Conserved Protein Domain Family
PRK12668

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PRK12668: PRK12668 
Na(+)/H(+) antiporter subunit D
Statistics
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PSSM-Id: 237168
Aligned: 39 rows
Threshold Bit Score: 590.328
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
289583091   7 DILAYAYPPLIVFAAALLVLVLPRLL-----GFAVGTLSLASVVAISLlaPEGAHLTRTFLGFqDIH-PFLIDDFTRMMG 80 
55380052    2 SMLTVVPPVVVLLALAIAVSRLPRRAg---hAVGALVPALAVPWALAV--PEGAHLQTQFLGF-DAV-LLNVDPFSRLMG 74 
15789774    1 MIDTFVPPFVPVLVAALLVPFLSRRTg---hALGAVASAAVVPYVWLV--ATGAHLPVKLFGF-HAI-LLNVDPFSTLMG 73 
169235492   1 MIDTFVPPFVPVLVAALLVPFLSRRTg---hALGAVASAAVVPYVWLV--ATGAHLPVKLFGF-HAI-LLNVDPFSTLMG 73 
206890015   1 -MTDFIHPGVVLIFGALLLPALPKNMr---gPYSVLIATVGFFLTLIA--EQGFYGYMSLFGM-DISpLVRVDKLSLLFA 73 
222479278   3 PILTSLPPYVVLAAAAFLVLGLPRRAghaaaALATAFTFAQAVLLGDG--GTGAYVATQLFGF-DVI-LFNVDQFSLLMG 78 
284176178   5 DLLTMAYPPLLVFAAALLVLVLPRIA-----GFAAGALSLAGVLAISVyaPEGSYLTGTFLGF-DVV-AFHVDGFSQMIG 77 
257388904   2 TGLATVPPVFVLLAVALLVAVLPRRVg---hGLGILATGALVPWSLSI--SAGVYHDVTFLGF-DAV-LLNVDEFSRLMG 74 
110667639  49 EFVIPFPPAFAILSIALIAPFLSRRVg---hVLGVIVTAGVAVISLVS--PVGAHLPVTFLGF-DAV-LFNVDAFSRVMG 121
300711757   5 DLLASVPPALVVLFAALLVTLFPRTAg---yAVSALATIYVFVVSLVV--PPGEYLPVVFLGF-DAQ-LLLVDDFSRLLG 77 
289583091  81 IALGFLGTFAVIYAYSSEASRKLAAiALAYVASALGAAFAGDWLVLVFMWEIMALTSTLLVWQYGGD-AVRAGYRYALAH 159
55380052   75 IIFGLIAAVAVLYSYASEANTTQTGyALSYVATSFGAVFAGDWLTLIFFWELMAVTSTLLVWHYGGK-AVRAGFRYALLH 153
15789774   74 LIFGLIGAAGVVYSYASDAENIQTAfALGYVGTSLGAVFAGDWLTLIFFWELMAATSTLLVWHYGGK-AVRAGFRYALAH 152
169235492  74 LIFGLIGAAGVVYSYASDAENIQTAfALGYVGTSLGAVFAGDWLTLIFFWELMAATSTLLVWHYGGK-AVRAGFRYALAH 152
206890015  74 YIFSFIGLIGIIYCYHIDDWIQQLA-GLFYTGASVGVSFAADILSFYLFWEMLSFCAVLLIWSQRTKeATEAGYRYILVH 152
222479278  79 VVVGFLATAAVLYAYGTEAPKWVTAfALIYVSSTVGTIYAGDWLTLIFFWELMAVTSTLLVWQYGGK-AVRAGYRYALFH 157
284176178  78 IGLGFLGICSVIYAYSSGASRELVAiALTYVASSLGAAFAGDWLVLVFMWELMAVTSTLVVWHYGGD-AVRAGFRYALFH 156
257388904  75 LIFGIIGAVAVLYSLASDAERVQTAfALSYVATSVGAVFAGDWLTLIFFWELMAVTSTLLVWHYGGK-AVRAGFRYALLH 153
110667639 122 VIFGTIGAAAVLYSYSSQASNRQTAfALGYVGTSIGSVFAGDWLTLVFFWELMAITSTALVWDYGGE-AVRAGFRYAIYH 200
300711757  78 LGFGFLGTAAVAYAASSGLPKSSMAlVMSYVASVAGVIFAGDWLTILFFWELMAVTSTLVVWVYGGD-AVRAGFRYAIAH 156
289583091 160 GIGGSLVLFAVIAQYAAV-GS------FAMVTEaGETVGfad--giPLLLAVLGIGVNVAFVGFHTWLPDTYPRPHFAAS 230
55380052  154 GLGGTLLMAAILRHYVEV-ET------FLFASVpGGPETagittglAAALAAIGIGVNVGFIGLHAWLPDTYPRPHIAAS 226
15789774  153 GIGGTLLLAAIIWQFAET-GT------FLFGSVpGGPETaglagsiAPVLAALGIGVNVGFVGLHAWLPDTYPRPHIAAS 225
169235492 153 GIGGTLLLAAIIWQFAET-GT------FLFGSVpGGPETaglagsiAPVLAALGIGVNVGFVGLHAWLPDTYPRPHIAAS 225
206890015 153 VAGGLSLFAGIMIYISQT-GS------FQFDSFmSYSGEl------FWWLTLIGFILCAAVPPLHAWLPDAYPSATIYGS 219
222479278 158 GIGGTFLLGAVVVHGASMlGSvpageiFLFSSTtGIHAS-------ATLLAAIGIGVNCGFIFLHTWLPDTYPRPHVAAS 230
284176178 157 GTGGVIVLLAVAAHYVEA-GT------FVYDGTgIASGL-------PAMLAVLGMGVNVGFIGLHTWLPDTYPRPHFAAS 222
257388904 154 GLGGSLLMGAILWHYSVA-GT------FLFTGEgIAAGP-------AAILAALGIGVNVGFVGLHTWLPDTYPRPHIAAS 219
110667639 201 GIGGSLLIAAVIWHYVDV-GS------FLFTAAsGLTAGi------PAALAAVGIGVNVGFVGLHVWLPDTYPRPHIAAS 267
300711757 157 GTGGVLLIWAVAWHYVET-GS------LALEGGiAPGAP--------ALLAALGVGINCAFIGLHTWLPDTYPRPHIAAS 221
289583091 231 VFLAAFTTKTSAYVLYRAIPe---G--NLLLAYMGGAMAVYGVVFALLQHDMRALLSYHIQAQLGYMVAGIGIG-----S 300
55380052  227 VFLCVFTTKTGVYGMYRAFPn---G--HEAIAYMGGGMAIFGALFALFQNDMRRLLSYHIQSQVGYMVAGVGIG-----T 296
15789774  226 VFLCVFTTKTGVYGLYRVFPe--hG--NMAVAYMGGAMAVFGAMMALFQNDMRRLLSYHIQSQVGYMVAGVGIG-----S 296
169235492 226 VFLCVFTTKTGVYGLYRVFPe--hG--NMAVAYMGGAMAVFGAMMALFQNDMRRLLSYHIQSQVGYMVAGVGIG-----S 296
206890015 220 VFLNPFTTKAAVYALIRGFP----G--AEILIYLGSVMAVYGVIYALLENNLRRLLSYHIVSQVGYMVAGVGLGt----I 289
222479278 231 VFLSVFTTKTAVYVMYRAFPe---G--GMWLAYLGGFMAVYGAFFALLQYDPRRLLSYHIQAQVGYMLAGLGLA-----T 300
284176178 223 VFLSVYTTKTSAFVLYRAFPigaeSelGIYIAYMGGLMSVYGATFALLQHDMRALLSYHIQAQLGYIVAGIGMGawmveT 302
257388904 220 VFLCVFTTKTGVYGMYRAFPd---G--HLLIAYMGGAMAVFGVCYALLQNDMRRLLSYHIQSQVGYMVAGVGIG-----S 289
110667639 268 VFLSVYTTKTGVYGLARAFPd---G--NVLIAYMGAAMALVGVVYALLQNDMRRLLSYHIQSQVGYMVAGIGIG-----T 337
300711757 222 VFLSVFTTKSSAYVLYQAFPd---G--HLYLAYMGGLMAVYGATFALLQHDMRALLSYHIQAQLGYIVAGIGIG-----S 291
289583091 301 AI---GIAGAMGHLFNNVLYKSLLFMAVGVVIYRTGENDLYKLGGLWREMPLTAIAFAIGALSITAVPGFSGFISKGMVL 377
55380052  297 SL---AQAGAFAHVFNHILYKGLLFMTAGVVIYRTGTESLKKLGGLWREMPITAGAFSVAALSIAGFPGFNGFVSKGIII 373
15789774  297 AL---AQAGAFAHVFNHILYKGLLFMTAGVIVYRTGEERLPKLGGLAREMPITAGAFTVAALSISGFPGFNGFVSKGIII 373
169235492 297 AL---AQAGAFAHVFNHILYKGLLFMTAGVIVYRTGEERLPKLGGLAREMPITAGAFTVAALSISGFPGFNGFVSKGIII 373
206890015 290 TL---GLNGSASHAFNHILYKCLLFMSAGAVIYATGKEKMTELGDFGKYAPLTAISFFVGAFSIAGFPLTNGFIGKSPII 366
222479278 301 AVgdfAVTGGFAHLFNNVLYKSLLFMAVGVVIYRTGVEDIRDMGGLWRVMPVTFLVYLVGAASITAVPGFNGFISKGMVI 380
284176178 303 EI---ATAGAMSHLFNNILFKSLLFMAVGVVIFRTGEEDLYKLGGLWREMPLTAIGFGLGALSITAIPGFNGYISKGMLF 379
257388904 290 VL---GVGGAFAHVFNHILYKALLFMTAGVVIYRTGEESLKKLGGLAREMPITAGAFSVAALSIAGFPGFNGFVSKGIVI 366
110667639 338 AL---ATAGAFAHVFNHILYKALLFMTAGVVVSRVGEENLKYLGGLRRYLPLTALAFGIAALSISGFPGFNGFVSKGMIT 414
300711757 292 AI---GVAGAMAHLFNNILFKALLFMAVGVIIYRTGEEDLYELGGLWREMPLTALGYLFGALSITAIPGFNGFISKGMIL 368
289583091 378 DAADPAyyg-----gsEYQALYWLLFIGAIGTFLSF-IKLGYYVFLHG--PSDY---------TVKDSRTGQTVAMFSVG 440
55380052  374 SGSHYTfgkgp-lplgEFYTLEWMLLLGGVGTFMSF-IKFGYYAFFHG--EYDD---------SVPDANRGQSIAMVAVA 440
15789774  374 SASHYMhapl--vtvgEFTGLQVLLLLGGVGTFMSF-IKFGYYAFFHG--SYDG---------TVKDANRGQAAAMVAIA 439
169235492 374 SASHYMhapl--vtvgEFTGLQVLLLLGGVGTFMSF-IKFGYYAFFHG--SYDG---------TVKDANRGQAAAMVAIA 439
206890015 367 SAAGEL----------KNAFAYIMLNVATCGTIISIiCKMGYYTFFSE--KKADy--------QVKEIPLNMKIAMLTTS 426
222479278 381 DSAHEIhnfe---llfGEGLLWWLLILGGVGTFMSF-IKLGYYMFFHG--SATL---------SPKDATRFQTVGMVLAG 445
284176178 380 DAADPHyyg-----vhEFEALYWLLWIGAIGTLLSF-IKLGYYVFFHG--ESDI---------SVPDARPGQTIAMLGLG 442
257388904 367 SASHYDfkkealvhvgEYTGLELLLLLGGVGTFMSF-IKFGYYAFFHG--EHDG---------EVRDANRGQSVAMVVVA 434
110667639 415 AAADKK----------NFDGIFYILLAAGVGTFMSF-IKFGYYAFIRStpDSGViagsenadaDIISSAIGQRVAMLSVA 483
300711757 369 DAADPHyyg-----apEYEALYWLLMAGAVGTLLSF-IKLGYYAFLHG--PATT---------DVKDAKPGQTVGMLSVG 431
289583091 441 GACVLLGLpaigWPV-FADLLPl-----------VDgISipdmaineLEPYSDTHLQDALILIVISVIGFKLIRKP--LS 506
55380052  441 ALCIIYGV----YDTaLFTILP------------FD-VTsgavvdhvYKTYTVPHLIEGVVLAVLGLLCFAVTKKp-lSK 502
15789774  440 ALCLGYGL----YPEgLFGILP------------ID-VTtnppvghvYTTYTMSHLTEGVALAVLGVIGFVLVKAp-lSG 501
169235492 440 ALCLGYGL----YPEgLFGILP------------ID-VTtnppvghvYTTYTMSHLTEGVALAVLGVIGFVLVKAp-lSG 501
206890015 427 ALCILIGI----FPQfFYNFLP------------YP-ID--------YEPYTVQHILDTLGIFSFTGLVFAMFLKTlkPK 481
222479278 446 GACVFFGTp--fTYGyLVELMP------------FT-AEva----peLHPYSTSHLTESAALLVAGFVGFFALKRPlgWL 506
284176178 443 GACLLFGV----WWQgLADLAPtihahggefsfvYP-NDge----ghLHPYSSSHLETAGILTAVALVTFAVVRKPlsKL 513
257388904 435 VLCVVYGL----YDTaLFSILP------------VDvTAasl--ahpYETYTIPHVAEGVVLAVLGLVGFYATKKp-lSK 495
110667639 484 TLCILFGL----FPDaLFALLP------------GStTD--------AHPFTLGHLTEGIVLAVLGIIGFALVKRp-iSN 538
300711757 432 VVCLGVGV----FWPtFIDLLP------------FS-AEl------dLHPYSPGHLTDSAVLVAIAVVGFAVIRKp-lSA 487
289583091 507 KMDYSDPSLVVNPTGYYLGRGTMLAITDLYAAVDNAVVSGVKRCYwagnnpvlav-----------------detarrlp 569
55380052  503 LGRVPDIDSLYNPAVFYGSRGLVVGVTELYAAVDRAVVQATSVVTr---------------------------------- 548
15789774  502 LGRVPDVDAVYNRVLFYGTRALVVGVTELYAAVDRVVVAAASATA----------------------------------- 546
169235492 502 LGRVPDVDAVYNRVLFYGTRALVVGVTELYAAVDRVVVAAASATA----------------------------------- 546
206890015 482 SYINLDIDWFYRVGAKYSLKSLNKTVVPAEYGFINKIWRWLIDRIilplsskimay----------------edrkmngi 545
222479278 507 AHHMRDVDAVTYPAAFYLARGSVWGVTELWAAVDRAVMNAIAAVEwt--------------------------------- 553
284176178 514 D--LGDPARVVFPAGYYVGRWSMLATTELYRVVDAAAVGLVKRCYwignnpvlav-----------------daaarrvp 574
257388904 496 LGRVPDLDRIYNPAVFYGARGVVLGTIRLYGAVDRVAVRTATTATavat------------------------------h 545
110667639 539 IGKVPDIDTVINPGAFYLTRGLVRGTTEIFAIVDNAIQVIATRSLeitanpygsir----------------qpaaillq 602
300711757 488 LGHVHDVDRVLNPLVFYTGRVSVLAVTETFAAVDRAVVAVVRRCYwlanhpvlavgrvtrrlptwlvgdhspanggsras 567
289583091 570 mvDVPERQHADGGRps-----tIHLRAGIGTT---VLLLTIILTVIIWLLV 612
55380052  549 --AVTSPNDVIAGLrdd---dtLVHPMRAG-----IGLSILILAVFVTVAL 589
15789774  547 --GVVRAPDAVAGRllgdtdspVSLRADYSTS---ILVVAVVVAAFVVAIT 592
169235492 547 --GVVRAPDAVAGRllgdtdspVSLRADYSTS---ILVVAVVVAAFVVAIT 592
206890015 546 ptFMSNLAKTMSDG--------LAI-FHTGKIqdyAFYMLSFIGLVLLIYL 587
222479278 554 -aMHPREALGRAG---------VDVEIRTGIGr-sVLFLTLAAGVALFVFV 593
284176178 575 gvDVEDRQPTDGGRps-----tIHLRASIGTT---VLLLTVVLTVILLLLL 617
257388904 546 peRVAERFGANSQDdg-----pVTLRAGIGLS---VLVLALFVAVGLILLF 588
110667639 603 rdPDTLTDGSLQAT---------------------IGTSVLLVVVVLVIAF 632
300711757 568 sdRRFDGGTGVAGTnadsesarLYLRTTIGGT---IMLIVLALTIVLLVLV 615
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