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Zbtb26 zinc finger and BTB domain containing 26 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311910, updated on 4-Jan-2025

Summary

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Official Symbol
Zbtb26provided by RGD
Official Full Name
zinc finger and BTB domain containing 26provided by RGD
Primary source
RGD:1308561
See related
EnsemblRapid:ENSRNOG00000009346 AllianceGenome:RGD:1308561
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Orthologous to human ZBTB26 (zinc finger and BTB domain containing 26). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 41.3), Adrenal (RPKM 38.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zbtb26 in Genome Data Viewer
Location:
3q11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (41605097..41617706, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (21195319..21207925, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (21685339..21697945, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ring finger and CCCH-type domains 2 Neighboring gene small nucleolar RNA, C/D box 90 Neighboring gene uncharacterized LOC108350365 Neighboring gene zinc finger and BTB domain containing 6 like 1 Neighboring gene zinc finger and BTB domain containing 6 Neighboring gene RAB GTPase activating protein 1 Neighboring gene G protein-coupled receptor 21 Neighboring gene spermatid perinuclear RNA binding protein Neighboring gene U4 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107840.1 → NP_001101310.1  zinc finger and BTB domain-containing protein 26

    See identical proteins and their annotated locations for NP_001101310.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473983
    UniProtKB/TrEMBL
    A6JET2
    Conserved Domains (5) summary
    smart00225
    Location:45 → 138
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:311 → 331
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:309 → 331
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:34 → 134
    BTB; BTB/POZ domain
    pfam13465
    Location:326 → 348
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    41605097..41617706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234082.5 → XP_006234144.1  zinc finger and BTB domain-containing protein 26 isoform X1

    See identical proteins and their annotated locations for XP_006234144.1

    UniProtKB/TrEMBL
    A6JET3, D3ZG35
    Related
    ENSRNOP00000101964.1, ENSRNOT00000144886.1
    Conserved Domains (5) summary
    COG5236
    Location:269 → 381
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:300 → 320
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18214
    Location:8 → 129
    BTB_POZ_ZBTB26_Bioref; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26)
    pfam00096
    Location:298 → 320
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:315 → 337
    zf-H2C2_2; Zinc-finger double domain

  2. XM_039105270.2 → XP_038961198.1  zinc finger and BTB domain-containing protein 26 isoform X1

    UniProtKB/TrEMBL
    A6JET3, D3ZG35
    Related
    ENSRNOP00000096920.1, ENSRNOT00000110572.2
    Conserved Domains (5) summary
    COG5236
    Location:269 → 381
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:300 → 320
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18214
    Location:8 → 129
    BTB_POZ_ZBTB26_Bioref; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26)
    pfam00096
    Location:298 → 320
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:315 → 337
    zf-H2C2_2; Zinc-finger double domain

  3. XM_039105271.2 → XP_038961199.1  zinc finger and BTB domain-containing protein 26 isoform X1

    UniProtKB/TrEMBL
    A6JET3, D3ZG35
    Conserved Domains (5) summary
    COG5236
    Location:269 → 381
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:300 → 320
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18214
    Location:8 → 129
    BTB_POZ_ZBTB26_Bioref; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26)
    pfam00096
    Location:298 → 320
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:315 → 337
    zf-H2C2_2; Zinc-finger double domain

  4. XM_039105272.2 → XP_038961200.1  zinc finger and BTB domain-containing protein 26 isoform X1

    UniProtKB/TrEMBL
    A6JET3, D3ZG35
    Conserved Domains (5) summary
    COG5236
    Location:269 → 381
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:300 → 320
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18214
    Location:8 → 129
    BTB_POZ_ZBTB26_Bioref; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26)
    pfam00096
    Location:298 → 320
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:315 → 337
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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