E-value: 7.34e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  263 TVTEFKHPGHFYVQLYS------SEVLEYMNQLSASLKETYANMVPedgyLPVKGEVCVAKYTvdQTWNRavVEGVDVLQ 336
Cdd:cd20428      5 RVTNVCSDGTLYCQVPSkglsklNEILDKIEYYFHSRQMTSEYFVS----LPFCGKICLARYK--GKWAR--VEITNVHS 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  337 KKA-HVLYIDYGNEEIIPVDRIH----QLSRSISLFPPSAIKCYVSGVVPAAGEWTEDCV 391
Cdd:cd20428     77 SRAlDVHFLDTGTVASVKVSELReippPFLRELISIPPQALKCCLADLPLNIGMWTPDAV 136

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 35.74 E-value: 7.57e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1958643055  847 PRTGEACCAKYtnDDFWYRAIVLEASDSDVK--VLYADYGNVE 887
Cdd:cd20444      1 PTPGQMVIAKF--DGNHYRAIVLRVLNPDLKilVRFVDFGNVE 41

third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410487 Cd Length: 82 Bit Score: 36.31 E-value: 7.96e-03

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958643055  289 LSASLKETYANMVPEdgylPVKGEV---CVAKYTVDQTWNRAVVEGVdVLQKKAHVLYIDYGNEEIIPVDRIHQLSRSI 364
Cdd:cd20416      1 LQEKMIAEYENSKPE----PVKWENdmhCAVQIQDKKQWRRGQIIRV-VSDTLVEVFLYDFGNKEVVNIDCLRKLEENL 74

Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Mutations in human SMN lead to motor neuron degeneration and spinal muscular atrophy. SMN contains a central, highly conserved Tudor domain that is required for U snRNP assembly and Sm protein binding and has been shown to bind arginine-glycine-rich motifs in an methylarginine-dependent manner.

Pssm-ID: 410469 Cd Length: 56 Bit Score: 35.71 E-value: 8.27e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958643055  621 EVGRPCCACFAGDGNWYRALVKEI-LPSGNVKVHFVDYGNVEEV 663
Cdd:cd20398      2 KVGDKCRAVYSEDGIIYEATIVSIdAERGTCVVRYTGYGNEEEQ 45

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 38.10 E-value: 8.95e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643055  584 GEFYCHCLKDDalKKLDDLNKSLADycaQKPPNGFKAEV----GRPCCACFAGDGNWYRALVKEILPS-GNVKVHFVDYG 658
Cdd:cd20442     15 GTFYVRLLRNS--EQLTDLESLIAK---EAKKCKFVPVEdikeGLECLAKSKKNLKWYRAVVEHLYPEtEKMLVFFVDHG 89


                   ....*
gi 1958643055  659 NVEEV 663
Cdd:cd20442     90 ITEVV 94