Ntn4 netrin 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ntn4provided by RGD
Official Full Name: netrin 4provided by RGD
Primary source: RGD:1565947
See related: EnsemblRapid:ENSRNOG00000005573 AllianceGenome:RGD:1565947
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565947
Summary: Predicted to enable laminin-1 binding activity. Predicted to be involved in several processes, including axon guidance; basement membrane assembly; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within neuron remodeling and regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling. Predicted to be located in basement membrane. Predicted to be part of laminin complex. Orthologous to human NTN4 (netrin 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Heart (RPKM 128.3), Kidney (RPKM 120.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (30073637..30187407)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (28186611..28300390)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (34533543..34649330)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased expression of Netrin-4 is associated with allodynia in a trigeminal neuropathic pain model rats by infraorbital nerve injury.
Title: Increased expression of Netrin-4 is associated with allodynia in a trigeminal neuropathic pain model rats by infraorbital nerve injury.
the Unc5B receptor and subsequent activation of the tyrosine phosphatase SHP2 mediated Netrin-4-induced pain signaling in the spinal cord.
Title: Dorsal horn interneuron-derived Netrin-4 contributes to spinal sensitization in chronic pain via Unc5B.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables laminin-1 binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in basement membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling	ISO Inferred from Sequence Orthology more info
involved_in substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of laminin complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: netrin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106780.1 → NP_001100250.1 netrin-4 precursor

See identical proteins and their annotated locations for NP_001100250.1

Status: PROVISIONAL

Source sequence(s)

CH473960

UniProtKB/TrEMBL

A6IFZ2, F1M4Q9

Related

ENSRNOP00000007412.8, ENSRNOT00000007412.9

Conserved Domains (4) summary

cd00055
Location:261 → 320

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03578
Location:517 → 626

NTR_netrin-4_like; NTR domain, Netrin-4-like subfamily; composed of the C-terminal NTR domains of netrin-4 (beta netrin) and similar proteins. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration during neural ...

pfam00053
Location:395 → 449

Laminin_EGF; Laminin EGF domain

pfam00055
Location:43 → 260

Laminin_N; Laminin N-terminal (Domain VI)