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Conserved domains on  [gi|62648314|ref|XP_575715|]
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sulfotransferase 6B1 isoform X2 [Rattus norvegicus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
37-275 1.65e-70

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 218.75  E-value: 1.65e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62648314    37 EDDIFLVSYPKSGTHWLAEVIERIPN--AGITLTSPV-----------ELGDISKFEELRMVPKR-------RVIPTHLN 96
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNrgDFEKSEEPHlfnnhnrspflEWYPGDTYFDVAEGPVRlnalpspRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62648314    97 YEMLPVTVKQKQCKIIYIVRNPKDTAVSMFHYYRDNPNLPSTETWAAFLELFLKGDVVYGSWFDHVLSWEEHKNDKNVLF 176
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62648314   177 LFYEEMKKDFVKSLKKITAFLGIDVNDSEMGKIARSTSFSEMKSNAAKencdpNHVicALTSNRNLVFRKGVVGDWINYF 256
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCL-----NYS--KLPKEVSPFFRKGLVGDWKNYF 233

                         250
                  ....*....|....*....
gi 62648314   257 TPKQNRAFDELFTEKMRNS 275
Cdd:pfam00685 234 TPEQAEKFDEIYQEKMKGT 252
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
37-275 1.65e-70

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 218.75  E-value: 1.65e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62648314    37 EDDIFLVSYPKSGTHWLAEVIERIPN--AGITLTSPV-----------ELGDISKFEELRMVPKR-------RVIPTHLN 96
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNrgDFEKSEEPHlfnnhnrspflEWYPGDTYFDVAEGPVRlnalpspRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62648314    97 YEMLPVTVKQKQCKIIYIVRNPKDTAVSMFHYYRDNPNLPSTETWAAFLELFLKGDVVYGSWFDHVLSWEEHKNDKNVLF 176
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62648314   177 LFYEEMKKDFVKSLKKITAFLGIDVNDSEMGKIARSTSFSEMKSNAAKencdpNHVicALTSNRNLVFRKGVVGDWINYF 256
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCL-----NYS--KLPKEVSPFFRKGLVGDWKNYF 233

                         250
                  ....*....|....*....
gi 62648314   257 TPKQNRAFDELFTEKMRNS 275
Cdd:pfam00685 234 TPEQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 24-280 1.16e-33

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 125.80  E-value: 1.16e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62648314   24 EELLGSLDSFDAREDDIFLVSYPKSGTHWLAEVIERIPNAG--------ITLTSPVEL-----GDISKFEELRMVPKRR- 89
Cdd:PLN02164  66 EGLLHAQEFFQARPNDFLVCSYPKTGTTWLKALTFAIANRSrfddssnpLLKRNPHEFvpyieIDFPFFPSVDVLKDKGn 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62648314   90 -VIPTHLNYEMLPVTVKQKQCKIIYIVRNPKDTAVSMFHY-YRDNPNLPSTETWAAFLELFLKGDVVYGSWFDHVLS-WE 166
Cdd:PLN02164 146 tLFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGyWK 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62648314  167 EHK-NDKNVLFLFYEEMKKDFVKSLKKITAFLGIDVNDSE-----MGKIARSTSFSEMKSNAAKENCDPNHVICALTSNr 240
Cdd:PLN02164 226 AYQeNPDRILFLKYETMRADPLPYVKRLAEFMGYGFTAEEeekgvVEKVVKLCSFETLKNLEANKGEKDREDRPAVYAN- 304

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 62648314  241 NLVFRKGVVGDWINYFTPKQNRAFDELFTEKMRNSEVGRH 280
Cdd:PLN02164 305 SAYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGLLEH 344
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
37-275 1.65e-70

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 218.75  E-value: 1.65e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62648314    37 EDDIFLVSYPKSGTHWLAEVIERIPN--AGITLTSPV-----------ELGDISKFEELRMVPKR-------RVIPTHLN 96
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNrgDFEKSEEPHlfnnhnrspflEWYPGDTYFDVAEGPVRlnalpspRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62648314    97 YEMLPVTVKQKQCKIIYIVRNPKDTAVSMFHYYRDNPNLPSTETWAAFLELFLKGDVVYGSWFDHVLSWEEHKNDKNVLF 176
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62648314   177 LFYEEMKKDFVKSLKKITAFLGIDVNDSEMGKIARSTSFSEMKSNAAKencdpNHVicALTSNRNLVFRKGVVGDWINYF 256
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCL-----NYS--KLPKEVSPFFRKGLVGDWKNYF 233

                         250
                  ....*....|....*....
gi 62648314   257 TPKQNRAFDELFTEKMRNS 275
Cdd:pfam00685 234 TPEQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 24-280 1.16e-33

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 125.80  E-value: 1.16e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62648314   24 EELLGSLDSFDAREDDIFLVSYPKSGTHWLAEVIERIPNAG--------ITLTSPVEL-----GDISKFEELRMVPKRR- 89
Cdd:PLN02164  66 EGLLHAQEFFQARPNDFLVCSYPKTGTTWLKALTFAIANRSrfddssnpLLKRNPHEFvpyieIDFPFFPSVDVLKDKGn 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62648314   90 -VIPTHLNYEMLPVTVKQKQCKIIYIVRNPKDTAVSMFHY-YRDNPNLPSTETWAAFLELFLKGDVVYGSWFDHVLS-WE 166
Cdd:PLN02164 146 tLFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGyWK 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62648314  167 EHK-NDKNVLFLFYEEMKKDFVKSLKKITAFLGIDVNDSE-----MGKIARSTSFSEMKSNAAKENCDPNHVICALTSNr 240
Cdd:PLN02164 226 AYQeNPDRILFLKYETMRADPLPYVKRLAEFMGYGFTAEEeekgvVEKVVKLCSFETLKNLEANKGEKDREDRPAVYAN- 304

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 62648314  241 NLVFRKGVVGDWINYFTPKQNRAFDELFTEKMRNSEVGRH 280
Cdd:PLN02164 305 SAYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGLLEH 344
Sulfotransfer_3 pfam13469
Sulfotransferase family;
40-203 8.70e-09

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 53.83  E-value: 8.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62648314    40 IFLVSYPKSGT-------------HWLAEVIERIPNAGITLTSPVELgdiskFEELRMVPK--RRVI---PTHLNY---- 97
Cdd:pfam13469   1 IFIVGLPRSGTtllhrllaahpdvRPPEETWFVIPRILALLQAWGKS-----LEALARVPSyaRWLCdksPSHLFHldll 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62648314    98 -EMLPvtvkqkQCKIIYIVRNPKDTAV-SMFHYYRDNpnlpsTETWAAFLELFLKGDVVYgsWFDHVLSWEEHK---NDK 172
Cdd:pfam13469  76 lKAFP------DAKFIHLHRDPVDTVIsSYCSLFGFT-----LSSYSTAFLRDIGLALAR--WSRAYERLMAARarvPPG 142

                         170       180       190
                  ....*....|....*....|....*....|.
gi 62648314   173 NVLFLFYEEMKKDFVKSLKKITAFLGIDVND 203
Cdd:pfam13469 143 RFLDVRYEDLVADPEGTLRRILEFLGLPWDD 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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