Conserved Protein Domain Family
7tmA_OR9G-like

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cd15418: 7tmA_OR9G-like 
olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320540
Aligned: 8 rows
Threshold Bit Score: 437.676
Created: 17-Jan-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                 #  ##           ###### 
Q8NGQ1        39 QPILFGVFLMLYLITLSGNMTLVILIRTDSHLHTPMYFFIGNLSFLDFWYTSVYTPKILASCVSEDKRISLAGCGAQLFF 118 human
P0C7N8        23 QLGLFVVFLGVYSLTVVGNSTLIVLICNDSHLHTPMYFVVGNLSFLDLWYSSVYTPKILVICISEDKSISFAGCLCQFFF 102 human
XP_008110564  24 QLILFVVFLNIYLLSLVGNITLIALICNSSRLHTPMYFFIGNLSFLDLWYSSVYTPKIIMNCISDDKSISFGGCLPQFFF 103 green anole
XP_007431480  25 RIILFVVFLVSYTLTLTGNLGLMALIYLDSRLHTPMYYFVGSLSFLDIWYSSVYTPRILYDCVSKNNHISLAGCAAQFFF 104 Burmese python
XP_005514907 219 QLLLFPVFTLIYIITLVGNVTLIMVIHRSSQLHTPMYFFIGNLSFLDLWYSSIYIPKILLNCISEDKSISFAGCAAQFFA 298 rock pigeon
XP_006026095  25 QVTLFVIFLFSYILTLMGNLGLTALICLDLRLHTPMYFFVGSLSFLDTWYSSVYTPRILADCISKSKIMSYTGCVIQYFF 104 Chinese alligator
XP_006026124  30 RAALFVIFLCTYTLTLMGNLGLMVLIFLNSCLHTPMYFFVGNLSFLDTWYSSVYMPRILVDCISKSNVISYAGCAAQFFF 109 Chinese alligator
XP_006026127  30 QAFLFFAFLLSYILTLMGNLGLIILIFLNSCLHTPMYFFVGSLSFLDMWYSTVYTPRILADCMVKSKIISYAACATQFFF 109 Chinese alligator
Feature 1        ##  #                                            # #####                        
Q8NGQ1       119 SCVVAYTECYLLAAMAYDRHAAICNPLLYSGTMSTALCTGLVAGSYIGGFLNAIAHTAntFRLHFCGKNIIDHFFCDAPP 198 human
P0C7N8       103 SAGLAYSECCLLAAMAYDRYVAISKPLLYAQAMSIKLCALLVAVSYCGGFINSSIITKktFSFNFCCENIIDDFFCDLLP 182 human
XP_008110564 104 SAGSAYSECYLLAAMAYDRYIAIANPLAHTHAMSNKVCMGLVALSYLFGFMNATIMTTetFTLSFCDXKVIDDFFCDLPP 183 green anole
XP_007431480 105 SAGLGWSECFLLAFMAYDRFVAICNPLLYTTAMPKKLCLVLGAYVVGFANSIAHTANT--FCLRFCGSNVINHYFCDVPP 182 Burmese python
XP_005514907 299 SAGSAGIECYLLAAMAYDRYVAISNPLLYTAVKSKKLCMGLVAASYLTGFANSILITSrtFNLSFCDSNIIDDFFCYLPP 378 rock pigeon
XP_006026095 105 SAAVVHTECFLLAAMAYDRYVAICNPLLYSSAMTKKLCIQLVASSYAVGFANAIAHTGnmFRLRFCGDNTINHFFCDALP 184 Chinese alligator
XP_006026124 110 SAGLAHTECFLLAAMAYDRYVAICNPLLYSSVMTRKLCSQLVAGSYVAGFINTIVHTGntFRLHFCGDNTIDHFFCDVPP 189 Chinese alligator
XP_006026127 110 SVFLAQSECFLLAVMAYDRYVAICNPLLYSSIMTRSFCFQLVAASYAAGFTNAIVHTSntFHLHFCGDNIIDHYFCDALP 189 Chinese alligator
Feature 1                   #  ### ### ##                                            #  ## ##  # 
Q8NGQ1       199 LVKMSCTNTRVYEKVLLGVVGFTVLSSILAILISYVNILLAILRIHSASGRHKAFSTCASHLISVMLFYGSLLFMYSRPs 278 human
P0C7N8       183 LVKLACGEKGCYKFLMYFLLASNVICPAVLILASYLFIITSVLRISSSQGRLKAFSTCSSHLTSVTLYYGSILYIYALPr 262 human
XP_008110564 184 LVKLACNVPRSYQSVLYFILVLNVISPSALILASYAFILAAILRIRSTKGRQKAFSTCAAHLTAVTLYYGSILFIYSRSs 263 green anole
XP_007431480 183 LVKMACDDTQVYELILTALIGFNLLAATAIIVKSYIGIVAAIVRIHSAAGRRKAFSTCSAHLLSVSLFYGSMLIIYSTPn 262 Burmese python
XP_005514907 379 VVNLSCDVTDSYQLLLYFILTYNIIIPSVLNLTSYASILATVLKMRSAVGQWKAFSTCATHLTSVTIYYSSILFIYARP- 457 rock pigeon
XP_006026095 185 LMKLACDDIRVYEIILAAIVGCNVGTAIVLVLCSYTAIVAAIVRIHSATGRRKAFSTCSAHLVSVTFFYGSHLFIYLRPs 264 Chinese alligator
XP_006026124 190 LMKMACDNTQVYEFILTAAVGFSVVATTALILGSYTGIVAAILRIRSATGRHKTFSTCSAHLISVLLYYGSLLFMYLQPr 269 Chinese alligator
XP_006026127 190 LMKMACDDTHVYNLILAITLGCNMVAITALILGSYTAILAAIFCIHSHSGRHKAFTTCSAHLISISLFYGSIFIMYLQPs 269 Chinese alligator
Feature 1            ## ###  #  ##                        
Q8NGQ1       279 STYSLERDKVAALFYTVINPLLNPLIYSLRNKDIKEAFRKA 319 human
P0C7N8       263 SSYSFDMDKIVSTFYTEVLPMLNPMIYSLRNKDVKEALKKL 303 human
XP_008110564 264 SSYALERDKVVSVFYTVVFPMLNPLIYSLRNKEIKDVLKKL 304 green anole
XP_007431480 263 SQHTPNWDKANALFYTVVNPLVNPLIYSLRNKDVKAAFKKA 303 Burmese python
XP_005514907 458 SSSFVGRNKVVSVFYTVVIPMLNPFIYSLRNQEVKEALKRL 498 rock pigeon
XP_006026095 265 SQHTPEGDKVAALFYTVVNPLLNPVIYSLRNKDVKEALKKA 305 Chinese alligator
XP_006026124 270 SLHTPDRDKVTAVFCTVVNPLVNPLIYSLRNKDVKEAFRTT 310 Chinese alligator
XP_006026127 270 SQHIPDWDKVGALFYTVVNPLVNPIIYSLRNKDVKKALKTV 310 Chinese alligator

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