5VLA


Conserved Protein Domain Family
Inhibitor_I9
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pfam05922: Inhibitor_I9 
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Peptidase inhibitor I9
This family includes the proteinase B inhibitor from Saccharomyces cerevisiae and the activation peptides from peptidases of the subtilisin family. The subtilisin propeptides are known to function as molecular chaperones, assisting in the folding of the mature peptidase, but have also been shown to act as 'temporary inhibitors'.
Links
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Statistics
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PSSM-Id: 428674
Aligned: 71 rows
Threshold Bit Score: 43.4365
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5VLA_A        77 TYVVVLKEeTHLSQ-----SERTARRLQA-------------Q--------AARRGy--------LTKILHVFHG---LL 119 human
G1X8P8        39 KYIVVLKKgLSDSA------VSKHTNRISsf---------hsN--------VARDLtg-----arAHGVGRKFRFsstGF 90  Orbilia oligosp...
C5FPS1        34 SYIVVMKDgTTEED------FTHHQSWVQsi---------htHn-------VTRRGll------dNAGVRHKYGFg--SM 83  Microsporum can...
XP_001391470  43 SYIVVFKKhVTSEL------ASAHHSWVQdi---------hdSqse--rteLKK-RslfglgdevYLGLKNTFDIa-gSL 103
CAP96594      43 SYIVVFKKhVDPSS------ASAHQSWLQev---------htAhtg--rmeLKKRSlfgf-dfeaFMGLKHTFHIa-gSL 103
P58371        43 AYIIKFKKhVDHKS------AADHQMWIQkvhgerederlelRkrgl-fdsVnd----------aFTGLKHTYNVg-sGF 104 Pyricularia ory...
XP_001905001  43 aYIVKFKKhVTEEK------VSDHHTWIQel---------htTreneridlKKRGQfplv--ddvFHGLKHTYKVg-sEF 104
P25036        70 RYVIVFNEdISLQQ------IQSHMQVVQkdhstsvgk----ltendafwrVISSSvss---ksqFGGIDNFFDIn-gLF 135 Saccharomyces c...
P09232       182 RYIIVFKRgAPQEEidfhkENVQQAQLQSvenlsa----------edaffiSTKDTsls---tseAGGIQDSFNId-nLF 247 Saccharomyces c...
P40903        85 HYIIVLQPdLSEQE------FQAHTNWVSemhqmd-----------iasqeDEYYDtsd---snyMFGLKHVYDFgedSF 144 Schizosaccharom...

5VLA_A       120 PGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQ 152 human
G1X8P8        91 NGYVGGFDKATLQEILNSPEVDYVEQDTVVTTy 123 Orbilia oligospora ATCC 24927
C5FPS1        84 MGYAGLFDEDTIKDISDDPKVMFVEPDTTITIH 116 Microsporum canis CBS 113480
XP_001391470 104 IGYSGHFHEDVIEQVRRHPDVDYIERDSEVHTM 136
CAP96594     104 LGYAGHFHEDVIEQIRRHPDVDYIEKDSEVRTM 136
P58371       105 LGYAGHFDEETIEKVRRHPDVEAIERDTIVHTM 137 Pyricularia oryzae 70-15
XP_001905001 105 LGYAGHFDEETIEKVRRHPDVEYIERDSIVHTM 137
P25036       136 RGYTGYFTDEIIKIISQDPIIKFVEQETTVKIS 168 Saccharomyces cerevisiae S288C
P09232       248 SGYIGYFTQEIVDLIRQNPLVDFVERDSIVEAT 280 Saccharomyces cerevisiae S288C
P40903       145 KGYSGQFSSNIVEQIRLHPHVIAVERDQVVSIK 177 Schizosaccharomyces pombe 972h-
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