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Conserved domains on  [gi|1958643955|ref|XP_038961941|]
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transforming growth factor beta activator LRRC32 isoform X2 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 18077502)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-278 1.66e-27

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd00116:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 319  Bit Score: 113.60  E-value: 1.66e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955  55 LYLSGNRLQSI---LVSPLSFYTA---LRHLDLSDNEISFLQPGVFQAL---PYLEHLNLAHNRLA-AGMALNSGGLGRL 124
Cdd:cd00116    56 LCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGdRGLRLLAKGLKDL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 125 PLVV-SLDLSGNSLHGSLVERLLGEAP---RLRTLSLAENSLT-RLARHTFWGMPA---MEQLDLHSNVLMDIEDGAFEA 196
Cdd:cd00116   136 PPALeKLVLGRNRLEGASCEALAKALRanrDLKELNLANNGIGdAGIRALAEGLKAncnLEVLDLNNNGLTDEGASALAE 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 197 ----LPQLTHLNLSRNSLT--CISDFSLQ------QLQVLDLSCNSIET--FQTAPESQAQF-QLAWLDLRENKL----- 256
Cdd:cd00116   216 tlasLKSLEVLNLGDNNLTdaGAAALASAllspniSLLTLSLSCNDITDdgAKDLAEVLAEKeSLLELDLRGNKFgeega 295

                         250       260
                  ....*....|....*....|....
gi 1958643955 257 -LHFPDLAMF-PRLIYLNVSNNLI 278
Cdd:cd00116   296 qLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
126-548 1.30e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 1.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 126 LVVSLDLSGNSLHGSLVERLLGEAPRLRTLSLAENSLTRLARHTFWGMPAMEQLDLHSNVLMDIEDGAFEALPQLTHLNL 205
Cdd:COG4886    24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 206 SRNSLTcisdFSLQQLQVLDLSCNSIETFqtaPESQAQF-QLAWLDLRENKLLHFPD-LAMFPRLIYLNVSNNLIqlpTG 283
Cdd:COG4886   104 SGNEEL----SNLTNLESLDLSGNQLTDL---PEELANLtNLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQL---TD 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 284 LPqdsedlhapsegwsasllsnpsrnASIHPLSQLLNLDLSYNEIELVPAGfLEHLTSLRFLNLSRNCLRSFEArRAGSL 363
Cdd:COG4886   174 LP------------------------EELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANL 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 364 PCLVLLDLSHNVLEAL-ELGTkvLGSLKTLLLQDNTLRELPPytFAGLASLQRLNLQGNQVSPCGGQ---AEPGPPGCVD 439
Cdd:COG4886   228 TNLETLDLSNNQLTDLpELGN--LTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKeleLLLGLNSLLL 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 440 FSGIPTLHFLNMAGNSMETLRAGSFLHTPLTELDLSANPGLDVATGALVGLEASLEVLELQGNGLVVLRVDLPCFRRLKR 519
Cdd:COG4886   304 LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383

                         410       420
                  ....*....|....*....|....*....
gi 1958643955 520 LNLAENRLSHLPAWTRAVSLEVLDLRNNS 548
Cdd:COG4886   384 LLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 55-278 1.66e-27

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 113.60  E-value: 1.66e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955  55 LYLSGNRLQSI---LVSPLSFYTA---LRHLDLSDNEISFLQPGVFQAL---PYLEHLNLAHNRLA-AGMALNSGGLGRL 124
Cdd:cd00116    56 LCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGdRGLRLLAKGLKDL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 125 PLVV-SLDLSGNSLHGSLVERLLGEAP---RLRTLSLAENSLT-RLARHTFWGMPA---MEQLDLHSNVLMDIEDGAFEA 196
Cdd:cd00116   136 PPALeKLVLGRNRLEGASCEALAKALRanrDLKELNLANNGIGdAGIRALAEGLKAncnLEVLDLNNNGLTDEGASALAE 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 197 ----LPQLTHLNLSRNSLT--CISDFSLQ------QLQVLDLSCNSIET--FQTAPESQAQF-QLAWLDLRENKL----- 256
Cdd:cd00116   216 tlasLKSLEVLNLGDNNLTdaGAAALASAllspniSLLTLSLSCNDITDdgAKDLAEVLAEKeSLLELDLRGNKFgeega 295

                         250       260
                  ....*....|....*....|....
gi 1958643955 257 -LHFPDLAMF-PRLIYLNVSNNLI 278
Cdd:cd00116   296 qLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-344 4.02e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 4.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955  51 DIQALYLSGNRLQSILVSpLSFYTALRHLDLSDNEISFLqPGVFQALPYLEHLNLAHNRLAAGmalnSGGLGRLPLVVSL 130
Cdd:COG4886   114 NLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL----PEELGNLTNLKEL 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 131 DLSGNSLhgSLVERLLGEAPRLRTLSLAENSLTRLARhTFWGMPAMEQLDLHSNVLMDIEDgaFEALPQLTHLNLSRNSL 210
Cdd:COG4886   188 DLSNNQI--TDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 211 TCISD-FSLQQLQVLDLSCNSIETFQTAPESQAQFQLAWLDLRENKLLHFPDLAMFPRLIYLNVSNNLIQLPTGLPQDSE 289
Cdd:COG4886   263 TDLPPlANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958643955 290 DLHAPSEGWSASLLSNPSRNASIHPLSQLLNLDLSYNEIELVPAGFLEHLTSLRF 344
Cdd:COG4886   343 SLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
126-548 1.30e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 1.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 126 LVVSLDLSGNSLHGSLVERLLGEAPRLRTLSLAENSLTRLARHTFWGMPAMEQLDLHSNVLMDIEDGAFEALPQLTHLNL 205
Cdd:COG4886    24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 206 SRNSLTcisdFSLQQLQVLDLSCNSIETFqtaPESQAQF-QLAWLDLRENKLLHFPD-LAMFPRLIYLNVSNNLIqlpTG 283
Cdd:COG4886   104 SGNEEL----SNLTNLESLDLSGNQLTDL---PEELANLtNLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQL---TD 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 284 LPqdsedlhapsegwsasllsnpsrnASIHPLSQLLNLDLSYNEIELVPAGfLEHLTSLRFLNLSRNCLRSFEArRAGSL 363
Cdd:COG4886   174 LP------------------------EELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANL 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 364 PCLVLLDLSHNVLEAL-ELGTkvLGSLKTLLLQDNTLRELPPytFAGLASLQRLNLQGNQVSPCGGQ---AEPGPPGCVD 439
Cdd:COG4886   228 TNLETLDLSNNQLTDLpELGN--LTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKeleLLLGLNSLLL 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 440 FSGIPTLHFLNMAGNSMETLRAGSFLHTPLTELDLSANPGLDVATGALVGLEASLEVLELQGNGLVVLRVDLPCFRRLKR 519
Cdd:COG4886   304 LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383

                         410       420
                  ....*....|....*....|....*....
gi 1958643955 520 LNLAENRLSHLPAWTRAVSLEVLDLRNNS 548
Cdd:COG4886   384 LLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-437 2.43e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 76.81  E-value: 2.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955  43 QVPSVLS--LDIQALYLSGNRLQSILVSPLSFYTALRHLDLSDNEIS------FLQ------------------PGVFQA 96
Cdd:PLN00113  251 PIPSSLGnlKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgeipelVIQlqnleilhlfsnnftgkiPVALTS 330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955  97 LPYLEHLNLAHNRLAAGMALNsggLGRLPLVVSLDLSGNSLHGSLVERLLgEAPRLRTLSLAENSLTRLARHTFWGMPAM 176
Cdd:PLN00113  331 LPRLQVLQLWSNKFSGEIPKN---LGKHNNLTVLDLSTNNLTGEIPEGLC-SSGNLFKLILFSNSLEGEIPKSLGACRSL 406

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 177 EQLDLHSNVLMDIEDGAFEALPQLTHLNLSRNSLTC-ISD--FSLQQLQVLDLSCNSIetFQTAPESQAQFQLAWLDLRE 253
Cdd:PLN00113  407 RRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGrINSrkWDMPSLQMLSLARNKF--FGGLPDSFGSKRLENLDLSR 484

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 254 NKLLH-FPD-LAMFPRLIYLNVSNNLIqlpTGlpqdsedlHAPSEgwsaslLSNpsrnasihpLSQLLNLDLSYNEIE-L 330
Cdd:PLN00113  485 NQFSGaVPRkLGSLSELMQLKLSENKL---SG--------EIPDE------LSS---------CKKLVSLDLSHNQLSgQ 538

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 331 VPAGFLEhLTSLRFLNLSRNCLRSFEARRAGSLPCLVLLDLSHNVLEalelgtkvlGSLktlllqdntlrelpPYTFAGL 410
Cdd:PLN00113  539 IPASFSE-MPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLH---------GSL--------------PSTGAFL 594

                         410       420
                  ....*....|....*....|....*..
gi 1958643955 411 AsLQRLNLQGNqVSPCGGQAEPGPPGC 437
Cdd:PLN00113  595 A-INASAVAGN-IDLCGGDTTSGLPPC 619
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 123-575 1.44e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.03  E-value: 1.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 123 RLPLVVSLDLSGNSLHGSLVERLLGEAPRLRTLSLAENSLTRLARHTFwgMPAMEQLDLHSNVL---MDIEDGAFEalpQ 199
Cdd:PLN00113   91 RLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLsgeIPNDIGSFS---S 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 200 LTHLNLSRNSLTC---ISDFSLQQLQVLDLSCNSIeTFQTAPESQAQFQLAWLDLRENKLL-HFPDlaMFPRLIYLN--- 272
Cdd:PLN00113  166 LKVLDLGGNVLVGkipNSLTNLTSLEFLTLASNQL-VGQIPRELGQMKSLKWIYLGYNNLSgEIPY--EIGGLTSLNhld 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 273 -VSNNLI-QLPTGLpQDSEDLHAPSegWSASLLSNPSRNaSIHPLSQLLNLDLSYNEIELVPAGFLEHLTSLRFLNLSRN 350
Cdd:PLN00113  243 lVYNNLTgPIPSSL-GNLKNLQYLF--LYQNKLSGPIPP-SIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSN 318

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 351 CLRSFEARRAGSLPCLVLLDL--------------SHNVLEALELGTKVL-----------GSLKTLLLQDNTLRELPPY 405
Cdd:PLN00113  319 NFTGKIPVALTSLPRLQVLQLwsnkfsgeipknlgKHNNLTVLDLSTNNLtgeipeglcssGNLFKLILFSNSLEGEIPK 398

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 406 TFAGLASLQRLNLQGNQVSpcgGQAEPGppgcvdFSGIPTLHFlnmagnsmetlragsflhtplteLDLSANpgldvatg 485
Cdd:PLN00113  399 SLGACRSLRRVRLQDNSFS---GELPSE------FTKLPLVYF-----------------------LDISNN-------- 438

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 486 alvgleaslevlELQGNgLVVLRVDLPcfrRLKRLNLAENRLS-HLPAWTRAVSLEVLDLRNNSFSLLPGNAMGGLeTSL 564
Cdd:PLN00113  439 ------------NLQGR-INSRKWDMP---SLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSL-SEL 501

                         490
                  ....*....|.
gi 1958643955 565 RRLYLQGNPLS 575
Cdd:PLN00113  502 MQLKLSENKLS 512
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 199-424 7.22e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 7.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 199 QLTHLNLSRNSLTCISDFSL-QQLQVLDLscnsietfqtapesqaqfqlawldlRENKLLHFPDLAMFPRLIYLNVSNNL 277
Cdd:cd21340     3 RITHLYLNDKNITKIDNLSLcKNLKVLYL-------------------------YDNKITKIENLEFLTNLTHLYLQNNQ 57

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 278 IqlptglpqdsedlhapsegwsasllsnpSRNASIHPLSQLLNLDLSYNEIELVpAGfLEHLTSLRFLNLSRNCLRS--- 354
Cdd:cd21340    58 I----------------------------EKIENLENLVNLKKLYLGGNRISVV-EG-LENLTNLEELHIENQRLPPgek 107

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958643955 355 --FEARRAGSL-PCLVLLDLSHNVLEALElGTKVLGSLKTLLLQDNTLRELPP--YTFAGLASLQRLNLQGNQVS 424
Cdd:cd21340   108 ltFDPRSLAALsNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
150-210 5.28e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 5.28e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958643955 150 PRLRTLSLAENSLTRLARHTFWGMPAMEQLDLHSNVLMDIEDGAFEALPQLTHLNLSRNSL 210
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
316-376 6.59e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 6.59e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958643955 316 SQLLNLDLSYNEIELVPAGFLEHLTSLRFLNLSRNCLRSFEARRAGSLPCLVLLDLSHNVL 376
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 55-278 1.66e-27

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 113.60  E-value: 1.66e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955  55 LYLSGNRLQSI---LVSPLSFYTA---LRHLDLSDNEISFLQPGVFQAL---PYLEHLNLAHNRLA-AGMALNSGGLGRL 124
Cdd:cd00116    56 LCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGdRGLRLLAKGLKDL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 125 PLVV-SLDLSGNSLHGSLVERLLGEAP---RLRTLSLAENSLT-RLARHTFWGMPA---MEQLDLHSNVLMDIEDGAFEA 196
Cdd:cd00116   136 PPALeKLVLGRNRLEGASCEALAKALRanrDLKELNLANNGIGdAGIRALAEGLKAncnLEVLDLNNNGLTDEGASALAE 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 197 ----LPQLTHLNLSRNSLT--CISDFSLQ------QLQVLDLSCNSIET--FQTAPESQAQF-QLAWLDLRENKL----- 256
Cdd:cd00116   216 tlasLKSLEVLNLGDNNLTdaGAAALASAllspniSLLTLSLSCNDITDdgAKDLAEVLAEKeSLLELDLRGNKFgeega 295

                         250       260
                  ....*....|....*....|....
gi 1958643955 257 -LHFPDLAMF-PRLIYLNVSNNLI 278
Cdd:cd00116   296 qLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-344 4.02e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 4.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955  51 DIQALYLSGNRLQSILVSpLSFYTALRHLDLSDNEISFLqPGVFQALPYLEHLNLAHNRLAAGmalnSGGLGRLPLVVSL 130
Cdd:COG4886   114 NLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL----PEELGNLTNLKEL 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 131 DLSGNSLhgSLVERLLGEAPRLRTLSLAENSLTRLARhTFWGMPAMEQLDLHSNVLMDIEDgaFEALPQLTHLNLSRNSL 210
Cdd:COG4886   188 DLSNNQI--TDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 211 TCISD-FSLQQLQVLDLSCNSIETFQTAPESQAQFQLAWLDLRENKLLHFPDLAMFPRLIYLNVSNNLIQLPTGLPQDSE 289
Cdd:COG4886   263 TDLPPlANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958643955 290 DLHAPSEGWSASLLSNPSRNASIHPLSQLLNLDLSYNEIELVPAGFLEHLTSLRF 344
Cdd:COG4886   343 SLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
126-548 1.30e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 1.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 126 LVVSLDLSGNSLHGSLVERLLGEAPRLRTLSLAENSLTRLARHTFWGMPAMEQLDLHSNVLMDIEDGAFEALPQLTHLNL 205
Cdd:COG4886    24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 206 SRNSLTcisdFSLQQLQVLDLSCNSIETFqtaPESQAQF-QLAWLDLRENKLLHFPD-LAMFPRLIYLNVSNNLIqlpTG 283
Cdd:COG4886   104 SGNEEL----SNLTNLESLDLSGNQLTDL---PEELANLtNLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQL---TD 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 284 LPqdsedlhapsegwsasllsnpsrnASIHPLSQLLNLDLSYNEIELVPAGfLEHLTSLRFLNLSRNCLRSFEArRAGSL 363
Cdd:COG4886   174 LP------------------------EELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANL 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 364 PCLVLLDLSHNVLEAL-ELGTkvLGSLKTLLLQDNTLRELPPytFAGLASLQRLNLQGNQVSPCGGQ---AEPGPPGCVD 439
Cdd:COG4886   228 TNLETLDLSNNQLTDLpELGN--LTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKeleLLLGLNSLLL 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 440 FSGIPTLHFLNMAGNSMETLRAGSFLHTPLTELDLSANPGLDVATGALVGLEASLEVLELQGNGLVVLRVDLPCFRRLKR 519
Cdd:COG4886   304 LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383

                         410       420
                  ....*....|....*....|....*....
gi 1958643955 520 LNLAENRLSHLPAWTRAVSLEVLDLRNNS 548
Cdd:COG4886   384 LLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-422 1.93e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 1.93e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955  39 LSLLQVPSVLSLDIQALYLSGNRLQSILVSPLSFYTALRHLDLSDNEISFLQPGVFQALPYLEHLNLAHNRlaagmalns 118
Cdd:COG4886    37 LLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE--------- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 119 gGLGRLPLVVSLDLSGNSLhgSLVERLLGEAPRLRTLSLAENSLTRLARhTFWGMPAMEQLDLHSNVLMDIeDGAFEALP 198
Cdd:COG4886   108 -ELSNLTNLESLDLSGNQL--TDLPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLT 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 199 QLTHLNLSRNSLTCISD--FSLQQLQVLDLSCNSIETFqtaPESQAQF-QLAWLDLRENKLLHFPDLAMFPRLIYLNVSN 275
Cdd:COG4886   183 NLKELDLSNNQITDLPEplGNLTNLEELDLSGNQLTDL---PEPLANLtNLETLDLSNNQLTDLPELGNLTNLEELDLSN 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 276 NLIqlpTGLPQDSEdlhapsegwsasllsnpsrnasihpLSQLLNLDLSYNEIELVPAGFLEHLTSLRFLNLSRNCLRSF 355
Cdd:COG4886   260 NQL---TDLPPLAN-------------------------LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958643955 356 EARRAGSLPCLVLLDLSHNVLEALELGTKVLGSLKTLLLQDNTLRELPPYTFAGLASLQRLNLQGNQ 422
Cdd:COG4886   312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEAT 378
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-410 5.66e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 5.66e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955  38 GLSLLQVPSVLSLDIQALYLSGNRLQSILVSPLSFYTALRHLDLSDNEISFLQPGVFQALPYLEHLNLAHNRLAAGMALN 117
Cdd:COG4886     9 TLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 118 SGGLGRLPLVVSLDLSGNslhgslveRLLGEAPRLRTLSLAENSLTRLARHtFWGMPAMEQLDLHSNVLMDIEDgAFEAL 197
Cdd:COG4886    89 LTDLGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 198 PQLTHLNLSRNSLTCISDF--SLQQLQVLDLSCNSIETFqtaPESQAQF-QLAWLDLRENKLLHFPD-LAMFPRLIYLNV 273
Cdd:COG4886   159 TNLKSLDLSNNQLTDLPEElgNLTNLKELDLSNNQITDL---PEPLGNLtNLEELDLSGNQLTDLPEpLANLTNLETLDL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 274 SNNLIqlpTGLPqdsedlhapsegwsasllsnpsrnaSIHPLSQLLNLDLSYNEIELVPagFLEHLTSLRFLNLSRNCLR 353
Cdd:COG4886   236 SNNQL---TDLP-------------------------ELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLT 285

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958643955 354 SFEARRAGSLPCLVLLDLSHNVLEALELGTKVLGSLKTLLLQDNTLRELPPYTFAGL 410
Cdd:COG4886   286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
295-575 9.87e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 9.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 295 SEGWSASLLSNPSRNASIHPLSQLLNLDLSYNEIELVPAGFLEHLTSLRFLNLSRNCLRSFEARRAGSLPCLVLLDLSHN 374
Cdd:COG4886    27 LLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 375 vlealeLGTKVLGSLKTLLLQDNTLRELPPyTFAGLASLQRLNLQGNQVSPCGgqaepgppgcVDFSGIPTLHFLNMAGN 454
Cdd:COG4886   107 ------EELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLP----------EPLGNLTNLKSLDLSNN 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 455 SMETLRAGSFLHTPLTELDLSANPgLDVATGALVGLEaSLEVLELQGNGLVVLRVDLPCFRRLKRLNLAENRLSHLPAWT 534
Cdd:COG4886   170 QLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELG 247

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1958643955 535 RAVSLEVLDLRNNSFSLLPGNamGGLeTSLRRLYLQGNPLS 575
Cdd:COG4886   248 NLTNLEELDLSNNQLTDLPPL--ANL-TNLKTLDLSNNQLT 285
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-437 2.43e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 76.81  E-value: 2.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955  43 QVPSVLS--LDIQALYLSGNRLQSILVSPLSFYTALRHLDLSDNEIS------FLQ------------------PGVFQA 96
Cdd:PLN00113  251 PIPSSLGnlKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgeipelVIQlqnleilhlfsnnftgkiPVALTS 330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955  97 LPYLEHLNLAHNRLAAGMALNsggLGRLPLVVSLDLSGNSLHGSLVERLLgEAPRLRTLSLAENSLTRLARHTFWGMPAM 176
Cdd:PLN00113  331 LPRLQVLQLWSNKFSGEIPKN---LGKHNNLTVLDLSTNNLTGEIPEGLC-SSGNLFKLILFSNSLEGEIPKSLGACRSL 406

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 177 EQLDLHSNVLMDIEDGAFEALPQLTHLNLSRNSLTC-ISD--FSLQQLQVLDLSCNSIetFQTAPESQAQFQLAWLDLRE 253
Cdd:PLN00113  407 RRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGrINSrkWDMPSLQMLSLARNKF--FGGLPDSFGSKRLENLDLSR 484

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 254 NKLLH-FPD-LAMFPRLIYLNVSNNLIqlpTGlpqdsedlHAPSEgwsaslLSNpsrnasihpLSQLLNLDLSYNEIE-L 330
Cdd:PLN00113  485 NQFSGaVPRkLGSLSELMQLKLSENKL---SG--------EIPDE------LSS---------CKKLVSLDLSHNQLSgQ 538

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 331 VPAGFLEhLTSLRFLNLSRNCLRSFEARRAGSLPCLVLLDLSHNVLEalelgtkvlGSLktlllqdntlrelpPYTFAGL 410
Cdd:PLN00113  539 IPASFSE-MPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLH---------GSL--------------PSTGAFL 594

                         410       420
                  ....*....|....*....|....*..
gi 1958643955 411 AsLQRLNLQGNqVSPCGGQAEPGPPGC 437
Cdd:PLN00113  595 A-INASAVAGN-IDLCGGDTTSGLPPC 619
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
268-552 8.31e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.81  E-value: 8.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 268 LIYLNVSNNLIQLPTGLPQDSEDLHAPSEGWSASLLSNPSRNASIHPLSQLLNLDLSYNEIELVPAGFLEHLTSLRFLNL 347
Cdd:COG4886    24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 348 SRNclrsfeaRRAGSLPCLVLLDLSHNVLEALELGTKVLGSLKTLLLQDNTLRELPPyTFAGLASLQRLNLQGNQVSPCG 427
Cdd:COG4886   104 SGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 428 gqaepgppgcVDFSGIPTLHFLNMAGNSMETLRAGSFLHTPLTELDLSANPgLDVATGALVGLEaSLEVLELQGNGLVVL 507
Cdd:COG4886   176 ----------EELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQ-LTDLPEPLANLT-NLETLDLSNNQLTDL 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1958643955 508 RvDLPCFRRLKRLNLAENRLSHLPAWTRAVSLEVLDLRNNSFSLL 552
Cdd:COG4886   244 P-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL 287
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-421 5.05e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 72.57  E-value: 5.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955  43 QVPSVLSL--DIQALYLSGNRLQSILVSPLSFYTALRHLDLSDNEISFLQPGVFQALPYLEHLNLAHNRLAAGMALNSGG 120
Cdd:PLN00113  203 QIPRELGQmkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFS 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 121 LGRLplvVSLDLSGNSLHGSLVErLLGEAPRLRTLSLAENSLTRLARHTFWGMPAMEQLDLHSNVLMDIEDGAFEALPQL 200
Cdd:PLN00113  283 LQKL---ISLDLSDNSLSGEIPE-LVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNL 358

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 201 THLNLSRNSLT-------CISDfslqQLQVLDLSCNSIETfQTAPESQAQFQLAWLDLRENKLL-HFP-DLAMFPRLIYL 271
Cdd:PLN00113  359 TVLDLSTNNLTgeipeglCSSG----NLFKLILFSNSLEG-EIPKSLGACRSLRRVRLQDNSFSgELPsEFTKLPLVYFL 433

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 272 NVSNNLIQLptglpqdsedlHAPSEGWSASLLS--NPSRNASIHPL------SQLLNLDLSYNEI-ELVPAGFLEhLTSL 342
Cdd:PLN00113  434 DISNNNLQG-----------RINSRKWDMPSLQmlSLARNKFFGGLpdsfgsKRLENLDLSRNQFsGAVPRKLGS-LSEL 501

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 343 RFLNLSRNCLRSFEARRAGSLPCLVLLDLSHNVLEA-LELGTKVLGSLKTLLLQDNTLRELPPYTFAGLASLQRLNLQGN 421
Cdd:PLN00113  502 MQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGqIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHN 581
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 52-211 1.42e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.50  E-value: 1.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955  52 IQALYLSGNRLQSIlvSPLSFYTALRHLDLSDNEISFLQPgvFQALPYLEHLNLAHNRLAagmalNSGGLGRLPLVVSLD 131
Cdd:cd21340    26 LKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS-----VVEGLENLTNLEELH 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 132 LS------GNSLHgSLVERLLGEAPRLRTLSLAENSLTRLArhTFWGMPAMEQLDLHSNVLMDIED--GAFEALPQLTHL 203
Cdd:cd21340    97 IEnqrlppGEKLT-FDPRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLREL 173


                  ....*...
gi 1958643955 204 NLSRNSLT 211
Cdd:cd21340   174 DLTGNPVC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 123-575 1.44e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.03  E-value: 1.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 123 RLPLVVSLDLSGNSLHGSLVERLLGEAPRLRTLSLAENSLTRLARHTFwgMPAMEQLDLHSNVL---MDIEDGAFEalpQ 199
Cdd:PLN00113   91 RLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLsgeIPNDIGSFS---S 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 200 LTHLNLSRNSLTC---ISDFSLQQLQVLDLSCNSIeTFQTAPESQAQFQLAWLDLRENKLL-HFPDlaMFPRLIYLN--- 272
Cdd:PLN00113  166 LKVLDLGGNVLVGkipNSLTNLTSLEFLTLASNQL-VGQIPRELGQMKSLKWIYLGYNNLSgEIPY--EIGGLTSLNhld 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 273 -VSNNLI-QLPTGLpQDSEDLHAPSegWSASLLSNPSRNaSIHPLSQLLNLDLSYNEIELVPAGFLEHLTSLRFLNLSRN 350
Cdd:PLN00113  243 lVYNNLTgPIPSSL-GNLKNLQYLF--LYQNKLSGPIPP-SIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSN 318

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 351 CLRSFEARRAGSLPCLVLLDL--------------SHNVLEALELGTKVL-----------GSLKTLLLQDNTLRELPPY 405
Cdd:PLN00113  319 NFTGKIPVALTSLPRLQVLQLwsnkfsgeipknlgKHNNLTVLDLSTNNLtgeipeglcssGNLFKLILFSNSLEGEIPK 398

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 406 TFAGLASLQRLNLQGNQVSpcgGQAEPGppgcvdFSGIPTLHFlnmagnsmetlragsflhtplteLDLSANpgldvatg 485
Cdd:PLN00113  399 SLGACRSLRRVRLQDNSFS---GELPSE------FTKLPLVYF-----------------------LDISNN-------- 438

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 486 alvgleaslevlELQGNgLVVLRVDLPcfrRLKRLNLAENRLS-HLPAWTRAVSLEVLDLRNNSFSLLPGNAMGGLeTSL 564
Cdd:PLN00113  439 ------------NLQGR-INSRKWDMP---SLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSL-SEL 501

                         490
                  ....*....|.
gi 1958643955 565 RRLYLQGNPLS 575
Cdd:PLN00113  502 MQLKLSENKLS 512
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 39-477 4.92e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.49  E-value: 4.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955  39 LSLLQVPSVLSLDIQALYLSGNRLQSILVSPLSfytaLRHLDLSDNEISFLQPGVFqaLPYLEHLNLAHNRLAAGMALNS 118
Cdd:PLN00113   87 SAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSS----LRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLSGEIPNDI 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 119 GGLGRLPLvvsLDLSGNSLHGSlVERLLGEAPRLRTLSLAENSLTRLARHTF-------W-----------------GMP 174
Cdd:PLN00113  161 GSFSSLKV---LDLGGNVLVGK-IPNSLTNLTSLEFLTLASNQLVGQIPRELgqmkslkWiylgynnlsgeipyeigGLT 236

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 175 AMEQLDLHSNVLMDIEDGAFEALPQLTHLNLSRNSLTCI---SDFSLQQLQVLDLSCNSIETfqTAPESQAQFQ-LAWLD 250
Cdd:PLN00113  237 SLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPippSIFSLQKLISLDLSDNSLSG--EIPELVIQLQnLEILH 314

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 251 LRENKLL-HFPD-LAMFPRLIYLNV-SNNLI-QLPTGLPQDSE----DLHAPS------EGWSAS-------LLSNpSRN 309
Cdd:PLN00113  315 LFSNNFTgKIPVaLTSLPRLQVLQLwSNKFSgEIPKNLGKHNNltvlDLSTNNltgeipEGLCSSgnlfkliLFSN-SLE 393

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 310 ASIHP----LSQLLNLDLSYNEI--ELvPAGFLEhLTSLRFLNLSRNCLRSFEARRAGSLPCLVLLDLSHNVLEALELGT 383
Cdd:PLN00113  394 GEIPKslgaCRSLRRVRLQDNSFsgEL-PSEFTK-LPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDS 471

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 384 KVLGSLKTLLLQDNTLRELPPYTFAGLASLQRLNLQGNQVSpcggqaepgppGCV--DFSGIPTLHFLNMAGNSMETLRA 461
Cdd:PLN00113  472 FGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS-----------GEIpdELSSCKKLVSLDLSHNQLSGQIP 540

                         490
                  ....*....|....*..
gi 1958643955 462 GSFLHTP-LTELDLSAN 477
Cdd:PLN00113  541 ASFSEMPvLSQLDLSQN 557
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
127-379 3.24e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 66.64  E-value: 3.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 127 VVSLDLSGNSLHgSLVERLLGEaprLRTLSLAENSLTRLARhtfwGMP-AMEQLDLHSNVLMDIEdgafEALPQ-LTHLN 204
Cdd:PRK15370  201 ITTLILDNNELK-SLPENLQGN---IKTLYANSNQLTSIPA----TLPdTIQEMELSINRITELP----ERLPSaLQSLD 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 205 LSRNSLTCISDFSLQQLQVLDLSCNSIETFqtaPEsqaqfqlawldlrenkllHFPDlamfpRLIYLNV-SNNLIQLPTG 283
Cdd:PRK15370  269 LFHNKISCLPENLPEELRYLSVYDNSIRTL---PA------------------HLPS-----GITHLNVqSNSLTALPET 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 284 LPQDSEDLHAPSEgwsaSLLSNPsrnASIHPlsQLLNLDLSYNEIELVPAGFLEHLTSlrfLNLSRNCLRSFEArragSL 363
Cdd:PRK15370  323 LPPGLKTLEAGEN----ALTSLP---ASLPP--ELQVLDVSKNQITVLPETLPPTITT---LDVSRNALTNLPE----NL 386

                         250
                  ....*....|....*..
gi 1958643955 364 P-CLVLLDLSHNVLEAL 379
Cdd:PRK15370  387 PaALQIMQASRNNLVRL 403
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 199-424 7.22e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 7.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 199 QLTHLNLSRNSLTCISDFSL-QQLQVLDLscnsietfqtapesqaqfqlawldlRENKLLHFPDLAMFPRLIYLNVSNNL 277
Cdd:cd21340     3 RITHLYLNDKNITKIDNLSLcKNLKVLYL-------------------------YDNKITKIENLEFLTNLTHLYLQNNQ 57

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 278 IqlptglpqdsedlhapsegwsasllsnpSRNASIHPLSQLLNLDLSYNEIELVpAGfLEHLTSLRFLNLSRNCLRS--- 354
Cdd:cd21340    58 I----------------------------EKIENLENLVNLKKLYLGGNRISVV-EG-LENLTNLEELHIENQRLPPgek 107

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958643955 355 --FEARRAGSL-PCLVLLDLSHNVLEALElGTKVLGSLKTLLLQDNTLRELPP--YTFAGLASLQRLNLQGNQVS 424
Cdd:cd21340   108 ltFDPRSLAALsNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
150-210 5.28e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 5.28e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958643955 150 PRLRTLSLAENSLTRLARHTFWGMPAMEQLDLHSNVLMDIEDGAFEALPQLTHLNLSRNSL 210
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 41-211 1.14e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 60.96  E-value: 1.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955  41 LLQVPSVLSLDIQALYLsGNRLQSILVSPLSFYTALRHLDLSDNEISflQPGV---FQALPY---LEHLNLAHNRL-AAG 113
Cdd:COG5238   204 LTQNTTVTTLWLKRNPI-GDEGAEILAEALKGNKSLTTLDLSNNQIG--DEGVialAEALKNnttVETLYLSGNQIgAEG 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 114 MALNSGGLGRLPLVVSLDLSGNSLHG----SLVERLLGEAPrLRTLSLAENSLT-----RLARHtFWGMPAMEQLDLHSN 184
Cdd:COG5238   281 AIALAKALQGNTTLTSLDLSVNRIGDegaiALAEGLQGNKT-LHTLNLAYNGIGaqgaiALAKA-LQENTTLHSLDLSDN 358

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1958643955 185 VLMDIEDGAF----EALPQLTHLNLSRNSLT 211
Cdd:COG5238   359 QIGDEGAIALakylEGNTTLRELNLGKNNIG 389
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
201-515 4.21e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.71  E-value: 4.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 201 THLNLSRNSLTCISDFSLQQLQVLDLSCNSIETFqtaPESqAQFQLAWLDLRENKLLHFPdlAMFPRLI-YLNVS-NNLI 278
Cdd:PRK15370  181 TELRLKILGLTTIPACIPEQITTLILDNNELKSL---PEN-LQGNIKTLYANSNQLTSIP--ATLPDTIqEMELSiNRIT 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 279 QLPTGLPqdsedlhapsegwsasllsnpsrnasihplSQLLNLDLSYNEIELVPAGFLEhltSLRFLNLSRNCLRSFEAR 358
Cdd:PRK15370  255 ELPERLP------------------------------SALQSLDLFHNKISCLPENLPE---ELRYLSVYDNSIRTLPAH 301

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 359 ragsLPC-LVLLDLSHNVLEALElGTKVLGsLKTLLLQDNTLRELPpytfAGLA-SLQRLNLQGNQVSPCggqAEPGPPg 436
Cdd:PRK15370  302 ----LPSgITHLNVQSNSLTALP-ETLPPG-LKTLEAGENALTSLP----ASLPpELQVLDVSKNQITVL---PETLPP- 367

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958643955 437 cvdfsgiptlhflnmagnsmetlragsflhtPLTELDLSANPGLDVATGalvgLEASLEVLELQGNGLVVLRVDLPCFR 515
Cdd:PRK15370  368 -------------------------------TITTLDVSRNALTNLPEN----LPAALQIMQASRNNLVRLPESLPHFR 411
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 179-374 4.97e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 4.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 179 LDLHSNVLMDIEDgaFEALPQLTHLNLSRNSLTCISDF-SLQQLQVLDLSCNSI---ETFQTAPEsqaqfqlawldLREn 254
Cdd:cd21340    29 LYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLeNLVNLKKLYLGGNRIsvvEGLENLTN-----------LEE- 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 255 kllhfpdlamfprliyLNVSNNliQLPTGLpqdsedlhapsegwsaSLLSNPsrnASIHPLSQ-LLNLDLSYNEIE-LVP 332
Cdd:cd21340    95 ----------------LHIENQ--RLPPGE----------------KLTFDP---RSLAALSNsLRVLNISGNNIDsLEP 137

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1958643955 333 agfLEHLTSLRFLNLSRNCLRSFE--ARRAGSLPCLVLLDLSHN 374
Cdd:cd21340   138 ---LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
40-244 1.68e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 57.78  E-value: 1.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955  40 SLLQVPSVLSLDIQALYLSGNRLQSIlvsPLSFYTALRHLDLSDNEISFLQpgvfQALPY-LEHLNLAHNRLAA------ 112
Cdd:PRK15370  210 ELKSLPENLQGNIKTLYANSNQLTSI---PATLPDTIQEMELSINRITELP----ERLPSaLQSLDLFHNKISClpenlp 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 113 ----GMALNSGGLGRLPL-----VVSLDLSGNSLhGSLVERLlgeAPRLRTLSLAENSLTRLARHTfwgMPAMEQLDLHS 183
Cdd:PRK15370  283 eelrYLSVYDNSIRTLPAhlpsgITHLNVQSNSL-TALPETL---PPGLKTLEAGENALTSLPASL---PPELQVLDVSK 355

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958643955 184 NVLMDIEdgafEALP-QLTHLNLSRNSLTCISDFSLQQLQVLDLSCNSIETFqtaPESQAQF 244
Cdd:PRK15370  356 NQITVLP----ETLPpTITTLDVSRNALTNLPENLPAALQIMQASRNNLVRL---PESLPHF 410
LRR_8 pfam13855
Leucine rich repeat;
55-110 4.72e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 4.72e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958643955  55 LYLSGNRLQSILVSPLSFYTALRHLDLSDNEISFLQPGVFQALPYLEHLNLAHNRL 110
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
76-137 1.01e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.01e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958643955  76 LRHLDLSDNEISFLQPGVFQALPYLEHLNLAHNRLAagmALNSGGLGRLPLVVSLDLSGNSL 137
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT---TLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
316-376 6.59e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 6.59e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958643955 316 SQLLNLDLSYNEIELVPAGFLEHLTSLRFLNLSRNCLRSFEARRAGSLPCLVLLDLSHNVL 376
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 388-553 1.98e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 1.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 388 SLKTLLLQDNTLRELPPYTFagLASLQRLNLQGNQVSPCGGqaepgppgcvdFSGIPTLHFLNMAGNSMETLragSFLH- 466
Cdd:cd21340    25 NLKVLYLYDNKITKIENLEF--LTNLTHLYLQNNQIEKIEN-----------LENLVNLKKLYLGGNRISVV---EGLEn 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 467 -TPLTELDLSAN---PG--LDVATGALVGLEASLEVLELQGNGLVVLRvDLPCFRRLKRLNLAENRLSHLPAWTRAVS-- 538
Cdd:cd21340    89 lTNLEELHIENQrlpPGekLTFDPRSLAALSNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEELLDLLSsw 167

                         170
                  ....*....|....*..
gi 1958643955 539 --LEVLDLRNNSFSLLP 553
Cdd:cd21340   168 psLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
515-574 3.49e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 3.49e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958643955 515 RRLKRLNLAENRLSHLP--AWTRAVSLEVLDLRNNSFSLLPGNAMGGLeTSLRRLYLQGNPL 574
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
366-423 4.17e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 4.17e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958643955 366 LVLLDLSHNVLEALELGT-KVLGSLKTLLLQDNTLRELPPYTFAGLASLQRLNLQGNQV 423
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
179-231 4.38e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 4.38e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958643955 179 LDLHSNVLMDIEDGAFEALPQLTHLNLSRNSLTCISD---FSLQQLQVLDLSCNSI 231
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgafSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 362-578 1.56e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.35  E-value: 1.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 362 SLPCLVLLDLSHNVL--EALELGTKVL---GSLKTLLLQDNTLRELPPYT------FAGLASLQRLNLQGNQVSPcggqa 430
Cdd:cd00116    21 KLLCLQVLRLEGNTLgeEAAKALASALrpqPSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLSDNALGP----- 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 431 ePGPPGCVDFSGIPTLHFLNMAGNSMET----LRAGSFLHTP--LTELDLSAN----PGLDVATGALVGLeASLEVLELQ 500
Cdd:cd00116    96 -DGCGVLESLLRSSSLQELKLNNNGLGDrglrLLAKGLKDLPpaLEKLVLGRNrlegASCEALAKALRAN-RDLKELNLA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 501 GN-----GLVVLRVDLPCFRRLKRLNLAENRLSH---------LPAWTravSLEVLDLRNNSFSLLP----GNAMGGLET 562
Cdd:cd00116   174 NNgigdaGIRALAEGLKANCNLEVLDLNNNGLTDegasalaetLASLK---SLEVLNLGDNNLTDAGaaalASALLSPNI 250

                         250
                  ....*....|....*.
gi 1958643955 563 SLRRLYLQGNPLSCCG 578
Cdd:cd00116   251 SLLTLSLSCNDITDDG 266
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 311-478 1.78e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 311 SIHPLSQLLNLDLSY---NEIELVPAgfLEHLTSLRFLNLSRNCLRSFEarRAGSLPCLVLLDLSHN---VLEALELgtk 384
Cdd:cd21340    16 KIDNLSLCKNLKVLYlydNKITKIEN--LEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNrisVVEGLEN--- 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 385 vLGSLKTLLLQDNTLRELPPYTF-----AGLA-SLQRLNLQGNQVSpcggqaEPGPpgcvdFSGIPTLHFLNMAGN---S 455
Cdd:cd21340    89 -LTNLEELHIENQRLPPGEKLTFdprslAALSnSLRVLNISGNNID------SLEP-----LAPLRNLEQLDASNNqisD 156

                         170       180
                  ....*....|....*....|....
gi 1958643955 456 METLrAGSFLHTP-LTELDLSANP 478
Cdd:cd21340   157 LEEL-LDLLSSWPsLRELDLTGNP 179
PLN03150 PLN03150
hypothetical protein; Provisional
 510-575 2.99e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.12  E-value: 2.99e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958643955 510 DLPCFRRLKRLNLAENRL-SHLPAWTRAV-SLEVLDLRNNSFSLLPGNAMGGLeTSLRRLYLQGNPLS 575
Cdd:PLN03150  437 DISKLRHLQSINLSGNSIrGNIPPSLGSItSLEVLDLSYNSFNGSIPESLGQL-TSLRILNLNGNSLS 503
PLN03150 PLN03150
hypothetical protein; Provisional
 91-163 7.30e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.96  E-value: 7.30e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958643955  91 PGVFQALPYLEHLNLAHNRLAAGMALNsggLGRLPLVVSLDLSGNSLHGSLVERlLGEAPRLRTLSLAENSLT 163
Cdd:PLN03150  435 PNDISKLRHLQSINLSGNSIRGNIPPS---LGSITSLEVLDLSYNSFNGSIPES-LGQLTSLRILNLNGNSLS 503
PLN03150 PLN03150
hypothetical protein; Provisional
 336-424 6.30e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 6.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 336 LEHLTSLrflNLSRNCLRSFEARRAGSLPCLVLLDLSHNVLEalelgtkvlGSLktlllqdntlrelpPYTFAGLASLQR 415
Cdd:PLN03150  441 LRHLQSI---NLSGNSIRGNIPPSLGSITSLEVLDLSYNSFN---------GSI--------------PESLGQLTSLRI 494


                  ....*....
gi 1958643955 416 LNLQGNQVS 424
Cdd:PLN03150  495 LNLNGNSLS 503
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 101-350 7.02e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.47  E-value: 7.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 101 EHLNLAHNRLAAGMALNSGGLGRLPLVVSLDLSGNSLHGSLVERL---LGEAPRLRTLSLAENSLT-----RLARHtFWG 172
Cdd:COG5238   156 VHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELaeaLTQNTTVTTLWLKRNPIGdegaeILAEA-LKG 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 173 MPAMEQLDLHSNvlmDIEDGAFEAL-------PQLTHLNLSRNSLTCISDFSL-------QQLQVLDLSCNSIetfqTAP 238
Cdd:COG5238   235 NKSLTTLDLSNN---QIGDEGVIALaealknnTTVETLYLSGNQIGAEGAIALakalqgnTTLTSLDLSVNRI----GDE 307

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 239 ESQAQFQLawldLRENKLLHFPDLAmfprliYLNVSNnliqlptglpqdsedlhapsEGWSAsLLSNPSRNASIHplsql 318
Cdd:COG5238   308 GAIALAEG----LQGNKTLHTLNLA------YNGIGA--------------------QGAIA-LAKALQENTTLH----- 351

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1958643955 319 lNLDLSYNEIE----LVPAGFLEHLTSLRFLNLSRN 350
Cdd:COG5238   352 -SLDLSDNQIGdegaIALAKYLEGNTTLRELNLGKN 386
PLN03150 PLN03150
hypothetical protein; Provisional
 52-141 3.33e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 3.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955  52 IQALYLSGNRLQSILVSPLSFYTALRHLDLSDNEISFLQPGVFQALPYLEHLNLAHNRLAAGMalnSGGLGRLPLVVSLD 131
Cdd:PLN03150  420 IDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSI---PESLGQLTSLRILN 496

                          90
                  ....*....|
gi 1958643955 132 LSGNSLHGSL 141
Cdd:PLN03150  497 LNGNSLSGRV 506
LRR_8 pfam13855
Leucine rich repeat;
98-186 3.50e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 3.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955  98 PYLEHLNLAHNRLaagmalnsgglgrlplvvsldlsgNSLHGSLVERLlgeaPRLRTLSLAENSLTRLARHTFWGMPAME 177
Cdd:pfam13855   1 PNLRSLDLSNNRL------------------------TSLDDGAFKGL----SNLKVLDLSNNLLTTLSPGAFSGLPSLR 52


                  ....*....
gi 1958643955 178 QLDLHSNVL 186
Cdd:pfam13855  53 YLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
198-256 3.71e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 3.71e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958643955 198 PQLTHLNLSRNSLTCISD---FSLQQLQVLDLSCNSIETFqtapeSQAQFQ----LAWLDLRENKL 256
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgafKGLSNLKVLDLSNNLLTTL-----SPGAFSglpsLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
315-350 4.30e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 4.30e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1958643955 315 LSQLLNLDLSYNEIELVPAGFLEHLTSLRFLNLSRN 350
Cdd:pfam13855  24 LSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PLN03150 PLN03150
hypothetical protein; Provisional
 52-140 4.38e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 4.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955  52 IQALYLSGNRLQSILVSPLSFYTALRHLDLSDNEISFLQPGVFQALPYLEHLNLAHNRLAagmalnsgglGRLPLVvsld 131
Cdd:PLN03150  444 LQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS----------GRVPAA---- 509


                  ....*....
gi 1958643955 132 LSGNSLHGS 140
Cdd:PLN03150  510 LGGRLLHRA 518
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 216-471 5.64e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 5.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 216 FSLQQLQVLDLSCNSIETF---QTAPESQAQFQLAWLDLRENKLLHFPD--------LAMFPRLIYLNVSNN-------- 276
Cdd:cd00116    20 PKLLCLQVLRLEGNTLGEEaakALASALRPQPSLKELCLSLNETGRIPRglqsllqgLTKGCGLQELDLSDNalgpdgcg 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 277 -LIQLPTGLPQDSEDLHAPSEGWSA------SLLSNPSRnasihplsqLLNLDLSYNEIELVP----AGFLEHLTSLRFL 345
Cdd:cd00116   100 vLESLLRSSSLQELKLNNNGLGDRGlrllakGLKDLPPA---------LEKLVLGRNRLEGAScealAKALRANRDLKEL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 346 NLSRNCLRSFEARRAG----SLPCLVLLDLSHNVLE-----ALELGTKVLGSLKTLLLQDNTLRELPPYTFA-----GLA 411
Cdd:cd00116   171 NLANNGIGDAGIRALAeglkANCNLEVLDLNNNGLTdegasALAETLASLKSLEVLNLGDNNLTDAGAAALAsallsPNI 250

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 412 SLQRLNLQGNQVSPCGGQAEPGPpgCVDFsgiPTLHFLNMAGNsmETLRAGSFLHTPLTE 471
Cdd:cd00116   251 SLLTLSLSCNDITDDGAKDLAEV--LAEK---ESLLELDLRGN--KFGEEGAQLLAESLL 303
LRR_8 pfam13855
Leucine rich repeat;
388-454 6.14e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 6.14e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643955 388 SLKTLLLQDNTLRELPPYTFAGLASLQRLNLQGNQ---VSPcggqaepgppgcVDFSGIPTLHFLNMAGN 454
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLlttLSP------------GAFSGLPSLRYLDLSGN 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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