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Conserved domains on  [gi|1958760377|ref|XP_038960401|]
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origin recognition complex subunit 4 isoform X6 [Rattus norvegicus]

Protein Classification

origin recognition complex subunit 4( domain architecture ID 13386334)

origin recognition complex subunit 4 is a component of the origin recognition complex (ORC), an ATP-dependent DNA-binding complex that binds origins of replication

CATH:  3.40.50.300
Gene Symbol:  ORC4
Gene Ontology:  GO:0006270|GO:0006260|GO:0005524|GO:0000808|GO:0003688
PubMed:  20130679|18208389|18466635|16828312|15037233|17241905
SCOP:  4000172|4000283

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ORC4_C pfam14629
Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of ...
 209-368 7.83e-50

Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of origin recognition complex subunit 4.


:

Pssm-ID: 464223  Cd Length: 212  Bit Score: 167.13  E-value: 7.83e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377 209 LSEDSTVLEVLQKHFNVNKNLQSLHMLLMLALNRVTVTHPFMTSADLMEAQHLCSLDAKASIVHGLSVLEICLIIAMKHL 288
Cdd:pfam14629  33 LLEDSTVQDILKRLYYTTKSVRSLLNSLILPVSKLSPDSPLLTAESLLSALSSQSPDSKLSLLRSLSVLELCLLIAAARL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377 289 NDIYEEEPFNFQMVYNEFQKFIQRK-------------AHSVYNFEKPVVMKAFEHLQQLELIKPMERTSVNS------- 348
Cdd:pfam14629 113 SEIYDTDTFNFEMVYDEYKKLAKRSkvspssatsqssaASGIRVWGRPVALKAWEHLLSLELLVPVGAVSTGGassgsgg 192

                         170       180
                  ....*....|....*....|
gi 1958760377 349 QREYQLVKLLLDNTQIMNAL 368
Cdd:pfam14629 193 GKEFRMVRLDITLEEIREAV 212
CDC6 super family cl34277
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
54-204 1.02e-10

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG1474:

Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 62.56  E-value: 1.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377  54 QYKHLIELLkRTAIYGES-NSLLIVGPRGSGKTTLLNHALKELMQIGDMSE-NVLQVHLNGLLQTNDKIALKEITRQLNL 131
Cdd:COG1474    34 EIEELASAL-RPALRGERpSNVLIYGPTGTGKTAVAKYVLEELEEEAEERGvDVRVVYVNCRQASTRYRVLSRILEELGS 112

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958760377 132 ENVVGDKvfG-SFAENLSFLLEALQKGNRtsscPVIFILDEFDLFAHQKNQTLLYNLFDISQS-AQTPIAVIGLT 204
Cdd:COG1474   113 GEDIPST--GlSTDELFDRLYEALDERDG----VLVVVLDEIDYLVDDEGDDLLYQLLRANEElEGARVGVIGIS 181
 
Name Accession Description Interval E-value
ORC4_C pfam14629
Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of ...
 209-368 7.83e-50

Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of origin recognition complex subunit 4.


Pssm-ID: 464223  Cd Length: 212  Bit Score: 167.13  E-value: 7.83e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377 209 LSEDSTVLEVLQKHFNVNKNLQSLHMLLMLALNRVTVTHPFMTSADLMEAQHLCSLDAKASIVHGLSVLEICLIIAMKHL 288
Cdd:pfam14629  33 LLEDSTVQDILKRLYYTTKSVRSLLNSLILPVSKLSPDSPLLTAESLLSALSSQSPDSKLSLLRSLSVLELCLLIAAARL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377 289 NDIYEEEPFNFQMVYNEFQKFIQRK-------------AHSVYNFEKPVVMKAFEHLQQLELIKPMERTSVNS------- 348
Cdd:pfam14629 113 SEIYDTDTFNFEMVYDEYKKLAKRSkvspssatsqssaASGIRVWGRPVALKAWEHLLSLELLVPVGAVSTGGassgsgg 192

                         170       180
                  ....*....|....*....|
gi 1958760377 349 QREYQLVKLLLDNTQIMNAL 368
Cdd:pfam14629 193 GKEFRMVRLDITLEEIREAV 212
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
54-204 1.02e-10

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 62.56  E-value: 1.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377  54 QYKHLIELLkRTAIYGES-NSLLIVGPRGSGKTTLLNHALKELMQIGDMSE-NVLQVHLNGLLQTNDKIALKEITRQLNL 131
Cdd:COG1474    34 EIEELASAL-RPALRGERpSNVLIYGPTGTGKTAVAKYVLEELEEEAEERGvDVRVVYVNCRQASTRYRVLSRILEELGS 112

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958760377 132 ENVVGDKvfG-SFAENLSFLLEALQKGNRtsscPVIFILDEFDLFAHQKNQTLLYNLFDISQS-AQTPIAVIGLT 204
Cdd:COG1474   113 GEDIPST--GlSTDELFDRLYEALDERDG----VLVVVLDEIDYLVDDEGDDLLYQLLRANEElEGARVGVIGIS 181
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 57-206 1.96e-08

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 52.92  E-value: 1.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377  57 HLIELLKRTAIYGESNSLLIVGPRGSGKTTLLNHALKELmqiGDMSENVLQVHLNGLlqtndkialkeitrqlnLENVVG 136
Cdd:cd00009     5 EAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANEL---FRPGAPFLYLNASDL-----------------LEGLVV 64

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958760377 137 DKVFGSFAENLSFLLEALQKgnrtsscPVIFILDEFDLFAHQKNQTLLYNLFDISQSAQTP--IAVIGLTCR 206
Cdd:cd00009    65 AELFGHFLVRLLFELAEKAK-------PGVLFIDEIDSLSRGAQNALLRVLETLNDLRIDRenVRVIGATNR 129
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 47-201 7.61e-08

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 51.74  E-value: 7.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377  47 NLFGVQVQYKHLIELLKRTAIyGESNSLLIVGPRGSGKTTLLNHALKelmQIGDMSENVLQ---VHLNGLLQTNDKIALK 123
Cdd:pfam13191   1 RLVGREEELEQLLDALDRVRS-GRPPSVLLTGEAGTGKTTLLRELLR---ALERDGGYFLRgkcDENLPYSPLLEALTRE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377 124 EITRQLNLENVV----------------GDKVFGSFAENLSFLLEALQKGNRTSSCPVIFILDEFDLFAHQkNQTLLYNL 187
Cdd:pfam13191  77 GLLRQLLDELESslleawraallealapVPELPGDLAERLLDLLLRLLDLLARGERPLVLVLDDLQWADEA-SLQLLAAL 155

                         170
                  ....*....|....
gi 1958760377 188 FDISQsaQTPIAVI 201
Cdd:pfam13191 156 LRLLE--SLPLLVV 167
cdc6 PRK00411
ORC1-type DNA replication protein;
59-222 3.32e-06

ORC1-type DNA replication protein;


Pssm-ID: 234751 [Multi-domain]  Cd Length: 394  Bit Score: 48.69  E-value: 3.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377  59 IELLK---RTAIYGESNS-LLIVGPRGSGKTTLLNHALKELMQIgdmSENVLQVHLNGLLQTNDKIALKEITRQLNLENV 134
Cdd:PRK00411   39 IEELAfalRPALRGSRPLnVLIYGPPGTGKTTTVKKVFEELEEI---AVKVVYVYINCQIDRTRYAIFSEIARQLFGHPP 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377 135 --VG---DKVFGSFAenlsfllEALQKGNRTsscpVIFILDEFDLFAHQKNQTLLYNLFDISQSAQ-TPIAVIG----LT 204
Cdd:PRK00411  116 psSGlsfDELFDKIA-------EYLDERDRV----LIVALDDINYLFEKEGNDVLYSLLRAHEEYPgARIGVIGissdLT 184

                         170
                  ....*....|....*...
gi 1958760377 205 CRLCLseDSTVLEVLQKH 222
Cdd:PRK00411  185 FLYIL--DPRVKSVFRPE 200
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 72-204 4.51e-06

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 46.21  E-value: 4.51e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377   72 NSLLIVGPRGSGKTTLLNHALKElmqigdmsenvLQVHLNGLLQTNDKIALKEITRQLNLENVVGDKVFGSFAENLSFLL 151
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARE-----------LGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLAL 71

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958760377  152 EALQKgnrtsSCPVIFILDEFDLFAHQKNQTLL----YNLFDISQSAQTPIAVIGLT 204
Cdd:smart00382  72 ALARK-----LKPDVLILDEITSLLDAEQEALLllleELRLLLLLKSEKNLTVILTT 123
TIGR02928 TIGR02928
orc1/cdc6 family replication initiation protein; Members of this protein family are found ...
 69-204 1.99e-05

orc1/cdc6 family replication initiation protein; Members of this protein family are found exclusively in the archaea. This set of DNA binding proteins shows homology to the origin recognition complex subunit 1/cell division control protein 6 family in eukaryotes. Several members may be found in genome and interact with each other. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274354 [Multi-domain]  Cd Length: 365  Bit Score: 46.09  E-value: 1.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377  69 GESNSLLIVGPRGSGKTTLLNHALKELMQI-GDMSENVLQVHLNGLLQTNDKIALKEITRQLNlenVVGDKV--FG-SFA 144
Cdd:TIGR02928  38 SRPSNVFIYGKTGTGKTAVTKYVMKELEEAaEDRDVRVVTVYVNCQILDTLYQVLVELANQLR---GSGEEVptTGlSTS 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958760377 145 ENLSFLLEALQKGNRTsscpVIFILDEFDLFAhQKNQTLLYNLFDISQSAQT---PIAVIGLT 204
Cdd:TIGR02928 115 EVFRRLYKELNERGDS----LIIVLDEIDYLV-GDDDDLLYQLSRARSNGDLdnaKVGVIGIS 172
 
Name Accession Description Interval E-value
ORC4_C pfam14629
Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of ...
 209-368 7.83e-50

Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of origin recognition complex subunit 4.


Pssm-ID: 464223  Cd Length: 212  Bit Score: 167.13  E-value: 7.83e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377 209 LSEDSTVLEVLQKHFNVNKNLQSLHMLLMLALNRVTVTHPFMTSADLMEAQHLCSLDAKASIVHGLSVLEICLIIAMKHL 288
Cdd:pfam14629  33 LLEDSTVQDILKRLYYTTKSVRSLLNSLILPVSKLSPDSPLLTAESLLSALSSQSPDSKLSLLRSLSVLELCLLIAAARL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377 289 NDIYEEEPFNFQMVYNEFQKFIQRK-------------AHSVYNFEKPVVMKAFEHLQQLELIKPMERTSVNS------- 348
Cdd:pfam14629 113 SEIYDTDTFNFEMVYDEYKKLAKRSkvspssatsqssaASGIRVWGRPVALKAWEHLLSLELLVPVGAVSTGGassgsgg 192

                         170       180
                  ....*....|....*....|
gi 1958760377 349 QREYQLVKLLLDNTQIMNAL 368
Cdd:pfam14629 193 GKEFRMVRLDITLEEIREAV 212
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
54-204 1.02e-10

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 62.56  E-value: 1.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377  54 QYKHLIELLkRTAIYGES-NSLLIVGPRGSGKTTLLNHALKELMQIGDMSE-NVLQVHLNGLLQTNDKIALKEITRQLNL 131
Cdd:COG1474    34 EIEELASAL-RPALRGERpSNVLIYGPTGTGKTAVAKYVLEELEEEAEERGvDVRVVYVNCRQASTRYRVLSRILEELGS 112

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958760377 132 ENVVGDKvfG-SFAENLSFLLEALQKGNRtsscPVIFILDEFDLFAHQKNQTLLYNLFDISQS-AQTPIAVIGLT 204
Cdd:COG1474   113 GEDIPST--GlSTDELFDRLYEALDERDG----VLVVVLDEIDYLVDDEGDDLLYQLLRANEElEGARVGVIGIS 181
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 57-206 1.96e-08

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 52.92  E-value: 1.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377  57 HLIELLKRTAIYGESNSLLIVGPRGSGKTTLLNHALKELmqiGDMSENVLQVHLNGLlqtndkialkeitrqlnLENVVG 136
Cdd:cd00009     5 EAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANEL---FRPGAPFLYLNASDL-----------------LEGLVV 64

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958760377 137 DKVFGSFAENLSFLLEALQKgnrtsscPVIFILDEFDLFAHQKNQTLLYNLFDISQSAQTP--IAVIGLTCR 206
Cdd:cd00009    65 AELFGHFLVRLLFELAEKAK-------PGVLFIDEIDSLSRGAQNALLRVLETLNDLRIDRenVRVIGATNR 129
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 47-201 7.61e-08

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 51.74  E-value: 7.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377  47 NLFGVQVQYKHLIELLKRTAIyGESNSLLIVGPRGSGKTTLLNHALKelmQIGDMSENVLQ---VHLNGLLQTNDKIALK 123
Cdd:pfam13191   1 RLVGREEELEQLLDALDRVRS-GRPPSVLLTGEAGTGKTTLLRELLR---ALERDGGYFLRgkcDENLPYSPLLEALTRE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377 124 EITRQLNLENVV----------------GDKVFGSFAENLSFLLEALQKGNRTSSCPVIFILDEFDLFAHQkNQTLLYNL 187
Cdd:pfam13191  77 GLLRQLLDELESslleawraallealapVPELPGDLAERLLDLLLRLLDLLARGERPLVLVLDDLQWADEA-SLQLLAAL 155

                         170
                  ....*....|....
gi 1958760377 188 FDISQsaQTPIAVI 201
Cdd:pfam13191 156 LRLLE--SLPLLVV 167
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
51-206 1.25e-07

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 53.66  E-value: 1.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377  51 VQVQYKHLIELLKRT-AIYGESNSLLIVGPRGSGKTTLLNHALKELMQIGDMSENVLQVHLNgllqtndkiaLKEITRQL 129
Cdd:COG5635   159 VPLNLLERIESLKRLeLLEAKKKRLLILGEPGSGKTTLLRYLALELAERYLDAEDPIPILIE----------LRDLAEEA 228

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958760377 130 NLENVVGDKVFGSFAENLSFLLEALQKGNrtsscpVIFILDEFDLFAHQKNQTLLYNLFDISQSAQTPIAVIgLTCR 206
Cdd:COG5635   229 SLEDLLAEALEKRGGEPEDALERLLRNGR------LLLLLDGLDEVPDEADRDEVLNQLRRFLERYPKARVI-ITSR 298
COG1672 COG1672
Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];
59-172 2.95e-06

Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];


Pssm-ID: 441278 [Multi-domain]  Cd Length: 324  Bit Score: 48.76  E-value: 2.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377  59 IELLKRtAIYGESNSLLIV-GPRGSGKTTLLNHALKElmqigdmsENVlqVHLNgLLQTNDKIALKEITRQLN--LENVV 135
Cdd:COG1672     9 LEELEK-LYESDGGELVVVyGRRRVGKTSLIKEFLKE--------KPA--IYFD-AREESERESLRDFSEALAeaLGDPL 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1958760377 136 GDKVFGSFAENLSFLLEALQKGnrtsscPVIFILDEF 172
Cdd:COG1672    77 SKKEFESWEEAFEYLAELAEGK------RLVIVIDEF 107
cdc6 PRK00411
ORC1-type DNA replication protein;
59-222 3.32e-06

ORC1-type DNA replication protein;


Pssm-ID: 234751 [Multi-domain]  Cd Length: 394  Bit Score: 48.69  E-value: 3.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377  59 IELLK---RTAIYGESNS-LLIVGPRGSGKTTLLNHALKELMQIgdmSENVLQVHLNGLLQTNDKIALKEITRQLNLENV 134
Cdd:PRK00411   39 IEELAfalRPALRGSRPLnVLIYGPPGTGKTTTVKKVFEELEEI---AVKVVYVYINCQIDRTRYAIFSEIARQLFGHPP 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377 135 --VG---DKVFGSFAenlsfllEALQKGNRTsscpVIFILDEFDLFAHQKNQTLLYNLFDISQSAQ-TPIAVIG----LT 204
Cdd:PRK00411  116 psSGlsfDELFDKIA-------EYLDERDRV----LIVALDDINYLFEKEGNDVLYSLLRAHEEYPgARIGVIGissdLT 184

                         170
                  ....*....|....*...
gi 1958760377 205 CRLCLseDSTVLEVLQKH 222
Cdd:PRK00411  185 FLYIL--DPRVKSVFRPE 200
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 72-204 4.51e-06

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 46.21  E-value: 4.51e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377   72 NSLLIVGPRGSGKTTLLNHALKElmqigdmsenvLQVHLNGLLQTNDKIALKEITRQLNLENVVGDKVFGSFAENLSFLL 151
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARE-----------LGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLAL 71

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958760377  152 EALQKgnrtsSCPVIFILDEFDLFAHQKNQTLL----YNLFDISQSAQTPIAVIGLT 204
Cdd:smart00382  72 ALARK-----LKPDVLILDEITSLLDAEQEALLllleELRLLLLLKSEKNLTVILTT 123
AAA_22 pfam13401
AAA domain;
73-201 1.41e-05

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 44.25  E-value: 1.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377  73 SLLIVGPRGSGKTTLLNHALKELMQigdmsENVLQVHLNGLLQTNDKIALKEITRQLNLEnvvgdkvfGSFAENLSFLLE 152
Cdd:pfam13401   7 ILVLTGESGTGKTTLLRRLLEQLPE-----VRDSVVFVDLPSGTSPKDLLRALLRALGLP--------LSGRLSKEELLA 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1958760377 153 ALQKGNRTSSCPVIFILDEFDLFahqkNQTLLYNLFDISQSAQTPIAVI 201
Cdd:pfam13401  74 ALQQLLLALAVAVVLIIDEAQHL----SLEALEELRDLLNLSSKLLQLI 118
TIGR02928 TIGR02928
orc1/cdc6 family replication initiation protein; Members of this protein family are found ...
 69-204 1.99e-05

orc1/cdc6 family replication initiation protein; Members of this protein family are found exclusively in the archaea. This set of DNA binding proteins shows homology to the origin recognition complex subunit 1/cell division control protein 6 family in eukaryotes. Several members may be found in genome and interact with each other. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274354 [Multi-domain]  Cd Length: 365  Bit Score: 46.09  E-value: 1.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377  69 GESNSLLIVGPRGSGKTTLLNHALKELMQI-GDMSENVLQVHLNGLLQTNDKIALKEITRQLNlenVVGDKV--FG-SFA 144
Cdd:TIGR02928  38 SRPSNVFIYGKTGTGKTAVTKYVMKELEEAaEDRDVRVVTVYVNCQILDTLYQVLVELANQLR---GSGEEVptTGlSTS 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958760377 145 ENLSFLLEALQKGNRTsscpVIFILDEFDLFAhQKNQTLLYNLFDISQSAQT---PIAVIGLT 204
Cdd:TIGR02928 115 EVFRRLYKELNERGDS----LIIVLDEIDYLV-GDDDDLLYQLSRARSNGDLdnaKVGVIGIS 172
ATPase_2 pfam01637
ATPase domain predominantly from Archaea; This family contain a conserved P-loop motif that is ...
 74-219 8.86e-05

ATPase domain predominantly from Archaea; This family contain a conserved P-loop motif that is involved in binding ATP. There are eukaryote members as well as archaeal members in this family.


Pssm-ID: 376582 [Multi-domain]  Cd Length: 222  Bit Score: 43.46  E-value: 8.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377  74 LLIVGPRGSGKTTLLNHALKELMQIGDMSENVLQVHLNGLLQTNDKIALKEitrqlnLENVVGDKVFGSFAE-------N 146
Cdd:pfam01637  23 YVIYGPEGCGKTALLRESIENLLDLGYYVIYYDPLRRYFISKLDRFEEVRR------LAEALGIAVPKAELEesklaflA 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958760377 147 LSFLLEALqkgNRTSSCPVIFILDEFDLFAHQKNQTL---LYNLFDISQSAQTPIAVIgltcrlCLSEDSTVLEVL 219
Cdd:pfam01637  97 IELLLEAL---KRRGKKIAIIIDEVQQAIGLNGAELLvkeLLNLIEYLTKEYHLCHVI------CLSSEGLFIELV 163
COG1373 COG1373
Predicted ATPase, AAA+ superfamily [General function prediction only];
55-171 2.64e-04

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440984 [Multi-domain]  Cd Length: 405  Bit Score: 42.62  E-value: 2.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377  55 YKHLIELLKRTAIygesnsLLIVGPRGSGKTTLLNHALKELMQIgdmsenvlqvhlngllqtndkialkeitRQLNLENv 134
Cdd:COG1373    10 LDKLLKLLDNRKA------VVITGPRQVGKTTLLKQLAKELENI----------------------------LYINLDD- 54

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1958760377 135 vgDKVFGSFAENLSFLLEALQKGNRTsscPVIFILDE 171
Cdd:COG1373    55 --PRLRALAEEDPDDLLEALKELYPG---KTYLFLDE 86
AAA_19 pfam13245
AAA domain;
70-112 5.08e-04

AAA domain;


Pssm-ID: 433059 [Multi-domain]  Cd Length: 136  Bit Score: 39.89  E-value: 5.08e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1958760377  70 ESNSLLIVGPrGSGKTTLLNHALKELMQIGDMSENVLQVHLNG 112
Cdd:pfam13245  11 SKVVLLTGGP-GTGKTTTIRHIVALLVALGGVSFPILLAAPTG 52
AAA_14 pfam13173
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 74-171 8.63e-04

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 463799 [Multi-domain]  Cd Length: 128  Bit Score: 39.11  E-value: 8.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377  74 LLIVGPRGSGKTTLLNHALKELMQigdmSENVLQVHLngllqtnDKIALKEItrqlnlenvvgdkvfgSFAENLSFLLEA 153
Cdd:pfam13173   5 LVITGPRQVGKTTLLLQLIKELLP----PENILYINL-------DDPRLLKL----------------ADFELLELFLEL 57

                          90
                  ....*....|....*...
gi 1958760377 154 LQKGNRtsscpvIFILDE 171
Cdd:pfam13173  58 LYPGKT------YLFLDE 69
VI_IcmF TIGR03348
type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to ...
 51-91 2.16e-03

type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to be associated with type VI secretion systems. [Cellular processes, Pathogenesis]


Pssm-ID: 274531 [Multi-domain]  Cd Length: 1169  Bit Score: 40.40  E-value: 2.16e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1958760377   51 VQVQYKHLIELLKRTAIYGEsNSL------LIVGPRGSGKTTLLNHA 91
Cdd:TIGR03348   86 LRARFNEALALLKRSRLGGR-RYLydlpwyLVIGPPGSGKTTLLQNS 131
VirB11 COG0630
Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell ...
 73-135 2.30e-03

Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell motility, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440395 [Multi-domain]  Cd Length: 462  Bit Score: 40.06  E-value: 2.30e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958760377  73 SLLIVGPRGSGKTTLLNhALkeLMqigdmsenvlqvhlngLLQTNDKIALKEITRQLNL--ENVV 135
Cdd:COG0630   292 SVLVAGGTASGKTTLLN-AL--LS----------------FIPPDAKIVTIEDTRELNLphENWI 337
AAA_35 pfam14516
AAA-like domain; This family of proteins are part of the AAA superfamily.
 76-177 3.09e-03

AAA-like domain; This family of proteins are part of the AAA superfamily.


Pssm-ID: 373105  Cd Length: 331  Bit Score: 39.42  E-value: 3.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760377  76 IVGPRGSGKTTLLNHALKELMQIGDMSenvlqVHLNglLQTNDKIALK-----------EITRQLNLENVVG---DKVFG 141
Cdd:pfam14516  36 IKAPRQMGKTSLLLRILAYAQQQGYRT-----VYLD--FQLADKAILTdldkflrwfcaNISRQLGLPPKLDdywDEDLG 108

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1958760377 142 SfaeNLS-------FLLEALQKgnrtsscPVIFILDEFD-LFAH 177
Cdd:pfam14516 109 S---KVSctiyfedYLLPQIDR-------PLVLALDEVDrLFEY 142
DAP3 pfam10236
Mitochondrial ribosomal death-associated protein 3; This is a family of conserved proteins ...
 58-92 3.60e-03

Mitochondrial ribosomal death-associated protein 3; This is a family of conserved proteins which were originally described as death-associated-protein-3 (DAP-3). The proteins carry a P-loop DNA-binding motif, and induce apoptosis. DAP3 has been shown to be a pro-apoptotic factor in the mitochondrial matrix and to be crucial for mitochondrial biogenesis and so has also been designated as MRP-S29 (mitochondrial ribosomal protein subunit 29).


Pssm-ID: 431160  Cd Length: 310  Bit Score: 38.82  E-value: 3.60e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1958760377  58 LIELLKRTAIYGESNSLLIVGPRGSGKTTLLNHAL 92
Cdd:pfam10236  10 LIKKLKAADKSKKVVRFVLTGEPGSGKSVLLLQAM 44
PulE COG2804
Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell ...
 74-128 4.74e-03

Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442055 [Multi-domain]  Cd Length: 561  Bit Score: 39.02  E-value: 4.74e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958760377  74 LLIVGPRGSGKTTLLNHALKELMQIGDmseNVLQV------HLNGLLQT--NDKI------ALKEITRQ 128
Cdd:COG2804   316 ILVTGPTGSGKTTTLYAALNELNTPER---NIITVedpveyQLPGINQVqvNPKIgltfasALRSILRQ 381
T2SSE pfam00437
Type II/IV secretion system protein; This family contains components of both the Type II ...
 73-128 5.87e-03

Type II/IV secretion system protein; This family contains components of both the Type II protein secretion system (T2SS), including Type 4 pilus (T4P), and Type IV protein secretion system (T4SS) from Gram-negative bacteria. VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells during infection. The cytoplasmic T2S E ATPase is a Zn-containing protein thought to provide the mechanical force for the secretion process. T2S-E contains Walker A and B motifs, that are essential for secretion and ATPase activity. ATPase PulE and XcpR from Klebsiella oxytoca and Pseudomonas aeruginosa respectively are required for protein secretion via the T2SS. ATPase PilB is required for T4P extension.


Pssm-ID: 425681 [Multi-domain]  Cd Length: 269  Bit Score: 38.03  E-value: 5.87e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958760377  73 SLLIVGPRGSGKTTLLNHALKEL-------MQIGDMSENVL----QVHLN--GLLQTNDkiALKEITRQ 128
Cdd:pfam00437 132 NILVTGPTGSGKTTTLYAALGELntrdeniVTVEDPVEIQLeginQVQLNarAGVTFAD--LLRAILRQ 198
LolD COG1136
ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis];
76-89 6.36e-03

ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440751 [Multi-domain]  Cd Length: 227  Bit Score: 37.72  E-value: 6.36e-03
                          10
                  ....*....|....
gi 1958760377  76 IVGPRGSGKTTLLN 89
Cdd:COG1136    39 IVGPSGSGKSTLLN 52
cobW pfam02492
CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase ...
 75-97 9.38e-03

CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase expression / formation protein, and UreG a urease accessory protein. Both these proteins contain a P-loop nucleotide binding motif. HypB has GTPase activity and is a guanine nucleotide binding protein. It is not known whether UreG binds GTP or some other nucleotide. Both enzymes are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression. UreG is required for functional incorporation of the urease nickel metallocenter. GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins. This family of domains also contains P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, and the cobW gene product, which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans.


Pssm-ID: 396860  Cd Length: 179  Bit Score: 36.85  E-value: 9.38e-03
                          10        20
                  ....*....|....*....|...
gi 1958760377  75 LIVGPRGSGKTTLLNHALKELMQ 97
Cdd:pfam02492   4 VITGFLGSGKTTLLNHLLKQNRA 26
ABC_MJ0796_LolCDE_FtsE cd03255
ATP-binding cassette domain of the transporters involved in export of lipoprotein and ...
 76-89 9.72e-03

ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and Cell division ATP-binding protein FtsE; This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.


Pssm-ID: 213222 [Multi-domain]  Cd Length: 218  Bit Score: 37.08  E-value: 9.72e-03
                          10
                  ....*....|....
gi 1958760377  76 IVGPRGSGKTTLLN 89
Cdd:cd03255    35 IVGPSGSGKSTLLN 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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