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Conserved domains on  [gi|1958770614|ref|XP_038963949|]
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killer cell lectin-like receptor 2 isoform X6 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ly49 super family cl07131
Ly49-like protein, N-terminal region; The sequences making up this family are annotated as, or ...
 48-149 1.37e-37

Ly49-like protein, N-terminal region; The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).


The actual alignment was detected with superfamily member pfam08391:

Pssm-ID: 462461 [Multi-domain]  Cd Length: 119  Bit Score: 124.78  E-value: 1.37e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770614  48 SVTWKPIVIVLGILCSLLLVTVAVLLTHIFQSRQEKHEHEQRLNnLDQLYHVMKNDSSLMEERLRNKSLEFETCKNTLDN 127
Cdd:pfam08391   1 SVPWHLIVIALGILCSLLLVTVAVLGTKIFQYIQEKHELEETLN-LHQNCSIMQNDIYLKEEMLRNKSIECSILNNLLDS 79

                          90       100
                  ....*....|....*....|..
gi 1958770614 128 LNREQNRCYRESKIDLKCFKYK 149
Cdd:pfam08391  80 LNREQNRWYRKTKTVLKSLQHT 101
 
Name Accession Description Interval E-value
Ly49 pfam08391
Ly49-like protein, N-terminal region; The sequences making up this family are annotated as, or ...
 48-149 1.37e-37

Ly49-like protein, N-terminal region; The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).


Pssm-ID: 462461 [Multi-domain]  Cd Length: 119  Bit Score: 124.78  E-value: 1.37e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770614  48 SVTWKPIVIVLGILCSLLLVTVAVLLTHIFQSRQEKHEHEQRLNnLDQLYHVMKNDSSLMEERLRNKSLEFETCKNTLDN 127
Cdd:pfam08391   1 SVPWHLIVIALGILCSLLLVTVAVLGTKIFQYIQEKHELEETLN-LHQNCSIMQNDIYLKEEMLRNKSIECSILNNLLDS 79

                          90       100
                  ....*....|....*....|..
gi 1958770614 128 LNREQNRCYRESKIDLKCFKYK 149
Cdd:pfam08391  80 LNREQNRWYRKTKTVLKSLQHT 101
 
Name Accession Description Interval E-value
Ly49 pfam08391
Ly49-like protein, N-terminal region; The sequences making up this family are annotated as, or ...
 48-149 1.37e-37

Ly49-like protein, N-terminal region; The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).


Pssm-ID: 462461 [Multi-domain]  Cd Length: 119  Bit Score: 124.78  E-value: 1.37e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770614  48 SVTWKPIVIVLGILCSLLLVTVAVLLTHIFQSRQEKHEHEQRLNnLDQLYHVMKNDSSLMEERLRNKSLEFETCKNTLDN 127
Cdd:pfam08391   1 SVPWHLIVIALGILCSLLLVTVAVLGTKIFQYIQEKHELEETLN-LHQNCSIMQNDIYLKEEMLRNKSIECSILNNLLDS 79

                          90       100
                  ....*....|....*....|..
gi 1958770614 128 LNREQNRCYRESKIDLKCFKYK 149
Cdd:pfam08391  80 LNREQNRWYRKTKTVLKSLQHT 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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