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Tssk1b testis-specific serine kinase 1B [ Rattus norvegicus (Norway rat) ]

Gene ID: 288358, updated on 9-Dec-2024

Summary

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Official Symbol
Tssk1bprovided by RGD
Official Full Name
testis-specific serine kinase 1Bprovided by RGD
Primary source
RGD:1307352
See related
EnsemblRapid:ENSRNOG00000068894 AllianceGenome:RGD:1307352
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tssk1; Stk22a
Summary
Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in peptidyl-serine phosphorylation and spermatid development. Predicted to be located in motile cilium. Orthologous to human TSSK1B (testis specific serine kinase 1B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See Tssk1b in Genome Data Viewer
Location:
11q23
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96595216..96596639, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83090930..83092353, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87239410..87240833, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481038 Neighboring gene goosecoid homeobox 2 Neighboring gene ess-2 splicing factor homolog Neighboring gene testis-specific serine kinase 2 Neighboring gene DiGeorge syndrome critical region gene 2 Neighboring gene carbonic anhydrase 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of peptide substrate and small molecule inhibitors of testis-specific serine/threonine kinase1 (TSSK1) by the developed assays. Zhang L, et al. J Med Chem, 2009 Jul 23. PMID 19530700
  2. Targeted deletion of Tssk1 and 2 causes male infertility due to haploinsufficiency. Xu B, et al. Dev Biol, 2008 Jul 15. PMID 18533145, Free PMC Article
  3. Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis. Li Y, et al. Mol Hum Reprod, 2011 Jan. PMID 20729278, Free PMC Article
  4. Heat shock protein 90 functions to stabilize and activate the testis-specific serine/threonine kinases, a family of kinases essential for male fertility. Jha KN, et al. J Biol Chem, 2013 Jun 7. PMID 23599433, Free PMC Article
  5. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. Jaleel M, et al. FEBS Lett, 2005 Feb 28. PMID 15733851

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatid development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatid development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
testis-specific serine/threonine-protein kinase 1
Names
serine/threonine kinase 22A (spermiogenesis associated)
spermiogenesis associated
testis-specific serine kinase 1
NP_001011900.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011900.1 → NP_001011900.1  testis-specific serine/threonine-protein kinase 1

    See identical proteins and their annotated locations for NP_001011900.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083661
    UniProtKB/TrEMBL
    A0A8I6AN48, Q6V9Y2
    Related
    ENSRNOP00000105960.1, ENSRNOT00000151516.1
    Conserved Domains (2) summary
    smart00220
    Location:12 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14165
    Location:10 → 271
    STKc_TSSK1_2-like; Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    96595216..96596639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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