Conserved Protein Domain Family
TFP_LU_ECD_Ly6H
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cd23549: TFP_LU_ECD_Ly6H 
extracellular domain (ECD) found in lymphocyte antigen 6H (Ly-6H) and similar proteins
Ly-6H may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits alpha-3:beta-4-containing nAChRs maximum response. Ly-6H may play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. It seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons. Ly-6H contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).
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Statistics
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PSSM-Id: 467079
Aligned: 4 rows
Threshold Bit Score: 97.1305
Created: 27-Nov-2018
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O94772        26 LWCQDCTLTTnsSHCTPKq--CQPSDTVCASVRITDpsssrkdHSVNKMCAs--SCDFvkrhffsdylmgfinsgILKVD 101 human
XP_005395813  47 LWCQDCTLTTnsSQCTPKr--CQPADTVCVSVRITDpsssrkdHSVNKMCAl--SCEFikrhffseylmgfinsgILRVD 122 long-tailed chi...
ELW63419     351 LWCQDCTLTTnsSHCAPKq--CQPSDTVCASVRITDpsssrkdHSVNKMCAs--SCDFvrrhffsdylmgfinsgILKVD 426 Chinese tree shrew
XP_030067176  21 LSCQECTDLQh-NNCTSApkqCQSSQTHCVSILRQTvlsgsnmMSIIKSCGtkkDCDMttstn--------agnfQMITI 91  Microcaecilia u...

O94772       102 VDCCEKDLCNGA 113 human
XP_005395813 123 VECCDKDLCNGV 134 long-tailed chinchilla
ELW63419     427 VDCCRGDLCNGA 438 Chinese tree shrew
XP_030067176  92 SRCCNTDNCNTP 103 Microcaecilia unicolor
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