GEO DataSets

(Submitter supplied) Early childhood convulsions have been correlated with hippocampal neuron loss in patients with intractable temporal lobe epilepsy. Using a "two-hit" rat seizure model, we have shown that animals subjected to kainate (KA)- or hypoxia-induced seizures during early postnatal period showed no cell death, yet sustained more extensive neuronal death after second seizures in adulthood. An early life seizure, without causing overt cellular injury, predisposes the brain to the damaging effect of seizures in later life. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

30 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1642

Platform:

GPL85

60 Samples

Download data: CEL

(Submitter supplied) Mesial temporal lobe epilepsy (MTLE) is the most common medically refractory epilepsy syndrome; kainic acid (KA) induced seizures have been studied as a MTLE model as limbic seizures produced by systemic injections of KA result in a distinctive pattern of neurodegeneration in the hippocampus that resembles human hippocampal sclerosis. In our "2-hit" seizure model, animals subjected to seizures during week 2 of life become more susceptible to seizures later in life and sustain extensive hippocampal neuronal injury after second KA seizures in adulthood. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

30 Samples

Download data: CEL

Analysis of the hippocampus of immature animals up to 240 hours following kainite (KA) induced status epilepticus (SE). Unlike adults, KA-induced SE in immature animals causes neither cell death nor recurrent spontaneous seizures. Results provide insight into the molecular basis of these responses.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 age, 2 agent, 5 time sets

Platform:

GPL85

Series:

GSE4236

60 Samples

Download data: CEL

(Submitter supplied) Neuropsychiatric consequences of poorly controlled seizures that begin in childhood can be devastating. School failure or behavioral difficulty in a child with epilepsy is common and can become the focus of concern for families. Current antiepileptic drugs compound problems with their CNS side effects; effective therapy is currently limited as little is known about the cellular and molecular changes caused by seizures in the developing brain. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1626

Platform:

GPL341

12 Samples

Download data: CEL

Analysis of hippocampi of animals that were injected with kainic acid at postnatal day (P) 20 to induce early-life seizures and then housed in an enriched environment until P30. Results provide insight into the efficacy of environmental enrichment in reversing early-life seizure-induced changes.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 2 disease state, 2 protocol sets

Platform:

GPL341

Series:

GSE1833

12 Samples

Download data: CEL