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Conserved domains on  [gi|1958779887|ref|XP_038967097|]
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podocan isoform X2 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11471162)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-324 4.70e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.04  E-value: 4.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887   3 NGSSNVEILILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSNLRELYLQNNyltdegldnETFWKLSSLEYL 82
Cdd:COG4886    48 LLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  83 DLSSNNLSRVPAGLPR--SLVLLHLEKNVIQSVDADvLTPIRNLEYLLLHSNQLqaKGIhPLAFQGLKRLHTVHLYNNAL 160
Cdd:COG4886   119 DLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQL--TDL-PEELGNLTNLKELDLSNNQI 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 161 ERVPSGLPRRVRtlmilhnqitgigredfattyfLEELNLSYNRITSpqmhrdafrklrllrsldlsgnrlqtLPPGLPK 240
Cdd:COG4886   195 TDLPEPLGNLTN----------------------LEELDLSGNQLTD--------------------------LPEPLAN 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 241 nvhvlkvkrnelaalargalagMAKLRELYLTGNRLRS-RALGprawvDLAGLQLLDIAGNQLTEIPEGLP-PSLEYLYL 318
Cdd:COG4886   227 ----------------------LTNLETLDLSNNQLTDlPELG-----NLTNLEELDLSNNQLTDLPPLANlTNLKTLDL 279


                  ....*.
gi 1958779887 319 QNNKIS 324
Cdd:COG4886   280 SNNQLT 285
LRR_8 pfam13855
Leucine rich repeat;
311-371 9.67e-07

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 9.67e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958779887 311 PSLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLavGSVVESAFRRLKHLQVLDIEGN 371
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGN 59
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-324 4.70e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.04  E-value: 4.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887   3 NGSSNVEILILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSNLRELYLQNNyltdegldnETFWKLSSLEYL 82
Cdd:COG4886    48 LLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  83 DLSSNNLSRVPAGLPR--SLVLLHLEKNVIQSVDADvLTPIRNLEYLLLHSNQLqaKGIhPLAFQGLKRLHTVHLYNNAL 160
Cdd:COG4886   119 DLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQL--TDL-PEELGNLTNLKELDLSNNQI 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 161 ERVPSGLPRRVRtlmilhnqitgigredfattyfLEELNLSYNRITSpqmhrdafrklrllrsldlsgnrlqtLPPGLPK 240
Cdd:COG4886   195 TDLPEPLGNLTN----------------------LEELDLSGNQLTD--------------------------LPEPLAN 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 241 nvhvlkvkrnelaalargalagMAKLRELYLTGNRLRS-RALGprawvDLAGLQLLDIAGNQLTEIPEGLP-PSLEYLYL 318
Cdd:COG4886   227 ----------------------LTNLETLDLSNNQLTDlPELG-----NLTNLEELDLSNNQLTDLPPLANlTNLKTLDL 279


                  ....*.
gi 1958779887 319 QNNKIS 324
Cdd:COG4886   280 SNNQLT 285
LRR_8 pfam13855
Leucine rich repeat;
27-89 9.87e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 9.87e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958779887  27 PALYKLHLKNNKLEKIPPGAFSELSNLRELYLQNNYLTdeGLDNETFWKLSSLEYLDLSSNNL 89
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
18-329 1.55e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 69.34  E-value: 1.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  18 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSelsNLRELYLQnnyltdegldnetfwklssleyldlsSNNLSRVPAGLP 97
Cdd:PRK15370  190 LTTIPACIPEQITTLILDNNELKSLPENLQG---NIKTLYAN--------------------------SNQLTSIPATLP 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  98 RSLVLLHLEKNVIQSVDadvltpirnlEYLllhsnqlqakgihPLAFQglkrlhTVHLYNNALERVPSGLPRRVRTLMIL 177
Cdd:PRK15370  241 DTIQEMELSINRITELP----------ERL-------------PSALQ------SLDLFHNKISCLPENLPEELRYLSVY 291

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 178 HNQITGIgREDFATTyfLEELNLSYNRITSpqmhrdafrklrllrsldlsgnrlqtLPPGLPKNVHVLKVKRNelaalar 257
Cdd:PRK15370  292 DNSIRTL-PAHLPSG--ITHLNVQSNSLTA--------------------------LPETLPPGLKTLEAGEN------- 335

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958779887 258 galaGMAKLRElyltgnrlrsrALGPRawvdlagLQLLDIAGNQLTEIPEGLPPSLEYLYLQNNKISAVPAN 329
Cdd:PRK15370  336 ----ALTSLPA-----------SLPPE-------LQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPEN 385
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 11-213 1.80e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.27  E-value: 1.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  11 LILSSNFLRHVPK-HLPPALYKLHLKNNKLEKIPpgAFSELSNLRELYLQNNYLTD-EGLDNetfwkLSSLEYLDLSSNN 88
Cdd:cd21340     7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKiENLEN-----LVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  89 LSRVpAGL--PRSLVLLHLEKNVIQS-----VDADVLTPIRN-LEYLLLHSNQLQAkgIHPLAfqGLKRLhtvhlynnal 160
Cdd:cd21340    80 ISVV-EGLenLTNLEELHIENQRLPPgekltFDPRSLAALSNsLRVLNISGNNIDS--LEPLA--PLRNL---------- 144

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958779887 161 ervpsglprrvRTLMILHNQITGIGR--EDFATTYFLEELNLSYNRITSPQMHRD 213
Cdd:cd21340   145 -----------EQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKYRD 188
LRR_8 pfam13855
Leucine rich repeat;
311-371 9.67e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 9.67e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958779887 311 PSLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLavGSVVESAFRRLKHLQVLDIEGN 371
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 299-369 2.36e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 2.36e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958779887 299 GNQLTEIpEGLP--PSLEYLYLQNNKISAVpaNAFDSTPNLKGIFLRFNKLavgSVVESaFRRLKHLQVLDIE 369
Cdd:cd21340    33 DNKITKI-ENLEflTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI---SVVEG-LENLTNLEELHIE 98
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-324 4.70e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.04  E-value: 4.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887   3 NGSSNVEILILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSNLRELYLQNNyltdegldnETFWKLSSLEYL 82
Cdd:COG4886    48 LLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  83 DLSSNNLSRVPAGLPR--SLVLLHLEKNVIQSVDADvLTPIRNLEYLLLHSNQLqaKGIhPLAFQGLKRLHTVHLYNNAL 160
Cdd:COG4886   119 DLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQL--TDL-PEELGNLTNLKELDLSNNQI 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 161 ERVPSGLPRRVRtlmilhnqitgigredfattyfLEELNLSYNRITSpqmhrdafrklrllrsldlsgnrlqtLPPGLPK 240
Cdd:COG4886   195 TDLPEPLGNLTN----------------------LEELDLSGNQLTD--------------------------LPEPLAN 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 241 nvhvlkvkrnelaalargalagMAKLRELYLTGNRLRS-RALGprawvDLAGLQLLDIAGNQLTEIPEGLP-PSLEYLYL 318
Cdd:COG4886   227 ----------------------LTNLETLDLSNNQLTDlPELG-----NLTNLEELDLSNNQLTDLPPLANlTNLKTLDL 279


                  ....*.
gi 1958779887 319 QNNKIS 324
Cdd:COG4886   280 SNNQLT 285
LRR_8 pfam13855
Leucine rich repeat;
27-89 9.87e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 9.87e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958779887  27 PALYKLHLKNNKLEKIPPGAFSELSNLRELYLQNNYLTdeGLDNETFWKLSSLEYLDLSSNNL 89
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
18-329 1.55e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 69.34  E-value: 1.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  18 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSelsNLRELYLQnnyltdegldnetfwklssleyldlsSNNLSRVPAGLP 97
Cdd:PRK15370  190 LTTIPACIPEQITTLILDNNELKSLPENLQG---NIKTLYAN--------------------------SNQLTSIPATLP 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  98 RSLVLLHLEKNVIQSVDadvltpirnlEYLllhsnqlqakgihPLAFQglkrlhTVHLYNNALERVPSGLPRRVRTLMIL 177
Cdd:PRK15370  241 DTIQEMELSINRITELP----------ERL-------------PSALQ------SLDLFHNKISCLPENLPEELRYLSVY 291

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 178 HNQITGIgREDFATTyfLEELNLSYNRITSpqmhrdafrklrllrsldlsgnrlqtLPPGLPKNVHVLKVKRNelaalar 257
Cdd:PRK15370  292 DNSIRTL-PAHLPSG--ITHLNVQSNSLTA--------------------------LPETLPPGLKTLEAGEN------- 335

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958779887 258 galaGMAKLRElyltgnrlrsrALGPRawvdlagLQLLDIAGNQLTEIPEGLPPSLEYLYLQNNKISAVPAN 329
Cdd:PRK15370  336 ----ALTSLPA-----------SLPPE-------LQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPEN 385
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-347 1.90e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 1.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  36 NNKLEKIPPGAFSELSNLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNVIQSVDA 115
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 116 DVLTPIRNLEYLLLHSNQLQAKGIHPLAFQGLKRLHTVHLYNNALERVPSGLPR--RVRTLMILHNQITGIGrEDFATTY 193
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLP-EPLGNLT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 194 FLEELNLSYNRITS-PqmhrDAFRKLRLLRSLDLSGNRLQTLPPGLPKnvhvlkvkrnelaalargalagMAKLRELYLT 272
Cdd:COG4886   160 NLKSLDLSNNQLTDlP----EELGNLTNLKELDLSNNQITDLPEPLGN----------------------LTNLEELDLS 213

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958779887 273 GNRLRSRalgPRAWVDLAGLQLLDIAGNQLTEIPE-GLPPSLEYLYLQNNKISAVPANAfdSTPNLKGIFLRFNKL 347
Cdd:COG4886   214 GNQLTDL---PEPLANLTNLETLDLSNNQLTDLPElGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-371 7.09e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.18  E-value: 7.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887   1 MFNGSSNVEILILSSN-FLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSNLRELYLQNNYLTdeGLDNETFWKLSSL 79
Cdd:PLN00113  113 IFTTSSSLRYLNLSNNnFTGSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLV--GKIPNSLTNLTSL 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  80 EYLDLSSNNLS-RVPA--GLPRSLVLLHLEKN---------------------VIQSVDADV---LTPIRNLEYLLLHSN 132
Cdd:PLN00113  191 EFLTLASNQLVgQIPRelGQMKSLKWIYLGYNnlsgeipyeiggltslnhldlVYNNLTGPIpssLGNLKNLQYLFLYQN 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 133 QLQAKgIHPLAFqGLKRLHTVHLYNNALERVPSGLPRRVRTLMILH---NQITGIGREDFATTYFLEELNLSYNRItSPQ 209
Cdd:PLN00113  271 KLSGP-IPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHlfsNNFTGKIPVALTSLPRLQVLQLWSNKF-SGE 347

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 210 MHRDAFRKLRLLRSLDLSGNRLQTLPPGLPKNVHVLKVK--RNELAALARGALAGMAKLRELYLTGNRLRSRAlgPRAWV 287
Cdd:PLN00113  348 IPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLIlfSNSLEGEIPKSLGACRSLRRVRLQDNSFSGEL--PSEFT 425

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 288 DLAGLQLLDIAGNQLT---EIPEGLPPSLEYLYLQNNKISAVPANAFDSTpNLKGIFLRFNKLAvgSVVESAFRRLKHLQ 364
Cdd:PLN00113  426 KLPLVYFLDISNNNLQgriNSRKWDMPSLQMLSLARNKFFGGLPDSFGSK-RLENLDLSRNQFS--GAVPRKLGSLSELM 502


                  ....*..
gi 1958779887 365 VLDIEGN 371
Cdd:PLN00113  503 QLKLSEN 509
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 11-213 1.80e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.27  E-value: 1.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  11 LILSSNFLRHVPK-HLPPALYKLHLKNNKLEKIPpgAFSELSNLRELYLQNNYLTD-EGLDNetfwkLSSLEYLDLSSNN 88
Cdd:cd21340     7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKiENLEN-----LVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  89 LSRVpAGL--PRSLVLLHLEKNVIQS-----VDADVLTPIRN-LEYLLLHSNQLQAkgIHPLAfqGLKRLhtvhlynnal 160
Cdd:cd21340    80 ISVV-EGLenLTNLEELHIENQRLPPgekltFDPRSLAALSNsLRVLNISGNNIDS--LEPLA--PLRNL---------- 144

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958779887 161 ervpsglprrvRTLMILHNQITGIGR--EDFATTYFLEELNLSYNRITSPQMHRD 213
Cdd:cd21340   145 -----------EQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKYRD 188
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
11-239 1.43e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 63.18  E-value: 1.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  11 LILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPgafSELSNLRELYLQNNYLTD--EGLDnetfwklSSLEYLDLSSNN 88
Cdd:PRK15370  204 LILDNNELKSLPENLQGNIKTLYANSNQLTSIPA---TLPDTIQEMELSINRITElpERLP-------SALQSLDLFHNK 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  89 LSRVPAGLPRSLVLLHLEKNVIQSVDADVLTPIrnlEYLLLHSNQLQAkgihpLAFQGLKRLHTVHLYNNALERVPSGLP 168
Cdd:PRK15370  274 ISCLPENLPEELRYLSVYDNSIRTLPAHLPSGI---THLNVQSNSLTA-----LPETLPPGLKTLEAGENALTSLPASLP 345

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958779887 169 RRVRTLMILHNQITgIGREDFATTyfLEELNLSYNRITS-PQMHRDAFRKLRLLRsldlsgNRLQTLPPGLP 239
Cdd:PRK15370  346 PELQVLDVSKNQIT-VLPETLPPT--ITTLDVSRNALTNlPENLPAALQIMQASR------NNLVRLPESLP 408
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 27-329 2.36e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.56  E-value: 2.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  27 PALYKLHLKNNKLE-KIPPGAFSELSNLRELYLQNNYLTdeGLDNETFwkLSSLEYLDLSSNNLS-RVPA--GLPRSLVL 102
Cdd:PLN00113   93 PYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFT--GSIPRGS--IPNLETLDLSNNMLSgEIPNdiGSFSSLKV 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 103 LHLEKNVIQSVDADVLTPIRNLEYLLLHSNQLQakGIHPLAFQGLKRLHTVHL-YNNALERVPsglprrvrtlmilhNQI 181
Cdd:PLN00113  169 LDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLV--GQIPRELGQMKSLKWIYLgYNNLSGEIP--------------YEI 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 182 TGIGRedfattyfLEELNLSYNRITSPqmhrdafrklrllrsldlsgnrlqtLPPGLP--KNVHVLKVKRNELAALARGA 259
Cdd:PLN00113  233 GGLTS--------LNHLDLVYNNLTGP-------------------------IPSSLGnlKNLQYLFLYQNKLSGPIPPS 279

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958779887 260 LAGMAKLRELYLTGNRLRSRAlgPRAWVDLAGLQLLDIAGNQLT-EIPEGLP--PSLEYLYLQNNKISA-VPAN 329
Cdd:PLN00113  280 IFSLQKLISLDLSDNSLSGEI--PELVIQLQNLEILHLFSNNFTgKIPVALTslPRLQVLQLWSNKFSGeIPKN 351
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
8-205 3.61e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.64  E-value: 3.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887   8 VEILILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPpgafselSNLRElylqnnyltdegldnetfwklsSLEYLDLSSN 87
Cdd:PRK15370  243 IQEMELSINRITELPERLPSALQSLDLFHNKISCLP-------ENLPE----------------------ELRYLSVYDN 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  88 NLSRVPAGLPRSLVLLHLEKNVIQSVDAdVLTPirNLEYLLLHSNQLQA--KGIHPlafqglkRLHTVHLYNNALERVPS 165
Cdd:PRK15370  294 SIRTLPAHLPSGITHLNVQSNSLTALPE-TLPP--GLKTLEAGENALTSlpASLPP-------ELQVLDVSKNQITVLPE 363

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1958779887 166 GLPRRVRTLMILHNQITGIGREDFATTYFLEElnlSYNRI 205
Cdd:PRK15370  364 TLPPTITTLDVSRNALTNLPENLPAALQIMQA---SRNNL 400
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 6-206 5.06e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.40  E-value: 5.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887   6 SNVEILILSSNFLR-HVPKHLPPA--LYKLHLKNNKLEKIPPGAFSELSNLRELYLQNNYLTDEgLDNEtFWKLSSLEYL 82
Cdd:PLN00113  356 NNLTVLDLSTNNLTgEIPEGLCSSgnLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGE-LPSE-FTKLPLVYFL 433

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  83 DLSSNNLS-RVPAG---LPrSLVLLHLEKNVIQSVDADVLTPiRNLEYLLLHSNQLQakGIHPLAFQGLKRLHTVHLYNN 158
Cdd:PLN00113  434 DISNNNLQgRINSRkwdMP-SLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFS--GAVPRKLGSLSELMQLKLSEN 509

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958779887 159 ALE-RVPSGLP--RRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRIT 206
Cdd:PLN00113  510 KLSgEIPDELSscKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLS 560
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
7-97 8.12e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.87  E-value: 8.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887   7 NVEILILSSNFLRHVPKHLPPALYKLHLKNNKL----EKIPPgafselsNLRELYLQNNYLTD--EGLDnetfwklSSLE 80
Cdd:PRK15370  326 GLKTLEAGENALTSLPASLPPELQVLDVSKNQItvlpETLPP-------TITTLDVSRNALTNlpENLP-------AALQ 391

                          90
                  ....*....|....*..
gi 1958779887  81 YLDLSSNNLSRVPAGLP 97
Cdd:PRK15370  392 IMQASRNNLVRLPESLP 408
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
79-367 3.42e-09

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 58.63  E-value: 3.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  79 LEYLDLSSNNLSRVPAgLPRSLVLLHLEKNVIQSVDAdvlTPiRNLEYLLLHSNQLQAKGIHPLAFQGLKrlhtvhLYNN 158
Cdd:PRK15387  244 LRTLEVSGNQLTSLPV-LPPGLLELSIFSNPLTHLPA---LP-SGLCKLWIFGNQLTSLPVLPPGLQELS------VSDN 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 159 ALERVPSgLPRRVRTLMILHNQITGIGredfATTYFLEELNLSYNRITS-PQMHRDAFRklrllrsLDLSGNRLQTLPpG 237
Cdd:PRK15387  313 QLASLPA-LPSELCKLWAYNNQLTSLP----TLPSGLQELSVSDNQLASlPTLPSELYK-------LWAYNNRLTSLP-A 379

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 238 LPKNVHVLKVKRNELAALARGAlagmAKLRELYLTGNRLRSRALGPrawvdlAGLQLLDIAGNQLTEIPEGLP--PSLEY 315
Cdd:PRK15387  380 LPSGLKELIVSGNRLTSLPVLP----SELKELMVSGNRLTSLPMLP------SGLLSLSVYRNQLTRLPESLIhlSSETT 449

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958779887 316 LYLQNNKISAVPANAF---DSTPNLKGIFLRFNKLAVGSVVESafrRLKHLQVLD 367
Cdd:PRK15387  450 VNLEGNPLSERTLQALreiTSAPGYSGPIIRFDMAGASAPRET---RALHLAAAD 501
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 23-206 1.01e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 56.21  E-value: 1.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  23 KHLPPALYKLHLKNNKLEKIPPG------AFSELSNLRELYLQNNYLTDEGLDN-ETFWKLSSLEYLDLSSNNLS----- 90
Cdd:cd00116    47 LRPQPSLKELCLSLNETGRIPRGlqsllqGLTKGCGLQELDLSDNALGPDGCGVlESLLRSSSLQELKLNNNGLGdrglr 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  91 ---RVPAGLPRSLVLLHLEKNVIQSVD----ADVLTPIRNLEYLLLHSNQLQAKGIHPLAfQGLK---RLHTVHLYNNAL 160
Cdd:cd00116   127 llaKGLKDLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDAGIRALA-EGLKancNLEVLDLNNNGL 205

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958779887 161 ERVPSGL-------PRRVRTLMILHNQITGIGREDFATTYF-----LEELNLSYNRIT 206
Cdd:cd00116   206 TDEGASAlaetlasLKSLEVLNLGDNNLTDAGAAALASALLspnisLLTLSLSCNDIT 263
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
203-329 1.33e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 57.01  E-value: 1.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 203 NRITSPQMHRDAFRKLRLLRSLDLSGnrLQTLPPGLPKNVHVLKVKRNELAALARGALagmAKLRELYLTGNRLRSRalg 282
Cdd:PRK15370  164 NREEAVQRMRDCLKNNKTELRLKILG--LTTIPACIPEQITTLILDNNELKSLPENLQ---GNIKTLYANSNQLTSI--- 235

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1958779887 283 PRAWVDLagLQLLDIAGNQLTEIPEGLPPSLEYLYLQNNKISAVPAN 329
Cdd:PRK15370  236 PATLPDT--IQEMELSINRITELPERLPSALQSLDLFHNKISCLPEN 280
LRR_8 pfam13855
Leucine rich repeat;
311-371 9.67e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 9.67e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958779887 311 PSLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLavGSVVESAFRRLKHLQVLDIEGN 371
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
51-134 1.07e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  51 SNLRELYLQNNYLTDegLDNETFWKLSSLEYLDLSSNNlsrvpaglprslvllhleknvIQSVDADVLTPIRNLEYLLLH 130
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNL---------------------LTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 1958779887 131 SNQL 134
Cdd:pfam13855  58 GNRL 61
LRR_8 pfam13855
Leucine rich repeat;
265-323 1.06e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 1.06e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958779887 265 KLRELYLTGNRLRSraLGPRAWVDLAGLQLLDIAGNQLTEIPEGL---PPSLEYLYLQNNKI 323
Cdd:pfam13855   2 NLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPGAfsgLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
231-328 2.71e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 46.31  E-value: 2.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 231 LQTLPPGLPKNVHVLKVKRNELAALARGAlagmAKLRELYLTGNRLRSRALGPRAWVDLA--------------GLQLLD 296
Cdd:PRK15387  213 LTTLPDCLPAHITTLVIPDNNLTSLPALP----PELRTLEVSGNQLTSLPVLPPGLLELSifsnplthlpalpsGLCKLW 288

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958779887 297 IAGNQLTEIPEgLPPSLEYLYLQNNKISAVPA 328
Cdd:PRK15387  289 IFGNQLTSLPV-LPPGLQELSVSDNQLASLPA 319
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 5-163 3.34e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.42  E-value: 3.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887   5 SSNVEILILSSN--------FLRHVPKHLPPALYKLHLKNNKLEKIP----PGAFSELSNLRELYLQNNYLTDEGLDN-- 70
Cdd:cd00116   107 SSSLQELKLNNNglgdrglrLLAKGLKDLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDAGIRAla 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  71 ETFWKLSSLEYLDLSSNNLSrvpaglprslvllhlEKNVIQSvdADVLTPIRNLEYLLLHSNQLQAKGIHPLAFQ---GL 147
Cdd:cd00116   187 EGLKANCNLEVLDLNNNGLT---------------DEGASAL--AETLASLKSLEVLNLGDNNLTDAGAAALASAllsPN 249

                         170
                  ....*....|....*.
gi 1958779887 148 KRLHTVHLYNNALERV 163
Cdd:cd00116   250 ISLLTLSLSCNDITDD 265
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 52-206 3.78e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.55  E-value: 3.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  52 NLRELYLQNNYLTDEGLDN--ETFWKLSSLEYLDLSSNNLSrvpaglPRSLVLLhleknviqsvdADVLTPIRNLEYLLL 129
Cdd:COG5238   209 TVTTLWLKRNPIGDEGAEIlaEALKGNKSLTTLDLSNNQIG------DEGVIAL-----------AEALKNNTTVETLYL 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 130 HSNQLQAKGIHPLA--FQGLKRLHTVHL-YNNALERVPSGL------PRRVRTLMILHNQITGIGREDFATT----YFLE 196
Cdd:COG5238   272 SGNQIGAEGAIALAkaLQGNTTLTSLDLsVNRIGDEGAIALaeglqgNKTLHTLNLAYNGIGAQGAIALAKAlqenTTLH 351

                         170
                  ....*....|
gi 1958779887 197 ELNLSYNRIT 206
Cdd:COG5238   352 SLDLSDNQIG 361
LRR_8 pfam13855
Leucine rich repeat;
291-347 7.27e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 7.27e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 291 GLQLLDIAGNQLTEIPEGL---PPSLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKL 347
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 2-206 1.46e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.63  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887   2 FNGSSNVEILILSSNFL-----RHVPKHL--PPALYKLHLKNNKLE----KIPPGAFSELSNLRELYLQNNYLTDEGLDN 70
Cdd:COG5238   176 ALQNNSVETVYLGCNQIgdegiEELAEALtqNTTVTTLWLKRNPIGdegaEILAEALKGNKSLTTLDLSNNQIGDEGVIA 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  71 --ETFWKLSSLEYLDLSSNNLS-----RVPAGLPRSLVLLHLEKNVIQSVDADVLTPIRNLEY------LLLHSNQLQAK 137
Cdd:COG5238   256 laEALKNNTTVETLYLSGNQIGaegaiALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGnktlhtLNLAYNGIGAQ 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 138 GIHPL--AFQGLKRLHTVHLYNN--------ALERVPSGLPrRVRTLMILHNQITGIGREDFA---TTYFLEELNLSYNR 204
Cdd:COG5238   336 GAIALakALQENTTLHSLDLSDNqigdegaiALAKYLEGNT-TLRELNLGKNNIGKQGAEALIdalQTNRLHTLILDGNL 414


                  ..
gi 1958779887 205 IT 206
Cdd:COG5238   415 IG 416
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 25-206 2.66e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.85  E-value: 2.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  25 LPPALYKLHLKNNK-LEKIPPGafseLSNLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPA-------GL 96
Cdd:COG5238   131 LILYLALPRRINLIqVLKDPLG----GNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIeelaealTQ 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  97 PRSLVLLHLEKNVI--QSVD--ADVLTPIRNLEYLLLHSNQLQAKGIHPLA--FQGLKRLHTVHLYNN-----ALERVPS 165
Cdd:COG5238   207 NTTVTTLWLKRNPIgdEGAEilAEALKGNKSLTTLDLSNNQIGDEGVIALAeaLKNNTTVETLYLSGNqigaeGAIALAK 286

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1958779887 166 GLPRR--VRTLMILHNQITGIGREDFA----TTYFLEELNLSYNRIT 206
Cdd:COG5238   287 ALQGNttLTSLDLSVNRIGDEGAIALAeglqGNKTLHTLNLAYNGIG 333
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 265-371 1.03e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 265 KLRELYLTGNRLRSR---ALGPRAWVDLAG-LQLLDIAGNQLTEIpEGLPP--SLEYLYLQNNKISAVpanafdstpnlk 338
Cdd:cd21340    91 NLEELHIENQRLPPGeklTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPlrNLEQLDASNNQISDL------------ 157

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1958779887 339 giflrfnklavgSVVESAFRRLKHLQVLDIEGN 371
Cdd:cd21340   158 ------------EELLDLLSSWPSLRELDLTGN 178
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
25-182 2.16e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.15  E-value: 2.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  25 LPPALYKLHLKNNKLEKIPpgafSELSNLRELYLQNNYLTdegldneTFWKL-SSLEYLDLSSNNLSRVPAgLPRSLVLL 103
Cdd:PRK15387  300 LPPGLQELSVSDNQLASLP----ALPSELCKLWAYNNQLT-------SLPTLpSGLQELSVSDNQLASLPT-LPSELYKL 367

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958779887 104 HLEKNVIQSVDAdvlTPiRNLEYLLLHSNQLQAKGIHPlafqglKRLHTVHLYNNALERVPSgLPRRVRTLMILHNQIT 182
Cdd:PRK15387  368 WAYNNRLTSLPA---LP-SGLKELIVSGNRLTSLPVLP------SELKELMVSGNRLTSLPM-LPSGLLSLSVYRNQLT 435
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 299-369 2.36e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 2.36e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958779887 299 GNQLTEIpEGLP--PSLEYLYLQNNKISAVpaNAFDSTPNLKGIFLRFNKLavgSVVESaFRRLKHLQVLDIE 369
Cdd:cd21340    33 DNKITKI-ENLEflTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI---SVVEG-LENLTNLEELHIE 98
LRR_8 pfam13855
Leucine rich repeat;
98-160 2.39e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 2.39e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958779887  98 RSLVLLHLEKNVIQSVDADVLTPIRNLEYLLLHSNQLqaKGIHPLAFQGLKRLHTVHLYNNAL 160
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 2-88 2.84e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 37.52  E-value: 2.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887   2 FNGSSNVEILILSSNfLRHVPKHlppALYKLHLKN----NKLEKIPPGAFSELSNLRELYLQNNyLTDegLDNETFWKlS 77
Cdd:pfam13306  30 FSNCTSLKSITLPSS-LTSIGSY---AFYNCSLTSitipSSLTSIGEYAFSNCSNLKSITLPSN-LTS--IGSYAFSN-C 101

                          90
                  ....*....|.
gi 1958779887  78 SLEYLDLSSNN 88
Cdd:pfam13306 102 SLKSITIPSSV 112
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 52-89 2.87e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 2.87e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958779887  52 NLRELYLQNNYLTDEGLdnetFWKLSSLEYLDLSSNNL 89
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP----LAKLPNLETLDLSGNNK 35
PLN03150 PLN03150
hypothetical protein; Provisional
 29-96 5.72e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.03  E-value: 5.72e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958779887  29 LYKLHLKNNKLEKIPPGAFSELSNLRELYLQNNYLTdeGLDNETFWKLSSLEYLDLSSNNLS-RVPAGL 96
Cdd:PLN03150  444 LQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFN--GSIPESLGQLTSLRILNLNGNSLSgRVPAAL 510
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 55-371 7.01e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.11  E-value: 7.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887  55 ELYLQNNYLTDEGLDnETFWKLSSLEYLDLSSNNLSRVPAglprslvllhleknviqSVDADVLTPIRNLEYLLLHSNQL 134
Cdd:cd00116     2 QLSLKGELLKTERAT-ELLPKLLCLQVLRLEGNTLGEEAA-----------------KALASALRPQPSLKELCLSLNET 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 135 Q----AKGIHPLAFQGLKRLHTVHLYNNALervpsglprrvrtlmilhnQITGIGR-EDFATTYFLEELNLSYNRItspq 209
Cdd:cd00116    64 GriprGLQSLLQGLTKGCGLQELDLSDNAL-------------------GPDGCGVlESLLRSSSLQELKLNNNGL---- 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 210 mhrdafrklrLLRSLDLSGNRLQTLPPGLPKnvHVLKVKR--NELAALARGALAGMAKLRELYLTGNRLRS---RALGpR 284
Cdd:cd00116   121 ----------GDRGLRLLAKGLKDLPPALEK--LVLGRNRleGASCEALAKALRANRDLKELNLANNGIGDagiRALA-E 187

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958779887 285 AWVDLAGLQLLDIAGNQLTE-----IPEGLP--PSLEYLYLQNNKISAVPANAFDS-----TPNLKGIFLRFNKL---AV 349
Cdd:cd00116   188 GLKANCNLEVLDLNNNGLTDegasaLAETLAslKSLEVLNLGDNNLTDAGAAALASallspNISLLTLSLSCNDItddGA 267

                         330       340
                  ....*....|....*....|..
gi 1958779887 350 GSVVEsAFRRLKHLQVLDIEGN 371
Cdd:cd00116   268 KDLAE-VLAEKESLLELDLRGN 288
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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