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Ric1 RIC1 homolog, RAB6A GEF complex partner 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309306, updated on 9-Dec-2024

Summary

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Official Symbol
Ric1provided by RGD
Official Full Name
RIC1 homolog, RAB6A GEF complex partner 1provided by RGD
Primary source
RGD:1310016
See related
EnsemblRapid:ENSRNOG00000016172 AllianceGenome:RGD:1310016
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310016
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including positive regulation of GTPase activity; regulation of extracellular matrix constituent secretion; and retrograde transport, endosome to Golgi. Predicted to be located in membrane. Predicted to be part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex. Predicted to be active in Golgi membrane and cytosol. Orthologous to human RIC1 (RIC1 homolog, RAB6A GEF complex partner 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Lung (RPKM 191.2), Thymus (RPKM 175.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ric1 in Genome Data Viewer
Location:
1q52
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (236698901..236798099)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (227285510..227384553)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (247688778..247784219)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene programmed cell death 1 ligand 2 Neighboring gene uncharacterized LOC134485218 Neighboring gene uncharacterized LOC134485217 Neighboring gene endoplasmic reticulum metallopeptidase 1 Neighboring gene uncharacterized LOC120100017

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cranial skeletal system development ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of extracellular matrix constituent secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
guanine nucleotide exchange factor subunit RIC1
Names
RAB6A GEF complex partner 1
RAB6A-GEF complex partner protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427735.2 → NP_001414664.1  guanine nucleotide exchange factor subunit RIC1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6I0W8, D4A224
    Related
    ENSRNOP00000098850.1, ENSRNOT00000141897.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    236698901..236798099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231255.5 → XP_006231317.1  guanine nucleotide exchange factor subunit RIC1 isoform X1

    See identical proteins and their annotated locations for XP_006231317.1

    UniProtKB/TrEMBL
    A6I0W8
    Conserved Domains (2) summary
    pfam07064
    Location:736 → 993
    RIC1; RIC1
    sd00039
    Location:254 → 304
    7WD40; WD40 repeat [structural motif]

  2. XM_006231256.5 → XP_006231318.1  guanine nucleotide exchange factor subunit RIC1 isoform X2

    See identical proteins and their annotated locations for XP_006231318.1

    UniProtKB/TrEMBL
    A6I0W8
    Conserved Domains (2) summary
    pfam07064
    Location:735 → 992
    RIC1; RIC1
    sd00039
    Location:253 → 303
    7WD40; WD40 repeat [structural motif]

  3. XM_039101403.2 → XP_038957331.1  guanine nucleotide exchange factor subunit RIC1 isoform X3

    UniProtKB/TrEMBL
    A6I0W8
    Conserved Domains (2) summary
    sd00039
    Location:139 → 189
    7WD40; WD40 repeat [structural motif]
    pfam07064
    Location:621 → 878
    RIC1
Nucleotide Protein Strain
Heading Accession and Version

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