4V1A,3J7Y,4CE4


Conserved Protein Domain Family
DSRM_MRPL44
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cd19874: DSRM_MRPL44 
double-stranded RNA binding motif of mitochondrial 39S ribosomal protein L44 (MRPL44) and similar proteins
MRPL44 (also known as L44mt, MRP-L44, or mitochondrial large ribosomal subunit protein mL44) is a component of the 39S subunit of mitochondrial ribosome. It may play a role in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome. MRPL44 contains a RNase III-like domain and a double-stranded RNA binding motif (DSRM). DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.
Links
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Statistics
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PSSM-Id: 380703
Aligned: 28 rows
Threshold Bit Score: 103.055
Created: 24-Oct-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
putative RNA
Conserved site includes 27 residues -Click on image for an interactive view with Cn3D
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on structure evidence that Saccharomyces cerevisiae 54S Ribosomal Protein L3 (1VW4) binds dsRNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        ## #  #     # ## ##   #      ###      ## #### #   #              ####  #   #    
4V1A_h       224 TGKELFEMWTITNPMGLLVEELKKRKiSAPESRLTRQSGSTTALPVYFVGLYCDRK--LIAEGPGETVLVAEEEAARVAL 301 pig
NP_649541    217 NQKDLLEVWTPQEPIQLLEKICQERKlGEAEPRLLGDCGKNTVLAAYQVGIYANRQ--LLGKGFGEDVKTATETAALDAL 294 fruit fly
EFX80975     228 YGLDINELWNPADPVGNLTDILKREGkAEPEFRLIKHSGQNSVLAVYYVGVYSDKN--FIAEGAGESLEIAKEMAAREAL 305 common water flea
OQV24451     249 LDVDIDELWGLKNPMSVVADILQREGrAEPETRLLRRAGDATPEAIFLIGVYSDKK--LIGQSFGETLLIAEEMAARETL 326 Hypsibius dujar...
EEC00907     224 VGKDVNELWVVDKPIERLASLLQGQGmSPAEPRLLWDSGRTTLEASYCVGFYSDKK--LLGSSVGETVEIAQEMAARDAL 301 black-legged tick
CCD78687     225 SDIDLTELISIPNPLPLLQGILQSEGrGPPETRLLYQSSMNTVLACFEVGIYSDCQ--LVGEAPGESILIAEEEALRQSI 302 Schistosoma man...
ENN80129     283 VGKDVYDIWAPAQPYEYMLRLLQAKGvEQVEPRLCNQSASNTILANFQVGLYDAKSktCLGLGWGENIKTAKETAALDAI 362 mountain pine b...
XP_014227729 215 AEKDLIEIWCPEDPMEILNDILDREGrAYAESRIIGQTGVNTLIPVYNIAVYSNKE--FLGSGMGDSIEEAEKMAALNAL 292 Trichogramma pr...
XP_014254443 213 ATKDLSPMCTPDNPLEELSQSLMERGmPPFEPRLISAIGKNSILANYEVGMYCDRQ--MIGRGCGESIEIAQDMAACDSL 290 bed bug
OQR74492     199 CGKDVFDLWNPKDVTHMLNTLLQQQKlPPYEARLIGETGRNTLESLFYVGVYAGGK--QLGKGAGSTQAQALDVAVRDAL 276 Tropilaelaps me...

Feature 1              
4V1A_h       302 RKLFGF 307 pig
NP_649541    295 QSIFDT 300 fruit fly
EFX80975     306 KQLFHT 311 common water flea
OQV24451     327 RNFFRT 332 Hypsibius dujardini
EEC00907     302 RRWYGL 307 black-legged tick
CCD78687     303 KNFFKL 308 Schistosoma mansoni
ENN80129     363 QRLHAS 368 mountain pine beetle
XP_014227729 293 LRMFDL 298 Trichogramma pretiosum
XP_014254443 291 WRMWGV 296 bed bug
OQR74492     277 RRAFGV 282 Tropilaelaps mercedesae

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