GEO DataSets

(Submitter supplied) In this study, sntB gene deletion (ΔsntB), complementary (Com-sntB), and HA tag fused to snt2 strain (snt2-HA) strains were constructed by using the homologous recombination method, respectively. It was found in this study that SNTB plays a key role in development, secondary metabolism and pathogenicity of A. flavus. The mechanism was explored by Chromatin immunoprecipitation sequencing (ChIP-seq) and RNA sequencing (RNA-seq).

Organism:

Aspergillus flavus

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL30388 GPL33281

14 Samples

Download data: TXT

(Submitter supplied) In order to explore the bacteriostatic mechanism of Neolamarckia cadamba essential oil, the effect of Neolamarckia cadamba essential oil on microbial transcription in logarithmic growth phase was determined.

Organism:

Niallia circulans; Aspergillus flavus; Nakaseomyces glabratus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL30388 GPL33385 GPL33692

18 Samples

Download data: TXT

(Submitter supplied) Frequently observed in tropical and sub-tropical regions, crops contamination by aflatoxin B1 (AFB1) produced by Aspergillus flavus, is emerging in Europe, due to climate change. Many alternative methods are currently developed to reduce the use of chemical inputs to prevent mycotoxin contamination, such as biocontrol agents (BCAs). Actinobacteria are known to produce many bioactive compounds and some of them are able to reduce in vitro AFB1 concentration. more...

Organism:

Penicillium expansum; Aspergillus flavus

Type:

Expression profiling by array

Platform:

GPL28924

8 Samples

Download data: TXT

(Submitter supplied) Purpose: Aflatoxin B1 is the most toxic and carcinogenic compound in nature produced by Aspergillus fungi. In our study, we applied RNA-seq to compare the transcriptomic profiles of Aspergillus flavus strains in the presence and absence of medicinal plant Zanthoxylum bungeanum. Methods: mRNA profiles of Aspergillus flavus supplemented with 250 µg/ml of methanolic extract fraction (treated samples) or DMSO (control samples) were generated in triplicate, by an Illumina platform using paired-end 150 bp sequencing strategy. more...

Organism:

Aspergillus flavus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30353

6 Samples

Download data: XLSX

(Submitter supplied) purpose: to further gain insight into the effect of RGS proteins on aflatoxin biosynthesis in A. flavus NRRL3357. methods: two mutants ΔrgsA and ΔrgsE separately compared to WT were chose to conduct the analysis of transcriptomics. results: 1750 DEGs are found, including 720 upregulated genes and 1030 downregulated genes in (ΔrgsA vs WT); aflB, aflD, aflF, aflG, aflN, aflP, aflS from ΔrgsE were transcriptionally reduced relative to ΔrgsA in their expressions.

Organism:

Aspergillus flavus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30388

9 Samples

Download data: TXT

(Submitter supplied) Dimethyl sulfoxide (DSMO) is a simple molecule widely used because of its great solvating ability. Beyond its physico-chemical properties, it is also biologically active, including on fungal species. Aspergillus flavus is a saprophytic and famous pathogenic fungus able to produce Aflatoxin B1 (AFB1), a potent carcinogenic mycotoxin which may contaminate many food crops. The aim of this study was to characterize the effect of DMSO on A. more...

Organism:

Aspergillus flavus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30985

18 Samples

Download data: TXT

(Submitter supplied) Objective: Aspergillus flavus aflR, a gene encoding a Zn(II)2Cys6 DNA-binding domain, is an important transcriptional regulator of the aflatoxin biosynthesis gene cluster. Our previous results of GO analysis for the binding sites of AflR in A. flavus suggest that AflR may play an integrative regulatory role. This study aimed to investigate the integrative function of the aflR gene in A. flavus. Design: In this study, we used Aspergillus flavus NRRL3357 as a wild-type strain (WT) and constructed a knockout strain of A. more...

Organism:

Aspergillus flavus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30388

18 Samples

Download data: XLS

(Submitter supplied) The interaction between Aspergillus flavus and Zea mays is complex, and the identification of plant genes and pathways conferring resistance to the fungus has been challenging. Therefore authors undertook a systems biology approach involving dual RNA-seq to determine simultaneous response from the host and pathogen. What was dramatically highlighted in the analysis was upon infection there is uniformity in the development of the host and pathogen. more...

Organism:

Zea mays; Aspergillus flavus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23833

112 Samples

Download data: CSV

(Submitter supplied) We report here the AflR binding motif of Aspergillus flavus for the first time with the aid of ChIP-seq analysis. Of the 540 peak sequences associated with AflR binding events, 66.8% were located within 2 kb upstream (promoter region) of translational start sites. The identified 18-bp binding motif was a perfect palindromic sequence, 5′-CSSGGGWTCGAWCCCSSG’3′ with S representing G or C and W representing A or T. more...

Organism:

Aspergillus flavus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL23153

2 Samples

Download data: TAR, TXT

(Submitter supplied) Transcriptome data of A. flavus was assembled under four different conditions (two strains and two media) for omics data analyses of genes related to ustiloxin production. The used two strains were the over-expressed strain (ustR-oe) of the transcription factor in ustiloxin gene cluster, ustR, and the pyrG marker complemented strain (control). The two media were V8 juice liquid and potato dextrose broth (PDB) media. more...

Organism:

Aspergillus flavus

Type:

Expression profiling by array

Platform:

GPL27115

8 Samples

Download data: GPR

(Submitter supplied) Cytosine methylation is a conserved base modification, but explanations for its interspecific variation remain elusive. Only through taxonomic sampling of disparate groups can unifying explanations for interspecific variation be thoroughly tested. Here we leverage phylogenetic resolution of cytosine DNA methyltransferases (DNA MTases) and genome evolution to better understand widespread interspecific variation across 40 diverse fungal species. more...

Organism:

Agaricus bisporus; Mixia osmundae; Sporobolomyces roseus; Cordyceps militaris; Wolfiporia cocos; Spinellus fusiger; Hesseltinella vesiculosa; Microbotryum lychnidis-dioicae; Heterobasidion irregulare; Plenodomus lingam; Candida albicans; Coemansia reversa; Postia placenta; Coemansia spiralis; Kirkomyces cordensis; Metarhizium robertsii; Pseudogymnoascus destructans; Phycomyces blakesleeanus; Fusarium fujikuroi; Neurospora crassa; Pleurotus ostreatus; Aureobasidium pullulans; Laccaria bicolor; Uncinocarpus reesii; Parasitella parasitica; Botrytis cinerea; Tilletiopsis washingtonensis; Saccharomyces cerevisiae; Aspergillus flavus; Coprinopsis cinerea; Clavispora lusitaniae; Lobosporangium transversale; Radiomyces spectabilis; Flammula alnicola; Cryptococcus neoformans var. grubii; Candidozyma auris; Pyricularia oryzae KJ201; Syncephalis fuscata; Podospora anserina; Phanerodontia chrysosporium

Type:

Methylation profiling by high throughput sequencing; Third-party reanalysis

29 related Platforms

31 Samples

Download data: TSV, TXT, XLS

(Submitter supplied) RNA-seq was used to compare differential gene expressions for Aspergillus flavus wild type strain and ASPES transcription factor deletion strains.The goals of this study are to explore the aflatoxin regulation pathway in A. flavus.

Organism:

Aspergillus flavus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24281

12 Samples

Download data: TXT

(Submitter supplied) Linking cell reproduction and survival is a key task of all life forms. All fungi in the genus Aspergillus reproduce by forming asexual spores called conidia, of which formation is governed by the central regulatory circuit, BrlA->AbaA->WetA. Here, we report that WetA is a key multi-functional regulator that bridged spore differentiation, long-term survival, and chemical development in Aspergillus flavus.

Organism:

Aspergillus flavus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23153

6 Samples

Download data: TXT

(Submitter supplied) A gene co-expression network was generated using a dual RNA-seq study with the fungal pathogen A. flavus and its plant host Z. mays during the initial 3 days of infection. The analysis deciphered novel pathways and mapped genes of interest in both organisms during the infection. This network revealed a high degree of connectivity in many of the previously recognized pathways in Z. mays such as jasmonic acid, ethylene, and reactive oxygen species (ROS). more...

Organism:

Aspergillus flavus; Zea mays

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22349

22 Samples

Download data: XLSX

(Submitter supplied) Aspergillus flavus and A. parasiticus are two of the most important aflatoxin-producing species that contaminate agricultural commodities worldwide. Both species are heterothallic and undergo sexual reproduction in laboratory crosses. Here, we examine the possibility of interspecific matings between A. flavus and A. parasiticus. These species can be distinguished morphologically and genetically, as well as by their mycotoxin profiles. more...

Organism:

Aspergillus tamarii; Aspergillus parasiticus x Aspergillus flavus; Zea mays; Aspergillus caelatus; Aspergillus flavus; Aspergillus parasiticus; Aspergillus oryzae; Aspergillus nomiae

Type:

Genome variation profiling by array

Platform:

GPL8345

56 Samples

Download data: CEL, TXT

(Submitter supplied) Maize kernels are susceptible to infection by the opportunistic pathogen Aspergillus flavus. Infection results in reduction of grain quality and contamination of kernels with the highly carcinogenic mycotoxin, aflatoxin. To understand host response to infection by the fungus, transcription of approximately 9,000 maize genes were monitored during the host-pathogen interaction with a custom-designed Affymetrix GeneChip® DNA array. more...

Organism:

Zea mays; Aspergillus flavus; Aspergillus oryzae

Type:

Expression profiling by array

Platform:

GPL8345

18 Samples

Download data: CEL

(Submitter supplied) Aspergillus flavus is one of the major fungal molds that colonize peanut in the field and during storage. The impact to human and animal health and to economy in agriculture and commerce are significant since this mold produces the most potent natural toxins, aflatoxins, which are carcinogenic, mutagenic, immunosuppressive, and teratogenic. A strain of marine Bacillus megaterium isolated from the Yellow Sea of East China was evaluated for its effect to inhibit aflatoxin formation through down-regulating aflatoxin pathway gene expression in A. more...

Organism:

Aspergillus flavus

Type:

Expression profiling by array

Platform:

GPL17800

8 Samples

Download data: TXT

(Submitter supplied) Several are the inputs which are able to modulate mycotoxin synthesis. In particular, when a fungus receives an external stimulus reacts by activating, through a quite well-defined signal cascade, an evident switch in its lifestyle. This profound change is also due to the activation of global gene regulators and, in particular, of transcription factors able to switch on the mycotoxin gene clusters expression. more...

Organism:

Zea mays; Aspergillus oryzae; Aspergillus flavus

Type:

Expression profiling by array

Platform:

GPL8345

12 Samples

Download data: CEL

(Submitter supplied) Aspergillus flavus is a common saprophyte and opportunistic pathogen producing aflatoxin (AF) and many other secondary metabolites. 5-Azacytidine (5-AC), a derivative of nucleoside cytidine, is widely used for studies in epigenetics and cancer biology as an inactivator of DNA methyltransferase and is also used for studying secondary metabolism in fungi. Our previous studies showed that 5-AC affects development and inhibits AF production in A. more...

Organism:

Aspergillus flavus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL15956

3 Samples

Download data: TXT

(Submitter supplied) Aspergillus flavus is the major producer of carcinogenic aflatoxins in crops worldwide. Natural populations of A. flavus show tremendous variation in aflatoxin production some of which can be attributed to extreme environmental conditions (e.g., drought), differential regulation of the aflatoxin biosynthetic pathway, missing cluster genes or loss-of-function mutations. Understanding the evolutionary processes that generate genetic diversity in A. more...

Organism:

Aspergillus oryzae; Zea mays; Aspergillus flavus

Type:

Genome variation profiling by array

Platform:

GPL13221

19 Samples

Download data: CEL