Conserved Protein Domain Family
DUF4553

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pfam15090: DUF4553 
Domain of unknown function (DUF4553)
This family of proteins is functionally uncharacterized. This family of proteins is found in vertebrates. This family includes the human protein C10orf12.
Statistics
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PSSM-Id: 464496
Aligned: 8 rows
Threshold Bit Score: 538.348
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005048721 1065 TDMADSKPKFMEWCAEEDNQELIAEFNTQYMKIQKGWIQLEKEVQPAPKVKNKADKLKEI-WKSKKRTRKSRGSLEVQKL 1143
XP_016851120 1078 EVLSDNKPSFVEWCAEDENQELITNFNTQYMKTQKGWIQLEKEAQPAPKVKNKSDKLKEI-WKSKKRTRKFKGATEVQKL 1156
Q3TNU4        129 DPVISSNPLLRWWATSASNDSLLEELNNRFEQITNAWVQVSKDEAQNFVHKTEYT--KGDhCEAASPLETCLLELEV--- 203  house mouse
XP_010712915  982 MDAEDSKPRFMEWCAEEENQELIAEFNAQYMKVQKGWIQLEKEVQPAPKVKNKADKLKEI-WKSKKRTRKSRGALEVQKL 1060
XP_020929962 1086 DTVADDQPKFVEWCAEEENQELIANFNAQYMKVQKGWIQLEKEAQPTPRARNKSDKLKEI-WKSKKRSRKCRGALEVQKF 1164
EGV99270     1113 DTVVGEQPKFMGWCAEEENQELIANFNAQYLKVQKGWIQLEKEAQPTARARSKSDKLKEI-WKSKKRSRKCRGSLEVQKF 1191
XP_007661801  949 DPPVDDKPKFVEWCSEEENQELIADFNAQYMRVQKGWIQLEKEAQPAPRAKNKSDKLKEI-WKSKKRSRKCRGLLEVQKL 1027
XP_014351254 1083 DAARDDRPKFLECCLEEENQELIANFNAKYVKVHKGWIQLEKENPPVQKAKSKSDKLKEI-WKSKKRARKCRSTYEVQKL 1161 coelacanth
XP_005048721 1144 SPVQMLFMKAFKLSDICQWFLETTETRSLVIVKKLNTRLPGEIPPMKVPMQKYSSSslYPSSLQAERLKKHLKKFAATTP 1223
XP_016851120 1157 SPVQMLFMKAFDLSNICKWFMETTETKSLVIVKKMNTRLPGDMPPIKLPLQKGCSS--YPSSLQAERLKKHLKKFAAMTP 1234
Q3TNU4        204 SPVKMLFQKKYNLNELCTWFMQTTETQSLSLVRKANARNPLEVIST-----KGIKLgvKCCGFNASPFRKHFKKFAVSSP 278  house mouse
XP_010712915 1061 SPVQMLFMKAYKLSDICQWFLETTETRSLVIVKKLNTRLPGEIPPIKVPMQKYSSSglYPSSLQAERLKKHLKKFAATTP 1140
XP_020929962 1165 SPVQMLFMTNFKLSNVCKWFLETTETRSLVIVKKLNTRLPGDIPPVKHPLQKYSPSslYPSSLQAERLKKHLKKFPGATP 1244
EGV99270     1192 SPVQMLFMTNFKLSNICKWFLETTETRSLVIVKKLNTRLPGDVPLVKHPLQKYPPStlFPSSLQAERLKKHLKKFPGAIP 1271
XP_007661801 1028 SPIQMLFMKAFKLSNICRWFLETTETRSLVIVKKLNTRLPGDVPPIKIPLQKYPPSglYPSSLQAERLKKHLKKFPGTTP 1107
XP_014351254 1162 SPVQRLFMKKFNLSNICRWFLETTETKSLVIVKKINTRIPGDIQSTKAPLQKYSSLaiDPSS-QAERLKKHLKKFAVASP 1240 coelacanth
XP_005048721 1224 ARN----------------NLKNQKLWAKIRENADKAEAEEATTPNQASPTDASTKE-LSEDKTIQPALSLPTQASTRIL 1286
XP_016851120 1235 AKN----------------TIKTQRLLAKLRENTEEIEEEQVASPKQAPSSEINLEN-GIQAKTAQPPVCAPVQTSSRIL 1297
Q3TNU4        279 SKPagkfhilhkmvgspllNVKSNLTLARLKRTEFKN---------------------LHCERWRR-EERPYSHRTVDWS 336  house mouse
XP_010712915 1141 ARN----------------NLKNQKLWAKIRENADKAEAEEGNVAGQPPPPEASPEE-MSQERGAQPTPSLPTQASTRIL 1203
XP_020929962 1245 ARN----------------NWKTQKLWAKFRENPDQVELEDGSDVSPSPSPEDRTEE-VKEGRNSHPPTNSPTPASTRIL 1307
EGV99270     1272 ARN----------------NWKTQKLWAKLRENHGQVEPEAGSDISLGPNSEDSAEE-VREGRNSHPPTNLPTPASTRIL 1334
XP_007661801 1108 ARN----------------NWKTQKLWARLRENAEKGAPEEPPAGPLGSHPEAGPEDgGEEPESAPPAPTLPSPASSRIL 1171
XP_014351254 1241 AKS----------------TWKSPKLWAKAKEKEDNNRTESRLDESASTSTKTDHST-ESKVKDLRRHNSVKNPAGARIL 1303 coelacanth
XP_005048721 1287 RKYSNLRGKLRAQQRVVKAEKrSDGPGDHPPPESKQSRKSVCINP-LMSPKLALQIKAAAFPAKSPSVDGTgKGRKGKSr 1365
XP_016851120 1298 RKYSNLRGKLHGFHKIVKREK-NDSVAKHLSNESKPSSKSLSIKP-LMSPKLVQQVKASSLPTKSNVAEKGkKVKRGKDr 1375
Q3TNU4        337 SKRRNLR--LFCQNPSWTNSEgQTNAETSLNGKGTV-GNQWASPPePRVTFAKKRVAVHDFRTHASLESKF--------- 404  house mouse
XP_010712915 1204 RKYSQLRGKLRAQHRATRTDRrGDVPGEQPGPEGKTSRKSLCINP-LMSPKLALQIKADAFPTKSPSADGAgKGRKGKSk 1282
XP_020929962 1308 RKYSNIRGKLRAQQRLIKNEKmESPFG--PAVESKQSCKSVCINP-LMSPKLALQVGADGFPVKPKSTDGT-KGRKGKQ- 1382
EGV99270     1335 RKYSNIRGKLRAQ-------RlENSLG--GVSEIKQGRKSVCINP-LMSPKLALQVGADGFPVNPKKAEGN-KGRRGKQ- 1402
XP_007661801 1172 RKYSNLRGKLRAQQRLARAEKkAESAP-DPPPEQKQSRKSVCINP-LMSPKLALQVNADGFPVKSGPADGS-RGRKGKA- 1247
XP_014351254 1304 RKYSNIRDKLRTQHQINKKEKtSPSSS-----QTEKGSKSVCINS-LLSPKLASQPKLDDSCSKPALVEAEiKGR-GRKk 1376 coelacanth
XP_005048721 1366 sQEDPLPKVDLQLSKKKKMLKESGSTqersSSSTK----------------D-KLPAKKASKIKHSevsaKSPATRKQTA 1428
XP_016851120 1376 sQEVTLSKGNLQQSKKKALNESSKPQ----SSSSK----------------E-SIPLKKGSKLKHM----ESPTTKKQPA 1430
Q3TNU4        405 -----NGTGGGQTDSEKEQIMESVSShnwrSKTLK----------------DcRIFLRKINCLEHRntfkLNTIIYSPES 463  house mouse
XP_010712915 1283 gQEEPSPRAE-HLSRKKRTLKESEVTqeraGSSGK----------------D-KVPAKKAGKVKHSevgtKAPATRKQ-- 1342
XP_020929962 1383 -VSEVLPKAEVQNKRKRTEGGS--------TQDRK----------------D-KGPGMKASKEKHVdgstKTPAAKKPAA 1436
EGV99270     1403 -MPETLLRAEGQNKRKRAEGCG--------TQDDK----------------D-KGPATKAS---------RVLSAKKLAA 1447
XP_007661801 1248 -QAEGPPKVDLPPGKKKKSEENHPREr--sASSTK----------------D-RLPAKKTNKTKGAaapaRAPTTRKRAA 1307
XP_014351254 1377 lQEEIVA---VRPERRKRINADTSLTnadqNPSSKdkllrrtrrgkntdltG------------------KSPVLRRRTP 1435 coelacanth
XP_005048721 1429 MERSNKLARKmSLKEKRV---PKKQLEKMRLPMRKGKENTSRRAVLP-PSHEELSKPPKQK-PLGESSTRSQKM--ANKK 1501
XP_016851120 1431 MKKSSKLASQ-NEKTKKL---IDLRPGKGKSTTQKAKVNSSQKATPQsSRPEGPAKPLKQK-VGQDSSSRPQKA--FSKK 1503
Q3TNU4        464 VDSGG-SQAQpEESKRFS---LRSHSARQNSFKKQNEERANPKANSPa--SSRLTGELDSS-HLSKHVNFDKNp-dHSEA 535  house mouse
XP_010712915 1343 VERSSKLAKKmSSKEKRA---PKRQLEKVRLPVRKGKENTSRRAAPP-PGHEELGPSPRHR-PLGESSTRAQKM--ANKK 1415
XP_020929962 1437 RDRISQPPKK-KENKVKI---PKKSPGKSCPPSRKEKENTNKRPSQPs-TSEVVTKPAKQK-GAGESSSRPQKA--TNRK 1508
EGV99270     1448 KDRVSQLSKKmTLKENKVr-iCKKAPRKSCPPSRKEKENTNKRPSHPaAASEALTKPGKQR-ATGEASSRPPKArrKSRK 1525
XP_007661801 1308 LEKITKLAKKaSPKERKAkkgSKKPPGKSAPPVRKGKESPNKKPSPR----EPLPKSPKSKgAAGEPSHRSQKA--SDRR 1381
XP_014351254 1436 VGATGSASKKtGPRGAKVknsIKKPKGK--PPVKKRVKSRSLKQNA--AASKKVTKSSKQR-TTVGSSRKPQKGsgKGKG 1510 coelacanth
XP_005048721 1502 HSSG-----KTLTRSMKKMQENSVSQG--KRKLRAKVDCSHSKRSRLDP 1543
XP_016851120 1504 AAKG-----KTLTKSVKQMQENSKGQS--KKKLRATKDSPPSKRRRMDA 1545
Q3TNU4        536 LSKL-----SKRKRPPWKTTEMSA-KR--HKRQSCNSGQMANYCTKSQV 576  house mouse
XP_010712915 1416 AGGG-----KALPRAVRKGQEGSSSQG--KRKLRAKGDCSHSKRSRLDA 1457
XP_020929962 1509 QSSG-----KTRARPSTKTPENSAAQR--KRKLKAKLDSSHSKRRRLDA 1550
EGV99270     1526 LSSG-----RGRARPLTKSPENRAAQR--KRKLKAKLDSSQGKRRRLDA 1567
XP_007661801 1382 AGSG-----KSQTRSVKKTQESSGAQR--KRKLRAKLDCSHNKRRRLDT 1423
XP_014351254 1511 KGKGkqnmvKTLTRSKRKNVGSTKMRAplKRKVTEKLGPTPNKRRRVDS 1559 coelacanth
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