Conserved Protein Domain Family
POU2F1_C

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pfam19536: POU2F1_C 
POU domain, class 2, transcription factor 1 C-terminal
This domain represents the C-terminal region of the POU domain, class 2 subfamily, transcription factor 1, which is localized adjacent to the homeobox domain. This transcription factor activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins.
Statistics
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PSSM-Id: 437368
Aligned: 12 rows
Threshold Bit Score: 154.251
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_008326261 419 STPIKTIFTPSSPLVASPACLVTSstiNTPTTLTVNPV-MPLTSTSVSSLSFTGt-TVGA--TNTTSVIS--NAPMVTTA 492
5_pfamImport   1 CTPIKTLFTPSSPLVASTASLVSSptiNTPTTLTVNSV-MPLTSTSVSSLSFTG--VYRC--TNTASVIS--AAPIFTTA 73 
8_pfamImport   1 SSPIKAIFPSPTSLVATTPSLVTS---SAATTLTVNPV-LPLTSAAVTSLSVTGn-SLKTf-SGCSFLYS--GKHPSSSS 72 
XP_013867088 347 NTPIKTIFTPSSPLVASTASLVSSpsiNTSTTLTVNPV-MPLTSTSVSSVTFTGt-AVGG--TNTASVIS--TAPVNATS 420
XP_013131638 396 NTPIKSIFTPSSPLVASTASLDSSptiTTPTTLTVNPV-MPLTNTSIANLSFTGt-AVGA--TNTASVIS--TAPVVSTA 469 Nile tilapia
XP_017213140 405 STPIKAIFSPTTTLVPSTASLITS---NTPTTMTVNPV-LPLTSTSVSGISFTGt-TLGSaiNNTASVIS--TAPAATTA 477 zebrafish
XP_005663189 472 SSPIKAIFPSPTSLVATTPSLVTS---SAATTLTVNPV-LPLTSAAVTNLSVTGt-TDTTs-NNTATVIS--TAPPASSA 543 pig
XP_020379152   1 -------------------------------------MqMPASSAGVTNFSISGttASGTapTNVASVITglSSAVSTSA 43  whale shark
XP_015219797 407 STPIKAIFPNPNTMVPSTASLVTS---NTPTTLTVTNL--GFTGTT-------Gi-GPAT--TNTASVIS--TTPVASSA 469 spotted gar
XP_028969253 416 STPIKSIFSPTSPLVASTASLLTS---TTPTTLTVNPG-MPMNSTSVSGQTFTGttASGAt-TNTASVIS--TTPMVTTV 488 northern pike
XP_022536330 439 STPIKAIFSTSTALAPSTASLVTS---TTPTTLTVNPV-LPLTSTSVSSMGFTVt-TVGApsTNTASVIS--TVPAICTA 511 Mexican tetra
XP_011606442 382 STPIKTIFTPSSPLVASTASLVSSptiNTSSTLTVNTV-MPLTSTSVSSLPFTGt-TIGP--TNTASVIS--TASMVTAA 455 torafugu
XP_008326261 493 tSS---SSSPATSQSMTAESKTh--aAAVPTQAATSIGTTLGTGQVMVAAPGLS----------AALQGA--QLPttASF 555
5_pfamImport  74 -SSpslSPSPTTIQSGNSESKV----QTILNQVPTSIATTLGTGQVMVSASGLS----------AALQGA--QLP--GSF 134
8_pfamImport  73 iHGrqlPSIPTSSGPSSDALGVeycnSLSLTTLS--LESPQGSADILSPKSYLLhk------grGARCGAr-RGPrsVAR 143
XP_013867088 421 tSSpsvSPSTTTFQSTSTDSKAg--lHAIVTQTPTSVATTLGAGQVMVAAPSLS----------AALQGAa-QLStsSSF 487
XP_013131638 470 tSSpslSTSQTSNQSTTTESKAgtqaQTIFTQAPSSIATSLGTGQVMVAAPGLS----------AALQGAa-SLPs-ASF 537 Nile tilapia
XP_017213140 478 sSSpslSPSPTAVQTSSSEQASaqetLTAVSQAPSSLASTLGTGQVMVAAPSLS----------AALQGAa-QLPtsASI 546 zebrafish
XP_005663189 544 vTSpslSPSPSASASTSEASSAsetsTTQTTSTP--LSSPLGTSQVMVTASGLQta------aaAALQGAa-QLPanASL 614 pig
XP_020379152  44 vTSpslTPSPSASISVTESSSSsdanTTQSTSTG--LVNPLCTSQITVSASGLQtganalqaaaAQVSTGa-GLAtnPGL 120 whale shark
XP_015219797 470 vTSpslSPSPTSLHAP-ITESPssqeTSTTTQAPSSMSSPLGSGQVMVTAPGLS----------AALQGAatQLPtnAGL 538 spotted gar
XP_028969253 489 tSSpslSPSPTALRST-AVETGgtheQAAVTQAPSSLATTLGTGQVMVAGPGLS----------AALQGAa-QMPtsASF 556 northern pike
XP_022536330 512 tSSpslSPSPSALHASSSESSVaqepITTVTQAPSSLASTLASGQVMVAAPGLS----------AALQGAt-QLPtsASI 580 Mexican tetra
XP_011606442 456 nSSpslSPSPTINQARIAESKAv--sNAQTSITPTSIATTVGAGQVMVASPGLS----------AALHSAa-QLPtsASF 522 torafugu
XP_008326261 556 AAMAAAA-GLNPGL--MASSQFAPGGALLSLTpGGLSSTLGSAFLSNSTLATIQ----ALASNGtipITSLDGs-NLLFA 627
5_pfamImport 135 AAMAAAA-GLNSGL--MASSQFSPGGALLSLT-GGLGGGLSPALMSNSTLATIQ----ALASSG---ITSLDG--NLLFA 201
8_pfamImport 144 ALPAAAG-RFADPHerATGPRFTVKGALLSLNpGTLGGALSPALMSNSTLATIQ----ALASGGslpITSLDAtgNLVFA 218
XP_013867088 488 AAMAAAAaGLNSSL--MTSPQFAPGGALLSLTpGGLSSALSPALMSNNTLATIQ----ALASGGtisLPSLDAg-NLLFA 560
XP_013131638 538 AAMAAAA-GLNPAL--MASSQFTQGGALLSLApGGLGSALSPALMSNSTLATIQ----ALASSGtipITSLDGs-NLLFA 609 Nile tilapia
XP_017213140 547 AAMAAAA-GLNPGL--MASSQFAPGGALLSLApGGLGSALSPALMSNSTLATIQ----ALASSGtlpITSLDGsgNLLFA 619 zebrafish
XP_005663189 615 AAMAAAA-GLNPGL--MAPSQFAAGGALLSLNpGTLGGALSPALMSNSTLATIQ----ALASGGslpITSLDAtgNLVFA 687 pig
XP_020379152 121 AAMAAAAgLANPAL--MSAPQFAAGGALLSLNpGSLGGALGPALMSNSTLATIQ----ALASSGtlpITSLDAsgNLLFA 194 whale shark
XP_015219797 539 AAMAAAA-GLNPGL--MASSQFSPGGALLSLNpGTLGSALSPALMSNSTLATIQ----ALASSGtlpITSLDGsgNLLFA 611 spotted gar
XP_028969253 557 AAMA----GLNPGL--MASSQFNPGGALLSLApGGLGGALNPAMLSNSTLATIQglwsALASGGtlpITSLDGsgNLLFA 630 northern pike
XP_022536330 581 AAMAAAA-GLSPGL--MASSQFTPGGALLSLApGGLGSALSPALMSNSTLATIQgvwsALASSGtlpITSLDGsgNFLFA 657 Mexican tetra
XP_011606442 523 AAMAAAA-GLNPGL--MASSQFAPGGALLSLTpGGLGCALSPALMSNSTLATIQ----ALASSGtipITSLDGs-NLLFA 594 torafugu
XP_008326261 628 NT-SGSngsn---mvtFLNPQNLSLLN--NPVSLLSTG-G-----LQVDAH-----HQSTA--VPVQTSTISTASK---A 685
5_pfamImport 202 NT-STGtp-------iFLSPQNLSLLTs-SPLSLVSAG-Pgg-lqVTSDAH-----HQASAaaVPVQASTITTASK---A 262
8_pfamImport 219 N---AGgapnivtaplFLNPQNLSLLTs-NPVSLVSAAaAsagnsGPVASL-----HATSTstESIQNSLFTVASAsgaA 289
XP_013867088 561 NT-SAAntpnlvttplFLNPQNLSLLTs-NPVSLVSTG-Tgg-lhVTTDAH-----HQAASaaVPVQTSTITTASK---A 628
XP_013131638 610 NT-SAGntpnlvttplFLNPQNLSLLTs-NPVSLVSTG-Agg-lqVTADGH-----HQASTaaVPVQASTITTAPK---A 677 Nile tilapia
XP_017213140 620 NT-SAGstpnlvtaplFLNPQNLSLLAs-NPVSLVSAGgAag-aaGALNLHftadaHQSAVttATMPASTITTASK---A 693 zebrafish
XP_005663189 688 N---AGgapnivtaplFLNPQNLSLLTs-NPVSLVSAAaAsagnsGPVASL-----HATSTsaESIQNSLFTVASAs-gA 757 pig
XP_020379152 195 NaaNPGgtpnivtgplFLNPQNLSLLTsnPAVSLISAAgt----tGHAASL-----QMASMstDSSQNSSFTVTSAg--G 263 whale shark
XP_015219797 612 N---ANaggnlvtaplFLNPQNLSLLTs-NPVSLVSSAaAsagasAQALNL-----QVTSAagESNQSAVTSVAGPa--A 680 spotted gar
XP_028969253 631 NT-SAGstpnlvtaplFLNPQNLSLLTs-NPVSLVSAGtAgg-gsLQVTAD-----HQVTTttVPVPASTVTMASK---A 699 northern pike
XP_022536330 658 NA-SAGstpnlvtaplFLNPQNLSLLTs-NPVSLVSAGgArg-lpEPSTCT-----LPLTPttVPSPRRPCLPPQS---P 726 Mexican tetra
XP_011606442 595 NA-SAGntpnlvttplFLNPQNLSVLTs-NPVSLVSAGgg---lqVTADTH-----HQPTTa-VSVQASTISTASK---A 660 torafugu
XP_008326261 686 Q 686
5_pfamImport 263 Q 263
8_pfamImport 290 A 290
XP_013867088 629 Q 629
XP_013131638 678 Q 678 Nile tilapia
XP_017213140 694 Q 694 zebrafish
XP_005663189 758 A 758 pig
XP_020379152 264 A 264 whale shark
XP_015219797 681 A 681 spotted gar
XP_028969253 700 Q 700 northern pike
XP_022536330 727 P 727 Mexican tetra
XP_011606442 661 Q 661 torafugu
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