Conserved Protein Domain Family
Noc2

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pfam03715: Noc2 
Noc2p family
At least one member, Noc2p from yeast, is required for a late step in 60S subunit export from the nucleus. It has also been shown to co-precipitate with Nug1p, a nuclear GTPase also required for ribosome nucleus export. This family was formerly known as UPF0120.
Statistics
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PSSM-Id: 461023
Aligned: 118 rows
Threshold Bit Score: 197.366
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4UI93       322 TIVDLLLKRCYSSHVKSVMNg-ITLKNYGLFKVSKNCISELYLNApFDNLYMFSFKTITNLAYNVRREwNNTGkekkpkk 400 Theileria annulata
EFC50723     356 PFLELCIKGIYYTLLRNSKG--YNPSTFHQIEFLKNCLVELSTIN-FTSTYHHAFTYIRELAITVRRA-MDST------- 424
Q4QDM8       306 MYQSAAFKGIFLTLIRTAHQ--YNIHNQTTVAFLMNCVVDLYGTD-MEAAYQHAFVYLRQLAIYLRAA-LQQQ------- 374 Leishmania major
Q389A0       302 MYQSTAFKGVFLTLIRTAHS--YNIRNAPLLAFLTNCVVDLYGTD-MEAAYQHAFVYLRQLAIYLRGA-LQQQ------- 370 Trypanosoma brucei
Q4DPD9       302 MYQSAAFKGIFLTLVKKAYH--YNIHNASLIAFLINCVVDLYGTD-MEAAYQHTFVYLRQLAIYLRSA-LHQQ------- 370 Trypanosoma cruzi
O17580       327 QHFVPLYKTAYVAFVANSKI--VTNETWPLLQFMHRTFAELTILN-PEQAYKYAFVYIRQTAVHLRNAmISKG------- 396 Caenorhabditis ...
O13874       227 SLSVAVFQVFYSPLLDFFKSspSEVNDFDTLEELQLFLIELLSLN-SRFYQKIAFAYLSQLDAHLKRClKESE------- 298 Schizosaccharom...
EPY52569     219 SLIVSTFQYFYVQLISFFKSspAQSGNLDTVEEMQLFLIELLSLS-HDTCKKIFLSYTHQLNTHLQNClKQAD------- 290
EDO07228     358 DSLHFLMTRCYRTLVSAGCVe-RNLKNFTLFKMSQNCVAELFSHApEAAIYIFAFKSIRDLAINVRREwMALNdrk---- 432
XP_001025758 184 EEVDKIFRRVYAAYFENVRH--VSWRTYESVIFMINCYTELMMEH-KDAAYYIGFSYLRQIAVLLKDN-MAKK------- 252 Tetrahymena the...
Q4UI93       401 ketnskedkTkkp--lnvNTTILSVCSWGFIESVNIWINVLSRS-----DNKMKTLIYPLVTVINSAIKIkISNKRQIPF 473 Theileria annulata
EFC50723     425 ---------V--------QNGYALCYNWKFFHCLDAWSKVICAYy---kQENISALLYPVTQIAMAAIGL-TNSAKHYPF 483
Q4QDM8       375 ---------T--------QSNVRAVVNWQYLNALRTWGAVVSTYs---ePNQLGPLIHPVVQIATALMDL-FSSPRMFPM 433 Leishmania major
Q389A0       371 ---------S--------QSNVRAVVNWQYLNALRAWGAVVSNYs---eASQLGPLIHPVVQLATGLMDL-FSSPRMFPM 429 Trypanosoma brucei
Q4DPD9       371 ---------T--------QSNVRAVVNWQYLNALRTWGAVVSKYs---ePSQLGPLIHPIVQIALGLMDL-FSSPRMFPM 429 Trypanosoma cruzi
O17580       397 ---------R--------KDLIFSIYNWQMMQCMYMWVRVIAKAhsvngAEQIGELVYPLIQVIVGIFKL-CNAPTFLPL 458 Caenorhabditis ...
O13874       299 ---------S--------SDAYKLIYNWQFTLSLRFWLHVISFLwn-dyESISKEISPIAINLTLDCIRL-IPTEQYYPL 359 Schizosaccharom...
EPY52569     291 ---------N--------VDAHKLIYNWQFTLSLQFWSEVICLLwe-dlQTICKEISPQLINLILDTMRL-IPSEQYYPM 351
EDO07228     433 ------krdKktpkksesHGMVLPVYSWGFVDAINLWVSTLARC-----KKHLIPLSYPLVTVILGAIKIrLPHIAYMPY 501
XP_001025758 253 ------------------GDEMK-VFNWQVINSLKLWSQTISRQp---aDEDLGQLLYPLVELIIGVNQF-SNSQEYVPL 309 Tetrahymena the...
Q4UI93       474 VLHLLISLNKLLDGTH-KFIPIMSLLYHVLDNi-KNIkqtvpseyfKNTlvtsninnpnklvkpfKllKSkgSLEKSEDI 551 Theileria annulata
EFC50723     484 KVKILTMLNQLSRDCDkSFIPISQTVFEILQL--------------KQA----------------IntPKqnQKPQPLYF 533
Q4QDM8       434 HLQIIEVLNHIASRADgLYIPVAPYLLRILTSpsVAL---------SQA----------------Q--NGvsSSADRVDL 486 Leishmania major
Q389A0       430 HLQVIEVLNHIALRADgVFIPVAPYLLRILTSpsIAL---------GHH----------------SngSGrgETGDPVDL 484 Trypanosoma brucei
Q4DPD9       430 HLQVIEVLNHISLRADgVFIPVAPYLLRMLTSpsIAL---------NRP----------------T--QGegEKFERVDL 482 Trypanosoma cruzi
O17580       459 RLHCCQLLIQLQASCT-NYIPILQVSCDCLEElaREL---------KSK----------------P--KPvkGAVKLPDI 510 Caenorhabditis ...
O13874       360 RLHLLKSLVNICRSTR-LYIPLSSQFLEMIPF---VL---------RRS----------------SplSDdkEVMYNFDM 410 Schizosaccharom...
EPY52569     352 RLRLLSSLVRICRSSH-LYIPLSSHFVEMAPF---FL---------KKS----------------RnlTRekDSAYNFDV 402
EDO07228     502 ILHMITALNQLSDGIQ-RFIPLCSILFNLLEQlknhd-----vaklKRR----------------EarESkkMLDNANDL 559
XP_001025758 310 KFHLIQCLNSIAQKTD-TFIPTLKLIKDVLNS--GEF---------RKK--------------------KtqSTKKPFDF 357 Tetrahymena the...
Q4UI93       552 MVKLRLSGKSVNSPQIYKVLYKYVELILIDHLGILSLNPSFPEYTNCICYHLKRYIKS---PEVlndFRNTVNSLLKVLN 628 Theileria annulata
EFC50723     534 EFKLKAVPEELKSREFHQRIIDDCCFLLLDHLANHSKSVAFPELSYPITNFLKKYVKShteTLHf-gISKQITNLVKHVN 612
Q4QDM8       487 LFTIRVKKSQARNGVYHRDIWQEALYLLTEHLSTHSHTVGFPEAFWAVESTLRKLRTQv-rVPK---VHSSINNLLRHIQ 562 Leishmania major
Q389A0       485 RFTIRVKKSQARNFSYHRSVWSECLYLLSEHLATHSHTVGFPEAFWSVEVTLKRLRTEv-kVPK---VHAQLSALLRHIQ 560 Trypanosoma brucei
Q4DPD9       483 QFTIRMKKAQSRSSSYHQNICFECLYLLTEHLATHSHTLGFPEAFWVVETTLKRLRSEv-kIPK---IHSQLTILLRHMQ 558 Trypanosoma cruzi
O17580       511 ECTLKCSSQFSDLPQWRKVISEHVFRTMMQSAHLLASQAAFPDVVLPINHRISAILETm-kNGD---HAHLFRGFQTKLK 586 Caenorhabditis ...
O13874       411 YSTLHVPKECLLSKSYRNNVRKEVILLMTEYFAIFSNSIAFPELSAPIIAQLRGLVNEs-------aPGKHVLTFLNKLE 483 Schizosaccharom...
EPY52569     403 LTTLHIPKECLASQTYRKNLRKVYLSVMTEYFATFSNSIAFPELAVPAISQFRTFISRy-------pSENSISQFVEKLV 475
EDO07228     560 MVMLKFSKKQLHASDTYKVLYRHVGLVLTDHIGLLSLHPSFPEFTIPVVAFLQKYVKS---NRVdhaFRSQCSKLVSMID 636
XP_001025758 358 SISLKIDNKYKNTNVLWNEIFKFGLDLSAEYLAIYSRDIGFPEMCYNYIKYLKKLSDSv-qFVV---YKMQIKELMKTIR 433 Tetrahymena the...
Q4UI93       629 ETNVVVTKLREG--MDDAALEGFNVFE------PEKIPMYKYRQDF 666 Theileria annulata
EFC50723     613 DNIIFVNESKSKinFTPLEFDKVIEFLk-----DTETPLDKYYANE 653
Q4QDM8       563 ATSQKIKAKRDQanFGPCDLAAVKQFEde--lkQKGSALASYYHTM 606 Leishmania major
Q389A0       561 TTNQKIVSKREQsgPGPCDLAAVKQMEde--lkASGNPLITYYQSL 604 Trypanosoma brucei
Q4DPD9       559 TTTQRIIARRDQagNGPCDLAAVKQLEde--lkAAGNPLSTYHQML 602 Trypanosoma cruzi
O17580       587 EHSRFVLDVLARksVDINDEMQVRAVRfd--lnNPDSPIKTFYRQW 630 Caenorhabditis elegans
O13874       484 STFSFVESRRMNvdFTLNDTSQVEAFEkd--ldWRSTPMGKLVSDT 527 Schizosaccharomyces pombe 972h-
EPY52569     476 ETYSFIQQKRLNieFTQKDHSQVIAFEqe--ldWRSTPIGK--AVR 517
EDO07228     637 QSATVIREKREKidLEKRQSMNLKVFEs----eSKQIPIYCYRMEQ 678
XP_001025758 434 ASVDLVLSKRKGvnFAPKNIEQDAKFSednfkdVKETPLEQLRNKI 479 Tetrahymena thermophila SB210
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