Conserved Protein Domain Family
CENP-I

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pfam07778: CENP-I 
Mis6
Mis6 is an essential centromere connector protein acting during G1-S phase of the cell cycle. Mis6 is thought to be required for recruiting CENP-A, the centromere- specific histone H3 variant, an important event for centromere function and chromosome segregation during mitosis.
Statistics
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PSSM-Id: 429654
Aligned: 5 rows
Threshold Bit Score: 905.409
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007669732   9 LCSQKRKRVSRGRRSTQTDLAAWRLGERTSGSKPVnlkTGQKQREEDFTSDDDQAqdgeRDSLRKALRYFEKGQISVPLR 88 
XP_006257277   8 RNSQQQNRISQGSNSRQTTLLDWKVKDKAGNSKSV---LEESSSLEDSNHADDQT----EDALQTAVEYFQKGPKKASLS 80 
XP_010599689   7 VNSEAQRRTSQGRLSDQ-------IKEKPSYSESIl-kHGQNNPEEDSEHA---------EVLQIALRYFEKGPIKTLQS 69 
XP_016153800   5 QSSRTPKQ--HVRSKSQTDLSAWRKGGRIDSEKSL----------QN-QSANDQKydsqEGSLKQALSYLEKVQGRVALK 71 
Q8AYS7         5 QSSKHSKRPLQVHHSNQTDLSAWRKGGTVDTEKSA----------QNRQSLSDQKndneQDSLEQALSYFEKIQDRVSLK 74  chicken
XP_007669732  89 KNPTLQKHLETVENVAWRTGLPPESIDTLLNVALSGRFAEAVNTRLLKCMIPTTLILETSIVAAVSWLCVGKCSGSNKIL 168
XP_006257277  81 KDSVLEKHLKTVENVAWNNGLAPEAIDILLNVALSGKFGNALSTRILKCMIPETHISEDSVVKAVSWLCVGKCSGNTKVL 160
XP_010599689  70 KGKTMEEHLKTVENVAWKNGLAPEKIDILLNVALSGKFGNSINTRILKCLIPATVISGDSVVKAVSWLCVGKCSGSTKVL 149
XP_016153800  72 KNSVLQKHLNAVESTALTQGLPPEGFEILLNVVLSGKFADTVNTCLLKCLIPASVIPENSVVKAVSWLCVRKCSANIQLL 151
Q8AYS7        75 KSEVLQKHLSTMESIALKRGLPPEGFDVLLDVALSGKLADTVNTRLLKSLIPASAIPESSIVSSVSWFCVSKCSSNIQLL 154 chicken
XP_007669732 169 FFRWLIAMFDFVDHKEQINSLYGFIFAFLQDENLCPYICHLLYLLTRRENVKPFRVRKLLDLQAKMGMQPHLQALLSLYK 248
XP_006257277 161 FYRWLVAMFDFIDHKKQINSLYGFFFVSLQDDTLCPYVCHLLYLLTKKENVKPFRARKLLDLQAKMGMQPHLQALLSLYK 240
XP_010599689 150 FFRWLVAMFDFVNEKDQVNSLYGFFFASLQDDALCPYVCHLLYLLTKKENVKPFRVRKLLDLQTKMGMQSHLQALLSLYK 229
XP_016153800 152 FLKWLITMFDFIDHKEQLRALYGFFFFFLQDDKMCPFVCHVLYLLTRKENVKAFRIRALLDLQAKMGMQSHLQALLSLYK 231
Q8AYS7       155 FLRWLITMFDFIDHKEQVHALYGIFFSFLNDEKLCPYICHVLYLLTRKENVKPFRVRRLLDLQSKMGMQPHLQALLSLYK 234 chicken
XP_007669732 249 FFCPELVSISLSTNRKTYFKDSECLWKTALSAVRQRNQGPSPGSPKLILGTTSIQSRRRKWNTSLVVPLCSSQDsnPQSG 328
XP_006257277 241 FFAPTLISVSLPVRKKIFFNNSKNLWTPALLAVKLRNQGIFPEPLKLQLGPTSGRSLKRKWNYHSVIPAVNSAK--KECR 318
XP_010599689 230 FFAPTLISVSLPVRKKIYFKNSENLWQMALIAVRQRNMGPSPVSLKLILGSAKVRPVNRKRNSYSVIPLPNSSNyvRECG 309
XP_016153800 232 LYCPEQVTITLPGKMKTYFKNPEGPWKAAIAAVRQRNQGTSALSQRMFLGTSQPQSRKRKWNAQLVIPASSTNNlgE--- 308
Q8AYS7       235 LFCPELVSITLPQKMKTYFKNADGPWKAAINAVRQRNQANSTVPQPLLLGTAQPHSRKRKWNTQLIVPASSANAqnLVVG 314 chicken
XP_007669732 329 NReLKLVHFLKTDESFPPEQLHTFSQLLQNAHCLELPSQMGSVLKNSLLLHYLNCIKDESVLLRLHYWINNTLKEDCIWH 408
XP_006257277 319 EK-MSLFDYLSNDRSLPVEQLQSFPQLLENIHCLELPSQMSSVLNSSLLLHYVNCVKDESILLRLSYWLSQTLQEECVWY 397
XP_010599689 310 KKeMSISDCLSNNGSFPVEQLQSFHQLLENIHCLELPCQMGSVLNSSLLLHYINCVRNESVLLRFYHWLSLTLQEECVWY 389
XP_016153800 309 DRqKNSVCLYSTNETFPVEQLQTFPQLLQNIHRLEFPSRMGSVLTNPLLLHYMNCVKDESIYLRLYYWMGQMLQEECTWC 388
Q8AYS7       315 GK-MSRADSYSANESFPVEQLRTFPQLLQNIHRLEFPSQMGSVLTNPLLLHYMNCSKDESVYLRLYYWMGQTLQEECTWC 393 chicken
XP_007669732 409 PTGDHLDNEEFKEFLNLIFRTECFLQEGFSSCEKFLYKSLPSWDGFGFRSQILPLVTWIPLRNFSEIKALLCEPLAQLFF 488
XP_006257277 398 NMNDYQQEKEFINFLDMVIRVQCFLQEGFYSCEAFLYKSLPLWDGFSCRSQFLKLLAWIPFSSFSEIKPLLLDHLAPLFF 477
XP_010599689 390 KVNNSEFGKEFTSLLDSIIRAQCFLQEGFYACEAFLYKSLPFWDGLCCRSQFLQLVSWIPFSNFCELKPLLFDHLAHLFF 469
XP_016153800 389 VVDNSS-EEEFKSFLETIYKSECFLQEGFSACEEFLYKTLPLWDGLCCRSEVLSLLSWISLSSFSDIKSYIYDPLAQLFF 467
Q8AYS7       394 VVDNNQYEEEFRGFLETVYKAECFLQEGFPSCEEFLYRSLPLWDGVSCRSQILQLVSWIPLSTFSEMKSQLCDPLAQLFF 473 chicken
XP_007669732 489 TSSIYFKCSILQTLRELLQNWLLSHATDMDEEPIINSP 526
XP_006257277 478 TSSIYFKCSLLQCLKDLLQNWLLWLSTEAQVQPMTDSP 515
XP_010599689 470 TSTIYFKCSVLQSLKELLQNWLLCLSTDIHMKPVLNSP 507
XP_016153800 468 TSSIYFKCSVIESLKELLQNWLNESQMHLEL-----SS 500
Q8AYS7       474 TSSLYFKCSVLESLKELLQNWLNWHVVQLDSES--DSQ 509 chicken
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