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Zbtb25 zinc finger and BTB domain containing 25 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314245, updated on 9-Dec-2024

Summary

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Official Symbol
Zbtb25provided by RGD
Official Full Name
zinc finger and BTB domain containing 25provided by RGD
Primary source
RGD:735076
See related
EnsemblRapid:ENSRNOG00000006441 AllianceGenome:RGD:735076
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
KUP; Zfp50; Znf46
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Orthologous to human ZBTB25 (zinc finger and BTB domain containing 25). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Thymus (RPKM 72.4), Adrenal (RPKM 51.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zbtb25 in Genome Data Viewer
Location:
6q24
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (100807083..100831555, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (95070699..95095888, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (99376415..99400834, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Neighboring gene A-kinase anchoring protein 5 Neighboring gene zinc finger and BTB domain containing 1 Neighboring gene uncharacterized LOC120103556 Neighboring gene heat shock protein family A (Hsp70) member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The KUP gene, located on human chromosome 14, encodes a protein with two distant zinc fingers. Chardin P, et al. Nucleic Acids Res, 1991 Apr 11. PMID 2027750, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 25
Names
zinc finger protein 46
zinc finger protein 50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433967.1 → NP_001420896.1  zinc finger and BTB domain-containing protein 25

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6AB68, A6HCA4, F7F1F5, Q6P754

  2. NM_001433968.1 → NP_001420897.1  zinc finger and BTB domain-containing protein 25

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6AB68, A6HCA4, F7F1F5, Q6P754

  3. NM_001433969.1 → NP_001420898.1  zinc finger and BTB domain-containing protein 25

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6AB68, A6HCA4, F7F1F5, Q6P754

  4. NM_199496.2 → NP_955790.1  zinc finger and BTB domain-containing protein 25

    See identical proteins and their annotated locations for NP_955790.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6AB68, A6HCA4, F7F1F5, Q6P754
    Related
    ENSRNOP00000008424.4, ENSRNOT00000008424.7
    Conserved Domains (3) summary
    sd00018
    Location:238 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18213
    Location:3 → 130
    BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)
    pfam00096
    Location:240 → 260
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    100807083..100831555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240236.5 → XP_006240298.1  zinc finger and BTB domain-containing protein 25 isoform X1

    Conserved Domains (3) summary
    sd00018
    Location:238 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18213
    Location:3 → 130
    BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)
    pfam00096
    Location:240 → 260
    zf-C2H2; Zinc finger, C2H2 type

  2. XM_006240237.5 → XP_006240299.1  zinc finger and BTB domain-containing protein 25 isoform X1

    Conserved Domains (3) summary
    sd00018
    Location:238 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18213
    Location:3 → 130
    BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)
    pfam00096
    Location:240 → 260
    zf-C2H2; Zinc finger, C2H2 type

  3. XM_039112270.2 → XP_038968198.1  zinc finger and BTB domain-containing protein 25 isoform X1

    Conserved Domains (3) summary
    sd00018
    Location:238 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18213
    Location:3 → 130
    BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)
    pfam00096
    Location:240 → 260
    zf-C2H2; Zinc finger, C2H2 type

  4. XM_039112269.2 → XP_038968197.1  zinc finger and BTB domain-containing protein 25 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AB68, A6HCA4, F7F1F5, Q6P754
    Conserved Domains (3) summary
    sd00018
    Location:238 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18213
    Location:3 → 130
    BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)
    pfam00096
    Location:240 → 260
    zf-C2H2; Zinc finger, C2H2 type

  5. XM_039112271.2 → XP_038968199.1  zinc finger and BTB domain-containing protein 25 isoform X2

    Conserved Domains (2) summary
    sd00018
    Location:125 → 147
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:127 → 147
    zf-C2H2; Zinc finger, C2H2 type
Nucleotide Protein Strain
Heading Accession and Version

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