Conserved Protein Domain Family
SH2_SH2D7

?
cd10417: SH2_SH2D7 
Src homology 2 domain found in the SH2 domain containing protein 7 (SH2D7)
SH2D7 contains a single SH2 domain. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.
Statistics
?
PSSM-Id: 199832
Aligned: 5 rows
Threshold Bit Score: 190.49
Created: 31-May-2011
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
phosphotyrosinehydrophobic
Feature 1:phosphotyrosine binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                       #                 #                   # #                        
A6NKC9        43 LQNGALPPWFHGFITRKQTEQLLRDKALGSFLIRLSDRATGYILSYRGSDRCRHFVINQLRN---RRYIISGDTQSHSTL 119 human
Q8BI17        43 LQNGVLPPWFHGFITRKQTEQLLRDKALGSFLIRLSDRAVGYILSYRGSDRCRHFVINQLRN---RRYLVSGDTLSHSTL 119 house mouse
NP_001094874  43 LQNGALPPWFHGFITRKQTEQLLRDKALGSFLIRLSDRATGYILSYRGSDRCRHFVINQLRN---RRYIISGDTQSHSTL 119 human
ACI33375     120 RPGRPMPRWLHGFATRREAEELLKDKQQGCFLLRLSESKIGFVLSYRGKDRCRHFIIEEEEGgrgACYLIAGEKSRHSSL 199 Atlantic salmon
XP_002923054  38 LQDGALPPWFHGFITRKQTEQLLGDKALGSFLIRLSDRATGYILSYRGSDRCRHFVINQLQN---RRYLVSGDTHSHTTL 114 giant panda
Feature 1                                 
A6NKC9       120 AELVHHYQeaQLEPFKEMLTAACPR 144 human
Q8BI17       120 DELLRHYQevQLEPFGETLAAACPR 144 house mouse
NP_001094874 120 AELVHHYQeaQLEPFKEMLTAACPR 144 human
ACI33375     200 QELVSYYTqfPVGPFNEILTTPCDE 224 Atlantic salmon
XP_002923054 115 ADLVRHYQevQFEPFGETLSAACPR 139 giant panda

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap