5D0K,5D0I,5D0M,5ULH


Conserved Protein Domain Family
RING-H2_RNF165
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cd16682: RING-H2_RNF165 
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RING finger, H2 subclass, found in RING finger protein 165 (RNF165) and similar proteins
RNF165, also known as Arkadia-like 2, Arkadia2, or Ark2C, is an E3 ubiquitin ligase with homology to the C-terminal half of RNF111. It is expressed specifically in the nervous system, and can serve to amplify neuronal responses to specific signals. It acts as a positive regulator of bone morphogenetic protein (BMP)-Smad signaling that is involved in motor neuron (MN) axon elongation. RNF165 contains two serine rich domains, a nuclear localization signal, an NRG-TIER domain, and a C-terminal C3H2C3-type RING-H2 finger that is responsible for the enhancement of BMP-Smad1/5/8 signaling in the spinal cord.
Links
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Statistics
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PSSM-Id: 438344
Aligned: 7 rows
Threshold Bit Score: 117.101
Created: 19-Mar-2015
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
Evidence:
  • Structure:5D0K; Homo sapiens RNF165 binds two Zn2+ ions.
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 #  #              # #  #  #          #  #         
5D0K_C        31 GEESDTDEKCTICLSMLEDGEDVRRLPCMHLFHQLCVDQWLAMSKKCPICRVDIETQLG 89  human
5D0I_A        36 GEESDTDEKCTICLSMLEDGEDVRRLPCMHLFHQLCVDQWLAMSKKCPICRVDIETQLG 94  human
5D0M_C        26 GEESDTDEKCTICLSMLEDGEDVRRLPCAHLFHQLCVDQWLAMSKKCPICRVDIETQLG 84  human
Q6ZSG1       285 GEESDTDEKCTICLSMLEDGEDVRRLPCMHLFHQLCVDQWLAMSKKCPICRVDIETQLG 343 golden snub-nosed monkey
XP_414696    289 GEESDTDEKCTICLSMLEDGEDVRRLPCMHLFHQVCVDQWLATSKKCPICRVDIETQLG 347 chicken
XP_005161046 250 DEESDVDEKCTICLSMLEDGEDVRRLPCMHLFHQACVDQWLATSRKCPICRVDIQTQLS 308 zebrafish
5ULH_C        31 GEESDTDEKCTICLSMLEDGEDVRRLPCAHLFHQLCVDQWLAMSKKCPICRVDIETQLG 89  human

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