2LMK


Conserved Protein Domain Family
ESP1_like
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cd14249: ESP1_like 
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Exocrine gland-secreting peptide 1 (ESP1) and similar pheromones
ESP1 is a peptide pheromone found in male mouse tear fluid, which is recognized by a specific G-protein-coupled receptor in the vomeronasal sensory neurons and affects female mouse sexual receptive behaviour. This small family appears restricted to rodents; the functions of members other than mouse ESP1 have not yet been determined.
Links
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Statistics
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PSSM-Id: 271208
Aligned: 16 rows
Threshold Bit Score: 40.4827
Created: 1-May-2013
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:putative receptor binding site [polypeptide binding site]
Evidence:
  • Comment:residues involved in c-Fos induction in the vomeronasal organ
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #   #        # ##                   #   #   #
2LMK_A         6 PQEVQRALARILCal--gELDKLVKDQANAGqq--eFKLPKDFTGRSKCR 51  house mouse
BAF92724      50 ERNFIESLESTLPas--nQDQTLFENMTNQHk----LNLSKMLSVLSKCC 93  house mouse
BAF92757      31 EGNIQGWEKVFCAs---nQEQTLCGDVANANqh--kLNLSQNMMSQRTCC 75  Norway rat
EGW03086      86 ELSIKDTLQRNFCas--hQYQTAFEDLTNDN-----QHLSALLISLRKCC 128 Chinese hamster
BAF92722      53 DKGNKQAPEKVFCas--iDDQTLVEDLATANqh--kLILSKNKISQSNCC 98  house mouse
XP_003510717 127 KGKIIEVLERMFYas--hQDLKLTVDEVNGNpy--iLDLCVVLTALRKCS 172 Chinese hamster
XP_003510718 101 KGNNTEALERKLWas--hQDERSSEDLANINqd--mLELSTVLNVLRKLC 146 Chinese hamster
BAF92727      22 DIETDSQLEHIVIqalegMLSPLHQDQADANnkhkcGHFAPSFNWEQNTH 71  house mouse
BAF92733      11 ISAYQEALEETNVc---qNTANLNSDSNLERlmlkqFRCYSILEEHMHCL 57  house mouse
BAF92735      11 ISAYQEALEETNVc---qNTANLNCDSNLEHlm-feSNLDAIQFSRNLCI 56  house mouse

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