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Conserved domains on  [gi|1958761504|ref|XP_038960808|]
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large neutral amino acids transporter small subunit 3 isoform X1 [Rattus norvegicus]

Protein Classification

MFS transporter( domain architecture ID 1905563)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 120-167 3.04e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17355:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 386  Bit Score: 43.41  E-value: 3.04e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958761504 120 LGFTIGsFLLSATTLPL-GILMDRFGPRPLRLVGSACFAASCTLMALAS 167
Cdd:cd17355    42 LAFTVG-LLAFGLAQPFvGRLLDRFGPRRVMLLGLLLLAAGLVLLALAT 89
FucP super family cl43255
Fucose permease [Carbohydrate transport and metabolism];
117-220 2.59e-03

Fucose permease [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG0738:

Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 40.22  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761504 117 MLNLGFTIGSFLLSattLPLGILMDRFGPRPLRLVGSACFAASCTLMALASrdtevlSPLIFLALSLngFAGICLTF--- 193
Cdd:COG0738    47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAP------SYPLLLLALF--LLGLGLGLldv 115

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958761504 194 ---TSLTLIY-DAGVSFMVIMFTWSGLACLI 220
Cdd:COG0738   116 aanPYVAALGpETAASRLNLLHAFFSLGALL 146
 
Name Accession Description Interval E-value
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 120-167 3.04e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 43.41  E-value: 3.04e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958761504 120 LGFTIGsFLLSATTLPL-GILMDRFGPRPLRLVGSACFAASCTLMALAS 167
Cdd:cd17355    42 LAFTVG-LLAFGLAQPFvGRLLDRFGPRRVMLLGLLLLAAGLVLLALAT 89
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
120-210 3.19e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 43.33  E-value: 3.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761504 120 LGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASrdtevlSPLIFLALSLngFAGICltftsltli 199
Cdd:COG2223    44 LLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV------SYWLLLLLGL--LLGIG--------- 106

                          90
                  ....*....|.
gi 1958761504 200 ydAGVSFMVIM 210
Cdd:COG2223   107 --GGGSFAVGI 115
MFS_1 pfam07690
Major Facilitator Superfamily;
117-201 6.82e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.02  E-value: 6.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761504 117 MLNLGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRdtevlSPLIFLALSLNGFAGICLTFTSL 196
Cdd:pfam07690  33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS-----LWLLLVLRVLQGLGAGALFPAAL 107


                  ....*
gi 1958761504 197 TLIYD 201
Cdd:pfam07690 108 ALIAD 112
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
117-220 2.59e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 40.22  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761504 117 MLNLGFTIGSFLLSattLPLGILMDRFGPRPLRLVGSACFAASCTLMALASrdtevlSPLIFLALSLngFAGICLTF--- 193
Cdd:COG0738    47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAP------SYPLLLLALF--LLGLGLGLldv 115

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958761504 194 ---TSLTLIY-DAGVSFMVIMFTWSGLACLI 220
Cdd:COG0738   116 aanPYVAALGpETAASRLNLLHAFFSLGALL 146
 
Name Accession Description Interval E-value
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 120-167 3.04e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 43.41  E-value: 3.04e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958761504 120 LGFTIGsFLLSATTLPL-GILMDRFGPRPLRLVGSACFAASCTLMALAS 167
Cdd:cd17355    42 LAFTVG-LLAFGLAQPFvGRLLDRFGPRRVMLLGLLLLAAGLVLLALAT 89
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
120-210 3.19e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 43.33  E-value: 3.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761504 120 LGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASrdtevlSPLIFLALSLngFAGICltftsltli 199
Cdd:COG2223    44 LLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV------SYWLLLLLGL--LLGIG--------- 106

                          90
                  ....*....|.
gi 1958761504 200 ydAGVSFMVIM 210
Cdd:COG2223   107 --GGGSFAVGI 115
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 124-199 4.20e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 42.95  E-value: 4.20e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958761504 124 IGSFLLSattlPL-GILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVlsPLIFLALSLNGFaGICLTFTSLTLI 199
Cdd:cd17503   225 LASAILS----PLvGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSL--WLIILPLFIRGL-GMGLVFMPLNTL 294
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 120-189 4.43e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 42.98  E-value: 4.43e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761504 120 LGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRdtevlSPLIFLALSlnGFAGI 189
Cdd:cd17353    42 LAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAIS-----LPLLFLGYG--VLGGI 104
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
120-201 4.88e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 42.65  E-value: 4.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761504 120 LGFTIGSFLLSA--TTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASrdtevlSPLIFLALS-LNGFAGICLTFTSL 196
Cdd:COG2814    47 AGLVVTAYLLGAalGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP------SLWLLLAARfLQGLGAGALFPAAL 120


                  ....*
gi 1958761504 197 TLIYD 201
Cdd:COG2814   121 ALIAD 125
MFS_1 pfam07690
Major Facilitator Superfamily;
117-201 6.82e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.02  E-value: 6.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761504 117 MLNLGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRdtevlSPLIFLALSLNGFAGICLTFTSL 196
Cdd:pfam07690  33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS-----LWLLLVLRVLQGLGAGALFPAAL 107


                  ....*
gi 1958761504 197 TLIYD 201
Cdd:pfam07690 108 ALIAD 112
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 120-197 7.75e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 42.16  E-value: 7.75e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958761504 120 LGFTIGSFLLSATTlplGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVlsPLIFLALSLNGFaGICLTFTSLT 197
Cdd:cd17321   211 LPLALAMLVAAPLA---GRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSV--WLLLPGLVLLGL-GLGLFATPLT 282
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 117-180 9.44e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 41.84  E-value: 9.44e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958761504 117 MLNLGFTIGSfllsattLPLGILMDRFGPRPLRLVGSACFAASCTLMALASrDTEVLSPLIFLA 180
Cdd:cd17475    39 ALNLGVAVSM-------LPAGWLLDRFGERRVLAVGLLLMGAAALLMALVG-SYPVLLVLLFLV 94
MFS_Mch1p_like cd17354
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ...
 113-197 1.16e-03

Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340912 [Multi-domain]  Cd Length: 385  Bit Score: 41.47  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761504 113 QQEEMLNLGFTigSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALA-SRDTEVLS-PLIFLALSLNGFAGIC 190
Cdd:cd17354    36 SQQQNNLLSVA--KDLGYLVGPLLGLLSDRLGPWLLLLIGAILFFPGYGVLWLVvTGLISDLSfWLMCLCFFLIGNSTSS 113


                  ....*..
gi 1958761504 191 LTFTSLT 197
Cdd:cd17354   114 LYTAALV 120
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
117-220 2.59e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 40.22  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761504 117 MLNLGFTIGSFLLSattLPLGILMDRFGPRPLRLVGSACFAASCTLMALASrdtevlSPLIFLALSLngFAGICLTF--- 193
Cdd:COG0738    47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAP------SYPLLLLALF--LLGLGLGLldv 115

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958761504 194 ---TSLTLIY-DAGVSFMVIMFTWSGLACLI 220
Cdd:COG0738   116 aanPYVAALGpETAASRLNLLHAFFSLGALL 146
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 115-201 3.07e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 40.10  E-value: 3.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761504 115 EEMLNLGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALAsrdteVLSPLIFLALSLNGFAGICLTFT 194
Cdd:cd06174    30 ASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA-----PSFWLLLLGRFLLGLGSGLIDPA 104


                  ....*..
gi 1958761504 195 SLTLIYD 201
Cdd:cd06174   105 VLALIAD 111
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 121-195 3.41e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.88  E-value: 3.41e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958761504 121 GFTIGSFLLSA--TTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASrdtevlSPLIFLALSLngFAGICLTFTS 195
Cdd:cd17489    34 GLVVGLFTLAAllARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT------SVALLLVLRL--IHGIGWGAFT 102
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
120-187 3.81e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 39.85  E-value: 3.81e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958761504 120 LGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASrdtevlSPLIFLAL-SLNGFA 187
Cdd:COG2271    49 LLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT------SFWQLLLLrFLLGLG 111
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
120-202 6.35e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.19  E-value: 6.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761504 120 LGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASrdtevLSPLIFLALSLNGFAGICLTFTSLTLI 199
Cdd:COG2814   247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG-----SLWLLLLALFLLGFGFGLLFPLLQALV 321


                  ...
gi 1958761504 200 YDA 202
Cdd:COG2814   322 AEL 324
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 117-200 6.64e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 39.11  E-value: 6.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761504 117 MLNLGFTIGSFLLsattlplGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVLSPLIFLalslngfAGIClTFTSL 196
Cdd:cd17365   214 LLNIGGVIGSLLL-------GWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFL-------AGAC-VNGAQ 278


                  ....
gi 1958761504 197 TLIY 200
Cdd:cd17365   279 VGLY 282
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 120-201 6.79e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 39.10  E-value: 6.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761504 120 LGFTIGSFLLS--ATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALAsRDTEVLspliFLALSLNGFAGICLTFTSLT 197
Cdd:cd17325    33 IGLIVAAYALAqlLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA-TSYWQL----LLARFLQGLASAAVWPAAMA 107


                  ....
gi 1958761504 198 LIYD 201
Cdd:cd17325   108 LIAD 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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