7QPO,6HJF,4JUU,2AZP,1TM0


Conserved Protein Domain Family
Pro_racemase

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pfam05544: Pro_racemase 
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Proline racemase
This family consists of proline racemase (EC 5.1.1.4) proteins which catalyze the interconversion of L- and D-proline in bacteria. This family also contains several similar eukaryotic proteins including Trypanosoma cruzi PA45-A, a protein with B-cell mitogenic properties which has been characterized as a co-factor-independent proline racemase.
Statistics
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PSSM-Id: 398923
Aligned: 14 rows
Threshold Bit Score: 424.017
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7QPO_A        43 VVDMHTGGEPLRIVLAGCPEVSGPTLLAKRRYMRQHLDHVRRRLMFEPRGHRDMYGAVLVPSELPDAHLGVLFLHNEGYS 122 human
6HJF_B        48 CIDMHTEGEAARIVTSGLPHIPGSNMAEKKAYLQENMDYLRRGIMLEPRGHDDMFGAFLFDPIEEGADLGIVFMDTGGYL 127 Trypanosoma cru...
4JUU_B        28 VIDSHTAGEPTRVVLAGFPDLGDGDLAQCRERFRSDFDHWRSAIACEPRGSDTMVGALLLPPRDPSACTGVIFFNNVGYL 107 Xanthomonas cam...
2AZP_A         8 IIDSHTGGEPTRLVIGGFPDLGQGDMAERRRLLGERHDAWRAACILEPRGSDVLVGALLCAPVDPEACAGVIFFNNSGYL 87  Pseudomonas aer...
1_pfamImport   1 CIDSHTCGNPVRLVAGGGPLLPHLPISERRDLFVRNHDWVRQALMFEPRGHDIMSGAVIYPAYRDDCDFAVIFIEVSGCL 80 
Q8YJ29         8 CVDGHTCGNPVRLVAGGGPNLNGSTMMEKCAHFLAEYDWIRTGLMFEPRGHDMMSGSILYPPTRPDCDVAVLFIETSGCL 87  Brucella melite...
WP_011051438   9 VVDCHAEGEVGKVIVGGVGNIPGTTMFEKKLYLEQHRDDIRKLVLQEPRGATWHNANIILPPSHPEASMGFVILEATEYP 88  Xanthomonas
Q988B5         9 VVGCHAEGEVGDVIIGGVLPPAGRTMMDKMITMERDHDHIRRMLICEPRGSVARHVNLLVPSTREDCAAGAIIMEPTEYP 88  Mesorhizobium loti
A9CH01         9 VISAHAEGEVGDVIVGGVKPPPGETIWEQSRFIARD-ETLRNFVLNEPRGGVFRHVNLLVPPKHPDADAAFIIMEPEDTP 87  Agrobacterium f...
Q9I489         9 IVSCHAEGEVGDVIVGGVAAPPGATLWEQSRWIARD-QDLRNFVLNEPRGGVFRHANLLVPAKDPRAQMGWIIMEPADTP 87  Pseudomonas aer...
7QPO_A       123 SMCGHAVLALGRFALDFGLVPAPpagTREARVN--IHCPCGLVTAFVACEDGr--SHGPVRFHSVPAFVLATDLMVDVPG 198 human
6HJF_B       128 NMCGHNSIAAVTAAVETGIVSVP---AKATNVPvvLDTPAGLVRGTAHLQSGtesEVSNASIINVPSFLYQQDVVVVLPK 204 Trypanosoma cru...
4JUU_B       108 GMCGHGTIGVVRTLAELGRIAPG---QHR------IETPVGTVGVALADDGT-------VSIDNVESYRHAAGVEVDVPG 171 Xanthomonas cam...
2AZP_A        88 GMCGHGTIGLVASLAHLGRIGPG---VHR------IETPVGEVEATLHEDGS-------VSVRNVPAYRYRRQVSVEVPG 151 Pseudomonas aer...
1_pfamImport  81 PMCGAGTIGLVTAAIEEGLVTPR---IPG-RLS--IETPAGKVDIQYDKPGE---FVESVRIFNVASYLHAADVEVNVPG 151
Q8YJ29        88 PMCGHGTIGTVTMAIEQGLVTPK---TPG-KLN--LDTPAGLVAIEYEQDGQ---YVERVRLTNVPAFLYAEGLEVECPD 158 Brucella melite...
WP_011051438  89 AMSGSNTICVATVLLETGILPMQ---EPITDLV--LEAPAGLIRVRCDCKDG---KVTRVKLVNQPAFVYHLDAKVEVAG 160 Xanthomonas
Q988B5        89 PMSGSNTICVATVLLETGMVPMQ---EPETRFK--LDMPGGVIEVRAQCRDG---KCVSITLRNAPAFVDRLDASIEVEG 160 Mesorhizobium loti
A9CH01        88 PMSGSNSICVSTVLLDGGIVPMQ---EPETHML--LEAPGGLVKVRAECRNG---KAERIFVQNLPSFAAKLDAELEVEG 159 Agrobacterium f...
Q9I489        88 PMSGSNSLCVATVLLDSGILPMR---EPLTRLL--LEAPGGLIEARAECRDG---KAERVEIRNVPSFADRLDAWIEVEG 159 Pseudomonas aer...
7QPO_A       199 H-GKVMVDIAYGGAFYAFVTAEKLGLDICSAKTRDLVDAASAVTEAVKAQFKINHPDSEDLAFLYGTILTDGKDAYTKe- 276 human
6HJF_B       205 PyGEVRVDIAFGGNFFAIVPAEQLGIDISVQNLSRLQEAGELLRTEINRSVKVQHPQLPHINTVDCVEIYGPPTNPEA-- 282 Trypanosoma cru...
4JUU_B       172 H-GRVRGDVAWGGNWFFITEQA--PCALGLAQQRELTAYTEAIRLALEAA----GITGEAGGEIDHIEISGVAPDGSG-- 242 Xanthomonas cam...
2AZP_A       152 I-GRVSGDIAWGGNWFFLVAGH--GQRLAGDNLDALTAYTVAVQQALDDQ----DIRGEDGGAIDHIELFADDPHA---- 220 Pseudomonas aer...
1_pfamImport 152 L-GKLVVDIAYGGNYYAVIEPQVGWPGLDGMTAGDVVDLSQKLRDALGTICDPVHPDDERIRGVHHAIWCDRPVSAEA-- 228
Q8YJ29       159 L-GPIKVDVAYGGNFYAIVEPQENYTDMDDYSALQLIAWSPVLRQRLNEKYKFQHPELPDINRLSHILWTGKPKHPQA-- 235 Brucella melite...
WP_011051438 161 I-GTVSADIAFGGMTFALVDASSLGFEIVPAEARELCEYGQKIKAAAAEQLDVAFPGNPDMPGITMTQFTGPLSRADGkf 239 Xanthomonas
Q988B5       161 L-GTLTVDIAYGGMFYAIVDAKALGFSIAPDEARELAVAGEKIRRAAREQLDVVHPQFDHVRGVSIVQFAMPFQGPGN-- 237 Mesorhizobium loti
A9CH01       160 L-GKLKVDTAYGGDSFVIVDAEAMGFSLKPEEAHEIARLGVRITNAANKALGFDHPENPDWRHFSFCLFAGKVERTAEgl 238 Agrobacterium f...
Q9I489       160 L-GSLQVDTAYGGDSFVIADARRLGFALRADEAAELVATGLKITHAANEQLGFRHPTNPDWDHLSFCQLAAPPERRDGvl 238 Pseudomonas aer...
7QPO_A       277 PTTNICVFADEQVDRSPTGSGVTARIALQYHKGLLELNQMRAFKsSATGSVFTGKAVREAKCGDFK------------AV 344 human
6HJF_B       283 NYKNVVIFGNRQADRSPCGTGTSAKMATLYAKGQLRIGETFVYE-SILGSLFQGRVLGEERIPGVKvpvtkdaeegmlVV 361 Trypanosoma cru...
4JUU_B       243 AARNFVLCPGLAYDRSPCGTGTSAKLACLAADGKLAEGERWLQQ-GILGSAFEGSY----RHSGRG-------------I 304 Xanthomonas cam...
2AZP_A       221 DSRNFVLCPGKAYDRSPCGTGTSAKLACLAADGKLLPGQPWRQA-SVIGSQFEGRYEWLDGQPGGP-------------I 286 Pseudomonas aer...
1_pfamImport 229 DGRGAVFYGDKAIDRSPGGTGTSARMAQLHGKGRLKAGETFRQE-SLIGTIFEGKVEEETTVGSFS------------GI 295
Q8YJ29       236 HARNAVFYGDKAIDRSPCGTGTSARMAQLAAKGKLKPGDEFIHE-SIIGSLFHGRVERAAEVAGRP------------AI 302 Brucella melite...
WP_011051438 240 FSRNTTIVSPGRCDRSPCGAGSSARLAALHAKGVLAKGDTLVHE-SIIGSRFECGIEDMSNVGDYP------------AV 306 Xanthomonas
Q988B5       238 VTRNTCIVSPGRSDRSPTGTGTSARMAVLQARGLMGVGDVLIHE-SIIGSRFTGRIVELAEIAGRK------------AI 304 Mesorhizobium loti
A9CH01       239 RAGAAVAIQPGKVDRSPTGTALSARMAVLHARGEMKEGETLTAV-SLIGSTFTGRILGTTTVGDRP------------AI 305 Agrobacterium f...
Q9I489       239 GANNAVVIRPGKIDRSPCGTGCSARMAVLQAKGQLRVGERFVGR-SIIGSEFHCHIESLTELGGRP------------AI 305 Pseudomonas aer...
7QPO_A       345 IVEVSGQAHYTGTASFIIEDDDPLRDGFL 373 human
6HJF_B       362 TAEITGKAFIMGFNTMLFDPTDPFKNGFT 390 Trypanosoma cruzi strain CL Brener
4JUU_B       305 APRISGHAFITARSQLLIDPADPFAWGIV 333 Xanthomonas campestris pv. campestris str. ATCC 33913
2AZP_A       287 VPTIRGRAHVSAEATLLLADDDPFAWGIR 315 Pseudomonas aeruginosa
1_pfamImport 296 RPSIGGWARIIGHNTIFVDDRDPLAHGFQ 324
Q8YJ29       303 VPSIAGWARMTGYNTIFIDDRDPFAHGFS 331 Brucella melitensis bv. 1 str. 16M
WP_011051438 307 VPSIAGQAWISGLSQLGLDPSDPYAEGFT 335 Xanthomonas
Q988B5       305 VPEITGRAWITGEHSYYLDPTDPYPQGYV 333 Mesorhizobium loti
A9CH01       306 LPEISGRGWITGIHQHMLDPSDPWPEGYR 334 Agrobacterium fabrum str. C58
Q9I489       306 LPCLSGRAWITGIHQYLLDPDDPWPQGYR 334 Pseudomonas aeruginosa PAO1
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