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Conserved domains on  [gi|1958775615|ref|XP_038965553|]
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granulocyte colony-stimulating factor receptor isoform X7 [Rattus norvegicus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10047472)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 438-515 5.40e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 5.40e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958775615  438 PELYLKHVGRTWAQLEWVPETPWLGMIPLTNYTIFWTDARDHSFSVTLNISFHDFVLDHLKPASLYHVYLMATSRAGS 515
Cdd:smart00060   5 SNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 339-427 5.92e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 36.71  E-value: 5.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775615 339 PAVTSLHAMAQDLGSIWVDWEAPSLLP---QGYLIEWGPDShkysNNSWRI--EPNGNTTGILLeDNIHPFQLYRITVAP 413
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYREKG----SGDWKEveVTPGSETSYTL-TGLKPGTEYEFRVRA 76

                          90
                  ....*....|....
gi 1958775615 414 LYPGTVGPPVNVYT 427
Cdd:cd00063    77 VNGGGESPPSESVT 90
 
Name Accession Description Interval E-value
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 438-515 5.40e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 5.40e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958775615  438 PELYLKHVGRTWAQLEWVPETPWLGMIPLTNYTIFWTDARDHSFSVTLNISFHDFVLDHLKPASLYHVYLMATSRAGS 515
Cdd:smart00060   5 SNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 435-525 1.58e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 41.33  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775615 435 PHAPE-LYLKHVGRTWAQLEWVPETPWLGmiPLTNYTIFWTDARDHSFSV--TLNISFHDFVLDHLKPASLYHVYLMATS 511
Cdd:cd00063     1 PSPPTnLRVTDVTSTSVTLSWTPPEDDGG--PITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 1958775615 512 RAG-STNSTGLTLMT 525
Cdd:cd00063    79 GGGeSPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 339-427 5.92e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 36.71  E-value: 5.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775615 339 PAVTSLHAMAQDLGSIWVDWEAPSLLP---QGYLIEWGPDShkysNNSWRI--EPNGNTTGILLeDNIHPFQLYRITVAP 413
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYREKG----SGDWKEveVTPGSETSYTL-TGLKPGTEYEFRVRA 76

                          90
                  ....*....|....
gi 1958775615 414 LYPGTVGPPVNVYT 427
Cdd:cd00063    77 VNGGGESPPSESVT 90
 
Name Accession Description Interval E-value
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 438-515 5.40e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 5.40e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958775615  438 PELYLKHVGRTWAQLEWVPETPWLGMIPLTNYTIFWTDARDHSFSVTLNISFHDFVLDHLKPASLYHVYLMATSRAGS 515
Cdd:smart00060   5 SNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 435-525 1.58e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 41.33  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775615 435 PHAPE-LYLKHVGRTWAQLEWVPETPWLGmiPLTNYTIFWTDARDHSFSV--TLNISFHDFVLDHLKPASLYHVYLMATS 511
Cdd:cd00063     1 PSPPTnLRVTDVTSTSVTLSWTPPEDDGG--PITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 1958775615 512 RAG-STNSTGLTLMT 525
Cdd:cd00063    79 GGGeSPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 339-427 5.92e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 36.71  E-value: 5.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775615 339 PAVTSLHAMAQDLGSIWVDWEAPSLLP---QGYLIEWGPDShkysNNSWRI--EPNGNTTGILLeDNIHPFQLYRITVAP 413
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYREKG----SGDWKEveVTPGSETSYTL-TGLKPGTEYEFRVRA 76

                          90
                  ....*....|....
gi 1958775615 414 LYPGTVGPPVNVYT 427
Cdd:cd00063    77 VNGGGESPPSESVT 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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