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Conserved domains on  [gi|1958779876|ref|XP_038967093|]
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podocan isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
108-373 4.80e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 4.80e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 108 QLEKIYPEELARLQRLETLNLQNNRLTSrgLPEEaFEHLTSLNYLYLANNKLTLAPRFLPNAlisvdfaanyltkiyglt 187
Cdd:COG4886   100 ELDLSGNEELSNLTNLESLDLSGNQLTD--LPEE-LANLTNLKELDLSNNQLTDLPEPLGNL------------------ 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 188 fgqkPNLRSVYLHNNKLADagLPDNMFNgSSNVEILILSSNFLRHVPKHL--PPALYKLHLKNNKLEKIPPgAFSELSNL 265
Cdd:COG4886   159 ----TNLKSLDLSNNQLTD--LPEELGN-LTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTNL 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 266 RELYLQNNYLTdeglDNETFWKLSSLEYLDLSSNNLSRVPAGLP-RSLVLLHLEKNVIQSVDADVLTPIRNLEYLLLHSN 344
Cdd:COG4886   231 ETLDLSNNQLT----DLPELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306

                         250       260
                  ....*....|....*....|....*....
gi 1958779876 345 QLQAKGIHPLAFQGLKRLHTVHLYNNALE 373
Cdd:COG4886   307 LLNLLELLILLLLLTTLLLLLLLLKGLLV 335
PRK15370 super family cl33128
type III secretion system effector E3 ubiquitin transferase SlrP;
230-541 4.13e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


The actual alignment was detected with superfamily member PRK15370:

Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 69.34  E-value: 4.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 230 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSelsNLRELYLQnnyltdegldnetfwklssleyldlsSNNLSRVPAGLP 309
Cdd:PRK15370  190 LTTIPACIPEQITTLILDNNELKSLPENLQG---NIKTLYAN--------------------------SNQLTSIPATLP 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 310 RSLVLLHLEKNVIQSVDadvltpirnlEYLllhsnqlqakgihPLAFQglkrlhTVHLYNNALERVPSGLPRRVRTLMIL 389
Cdd:PRK15370  241 DTIQEMELSINRITELP----------ERL-------------PSALQ------SLDLFHNKISCLPENLPEELRYLSVY 291

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 390 HNQITGIgREDFATTyfLEELNLSYNRITSpqmhrdafrklrllrsldlsgnrlqtLPPGLPKNVHVLKVKRNelaalar 469
Cdd:PRK15370  292 DNSIRTL-PAHLPSG--ITHLNVQSNSLTA--------------------------LPETLPPGLKTLEAGEN------- 335

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958779876 470 galaGMAKLRElyltgnrlrsrALGPRawvdlagLQLLDIAGNQLTEIPEGLPPSLEYLYLQNNKISAVPAN 541
Cdd:PRK15370  336 ----ALTSLPA-----------SLPPE-------LQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPEN 385
LRR_8 pfam13855
Leucine rich repeat;
523-583 5.35e-07

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 5.35e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958779876 523 PSLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLavGSVVESAFRRLKHLQVLDIEGN 583
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGN 59
LRRNT smart00013
Leucine rich repeat N-terminal domain;
68-99 2.82e-04

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.45  E-value: 2.82e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958779876   68 DCPRDCACSqEGVVDCGGIDLREFPGDLPEHT 99
Cdd:smart00013   1 ACPAPCNCS-GTAVDCSGRGLTEVPLDLPPDT 31
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
108-373 4.80e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 4.80e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 108 QLEKIYPEELARLQRLETLNLQNNRLTSrgLPEEaFEHLTSLNYLYLANNKLTLAPRFLPNAlisvdfaanyltkiyglt 187
Cdd:COG4886   100 ELDLSGNEELSNLTNLESLDLSGNQLTD--LPEE-LANLTNLKELDLSNNQLTDLPEPLGNL------------------ 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 188 fgqkPNLRSVYLHNNKLADagLPDNMFNgSSNVEILILSSNFLRHVPKHL--PPALYKLHLKNNKLEKIPPgAFSELSNL 265
Cdd:COG4886   159 ----TNLKSLDLSNNQLTD--LPEELGN-LTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTNL 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 266 RELYLQNNYLTdeglDNETFWKLSSLEYLDLSSNNLSRVPAGLP-RSLVLLHLEKNVIQSVDADVLTPIRNLEYLLLHSN 344
Cdd:COG4886   231 ETLDLSNNQLT----DLPELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306

                         250       260
                  ....*....|....*....|....*....
gi 1958779876 345 QLQAKGIHPLAFQGLKRLHTVHLYNNALE 373
Cdd:COG4886   307 LLNLLELLILLLLLTTLLLLLLLLKGLLV 335
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
71-309 7.32e-21

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 97.07  E-value: 7.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876  71 RDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIyPEELArlQRLETLNLQNNRLTSrgLPEEAFEHLTSLN 150
Cdd:PRK15370  173 RDCLKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSL-PENLQ--GNIKTLYANSNQLTS--IPATLPDTIQEME 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 151 ylyLANNKLTLAPRFLPNALISVDFAANYLTKIYGlTFGQKPNLRSVYLHNNKLADAGLPD-----NMFNGS-------- 217
Cdd:PRK15370  248 ---LSINRITELPERLPSALQSLDLFHNKISCLPE-NLPEELRYLSVYDNSIRTLPAHLPSgithlNVQSNSltalpetl 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 218 -SNVEILILSSNFLRHVPKHLPPALYKLHLKNNKL----EKIPPgafselsNLRELYLQNNYLTD--EGLDnetfwklSS 290
Cdd:PRK15370  324 pPGLKTLEAGENALTSLPASLPPELQVLDVSKNQItvlpETLPP-------TITTLDVSRNALTNlpENLP-------AA 389

                         250
                  ....*....|....*....
gi 1958779876 291 LEYLDLSSNNLSRVPAGLP 309
Cdd:PRK15370  390 LQIMQASRNNLVRLPESLP 408
LRR_8 pfam13855
Leucine rich repeat;
239-301 3.97e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.08  E-value: 3.97e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958779876 239 PALYKLHLKNNKLEKIPPGAFSELSNLRELYLQNNYLTdeGLDNETFWKLSSLEYLDLSSNNL 301
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
230-541 4.13e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 69.34  E-value: 4.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 230 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSelsNLRELYLQnnyltdegldnetfwklssleyldlsSNNLSRVPAGLP 309
Cdd:PRK15370  190 LTTIPACIPEQITTLILDNNELKSLPENLQG---NIKTLYAN--------------------------SNQLTSIPATLP 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 310 RSLVLLHLEKNVIQSVDadvltpirnlEYLllhsnqlqakgihPLAFQglkrlhTVHLYNNALERVPSGLPRRVRTLMIL 389
Cdd:PRK15370  241 DTIQEMELSINRITELP----------ERL-------------PSALQ------SLDLFHNKISCLPENLPEELRYLSVY 291

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 390 HNQITGIgREDFATTyfLEELNLSYNRITSpqmhrdafrklrllrsldlsgnrlqtLPPGLPKNVHVLKVKRNelaalar 469
Cdd:PRK15370  292 DNSIRTL-PAHLPSG--ITHLNVQSNSLTA--------------------------LPETLPPGLKTLEAGEN------- 335

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958779876 470 galaGMAKLRElyltgnrlrsrALGPRawvdlagLQLLDIAGNQLTEIPEGLPPSLEYLYLQNNKISAVPAN 541
Cdd:PRK15370  336 ----ALTSLPA-----------SLPPE-------LQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPEN 385
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 223-425 7.62e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.19  E-value: 7.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 223 LILSSNFLRHVPK-HLPPALYKLHLKNNKLEKIPpgAFSELSNLRELYLQNNYLTD-EGLDNetfwkLSSLEYLDLSSNN 300
Cdd:cd21340     7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKiENLEN-----LVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 301 LSRVpAGL--PRSLVLLHLEKNVIQS-----VDADVLTPIRN-LEYLLLHSNQLQAkgIHPLAfqGLKRLhtvhlynnal 372
Cdd:cd21340    80 ISVV-EGLenLTNLEELHIENQRLPPgekltFDPRSLAALSNsLRVLNISGNNIDS--LEPLA--PLRNL---------- 144

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958779876 373 ervpsglprrvRTLMILHNQITGIGR--EDFATTYFLEELNLSYNRITSPQMHRD 425
Cdd:cd21340   145 -----------EQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKYRD 188
LRR_8 pfam13855
Leucine rich repeat;
523-583 5.35e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 5.35e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958779876 523 PSLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLavGSVVESAFRRLKHLQVLDIEGN 583
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
477-535 5.47e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 5.47e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958779876 477 KLRELYLTGNRLRSraLGPRAWVDLAGLQLLDIAGNQLTEIPEGL---PPSLEYLYLQNNKI 535
Cdd:pfam13855   2 NLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPGAfsgLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
68-99 2.82e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.45  E-value: 2.82e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958779876   68 DCPRDCACSqEGVVDCGGIDLREFPGDLPEHT 99
Cdd:smart00013   1 ACPAPCNCS-GTAVDCSGRGLTEVPLDLPPDT 31
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 477-583 8.14e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 8.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 477 KLRELYLTGNRLRSR---ALGPRAWVDLAG-LQLLDIAGNQLTEIpEGLPP--SLEYLYLQNNKISAVpanafdstpnlk 550
Cdd:cd21340    91 NLEELHIENQRLPPGeklTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPlrNLEQLDASNNQISDL------------ 157

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1958779876 551 giflrfnklavgSVVESAFRRLKHLQVLDIEGN 583
Cdd:cd21340   158 ------------EELLDLLSSWPSLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 511-581 2.06e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 2.06e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958779876 511 GNQLTEIpEGLP--PSLEYLYLQNNKISAVpaNAFDSTPNLKGIFLRFNKLavgSVVESaFRRLKHLQVLDIE 581
Cdd:cd21340    33 DNKITKI-ENLEflTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI---SVVEG-LENLTNLEELHIE 98
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 68-96 6.60e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 34.53  E-value: 6.60e-03
                          10        20
                  ....*....|....*....|....*....
gi 1958779876  68 DCPRDCACSqEGVVDCGGIDLREFPGDLP 96
Cdd:pfam01462   1 ACPVPCHCS-ATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
108-373 4.80e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 4.80e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 108 QLEKIYPEELARLQRLETLNLQNNRLTSrgLPEEaFEHLTSLNYLYLANNKLTLAPRFLPNAlisvdfaanyltkiyglt 187
Cdd:COG4886   100 ELDLSGNEELSNLTNLESLDLSGNQLTD--LPEE-LANLTNLKELDLSNNQLTDLPEPLGNL------------------ 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 188 fgqkPNLRSVYLHNNKLADagLPDNMFNgSSNVEILILSSNFLRHVPKHL--PPALYKLHLKNNKLEKIPPgAFSELSNL 265
Cdd:COG4886   159 ----TNLKSLDLSNNQLTD--LPEELGN-LTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTNL 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 266 RELYLQNNYLTdeglDNETFWKLSSLEYLDLSSNNLSRVPAGLP-RSLVLLHLEKNVIQSVDADVLTPIRNLEYLLLHSN 344
Cdd:COG4886   231 ETLDLSNNQLT----DLPELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306

                         250       260
                  ....*....|....*....|....*....
gi 1958779876 345 QLQAKGIHPLAFQGLKRLHTVHLYNNALE 373
Cdd:COG4886   307 LLNLLELLILLLLLTTLLLLLLLLKGLLV 335
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
102-376 1.08e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.78  E-value: 1.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 102 LSLQNNQLEKIyPEELARLQRLETLNLQNNRLTSrgLPEEaFEHLTSLNYLYLANNKLTLAPRFLPN--ALISVDFAANY 179
Cdd:COG4886   118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTD--LPEP-LGNLTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNNQ 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 180 LTKIyGLTFGQKPNLRSVYLHNNKLADagLPDNMFNgSSNVEILILSSNFLRHVP--KHLPpALYKLHLKNNKLEKIPPG 257
Cdd:COG4886   194 ITDL-PEPLGNLTNLEELDLSGNQLTD--LPEPLAN-LTNLETLDLSNNQLTDLPelGNLT-NLEELDLSNNQLTDLPPL 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 258 AfsELSNLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNVIQSVDADVLTPIRNLE 337
Cdd:COG4886   269 A--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1958779876 338 YLLLHSNQLQAKGIHPLAFQGLKRLHTVHLYNNALERVP 376
Cdd:COG4886   347 LALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALL 385
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
71-309 7.32e-21

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 97.07  E-value: 7.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876  71 RDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIyPEELArlQRLETLNLQNNRLTSrgLPEEAFEHLTSLN 150
Cdd:PRK15370  173 RDCLKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSL-PENLQ--GNIKTLYANSNQLTS--IPATLPDTIQEME 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 151 ylyLANNKLTLAPRFLPNALISVDFAANYLTKIYGlTFGQKPNLRSVYLHNNKLADAGLPD-----NMFNGS-------- 217
Cdd:PRK15370  248 ---LSINRITELPERLPSALQSLDLFHNKISCLPE-NLPEELRYLSVYDNSIRTLPAHLPSgithlNVQSNSltalpetl 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 218 -SNVEILILSSNFLRHVPKHLPPALYKLHLKNNKL----EKIPPgafselsNLRELYLQNNYLTD--EGLDnetfwklSS 290
Cdd:PRK15370  324 pPGLKTLEAGENALTSLPASLPPELQVLDVSKNQItvlpETLPP-------TITTLDVSRNALTNlpENLP-------AA 389

                         250
                  ....*....|....*....
gi 1958779876 291 LEYLDLSSNNLSRVPAGLP 309
Cdd:PRK15370  390 LQIMQASRNNLVRLPESLP 408
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
123-373 3.44e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.46  E-value: 3.44e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 123 LETLNLQNNRLTSRGLPEEAFEHLTSLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNN 202
Cdd:COG4886    44 SLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGN 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 203 KLADagLPDNMFNgSSNVEILILSSNFLRHVPKHLP--PALYKLHLKNNKLEKIPPgAFSELSNLRELYLQNNYLTDEGl 280
Cdd:COG4886   124 QLTD--LPEELAN-LTNLKELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP- 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 281 dnETFWKLSSLEYLDLSSNNLSRVPAGLPR--SLVLLHLEKNVIQSVDAdvLTPIRNLEYLLLHSNQLqaKGIHPLAfqG 358
Cdd:COG4886   199 --EPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL--TDLPPLA--N 270

                         250
                  ....*....|....*
gi 1958779876 359 LKRLHTVHLYNNALE 373
Cdd:COG4886   271 LTNLKTLDLSNNQLT 285
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 119-583 3.85e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 88.75  E-value: 3.85e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 119 RLQRLETLNLQNNRLtSRGLPEEAFEHLTSLNYLYLANNKLTLA-PR-FLPNaLISVDFAANYLT-KIYgLTFGQKPNLR 195
Cdd:PLN00113   91 RLPYIQTINLSNNQL-SGPIPDDIFTTSSSLRYLNLSNNNFTGSiPRgSIPN-LETLDLSNNMLSgEIP-NDIGSFSSLK 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 196 SVYLHNNKLAdAGLPDNMFNGSSnVEILILSSN-FLRHVPKHLPP--ALYKLHLKNNKLEKIPPGAFSELSNLRELYLQN 272
Cdd:PLN00113  168 VLDLGGNVLV-GKIPNSLTNLTS-LEFLTLASNqLVGQIPRELGQmkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVY 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 273 NYLTdeGLDNETFWKLSSLEYLDLSSNNLS-RVPAGL--PRSLVLLHLEKNVIQSVDADVLTPIRNLEYLLLHSNQLQAK 349
Cdd:PLN00113  246 NNLT--GPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIfsLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGK 323

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 350 giHPLAFQGLKRLHTVHLYNNALE-RVPSGLPRR--VRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSpqmhrda 426
Cdd:PLN00113  324 --IPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHnnLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEG------- 394

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 427 frklrllrsldlsgnrlqTLPPGLP--KNVHVLKVKRNELAALARGALAGMAKLRELYLTGNRLRSRaLGPRAWvDLAGL 504
Cdd:PLN00113  395 ------------------EIPKSLGacRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGR-INSRKW-DMPSL 454

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 505 QLLDIAGNQLTeipEGLPPS-----LEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAvgSVVESAFRRLKHLQVLD 579
Cdd:PLN00113  455 QMLSLARNKFF---GGLPDSfgskrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS--GEIPDELSSCKKLVSLD 529


                  ....
gi 1958779876 580 IEGN 583
Cdd:PLN00113  530 LSHN 533
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 100-418 1.64e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 83.36  E-value: 1.64e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 100 NHLSLQNNQLEKIYPEELARLQRLETLNLQNNRLTSRgLPEEAFEhLTSLNYLYLANNKLTLAprfLPNALISVD----- 174
Cdd:PLN00113  239 NHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGP-IPPSIFS-LQKLISLDLSDNSLSGE---IPELVIQLQnleil 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 175 --FAANYLTKI-YGLTfgQKPNLRSVYLHNNKLAdAGLPDNMfNGSSNVEILILSSNFLR-HVPKHLPPA--LYKLHLKN 248
Cdd:PLN00113  314 hlFSNNFTGKIpVALT--SLPRLQVLQLWSNKFS-GEIPKNL-GKHNNLTVLDLSTNNLTgEIPEGLCSSgnLFKLILFS 389

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 249 NKLEKIPPGAFSELSNLRELYLQNNYLTDEgLDNEtFWKLSSLEYLDLSSNNLS-RVPAG---LPrSLVLLHLEKNVIQS 324
Cdd:PLN00113  390 NSLEGEIPKSLGACRSLRRVRLQDNSFSGE-LPSE-FTKLPLVYFLDISNNNLQgRINSRkwdMP-SLQMLSLARNKFFG 466

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 325 VDADVLTPiRNLEYLLLHSNQLQakGIHPLAFQGLKRLHTVHLYNNALE-RVPSGLP--RRVRTLMILHNQITGIGREDF 401
Cdd:PLN00113  467 GLPDSFGS-KRLENLDLSRNQFS--GAVPRKLGSLSELMQLKLSENKLSgEIPDELSscKKLVSLDLSHNQLSGQIPASF 543

                         330
                  ....*....|....*..
gi 1958779876 402 ATTYFLEELNLSYNRIT 418
Cdd:PLN00113  544 SEMPVLSQLDLSQNQLS 560
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 102-521 1.73e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 83.36  E-value: 1.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 102 LSLQNNQLEKIYPEELARLQRLETLNLQNNRLTSrGLPEEaFEHLTSLNYLYLANNKLTLAPRFLPNALIS---VDFAAN 178
Cdd:PLN00113  169 LDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVG-QIPRE-LGQMKSLKWIYLGYNNLSGEIPYEIGGLTSlnhLDLVYN 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 179 YLTKIYGLTFGQKPNLRSVYLHNNKLADAgLPDNMFnGSSNVEILILSSNFLR-HVPKHLP--PALYKLHLKNNKLEKIP 255
Cdd:PLN00113  247 NLTGPIPSSLGNLKNLQYLFLYQNKLSGP-IPPSIF-SLQKLISLDLSDNSLSgEIPELVIqlQNLEILHLFSNNFTGKI 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 256 PGAFSELSNLRELYLQNNYLTDEGLDNetFWKLSSLEYLDLSSNNLS-RVPAGLPRS--LVLLHLEKNVIQSVDADVLTP 332
Cdd:PLN00113  325 PVALTSLPRLQVLQLWSNKFSGEIPKN--LGKHNNLTVLDLSTNNLTgEIPEGLCSSgnLFKLILFSNSLEGEIPKSLGA 402

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 333 IRNLEYLLLHSNQLQakGIHPLAFQGLKRLHTVHLYNNALE-RVPSG---LPrRVRTLMILHNQITGiGREDFATTYFLE 408
Cdd:PLN00113  403 CRSLRRVRLQDNSFS--GELPSEFTKLPLVYFLDISNNNLQgRINSRkwdMP-SLQMLSLARNKFFG-GLPDSFGSKRLE 478

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 409 ELNLSYNRITSpqmhrdafrklrllrsldLSGNRLQTLPpglpkNVHVLKVKRNELAALARGALAGMAKLRELYLTGNRL 488
Cdd:PLN00113  479 NLDLSRNQFSG------------------AVPRKLGSLS-----ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1958779876 489 RSRAlgPRAWVDLAGLQLLDIAGNQLT-EIPEGL 521
Cdd:PLN00113  536 SGQI--PASFSEMPVLSQLDLSQNQLSgEIPKNL 567
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-335 2.13e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.36  E-value: 2.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876  80 VVDCGGIDLREFPGDLPEHTN--HLSLQNNQLEKIyPEELARLQRLETLNLQNNRLTSrgLPEEaFEHLTSLNYLYLANN 157
Cdd:COG4886   163 SLDLSNNQLTDLPEELGNLTNlkELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTD--LPEP-LANLTNLETLDLSNN 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 158 KLTLAPRF--LPNaLISVDFAANYLTKIYGLtfGQKPNLRSVYLHNNKLADAGLpDNMFNGSSNVEILILSSNFLRHVPK 235
Cdd:COG4886   239 QLTDLPELgnLTN-LEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKL-KELELLLGLNSLLLLLLLLNLLELL 314

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 236 HLPPALYKLHLKNNKLEKIPPGAFSELSNLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLL 315
Cdd:COG4886   315 ILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLL 394

                         250       260
                  ....*....|....*....|
gi 1958779876 316 HLEKNVIQSVDADVLTPIRN 335
Cdd:COG4886   395 TTTAGVLLLTLALLDAVNTE 414
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
201-559 2.59e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.36  E-value: 2.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 201 NNKLADAGLPDNMFNGSSNVEILILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSNLRELYLQNNyltdegl 280
Cdd:COG4886    34 LLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 281 dnETFWKLSSLEYLDLSSNNLSRVPAGLPRslvllhleknviqsvdadvltpIRNLEYLLLHSNQLQAkgIhPLAFQGLK 360
Cdd:COG4886   107 --EELSNLTNLESLDLSGNQLTDLPEELAN----------------------LTNLKELDLSNNQLTD--L-PEPLGNLT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 361 RLHTVHLYNNALERVPSGLPRrvrtlmiLHNqitgigredfattyfLEELNLSYNRITSpqmhrdafrklrllrsldlsg 440
Cdd:COG4886   160 NLKSLDLSNNQLTDLPEELGN-------LTN---------------LKELDLSNNQITD--------------------- 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 441 nrlqtLPPGLPKnvhvlkvkrnelaalargalagMAKLRELYLTGNRLRSRalgPRAWVDLAGLQLLDIAGNQLTEIPE- 519
Cdd:COG4886   197 -----LPEPLGN----------------------LTNLEELDLSGNQLTDL---PEPLANLTNLETLDLSNNQLTDLPEl 246

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1958779876 520 GLPPSLEYLYLQNNKISAVPANAfdSTPNLKGIFLRFNKL 559
Cdd:COG4886   247 GNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
154-535 8.95e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.43  E-value: 8.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 154 LANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEILILSSNFLRhv 233
Cdd:COG4886    17 LLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGD-- 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 234 pkhlPPALYKLHLKNNKlekippgAFSELSNLRELYLQNNYLTDEGldnETFWKLSSLEYLDLSSNNLSRVPAGLPR--S 311
Cdd:COG4886    95 ----LTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLP---EELANLTNLKELDLSNNQLTDLPEPLGNltN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 312 LVLLHLEKNVIQSVDADvLTPIRNLEYLLLHSNQLQAKgihPLAFQGLKRLHTVHLYNNALERVPSGLPR--RVRTLMIL 389
Cdd:COG4886   161 LKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 390 HNQITGIgrEDFATTYFLEELNLSYNRITSpqmhrdafrklrllrsldlsgnrlqtLPPglpknvhvlkvkrnelaalar 469
Cdd:COG4886   237 NNQLTDL--PELGNLTNLEELDLSNNQLTD--------------------------LPP--------------------- 267

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958779876 470 gaLAGMAKLRELYLTGNRLRSRALGPRAWVDLAGLQLLDIAGNQLTEIPEGLPPSLEYLYLQNNKI 535
Cdd:COG4886   268 --LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
LRR_8 pfam13855
Leucine rich repeat;
239-301 3.97e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.08  E-value: 3.97e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958779876 239 PALYKLHLKNNKLEKIPPGAFSELSNLRELYLQNNYLTdeGLDNETFWKLSSLEYLDLSSNNL 301
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
158-463 5.19e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 72.04  E-value: 5.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 158 KLTLAPRFLPNALISVDFAANYLTKiygLTFGQKPNLRSVYLHNNKLAD--AGLPDNmfngssnVEILILSSNFLRHVPK 235
Cdd:PRK15370  189 GLTTIPACIPEQITTLILDNNELKS---LPENLQGNIKTLYANSNQLTSipATLPDT-------IQEMELSINRITELPE 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 236 HLPPALYKLHLKNNKLEKIPpgafselsnlrelylqnNYLTDEgldnetfwklssLEYLDLSSNNLSRVPAGLPRSLVLL 315
Cdd:PRK15370  259 RLPSALQSLDLFHNKISCLP-----------------ENLPEE------------LRYLSVYDNSIRTLPAHLPSGITHL 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 316 HLEKNVIQSVDAdVLTPirNLEYLLLHsnqlqakgihplafqglkrlhtvhlyNNALERVPSGLPRRVRTLMILHNQITg 395
Cdd:PRK15370  310 NVQSNSLTALPE-TLPP--GLKTLEAG--------------------------ENALTSLPASLPPELQVLDVSKNQIT- 359

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958779876 396 IGREDFATTyfLEELNLSYNRITSpqmhrdafrklrllrsldlsgnrlqtLPPGLPKNVHVLKVKRNE 463
Cdd:PRK15370  360 VLPETLPPT--ITTLDVSRNALTN--------------------------LPENLPAALQIMQASRNN 399
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
230-541 4.13e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 69.34  E-value: 4.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 230 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSelsNLRELYLQnnyltdegldnetfwklssleyldlsSNNLSRVPAGLP 309
Cdd:PRK15370  190 LTTIPACIPEQITTLILDNNELKSLPENLQG---NIKTLYAN--------------------------SNQLTSIPATLP 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 310 RSLVLLHLEKNVIQSVDadvltpirnlEYLllhsnqlqakgihPLAFQglkrlhTVHLYNNALERVPSGLPRRVRTLMIL 389
Cdd:PRK15370  241 DTIQEMELSINRITELP----------ERL-------------PSALQ------SLDLFHNKISCLPENLPEELRYLSVY 291

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 390 HNQITGIgREDFATTyfLEELNLSYNRITSpqmhrdafrklrllrsldlsgnrlqtLPPGLPKNVHVLKVKRNelaalar 469
Cdd:PRK15370  292 DNSIRTL-PAHLPSG--ITHLNVQSNSLTA--------------------------LPETLPPGLKTLEAGEN------- 335

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958779876 470 galaGMAKLRElyltgnrlrsrALGPRawvdlagLQLLDIAGNQLTEIPEGLPPSLEYLYLQNNKISAVPAN 541
Cdd:PRK15370  336 ----ALTSLPA-----------SLPPE-------LQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPEN 385
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 223-425 7.62e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.19  E-value: 7.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 223 LILSSNFLRHVPK-HLPPALYKLHLKNNKLEKIPpgAFSELSNLRELYLQNNYLTD-EGLDNetfwkLSSLEYLDLSSNN 300
Cdd:cd21340     7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKiENLEN-----LVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 301 LSRVpAGL--PRSLVLLHLEKNVIQS-----VDADVLTPIRN-LEYLLLHSNQLQAkgIHPLAfqGLKRLhtvhlynnal 372
Cdd:cd21340    80 ISVV-EGLenLTNLEELHIENQRLPPgekltFDPRSLAALSNsLRVLNISGNNIDS--LEPLA--PLRNL---------- 144

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958779876 373 ervpsglprrvRTLMILHNQITGIGR--EDFATTYFLEELNLSYNRITSPQMHRD 425
Cdd:cd21340   145 -----------EQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKYRD 188
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
57-320 6.09e-10

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 62.49  E-value: 6.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876  57 SEEPEPGRATIDCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKI--YPEElarlqrLETLNLQNNRLT 134
Cdd:PRK15387  182 AEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLpaLPPE------LRTLEVSGNQLT 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 135 SRG-LPEEAFEhltslnyLYLANNKLTLAPRfLPNALISVDFAANYLTKIYGLtfgqKPNLRSVYLHNNKLAD-AGLPDN 212
Cdd:PRK15387  256 SLPvLPPGLLE-------LSIFSNPLTHLPA-LPSGLCKLWIFGNQLTSLPVL----PPGLQELSVSDNQLASlPALPSE 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 213 M-----FNGS--------SNVEILILSSNFLRHVPKhLPPALYKLHLKNNKLEKIPpgafSELSNLRELYLQNNYLTDEG 279
Cdd:PRK15387  324 LcklwaYNNQltslptlpSGLQELSVSDNQLASLPT-LPSELYKLWAYNNRLTSLP----ALPSGLKELIVSGNRLTSLP 398

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1958779876 280 LdnetfwKLSSLEYLDLSSNNLSRVPAgLPRSLVLLHLEKN 320
Cdd:PRK15387  399 V------LPSELKELMVSGNRLTSLPM-LPSGLLSLSVYRN 432
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 101-339 3.91e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 3.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 101 HLSLQNNQLEKIypEELARLQRLETLNLQNNRLTSRglpeEAFEHLTSLNYLYLANNKltlaprflpnalisvdfaanyL 180
Cdd:cd21340     6 HLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKI----ENLEFLTNLTHLYLQNNQ---------------------I 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 181 TKIYGLTfgqkpNLRSvylhnnkladaglpdnmfngssnveililssnflrhvpkhlppaLYKLHLKNNKLEKIppGAFS 260
Cdd:cd21340    59 EKIENLE-----NLVN--------------------------------------------LKKLYLGGNRISVV--EGLE 87

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 261 ELSNLRELYLQNNYL-TDEGL--DNETFWKLS-SLEYLDLSSNNLSRV-PAGLPRSLVLLHLEKNVIQSVDaDVLTPIRN 335
Cdd:cd21340    88 NLTNLEELHIENQRLpPGEKLtfDPRSLAALSnSLRVLNISGNNIDSLePLAPLRNLEQLDASNNQISDLE-ELLDLLSS 166


                  ....
gi 1958779876 336 LEYL 339
Cdd:cd21340   167 WPSL 170
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 115-350 7.51e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 57.75  E-value: 7.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 115 EELARLQRLETLNLQNNRLTSRGLP--EEAFEHLTSLNYLYLANNKLTLAPRFLpnalisvDFAANYLTKIYGLT----- 187
Cdd:cd00116    17 ELLPKLLCLQVLRLEGNTLGEEAAKalASALRPQPSLKELCLSLNETGRIPRGL-------QSLLQGLTKGCGLQeldls 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 188 --------------FGQKPNLRSVYLHNNKLADAGLP---DNMFNGSSNVEILILSSNFLRHVP-----KHLP--PALYK 243
Cdd:cd00116    90 dnalgpdgcgvlesLLRSSSLQELKLNNNGLGDRGLRllaKGLKDLPPALEKLVLGRNRLEGAScealaKALRanRDLKE 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 244 LHLKNNKLEkiPPG------AFSELSNLRELYLQNNYLTDEG--LDNETFWKLSSLEYLDLSSNNLSRVPA--------G 307
Cdd:cd00116   170 LNLANNGIG--DAGiralaeGLKANCNLEVLDLNNNGLTDEGasALAETLASLKSLEVLNLGDNNLTDAGAaalasallS 247

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1958779876 308 LPRSLVLLHLEKNVIQSVDA-DVLTPIRN---LEYLLLHSNQLQAKG 350
Cdd:cd00116   248 PNISLLTLSLSCNDITDDGAkDLAEVLAEkesLLELDLRGNKFGEEG 294
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
291-579 1.36e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 57.86  E-value: 1.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 291 LEYLDLSSNNLSRVPAgLPRSLVLLHLEKNVIQSVDAdvlTPiRNLEYLLLHSNQLQAKGIHPLAFQGLKrlhtvhLYNN 370
Cdd:PRK15387  244 LRTLEVSGNQLTSLPV-LPPGLLELSIFSNPLTHLPA---LP-SGLCKLWIFGNQLTSLPVLPPGLQELS------VSDN 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 371 ALERVPSgLPRRVRTLMILHNQITGIGredfATTYFLEELNLSYNRITS-PQMHRDAFRklrllrsLDLSGNRLQTLPpG 449
Cdd:PRK15387  313 QLASLPA-LPSELCKLWAYNNQLTSLP----TLPSGLQELSVSDNQLASlPTLPSELYK-------LWAYNNRLTSLP-A 379

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 450 LPKNVHVLKVKRNELAALARGAlagmAKLRELYLTGNRLRSRALGPrawvdlAGLQLLDIAGNQLTEIPEGLP--PSLEY 527
Cdd:PRK15387  380 LPSGLKELIVSGNRLTSLPVLP----SELKELMVSGNRLTSLPMLP------SGLLSLSVYRNQLTRLPESLIhlSSETT 449

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958779876 528 LYLQNNKISAVPANAF---DSTPNLKGIFLRFNKLAVGSVVESafrRLKHLQVLD 579
Cdd:PRK15387  450 VNLEGNPLSERTLQALreiTSAPGYSGPIIRFDMAGASAPRET---RALHLAAAD 501
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 235-418 1.88e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 56.21  E-value: 1.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 235 KHLPPALYKLHLKNNKLEKIPPG------AFSELSNLRELYLQNNYLTDEGLDN-ETFWKLSSLEYLDLSSNNLS----- 302
Cdd:cd00116    47 LRPQPSLKELCLSLNETGRIPRGlqsllqGLTKGCGLQELDLSDNALGPDGCGVlESLLRSSSLQELKLNNNGLGdrglr 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 303 ---RVPAGLPRSLVLLHLEKNVIQSVD----ADVLTPIRNLEYLLLHSNQLQAKGIHPLAfQGLK---RLHTVHLYNNAL 372
Cdd:cd00116   127 llaKGLKDLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDAGIRALA-EGLKancNLEVLDLNNNGL 205

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958779876 373 ERVPSGL-------PRRVRTLMILHNQITGIGREDFATTYF-----LEELNLSYNRIT 418
Cdd:cd00116   206 TDEGASAlaetlasLKSLEVLNLGDNNLTDAGAAALASALLspnisLLTLSLSCNDIT 263
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
415-541 3.37e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 56.63  E-value: 3.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 415 NRITSPQMHRDAFRKLRLLRSLDLSGnrLQTLPPGLPKNVHVLKVKRNELAALARGALagmAKLRELYLTGNRLRSRalg 494
Cdd:PRK15370  164 NREEAVQRMRDCLKNNKTELRLKILG--LTTIPACIPEQITTLILDNNELKSLPENLQ---GNIKTLYANSNQLTSI--- 235

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1958779876 495 PRAWVDLagLQLLDIAGNQLTEIPEGLPPSLEYLYLQNNKISAVPAN 541
Cdd:PRK15370  236 PATLPDT--IQEMELSINRITELPERLPSALQSLDLFHNKISCLPEN 280
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 93-365 1.26e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 54.41  E-value: 1.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876  93 GDLPEHTNHLSLqnnqLEKIYPEELARLQRLETLNLQNNRLTSRGLPE--EAFEHLTSLNYLYLANNkltlaprflPNAL 170
Cdd:COG5238   156 VHLLGLAARLGL----LAAISMAKALQNNSVETVYLGCNQIGDEGIEElaEALTQNTTVTTLWLKRN---------PIGD 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 171 ISVDFAANYLTKiygltfgqKPNLRSVYLHNNKLADAG---LPDNMFNGsSNVEILILSSNFLRH-----VPKHL--PPA 240
Cdd:COG5238   223 EGAEILAEALKG--------NKSLTTLDLSNNQIGDEGviaLAEALKNN-TTVETLYLSGNQIGAegaiaLAKALqgNTT 293

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 241 LYKLHLKNNKLEKIPPGAFSEL----SNLRELYLQNNYLTDEGLDN--ETFWKLSSLEYLDLSSNNLSRVPA-GLPRSLV 313
Cdd:COG5238   294 LTSLDLSVNRIGDEGAIALAEGlqgnKTLHTLNLAYNGIGAQGAIAlaKALQENTTLHSLDLSDNQIGDEGAiALAKYLE 373

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958779876 314 L------LHLEKNVIQSVDADVLTP---IRNLEYLLLHSNQLQAKgIHPLAFQGLKRLHTV 365
Cdd:COG5238   374 GnttlreLNLGKNNIGKQGAEALIDalqTNRLHTLILDGNLIGAE-AQQRLEQLLERIKSV 433
LRR_8 pfam13855
Leucine rich repeat;
102-159 1.37e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.37e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958779876 102 LSLQNNQLEKIYPEELARLQRLETLNLQNNRLTSrgLPEEAFEHLTSLNYLYLANNKL 159
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
192-275 4.53e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 4.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 192 PNLRSVYLHNNKLADagLPDNMFNGSSNVEILILSsnflrhvpkhlppalyklhlkNNKLEKIPPGAFSELSNLRELYLQ 271
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLS---------------------NNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 1958779876 272 NNYL 275
Cdd:pfam13855  58 GNRL 61
LRR_8 pfam13855
Leucine rich repeat;
263-346 4.58e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 4.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 263 SNLRELYLQNNYLTDegLDNETFWKLSSLEYLDLSSNNlsrvpaglprslvllhleknvIQSVDADVLTPIRNLEYLLLH 342
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNL---------------------LTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 1958779876 343 SNQL 346
Cdd:pfam13855  58 GNRL 61
LRR_8 pfam13855
Leucine rich repeat;
523-583 5.35e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 5.35e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958779876 523 PSLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLavGSVVESAFRRLKHLQVLDIEGN 583
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
477-535 5.47e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 5.47e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958779876 477 KLRELYLTGNRLRSraLGPRAWVDLAGLQLLDIAGNQLTEIPEGL---PPSLEYLYLQNNKI 535
Cdd:pfam13855   2 NLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPGAfsgLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 101-255 7.12e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.47  E-value: 7.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 101 HLSLQNNQLEKIypEELARLQRLETLNLQNNRLTSRglpeEAFEHLTSLNYLYLANNKLTLAPRFL--PNALISVdfaan 178
Cdd:cd21340    50 HLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVV----EGLENLTNLEELHIENQRLPPGEKLTfdPRSLAAL----- 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 179 yltkiygltfgqKPNLRSVYLHNNKLADaglpDNMFNGSSNVEILILSSNFLRHVPKHLP-----PALYKLHLKNNKLEK 253
Cdd:cd21340   119 ------------SNSLRVLNISGNNIDS----LEPLAPLRNLEQLDASNNQISDLEELLDllsswPSLRELDLTGNPVCK 182


                  ..
gi 1958779876 254 IP 255
Cdd:cd21340   183 KP 184
LRR_8 pfam13855
Leucine rich repeat;
121-204 9.12e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 9.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 121 QRLETLNLQNNRLTSrgLPEEAFEHLTSLNYLYLANNKLTlapRFLPNALisvdfaanyltkiYGLtfgqkPNLRSVYLH 200
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLT---TLSPGAF-------------SGL-----PSLRYLDLS 57


                  ....
gi 1958779876 201 NNKL 204
Cdd:pfam13855  58 GNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 93-301 1.75e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 1.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876  93 GDLPE------HTNHLSLQNNQLEKIYPEELARLQRLETLNLQNNRLTSRgLPEEaFEHLTSLNYLYLANNKLT---LAP 163
Cdd:PLN00113  370 GEIPEglcssgNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGE-LPSE-FTKLPLVYFLDISNNNLQgriNSR 447

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 164 RFLPNALISVDFAANYLTKIYGLTFGQKpNLRSVYLHNNKLAdaGLPDNMFNGSSNVEILILSSNFLR-HVPKHLPPA-- 240
Cdd:PLN00113  448 KWDMPSLQMLSLARNKFFGGLPDSFGSK-RLENLDLSRNQFS--GAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCkk 524

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958779876 241 LYKLHLKNNKLEKIPPGAFSELSNLRELYLQNNYLTDEGLDNetFWKLSSLEYLDLSSNNL 301
Cdd:PLN00113  525 LVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKN--LGNVESLVQVNISHNHL 583
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 264-418 3.51e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 46.71  E-value: 3.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 264 NLRELYLQNNYLTDEGLDN--ETFWKLSSLEYLDLSSNNLSrvpaglPRSLVLLhleknviqsvdADVLTPIRNLEYLLL 341
Cdd:COG5238   209 TVTTLWLKRNPIGDEGAEIlaEALKGNKSLTTLDLSNNQIG------DEGVIAL-----------AEALKNNTTVETLYL 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 342 HSNQLQAKGIHPLA--FQGLKRLHTVHLYNNAL-----ERVPSGLPR--RVRTLMILHNQITGIGREDFATT----YFLE 408
Cdd:COG5238   272 SGNQIGAEGAIALAkaLQGNTTLTSLDLSVNRIgdegaIALAEGLQGnkTLHTLNLAYNGIGAQGAIALAKAlqenTTLH 351

                         170
                  ....*....|
gi 1958779876 409 ELNLSYNRIT 418
Cdd:COG5238   352 SLDLSDNQIG 361
LRR_8 pfam13855
Leucine rich repeat;
503-559 4.48e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 4.48e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 503 GLQLLDIAGNQLTEIPEGL---PPSLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKL 559
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
443-540 6.50e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.92  E-value: 6.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 443 LQTLPPGLPKNVHVLKVKRNELAALARGAlagmAKLRELYLTGNRLRSRALGPRAWVDLA--------------GLQLLD 508
Cdd:PRK15387  213 LTTLPDCLPAHITTLVIPDNNLTSLPALP----PELRTLEVSGNQLTSLPVLPPGLLELSifsnplthlpalpsGLCKLW 288

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958779876 509 IAGNQLTEIPEgLPPSLEYLYLQNNKISAVPA 540
Cdd:PRK15387  289 IFGNQLTSLPV-LPPGLQELSVSDNQLASLPA 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 237-418 2.46e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.01  E-value: 2.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 237 LPPALYKLHLKNNK-LEKIPPGafseLSNLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPA-------GL 308
Cdd:COG5238   131 LILYLALPRRINLIqVLKDPLG----GNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIeelaealTQ 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 309 PRSLVLLHLEKNVI--QSVD--ADVLTPIRNLEYLLLHSNQLQAKGIHPLA--FQGLKRLHTVHLYNN-----ALERVPS 377
Cdd:COG5238   207 NTTVTTLWLKRNPIgdEGAEilAEALKGNKSLTTLDLSNNQIGDEGVIALAeaLKNNTTVETLYLSGNqigaeGAIALAK 286

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1958779876 378 GLPRR--VRTLMILHNQITGIGREDFA----TTYFLEELNLSYNRIT 418
Cdd:COG5238   287 ALQGNttLTSLDLSVNRIGDEGAIALAeglqGNKTLHTLNLAYNGIG 333
LRRNT smart00013
Leucine rich repeat N-terminal domain;
68-99 2.82e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.45  E-value: 2.82e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958779876   68 DCPRDCACSqEGVVDCGGIDLREFPGDLPEHT 99
Cdd:smart00013   1 ACPAPCNCS-GTAVDCSGRGLTEVPLDLPPDT 31
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 477-583 8.14e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 8.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 477 KLRELYLTGNRLRSR---ALGPRAWVDLAG-LQLLDIAGNQLTEIpEGLPP--SLEYLYLQNNKISAVpanafdstpnlk 550
Cdd:cd21340    91 NLEELHIENQRLPPGeklTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPlrNLEQLDASNNQISDL------------ 157

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1958779876 551 giflrfnklavgSVVESAFRRLKHLQVLDIEGN 583
Cdd:cd21340   158 ------------EELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
310-372 1.67e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.67e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958779876 310 RSLVLLHLEKNVIQSVDADVLTPIRNLEYLLLHSNQLqaKGIHPLAFQGLKRLHTVHLYNNAL 372
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 511-581 2.06e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 2.06e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958779876 511 GNQLTEIpEGLP--PSLEYLYLQNNKISAVpaNAFDSTPNLKGIFLRFNKLavgSVVESaFRRLKHLQVLDIE 581
Cdd:cd21340    33 DNKITKI-ENLEflTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI---SVVEG-LENLTNLEELHIE 98
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 264-301 2.10e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 2.10e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958779876 264 NLRELYLQNNYLTDEGLdnetFWKLSSLEYLDLSSNNL 301
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP----LAKLPNLETLDLSGNNK 35
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 214-300 4.13e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 37.52  E-value: 4.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 214 FNGSSNVEILILSSNfLRHVPKHlppALYKLHLKN----NKLEKIPPGAFSELSNLRELYLQNNyLTDegLDNETFWKlS 289
Cdd:pfam13306  30 FSNCTSLKSITLPSS-LTSIGSY---AFYNCSLTSitipSSLTSIGEYAFSNCSNLKSITLPSN-LTS--IGSYAFSN-C 101

                          90
                  ....*....|.
gi 1958779876 290 SLEYLDLSSNN 300
Cdd:pfam13306 102 SLKSITIPSSV 112
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 123-292 5.95e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 37.14  E-value: 5.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 123 LETLNLQNNrLTSrgLPEEAFEHLTSLNYLYLANNkltlaprflpnalisvdfaanyLTKIYGLTFgQKPNLRSVYLHNN 202
Cdd:pfam13306  13 LTSITIPSS-LTS--IGEYAFSNCTSLKSITLPSS----------------------LTSIGSYAF-YNCSLTSITIPSS 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779876 203 KLAdagLPDNMFNGSSNVEILILSSNflrhvpkhlppalyklhlknnkLEKIPPGAFSElSNLRELYLQNNyLTDegLDN 282
Cdd:pfam13306  67 LTS---IGEYAFSNCSNLKSITLPSN----------------------LTSIGSYAFSN-CSLKSITIPSS-VTT--IGS 117

                         170
                  ....*....|
gi 1958779876 283 ETFWKLSSLE 292
Cdd:pfam13306 118 YAFSNCSNLK 127
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 68-96 6.60e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 34.53  E-value: 6.60e-03
                          10        20
                  ....*....|....*....|....*....
gi 1958779876  68 DCPRDCACSqEGVVDCGGIDLREFPGDLP 96
Cdd:pfam01462   1 ACPVPCHCS-ATVVNCSDRGLTAVPRDLP 28
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 121-159 7.96e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 7.96e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958779876 121 QRLETLNLQNNRLTSrglpEEAFEHLTSLNYLYLANNKL 159
Cdd:pfam12799   1 PNLEVLDLSNNQITD----IPPLAKLPNLETLDLSGNNK 35
LRR_8 pfam13855
Leucine rich repeat;
475-514 9.09e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.81  E-value: 9.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1958779876 475 MAKLRELYLTGNRLRSraLGPRAWVDLAGLQLLDIAGNQL 514
Cdd:pfam13855  24 LSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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