Conserved Protein Domain Family
MIER1_3_C
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pfam19426: MIER1_3_C 
Mesoderm induction early response protein 1/3 C-terminal
This domain is found at the C-terminal of MIER1 and MIER3. MIER1 is a transcriptional repressor that regulates the expression of a number of genes including SP1 target genes, recruiting histone deacetylase 1 (HDAC1) through its ELM2 domain. It has two isoforms, alpha and beta, which differ in their C-terminal domains, both of them being able to interact with HDAC1. The gene encoding MIER3 has been identified as a candidate cancer susceptibility gene. MIER1 and 3 share two regions of high homology, one at the N-terminal and the second at the C-terminal, represented in this entry, which includes a short region located immediately downstream of the SANT extension that is 84% identical.
Links
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Statistics
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PSSM-Id: 437258
Aligned: 7 rows
Threshold Bit Score: 338.032
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
AAH80986     304 RTKFGKKRYNHHPGVTDYMDRLVDEAEV--LGAVGNSSa-LTC-Hs----RTDPLPDSQLNILNSITAND--LTALTNSV 373
XP_005166937 330 QNRFGKKKYSCYPGVTDLMDRLVDEAEG--LAVDGSSP--VCS-Aga-ggRLEASAEQQLGLLNSITASD--LTALSNSV 401
XP_023154868 342 QNRFGKKKYSSYPGVTDLMDRLVDEAEG--LAVDSSSS--VCS-GaggggRLETTTEQQLSLLNSITASD--LTALSNSV 414 clown anemonefish
XP_015222816 304 QNRFGKKKYSSYPGVTDLMDRLVDEAEG--LAVDSSSS--VCS-Ss---gRMDPTPDQQLSILNSITASD--LTALTNTV 373 spotted gar
XP_020375691 333 QTRFGKKRYNLHPGVTDYMDRLVDEAEMgmLSRSVHSPs-ICSsVn----RPETISDHNL------MSSGheFAALTSVG 401 whale shark
XP_010586450 336 QTRFGKKRYNHHPGVTDYMDRLVDETEA--LGGTVNSSsaLTS-H-----RPEPVPDQQLNILNSFTASD--LTALTNSV 405 African savanna...
XP_006007775 320 QTRFAKKKYNLHPGVTDYMDRLIDEAEA--LGSAVSSTp-ICS-At----RTEPVPDPQLSILNSITPNE--LTALTNSV 389 coelacanth

AAH80986     374 ATVCN-SGEVNCLNE-GFPVLDALP-RVPVNHvpvgtEDLLTLPGNG-ESDCFNIFETGFYPSEVNTL--SLCSEEPERP 447
XP_005166937 402 ANVCNgPAEMSCLDSpFFPPLESLH-RAALNH-----DDQLSYGTNG-DGVCLNMLDSGFYRSDLGQLs-MCSSKDCERP 473
XP_023154868 415 ATVCS-PTEVSCLDSySFPPLESLH-RGSLNH-----DESLGFPSNGaDPDCLNMLDAGFYHSDLGQLggVCVNKDCERP 487 clown anemonefish
XP_015222816 374 ATVCN--PDVNCLDSyNFPALDSLH-RGALNH-----EEPLNFSANG-DTDCLNLLDAGFYHSDLNQI--NMCSEECERP 442 spotted gar
XP_020375691 402 T-ACS-VTDVNCLDSyNFPPLDSLHsKGPTTHvpvliEESLGLPANG-DTDCLNLFETGFYHSDLNQI--SMCNDESERP 476 whale shark
XP_010586450 406 ATVCN-PTDVSCLDD-SFPPLGNTP-RGQVNHvpvvtEELLNLPSNG-ESDCFNLFETGFYHSELNPM--NMCGEESERP 479 African savanna...
XP_006007775 390 VTVCN-AAEVNCLDGySFPPLDGLS-RGPVNHvpginEETLNLTTNG-DPDCFNLLETGFYHSDLNQM--NMCSEDSERP 464 coelacanth

AAH80986     448 AKRIKMGIsvPESYISDVsvnnlgvDFEN-----HTHHITSAKMAVSMADLSSLSTNEt-NSFLNSHTLH----HTALQS 517
XP_005166937 474 SKRLKMGL--SESFINDV-------DFEGr----RAHRITGATMAVSVTDFSGIGSEA--NAFISSHSRHh--qHTALQS 536
XP_023154868 488 SKRLKMAL--PDSFINDVsvgnlgvDFEArrtttHHHRITGAKMAVSVTDFGSLAGSGepNGFLGAHARHhtqhTAALQS 565 clown anemonefish
XP_015222816 443 AKRLKMGL--SEPFINDVsvnnlgvDFEN-----HAHHITSAKMAVSVTDFGSLSTSEs-NGFMNSHTLHq---HTALQS 511 spotted gar
XP_020375691 477 AKRLKMGIavQESFINDVsvnnlsvDFEN-----RTHHITSAKMSVSVADFSSLSGSEa-NGFINPHALHq---HTALQS 547 whale shark
XP_010586450 480 AKRLKMGIavPESFMNEVsvnnlgvDFEN-----HTHHITSAKMAVSVADFGSLSASEt-NGFISAHALHq---HAALHS 550 African savanna...
XP_006007775 465 AKRLKMGItvPENFMNDVsvnnlsmEFEN-----HTHHITSAKMSVSVADLSSLSASEa-NGFINSHTLHq---HTALQS 535 coelacanth

AAH80986     518 E 518
XP_005166937 537 D 537
XP_023154868 566 D 566 clown anemonefish
XP_015222816 512 E 512 spotted gar
XP_020375691 548 E 548 whale shark
XP_010586450 551 E 551 African savanna elephant
XP_006007775 536 E 536 coelacanth
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