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Lrpl1 LDL receptor related protein like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100910088, updated on 9-Dec-2024

Summary

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Official Symbol
Lrpl1provided by RGD
Official Full Name
LDL receptor related protein like 1provided by RGD
Primary source
RGD:6499975
See related
EnsemblRapid:ENSRNOG00000054809 AllianceGenome:RGD:6499975
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565014; AABR07026032.1
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in endocytosis. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward (RPKM 55.7) See more
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Genomic context

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See Lrpl1 in Genome Data Viewer
Location:
16q12.2
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (63125523..63174708, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (56422145..56471368, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (59997090..60046457, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097487 Neighboring gene claudin 23 Neighboring gene Tu translation elongation factor, mitochondrial, pseudogene 1 Neighboring gene uncharacterized LOC120097469 Neighboring gene uncharacterized LOC134482392 Neighboring gene multifunctional ROCO family signaling regulator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
low-density lipoprotein receptor-related protein 2-like; prolow-density lipoprotein receptor-related protein 1-like
Names
low-density lipoprotein receptor-related protein 1B-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    63125523..63174708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008771306.4 → XP_008769528.2  prolow-density lipoprotein receptor-related protein 1-like isoform X1

  2. XM_039095034.2 → XP_038950962.1  prolow-density lipoprotein receptor-related protein 1-like isoform X2

    UniProtKB/TrEMBL
    A0A8I6GL13
    Related
    ENSRNOP00000094150.2, ENSRNOT00000079224.3
    Conserved Domains (8) summary
    smart00192
    Location:1868 → 1901
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:1397 → 1438
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:1195 → 1236
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:995 → 1029
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:1373 → 1413
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:1829 → 1863
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    NF033759
    Location:39 → 261
    exchanger_TraA; outer membrane exchange protein TraA
    cl39070
    Location:429 → 471
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B

  3. XM_039095035.2 → XP_038950963.1  low-density lipoprotein receptor-related protein 2-like isoform X3

    Conserved Domains (8) summary
    smart00192
    Location:187 → 218
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:1397 → 1438
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:263 → 301
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:995 → 1029
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:1373 → 1413
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:1207 → 1235
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    NF033759
    Location:39 → 261
    exchanger_TraA; outer membrane exchange protein TraA
    cl39070
    Location:429 → 471
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
Nucleotide Protein Strain
Heading Accession and Version

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