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St6gal2 ST6 beta-galactoside alpha-2,6-sialyltransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301155, updated on 9-Dec-2024

Summary

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Official Symbol
St6gal2provided by RGD
Official Full Name
ST6 beta-galactoside alpha-2,6-sialyltransferase 2provided by RGD
Primary source
RGD:1559663
See related
EnsemblRapid:ENSRNOG00000046515 AllianceGenome:RGD:1559663
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ST6GalII; ST6Gal-II
Summary
Predicted to enable beta-galactoside alpha-2,6-sialyltransferase activity. Predicted to be involved in oligosaccharide metabolic process and sialylation. Predicted to be located in Golgi cisterna membrane. Predicted to be active in Golgi apparatus. Orthologous to human ST6GAL2 (ST6 beta-galactoside alpha-2,6-sialyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward (RPKM 43.8) See more
Orthologs
human mouse all
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Genomic context

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See St6gal2 in Genome Data Viewer
Location:
9q11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (9508928..9606900)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (9181744..9274161)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (6966291..7060499)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L27A like 9 Neighboring gene heterogeneous nuclear ribonucleoprotein D, pseudogene 2 Neighboring gene vomeronasal 2 receptor, 76 Neighboring gene SIK family kinase 3, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of the second type of human beta-galactoside alpha 2,6-sialyltransferase (ST6Gal II), which sialylates Galbeta 1,4GlcNAc structures on oligosaccharides preferentially. Genomic analysis of human sialyltransferase genes. Takashima S, et al. J Biol Chem, 2002 Nov 29. PMID 12235148
  2. Comparison of the enzymatic properties of mouse beta-galactoside alpha2,6-sialyltransferases, ST6Gal I and II. Takashima S, et al. J Biochem, 2003 Aug. PMID 12966079
  3. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Harduin-Lepers A, et al. Glycobiology, 2005 Aug. PMID 15843597
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-galactoside alpha-2,6-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-galactoside alpha-2,6-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables beta-galactoside alpha-2,6-sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in oligosaccharide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in oligosaccharide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in sialylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-galactoside alpha-2,6-sialyltransferase 2
Names
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
ST6Gal II
alpha 2,6-ST 2
NP_001094358.1
XP_006244322.1
XP_006244326.1
XP_038939078.1
XP_063122902.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100888.1 → NP_001094358.1  beta-galactoside alpha-2,6-sialyltransferase 2

    See identical proteins and their annotated locations for NP_001094358.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q701R3
    Related
    ENSRNOP00000067395.2, ENSRNOT00000072796.4
    Conserved Domains (1) summary
    pfam00777
    Location:277 → 507
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    9508928..9606900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266832.1 → XP_063122902.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q701R3

  2. XM_039083150.2 → XP_038939078.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q701R3
    Conserved Domains (1) summary
    pfam00777
    Location:277 → 507
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. XM_006244260.5 → XP_006244322.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_006244322.1

    UniProtKB/Swiss-Prot
    Q701R3
    Related
    ENSRNOP00000103643.1, ENSRNOT00000158020.1
    Conserved Domains (1) summary
    pfam00777
    Location:277 → 507
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  4. XM_006244264.5 → XP_006244326.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_006244326.1

    UniProtKB/Swiss-Prot
    Q701R3
    Conserved Domains (1) summary
    pfam00777
    Location:277 → 507
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. XR_005488860.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q701R3.1 GenPept UniProtKB/Swiss-Prot:Q701R3

Gene LinkOut

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