NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958782153|ref|XP_038967819|]
View 

cysteine-rich motor neuron 1 protein isoform X3 [Rattus norvegicus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CRIM1_C super family cl44859
Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) ...
 745-875 3.03e-72

Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) interacts with growth factors implicated in motor neuron differentiation and survival, playing a role in central nervous system development. It is upregulated in endothelial cells during tube formation. CRIM1 also modulates BMP activity, which affects its processing and delivery to the cell surface. This is CRIM1 C-terminal domain containing the transmembrane region.


The actual alignment was detected with superfamily member pfam19442:

Pssm-ID: 437274  Cd Length: 130  Bit Score: 233.20  E-value: 3.03e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782153 745 ENDIIHLPRDMGHLQVDYRDNNRLHPSEDSSLDSIVPVVVPIIICLSIIIAFLLINQKKQWIPLLCwYRTPTKPSSLNNQ 824
Cdd:pfam19442   1 ENDIVHQPRDMGHLQVDYREGSRPHPSEDSSLHSVAWVTVPIMIALVLIIALLLINQKKQWIPVPC-YRTPTKPSCLNNQ 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958782153 825 LVSVDCKKGTRVQVDGSQRMLRIAEPDARFSGFYSMQKQNHLQADNFYQTV 875
Cdd:pfam19442  80 LVYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQTV 130
IGFBP pfam00219
Insulin-like growth factor binding protein;
39-90 5.15e-08

Insulin-like growth factor binding protein;


:

Pssm-ID: 459717  Cd Length: 53  Bit Score: 50.02  E-value: 5.15e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958782153  39 PCDESKC-EEPRSCPGSIVQGVCGCCYMCARQRNESCGGAYGLhgaCDRGLRC 90
Cdd:pfam00219   4 PCDPERCpPPPPGCPAGVVLDGCGCCKVCARQEGEPCGVYTPP---CGKGLRC 53
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 657-711 5.87e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 47.03  E-value: 5.87e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958782153 657 CHFSGKTYADEERWDIDSCTHCYCLQGQTLCSTVSCPPLPCAEP--IKVEGSCCPMC 711
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 521-572 1.66e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 45.88  E-value: 1.66e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958782153 521 GGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQ--DSCCPQC 572
Cdd:pfam00093   4 NGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
241-294 2.97e-05

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.50  E-value: 2.97e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958782153  241 CYANGQIRAHGDRWREDDCTFCQCINGEP-HCVATAC--GQSCMHP--VKVPGECCPVC 294
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECppPPDCPNPerVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
174-228 3.28e-05

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.12  E-value: 3.28e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958782153  174 CVFNSVEYYDGDMFRMDNCRFCRCQGGVSI-CFTAQCGE-LNCERYY--VPEGECCPVC 228
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCPNPErvKPPGECCPRC 59
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 596-646 1.35e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 40.49  E-value: 1.35e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958782153 596 GDIFLAAESWKPDVCTSCVCMDSSISCYSESCPSVACERPVLRK--GQCCPYC 646
Cdd:pfam00093   5 GVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 405-430 9.13e-04

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


:

Pssm-ID: 460713  Cd Length: 26  Bit Score: 37.15  E-value: 9.13e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958782153 405 CPELPCSKVCPLGFQEDSHGCLICKC 430
Cdd:pfam02822   1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 450-500 2.17e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 37.02  E-value: 2.17e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958782153 450 DGHHHKNEESWH-DGCRECYCHNGKEMCALITCPVPACGNPT--IRPGQCCPSC 500
Cdd:pfam00093   4 NGVVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 377-402 5.96e-03

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


:

Pssm-ID: 460713  Cd Length: 26  Bit Score: 34.84  E-value: 5.96e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958782153 377 CRPTICDKFCPLGFLRNKHGCDICRC 402
Cdd:pfam02822   1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
 
Name Accession Description Interval E-value
CRIM1_C pfam19442
Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) ...
 745-875 3.03e-72

Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) interacts with growth factors implicated in motor neuron differentiation and survival, playing a role in central nervous system development. It is upregulated in endothelial cells during tube formation. CRIM1 also modulates BMP activity, which affects its processing and delivery to the cell surface. This is CRIM1 C-terminal domain containing the transmembrane region.


Pssm-ID: 437274  Cd Length: 130  Bit Score: 233.20  E-value: 3.03e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782153 745 ENDIIHLPRDMGHLQVDYRDNNRLHPSEDSSLDSIVPVVVPIIICLSIIIAFLLINQKKQWIPLLCwYRTPTKPSSLNNQ 824
Cdd:pfam19442   1 ENDIVHQPRDMGHLQVDYREGSRPHPSEDSSLHSVAWVTVPIMIALVLIIALLLINQKKQWIPVPC-YRTPTKPSCLNNQ 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958782153 825 LVSVDCKKGTRVQVDGSQRMLRIAEPDARFSGFYSMQKQNHLQADNFYQTV 875
Cdd:pfam19442  80 LVYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQTV 130
IGFBP pfam00219
Insulin-like growth factor binding protein;
39-90 5.15e-08

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 50.02  E-value: 5.15e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958782153  39 PCDESKC-EEPRSCPGSIVQGVCGCCYMCARQRNESCGGAYGLhgaCDRGLRC 90
Cdd:pfam00219   4 PCDPERCpPPPPGCPAGVVLDGCGCCKVCARQEGEPCGVYTPP---CGKGLRC 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 657-711 5.87e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 47.03  E-value: 5.87e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958782153 657 CHFSGKTYADEERWDIDSCTHCYCLQGQTLCSTVSCPPLPCAEP--IKVEGSCCPMC 711
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 521-572 1.66e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 45.88  E-value: 1.66e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958782153 521 GGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQ--DSCCPQC 572
Cdd:pfam00093   4 NGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
657-711 9.88e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 43.66  E-value: 9.88e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958782153  657 CHFSGKTYADEERWDIDSCTHCYCLQGQT-LCSTVSCPPLPC---AEPIKVEGSCCPMC 711
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECPPPPDcpnPERVKPPGECCPRC 59
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 37-95 1.58e-05

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 43.61  E-value: 1.58e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782153   37 CLPCDESKC-EEPRSCPGSIVQGVCGCCYMCARQRNESCGGAyglHGACDRGLRCVIRPP 95
Cdd:smart00121   3 CPPCDPARCpPCPPGCAELVRLDGCGCCPVCARQEGEPCGVY---TPRCAPGLRCQPPPG 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
241-294 2.97e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.50  E-value: 2.97e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958782153  241 CYANGQIRAHGDRWREDDCTFCQCINGEP-HCVATAC--GQSCMHP--VKVPGECCPVC 294
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECppPPDCPNPerVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
174-228 3.28e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.12  E-value: 3.28e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958782153  174 CVFNSVEYYDGDMFRMDNCRFCRCQGGVSI-CFTAQCGE-LNCERYY--VPEGECCPVC 228
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCPNPErvKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
521-572 4.90e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 41.73  E-value: 4.90e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958782153  521 GGEYFVEGETWNIDSCTQCTCHSGR-VLCETEVCPP-LLCQNPSRTQ--DSCCPQC 572
Cdd:smart00214   4 NGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKppGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 174-228 5.75e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 41.64  E-value: 5.75e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958782153 174 CVFNSVEYYDGDMFRMDNCRFCRCQGGVSICFTAQCGELNCE--RYYVPEGECCPVC 228
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPnpRLEIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 596-646 1.35e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.49  E-value: 1.35e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958782153 596 GDIFLAAESWKPDVCTSCVCMDSSISCYSESCPSVACERPVLRK--GQCCPYC 646
Cdd:pfam00093   5 GVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
596-646 4.18e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.04  E-value: 4.18e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958782153  596 GDIFLAAESWKPDVCTSCVCMDSS-ISCYSESCPSV-ACERPVLRK--GQCCPYC 646
Cdd:smart00214   5 GRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPPpDCPNPERVKppGECCPRC 59
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 405-430 9.13e-04

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 37.15  E-value: 9.13e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958782153 405 CPELPCSKVCPLGFQEDSHGCLICKC 430
Cdd:pfam02822   1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 450-500 2.17e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.02  E-value: 2.17e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958782153 450 DGHHHKNEESWH-DGCRECYCHNGKEMCALITCPVPACGNPT--IRPGQCCPSC 500
Cdd:pfam00093   4 NGVVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 245-294 5.85e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 40.06  E-value: 5.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958782153 245 GQIRAHGD---RWRED---DCTFCQCINGEPH---C--VATACGQ-SCMHPVKVPGECCPVC 294
Cdd:pfam14828 174 GQLQFHGAgalRVGPEacsDPSGCGCGNDENLeriCanVLQRCPPpHCLSPLRPEGHCCDVC 235
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 377-402 5.96e-03

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 34.84  E-value: 5.96e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958782153 377 CRPTICDKFCPLGFLRNKHGCDICRC 402
Cdd:pfam02822   1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
 
Name Accession Description Interval E-value
CRIM1_C pfam19442
Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) ...
 745-875 3.03e-72

Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) interacts with growth factors implicated in motor neuron differentiation and survival, playing a role in central nervous system development. It is upregulated in endothelial cells during tube formation. CRIM1 also modulates BMP activity, which affects its processing and delivery to the cell surface. This is CRIM1 C-terminal domain containing the transmembrane region.


Pssm-ID: 437274  Cd Length: 130  Bit Score: 233.20  E-value: 3.03e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782153 745 ENDIIHLPRDMGHLQVDYRDNNRLHPSEDSSLDSIVPVVVPIIICLSIIIAFLLINQKKQWIPLLCwYRTPTKPSSLNNQ 824
Cdd:pfam19442   1 ENDIVHQPRDMGHLQVDYREGSRPHPSEDSSLHSVAWVTVPIMIALVLIIALLLINQKKQWIPVPC-YRTPTKPSCLNNQ 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958782153 825 LVSVDCKKGTRVQVDGSQRMLRIAEPDARFSGFYSMQKQNHLQADNFYQTV 875
Cdd:pfam19442  80 LVYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQTV 130
IGFBP pfam00219
Insulin-like growth factor binding protein;
39-90 5.15e-08

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 50.02  E-value: 5.15e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958782153  39 PCDESKC-EEPRSCPGSIVQGVCGCCYMCARQRNESCGGAYGLhgaCDRGLRC 90
Cdd:pfam00219   4 PCDPERCpPPPPGCPAGVVLDGCGCCKVCARQEGEPCGVYTPP---CGKGLRC 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 657-711 5.87e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 47.03  E-value: 5.87e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958782153 657 CHFSGKTYADEERWDIDSCTHCYCLQGQTLCSTVSCPPLPCAEP--IKVEGSCCPMC 711
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 521-572 1.66e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 45.88  E-value: 1.66e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958782153 521 GGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQ--DSCCPQC 572
Cdd:pfam00093   4 NGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
657-711 9.88e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 43.66  E-value: 9.88e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958782153  657 CHFSGKTYADEERWDIDSCTHCYCLQGQT-LCSTVSCPPLPC---AEPIKVEGSCCPMC 711
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECPPPPDcpnPERVKPPGECCPRC 59
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 37-95 1.58e-05

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 43.61  E-value: 1.58e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782153   37 CLPCDESKC-EEPRSCPGSIVQGVCGCCYMCARQRNESCGGAyglHGACDRGLRCVIRPP 95
Cdd:smart00121   3 CPPCDPARCpPCPPGCAELVRLDGCGCCPVCARQEGEPCGVY---TPRCAPGLRCQPPPG 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
241-294 2.97e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.50  E-value: 2.97e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958782153  241 CYANGQIRAHGDRWREDDCTFCQCINGEP-HCVATAC--GQSCMHP--VKVPGECCPVC 294
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECppPPDCPNPerVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
174-228 3.28e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.12  E-value: 3.28e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958782153  174 CVFNSVEYYDGDMFRMDNCRFCRCQGGVSI-CFTAQCGE-LNCERYY--VPEGECCPVC 228
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCPNPErvKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
521-572 4.90e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 41.73  E-value: 4.90e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958782153  521 GGEYFVEGETWNIDSCTQCTCHSGR-VLCETEVCPP-LLCQNPSRTQ--DSCCPQC 572
Cdd:smart00214   4 NGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKppGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 174-228 5.75e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 41.64  E-value: 5.75e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958782153 174 CVFNSVEYYDGDMFRMDNCRFCRCQGGVSICFTAQCGELNCE--RYYVPEGECCPVC 228
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPnpRLEIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 596-646 1.35e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.49  E-value: 1.35e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958782153 596 GDIFLAAESWKPDVCTSCVCMDSSISCYSESCPSVACERPVLRK--GQCCPYC 646
Cdd:pfam00093   5 GVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
596-646 4.18e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.04  E-value: 4.18e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958782153  596 GDIFLAAESWKPDVCTSCVCMDSS-ISCYSESCPSV-ACERPVLRK--GQCCPYC 646
Cdd:smart00214   5 GRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPPpDCPNPERVKppGECCPRC 59
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 405-430 9.13e-04

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 37.15  E-value: 9.13e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958782153 405 CPELPCSKVCPLGFQEDSHGCLICKC 430
Cdd:pfam02822   1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 665-711 9.49e-04

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 42.76  E-value: 9.49e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958782153 665 ADEERWDIDSCTH---CYC---LQGQTLCSTVS--CPPLPCAEPIKVEGSCCPMC 711
Cdd:pfam14828 181 AGALRVGPEACSDpsgCGCgndENLERICANVLqrCPPPHCLSPLRPEGHCCDVC 235
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 450-500 2.17e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.02  E-value: 2.17e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958782153 450 DGHHHKNEESWH-DGCRECYCHNGKEMCALITCPVPACGNPT--IRPGQCCPSC 500
Cdd:pfam00093   4 NGVVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 245-294 5.85e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 40.06  E-value: 5.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958782153 245 GQIRAHGD---RWRED---DCTFCQCINGEPH---C--VATACGQ-SCMHPVKVPGECCPVC 294
Cdd:pfam14828 174 GQLQFHGAgalRVGPEacsDPSGCGCGNDENLeriCanVLQRCPPpHCLSPLRPEGHCCDVC 235
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 377-402 5.96e-03

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 34.84  E-value: 5.96e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958782153 377 CRPTICDKFCPLGFLRNKHGCDICRC 402
Cdd:pfam02822   1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 467-500 6.21e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 40.06  E-value: 6.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1958782153 467 CYCHNGK---EMCA--LITCPVPACGNPtIRP-GQCCPSC 500
Cdd:pfam14828 197 CGCGNDEnleRICAnvLQRCPPPHCLSP-LRPeGHCCDVC 235
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 241-294 6.88e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 35.48  E-value: 6.88e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958782153 241 CYANGQIRAHGDRWREDDCTFCQCINGEPHCVATACGQ-SCMHP--VKVPGECCPVC 294
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPlDCPNPrlEIPPGECCPVC 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH