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Poli DNA polymerase iota [ Rattus norvegicus (Norway rat) ]

Gene ID: 291526, updated on 9-Dec-2024

Summary

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Official Symbol
Poliprovided by RGD
Official Full Name
DNA polymerase iotaprovided by RGD
Primary source
RGD:1305212
See related
EnsemblRapid:ENSRNOG00000012111 AllianceGenome:RGD:1305212
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-directed DNA polymerase activity. Predicted to be involved in translesion synthesis. Predicted to act upstream of or within cellular response to UV-C. Predicted to be located in cytoplasmic ribonucleoprotein granule and nuclear speck. Orthologous to human POLI (DNA polymerase iota). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Testes (RPKM 31.6), Thymus (RPKM 19.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Poli in Genome Data Viewer
Location:
18q12.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (66389214..66409734, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (64116774..64134373, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (65749107..65768805, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482986 Neighboring gene similar to human chromosome 18 open reading frame 54 Neighboring gene StAR-related lipid transfer domain containing 6 Neighboring gene methyl-CpG binding domain protein 2 Neighboring gene uncharacterized LOC134483047 Neighboring gene RNA polymerase II, I and III subunit K, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. 129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation. McDonald JP, et al. J Exp Med, 2003 Aug 18. PMID 12925679, Free PMC Article
  2. Participation of mouse DNA polymerase iota in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer. Dumstorf CA, et al. Proc Natl Acad Sci U S A, 2006 Nov 28. PMID 17114294, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to UV-C ISO
Inferred from Sequence Orthology
more info
  
involved_in translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within translesion synthesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasmic ribonucleoprotein granule IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA polymerase iota
Names
polymerase (DNA directed), iota
polymerase (DNA) iota
NP_001099607.1
XP_006254962.1
XP_006254963.1
XP_017456377.1
XP_038952578.1
XP_038952582.1
XP_063133258.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106137.1 → NP_001099607.1  DNA polymerase iota

    See identical proteins and their annotated locations for NP_001099607.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473971
    UniProtKB/TrEMBL
    A0A8I6AJS8, A6IY06, D4A8I8
    Related
    ENSRNOP00000016189.5, ENSRNOT00000016189.8
    Conserved Domains (2) summary
    cd01703
    Location:51 → 431
    PolY_Pol_iota; DNA Polymerase iota
    COG0389
    Location:48 → 384
    DinP; Nucleotidyltransferase/DNA polymerase involved in DNA repair [Replication, recombination and repair]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    66389214..66409734 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277188.1 → XP_063133258.1  DNA polymerase iota isoform X1

    UniProtKB/TrEMBL
    A0A8I6AJS8
    Related
    ENSRNOP00000093921.2, ENSRNOT00000112218.2

  2. XM_006254900.5 → XP_006254962.1  DNA polymerase iota isoform X3

    UniProtKB/TrEMBL
    A0A8I6AJS8
    Conserved Domains (1) summary
    cl12025
    Location:51 → 408
    PolY; Y-family of DNA polymerases

  3. XM_006254901.5 → XP_006254963.1  DNA polymerase iota isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZP81, A0A8I6AJS8
    Related
    ENSRNOP00000079848.1, ENSRNOT00000101965.2
    Conserved Domains (1) summary
    cl12025
    Location:34 → 389
    PolY; Y-family of DNA polymerases

  4. XM_039096650.2 → XP_038952578.1  DNA polymerase iota isoform X2

    UniProtKB/TrEMBL
    A0A8I6AJS8
    Conserved Domains (2) summary
    cd01703
    Location:50 → 430
    PolY_Pol_iota; DNA Polymerase iota
    cd19318
    Location:696 → 721
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

  5. XM_017600888.3 → XP_017456377.1  DNA polymerase iota isoform X5

    UniProtKB/TrEMBL
    A0A8I6AJS8, A6IY07
    Conserved Domains (2) summary
    cd19318
    Location:634 → 659
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
    cl28996
    Location:1 → 368
    PolY; Y-family of DNA polymerases

  6. XM_039096654.2 → XP_038952582.1  DNA polymerase iota isoform X6

    Conserved Domains (1) summary
    cl28996
    Location:51 → 351
    PolY; Y-family of DNA polymerases
Nucleotide Protein Strain
Heading Accession and Version

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