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Flacc1 flagellum associated containing coiled-coil domains 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316413, updated on 9-Dec-2024

Summary

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Official Symbol
Flacc1provided by RGD
Official Full Name
flagellum associated containing coiled-coil domains 1provided by RGD
Primary source
RGD:1359362
See related
EnsemblRapid:ENSRNOG00000024917 AllianceGenome:RGD:1359362
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Als2cr12
Summary
Predicted to be located in cytoplasmic vesicle and outer dense fiber. Predicted to be active in cytoplasm. Orthologous to human FLACC1 (flagellum associated containing coiled-coil domains 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Testes (RPKM 458.9) and Kidney (RPKM 23.7) See more
Orthologs
human all
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Genomic context

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See Flacc1 in Genome Data Viewer
Location:
9q31
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (67809731..67837793, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (60315581..60343692, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (65665663..65693822, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100909946 Neighboring gene CASP8 and FADD-like apoptosis regulator Neighboring gene caspase 8 Neighboring gene uncharacterized LOC120094796 Neighboring gene trafficking kinesin protein 2 Neighboring gene transfer RNA valine (anticodon AAC) 15 Neighboring gene STE20 related adaptor beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of a sperm flagellum component encoded by the Als2cr12 gene. Choi E, et al. Gene Expr Patterns, 2011 Jun-Jul. PMID 21402173
  2. A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. Hadano S, et al. Nat Genet, 2001 Oct. PMID 11586298
  3. Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library. Choi E, et al. BMC Genomics, 2007 Jul 28. PMID 17662146, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in outer dense fiber ISO
Inferred from Sequence Orthology
more info
  
located_in outer dense fiber ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
flagellum-associated coiled-coil domain-containing protein 1
Names
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12
amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein homolog
amyotrophic lateral sclerosis 2 chromosome region 12
amyotrophic lateral sclerosis 2 chromosome region, candidate 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014101.1 → NP_001014123.1  flagellum-associated coiled-coil domain-containing protein 1

    See identical proteins and their annotated locations for NP_001014123.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079241
    UniProtKB/Swiss-Prot
    Q6AY08
    UniProtKB/TrEMBL
    A0A8I6A9L6
    Related
    ENSRNOP00000034322.3, ENSRNOT00000038431.5
    Conserved Domains (1) summary
    COG1196
    Location:98 → 410
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    67809731..67837793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267181.1 → XP_063123251.1  flagellum-associated coiled-coil domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A9L6

  2. XM_063267182.1 → XP_063123252.1  flagellum-associated coiled-coil domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AM75
    Related
    ENSRNOP00000094444.1, ENSRNOT00000099510.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AY08.1 GenPept UniProtKB/Swiss-Prot:Q6AY08

Gene LinkOut

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