Nkx1-1 NK1 homeobox 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nkx1-1provided by RGD
Official Full Name: NK1 homeobox 1provided by RGD
Primary source: RGD:1564874
See related: EnsemblRapid:ENSRNOG00000005113 AllianceGenome:RGD:1564874
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564874
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including nervous system process; regulation of generation of precursor metabolites and energy; and regulation of glucose metabolic process. Predicted to be active in nucleus. Orthologous to human NKX1-1 (NK1 homeobox 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (81521206..81524788)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (77296676..77300575)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (82603538..82607031)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of generation of precursor metabolites and energy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info