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Conserved domains on  [gi|1958643382|ref|XP_038960000|]
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latent-transforming growth factor beta-binding protein 4 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 418-459 4.40e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 59.21  E-value: 4.40e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958643382  418 CSLPILRNITKQICCCSRVGKAWGRGCQLCPPYGSEGFREIC 459
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
842-878 1.66e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 1.66e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1958643382   842 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYRPGPR 878
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1324-1366 2.15e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 2.15e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958643382 1324 VCSRPrLDRQATYTECCCLY-GEAWGMDCALCPAQDSDDFEALC 1366
Cdd:pfam00683    2 RCSNP-LPGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1157-1199 4.48e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 4.48e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958643382 1157 CDNILARNVTWQECCC-TVGEGWGSGCriQQCPGTETAEYQSLC 1199
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPC--ELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1013-1054 1.01e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.01e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1958643382  1013 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEgarDGRHCV 1054
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
884-919 6.43e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 6.43e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1958643382   884 DVDECSEEDLCQSG-ICTNTDGSFECICPPGHRAGPD 919
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
357-387 2.75e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.75e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1958643382   357 DVDECATGGRCQHG-ECANTRGGYTCVCPDGF 387
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 679-716 3.57e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.57e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958643382  679 DVDECtQSPGLCGRGA-CENLPGSFRCVCPAGFLGSACE 716
Cdd:cd00054      1 DIDEC-ASGNPCQNGGtCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
760-801 8.26e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 8.26e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958643382   760 DVDECArSPSPCAYG-RCENTEGSFKCVCPTGFQPnaaGSECE 801
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
637-678 2.61e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 2.61e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958643382   637 DVDECRRvPPPCDRG-RCENTPGSFLCVCPAGYQAaphGASCQ 678
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
595-631 2.69e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 2.69e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1958643382   595 DVDECRRvPTPCAPG-RCENTPGSFRCVCGTGFRAGPR 631
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
1538-1572 5.46e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 5.46e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1958643382  1538 DINECdeaeATSPLCVN-ARCVNTDGSFRCICRPGF 1572
Cdd:smart00179    1 DIDEC----ASGNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
718-752 8.01e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 8.01e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1958643382   718 DVDECAQqPPPCGPG-RCDNTLGSFHCACPAGFRSR 752
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
925-963 1.56e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.56e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1958643382   925 DIDECRERGPALCGSqRCENSPGSYRCvrDCDPGYHPGP 963
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRC--ECPPGYTDGR 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1260-1289 1.75e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.75e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958643382 1260 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1289
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
802-837 6.99e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 6.99e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1958643382   802 DVDECENHLAC-PGQECVNSPGSFQCRaCPVGYHLHR 837
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTDGR 36
EGF_CA super family cl21504
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1055-1083 8.31e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


The actual alignment was detected with superfamily member pfam07645:

Pssm-ID: 473889  Cd Length: 32  Bit Score: 35.29  E-value: 8.31e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958643382 1055 DVNECETLQGVC-GSALCENVEGSFLCVCP 1083
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCP 30
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 418-459 4.40e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 59.21  E-value: 4.40e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958643382  418 CSLPILRNITKQICCCSRVGKAWGRGCQLCPPYGSEGFREIC 459
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
842-878 1.66e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 1.66e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1958643382   842 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYRPGPR 878
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1324-1366 2.15e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 2.15e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958643382 1324 VCSRPrLDRQATYTECCCLY-GEAWGMDCALCPAQDSDDFEALC 1366
Cdd:pfam00683    2 RCSNP-LPGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1157-1199 4.48e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 4.48e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958643382 1157 CDNILARNVTWQECCC-TVGEGWGSGCriQQCPGTETAEYQSLC 1199
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPC--ELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1013-1054 1.01e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.01e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1958643382  1013 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEgarDGRHCV 1054
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 842-874 2.45e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.45e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958643382  842 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYR 874
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
884-919 6.43e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 6.43e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1958643382   884 DVDECSEEDLCQSG-ICTNTDGSFECICPPGHRAGPD 919
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1013-1048 6.52e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 6.52e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958643382 1013 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEGAR 1048
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
357-387 2.75e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.75e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1958643382   357 DVDECATGGRCQHG-ECANTRGGYTCVCPDGF 387
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 679-716 3.57e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.57e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958643382  679 DVDECtQSPGLCGRGA-CENLPGSFRCVCPAGFLGSACE 716
Cdd:cd00054      1 DIDEC-ASGNPCQNGGtCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 884-915 6.00e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 6.00e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958643382  884 DVDECSEEDLCQ-SGICTNTDGSFECICPPGHR 915
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
760-801 8.26e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 8.26e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958643382   760 DVDECArSPSPCAYG-RCENTEGSFKCVCPTGFQPnaaGSECE 801
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
679-716 8.68e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 8.68e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1958643382   679 DVDECtQSPGLCGRGA-CENLPGSFRCVCPAGF-LGSACE 716
Cdd:smart00179    1 DIDEC-ASGNPCQNGGtCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 357-391 1.07e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 1.07e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958643382  357 DVDECATGGRCQ-HGECANTRGGYTCVCPDGFLLDS 391
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
637-678 2.61e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 2.61e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958643382   637 DVDECRRvPPPCDRG-RCENTPGSFLCVCPAGYQAaphGASCQ 678
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
595-631 2.69e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 2.69e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1958643382   595 DVDECRRvPTPCAPG-RCENTPGSFRCVCGTGFRAGPR 631
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
1538-1572 5.46e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 5.46e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1958643382  1538 DINECdeaeATSPLCVN-ARCVNTDGSFRCICRPGF 1572
Cdd:smart00179    1 DIDEC----ASGNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 760-792 7.22e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 7.22e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1958643382  760 DVDECArSPSPCAY-GRCENTEGSFKCVCPTGFQ 792
Cdd:cd00054      1 DIDECA-SGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
884-913 7.53e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 7.53e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958643382  884 DVDEC-SEEDLC-QSGICTNTDGSFECICPPG 913
Cdd:pfam07645    1 DVDECaTGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 637-678 7.96e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 7.96e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958643382  637 DVDECRRVPPPCDRGRCENTPGSFLCVCPAGYqaapHGASCQ 678
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
718-752 8.01e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 8.01e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1958643382   718 DVDECAQqPPPCGPG-RCDNTLGSFHCACPAGFRSR 752
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1023-1053 8.63e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 38.35  E-value: 8.63e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958643382 1023 CGAHAMCQNLPGSFQCVCDQGYEGarDGRHC 1053
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTG--DGVTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 718-752 1.12e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.12e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958643382  718 DVDECAQQPPPCGPGRCDNTLGSFHCACPAGFRSR 752
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA pfam07645
Calcium-binding EGF domain;
760-790 1.36e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.36e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958643382  760 DVDECARSPSPCAY-GRCENTEGSFKCVCPTG 790
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
925-963 1.56e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.56e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1958643382   925 DIDECRERGPALCGSqRCENSPGSYRCvrDCDPGYHPGP 963
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRC--ECPPGYTDGR 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1538-1576 1.75e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.75e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958643382 1538 DINECdeaeATSPLCVN-ARCVNTDGSFRCICRPGFAPTH 1576
Cdd:cd00054      1 DIDEC----ASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1260-1289 1.75e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.75e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958643382 1260 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1289
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
1260-1289 1.94e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.94e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1958643382  1260 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1289
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
357-386 2.03e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.22  E-value: 2.03e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958643382  357 DVDECATGGR-CQHGE-CANTRGGYTCVCPDG 386
Cdd:pfam07645    1 DVDECATGTHnCPANTvCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1538-1571 4.30e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 4.30e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1958643382 1538 DINECDEAEATSPlcVNARCVNTDGSFRCICRPG 1571
Cdd:pfam07645    1 DVDECATGTHNCP--ANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
637-667 4.51e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 4.51e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958643382  637 DVDECRRVPPPCDR-GRCENTPGSFLCVCPAG 667
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
679-709 5.39e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 5.39e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958643382  679 DVDECTQSPGLCGRGA-CENLPGSFRCVCPAG 709
Cdd:pfam07645    1 DVDECATGTHNCPANTvCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 595-627 6.11e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 6.11e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1958643382  595 DVDECRRvPTPCAP-GRCENTPGSFRCVCGTGFR 627
Cdd:cd00054      1 DIDECAS-GNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
802-837 6.99e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 6.99e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1958643382   802 DVDECENHLAC-PGQECVNSPGSFQCRaCPVGYHLHR 837
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTDGR 36
EGF_CA pfam07645
Calcium-binding EGF domain;
1055-1083 8.31e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 8.31e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958643382 1055 DVNECETLQGVC-GSALCENVEGSFLCVCP 1083
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCP 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 802-837 9.52e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 9.52e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958643382  802 DVDECENHLAC-PGQECVNSPGSFQCRaCPVGYHLHR 837
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTGRN 36
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 418-459 4.40e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 59.21  E-value: 4.40e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958643382  418 CSLPILRNITKQICCCSRVGKAWGRGCQLCPPYGSEGFREIC 459
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
842-878 1.66e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 1.66e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1958643382   842 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYRPGPR 878
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1324-1366 2.15e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 2.15e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958643382 1324 VCSRPrLDRQATYTECCCLY-GEAWGMDCALCPAQDSDDFEALC 1366
Cdd:pfam00683    2 RCSNP-LPGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1157-1199 4.48e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 4.48e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958643382 1157 CDNILARNVTWQECCC-TVGEGWGSGCriQQCPGTETAEYQSLC 1199
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPC--ELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1013-1054 1.01e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.01e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1958643382  1013 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEgarDGRHCV 1054
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 842-874 2.45e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.45e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958643382  842 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYR 874
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
884-919 6.43e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 6.43e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1958643382   884 DVDECSEEDLCQSG-ICTNTDGSFECICPPGHRAGPD 919
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1013-1048 6.52e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 6.52e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958643382 1013 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEGAR 1048
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
357-387 2.75e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.75e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1958643382   357 DVDECATGGRCQHG-ECANTRGGYTCVCPDGF 387
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 679-716 3.57e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.57e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958643382  679 DVDECtQSPGLCGRGA-CENLPGSFRCVCPAGFLGSACE 716
Cdd:cd00054      1 DIDEC-ASGNPCQNGGtCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 884-915 6.00e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 6.00e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958643382  884 DVDECSEEDLCQ-SGICTNTDGSFECICPPGHR 915
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
760-801 8.26e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 8.26e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958643382   760 DVDECArSPSPCAYG-RCENTEGSFKCVCPTGFQPnaaGSECE 801
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
679-716 8.68e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 8.68e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1958643382   679 DVDECtQSPGLCGRGA-CENLPGSFRCVCPAGF-LGSACE 716
Cdd:smart00179    1 DIDEC-ASGNPCQNGGtCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 357-391 1.07e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 1.07e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958643382  357 DVDECATGGRCQ-HGECANTRGGYTCVCPDGFLLDS 391
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
637-678 2.61e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 2.61e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958643382   637 DVDECRRvPPPCDRG-RCENTPGSFLCVCPAGYQAaphGASCQ 678
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
595-631 2.69e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 2.69e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1958643382   595 DVDECRRvPTPCAPG-RCENTPGSFRCVCGTGFRAGPR 631
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
1538-1572 5.46e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 5.46e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1958643382  1538 DINECdeaeATSPLCVN-ARCVNTDGSFRCICRPGF 1572
Cdd:smart00179    1 DIDEC----ASGNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 760-792 7.22e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 7.22e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1958643382  760 DVDECArSPSPCAY-GRCENTEGSFKCVCPTGFQ 792
Cdd:cd00054      1 DIDECA-SGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
884-913 7.53e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 7.53e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958643382  884 DVDEC-SEEDLC-QSGICTNTDGSFECICPPG 913
Cdd:pfam07645    1 DVDECaTGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 637-678 7.96e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 7.96e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958643382  637 DVDECRRVPPPCDRGRCENTPGSFLCVCPAGYqaapHGASCQ 678
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
718-752 8.01e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 8.01e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1958643382   718 DVDECAQqPPPCGPG-RCDNTLGSFHCACPAGFRSR 752
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1023-1053 8.63e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 38.35  E-value: 8.63e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958643382 1023 CGAHAMCQNLPGSFQCVCDQGYEGarDGRHC 1053
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTG--DGVTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 718-752 1.12e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.12e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958643382  718 DVDECAQQPPPCGPGRCDNTLGSFHCACPAGFRSR 752
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA pfam07645
Calcium-binding EGF domain;
760-790 1.36e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.36e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958643382  760 DVDECARSPSPCAY-GRCENTEGSFKCVCPTG 790
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF smart00181
Epidermal growth factor-like domain;
360-392 1.49e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.50  E-value: 1.49e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1958643382   360 ECATGGRCQHGECANTRGGYTCVCPDGFLLDSS 392
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
925-963 1.56e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.56e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1958643382   925 DIDECRERGPALCGSqRCENSPGSYRCvrDCDPGYHPGP 963
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRC--ECPPGYTDGR 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1538-1576 1.75e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.75e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958643382 1538 DINECdeaeATSPLCVN-ARCVNTDGSFRCICRPGFAPTH 1576
Cdd:cd00054      1 DIDEC----ASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1260-1289 1.75e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.75e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958643382 1260 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1289
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
1260-1289 1.94e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.94e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1958643382  1260 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1289
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
357-386 2.03e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.22  E-value: 2.03e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958643382  357 DVDECATGGR-CQHGE-CANTRGGYTCVCPDG 386
Cdd:pfam07645    1 DVDECATGTHnCPANTvCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1538-1571 4.30e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 4.30e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1958643382 1538 DINECDEAEATSPlcVNARCVNTDGSFRCICRPG 1571
Cdd:pfam07645    1 DVDECATGTHNCP--ANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
637-667 4.51e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 4.51e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958643382  637 DVDECRRVPPPCDR-GRCENTPGSFLCVCPAG 667
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
679-709 5.39e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 5.39e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958643382  679 DVDECTQSPGLCGRGA-CENLPGSFRCVCPAG 709
Cdd:pfam07645    1 DVDECATGTHNCPANTvCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 595-627 6.11e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 6.11e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1958643382  595 DVDECRRvPTPCAP-GRCENTPGSFRCVCGTGFR 627
Cdd:cd00054      1 DIDECAS-GNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
802-837 6.99e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 6.99e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1958643382   802 DVDECENHLAC-PGQECVNSPGSFQCRaCPVGYHLHR 837
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTDGR 36
EGF_CA pfam07645
Calcium-binding EGF domain;
1055-1083 8.31e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 8.31e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958643382 1055 DVNECETLQGVC-GSALCENVEGSFLCVCP 1083
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCP 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 802-837 9.52e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 9.52e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958643382  802 DVDECENHLAC-PGQECVNSPGSFQCRaCPVGYHLHR 837
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTGRN 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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