Lhx8 LIM homeobox 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lhx8provided by RGD
Official Full Name: LIM homeobox 8provided by RGD
Primary source: RGD:1308749
See related: EnsemblRapid:ENSRNOG00000028348 AllianceGenome:RGD:1308749
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lhx7
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in forebrain neuron development and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including female gonad development; forebrain neuron differentiation; and odontogenesis of dentin-containing tooth. Predicted to be located in female germ cell nucleus. Predicted to be active in nucleus. Orthologous to human LHX8 (LIM homeobox 8). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Liver (RPKM 11.5), Thymus (RPKM 4.6) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 2q45

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (245904712..245929376, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (243244958..243269624, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (260572205..260598744, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lhx8 plays role as a suppressor gene of cell proliferation.
Title: Overexpression of Lhx8 inhibits cell proliferation and induces cell cycle arrest in PC12 cell line.
Data indicate that LIM homeobox 8 (Lhx8) regulates functions of cholinergic neurons by modulating tropomyosin receptor kinase A (TrkA) expression.
Title: LIM homeobox 8 (Lhx8) is a key regulator of the cholinergic neuronal function via a tropomyosin receptor kinase A (TrkA)-mediated positive feedback loop.
Although the potential interaction of Lhx8 with other factors remains unknown, our results suggested that neuronal subtype specification can be directly manipulated in the stage of immature newborn neurons by a specific transcription factor in vitro.
Title: LIM-homeobox gene Lhx8 promote the differentiation of hippocampal newborn neurons into cholinergic neurons in vitro.
Lhx8 was not associated with the MAP2-positive neurons differentiation on adherent conditions, but played a role in the specification of cholinergic neurons derived from hippocampal neural stem/progenitor cells in vitro
Title: Lhx8 promote differentiation of hippocampal neural stem/progenitor cells into cholinergic neurons in vitro.
Combined expression of Lhx7 and Gbx1 plays a role in the development of the cholinergic system of the basal forebrain.
Title: The homeobox genes Lhx7 and Gbx1 are expressed in the basal forebrain cholinergic system.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within female gonad development	ISO Inferred from Sequence Orthology more info
involved_in forebrain neuron development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within forebrain neuron development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within learning or memory	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in female germ cell nucleus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: LIM/homeobox protein Lhx8

Names: LIM homeobox protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012219.3 → NP_001012219.1 LIM/homeobox protein Lhx8 isoform 2

See identical proteins and their annotated locations for NP_001012219.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8J8Y3T8

Conserved Domains (3) summary

cd09381
Location:64 → 119

LIM1_Lhx7_Lhx8; The first LIM domain of Lhx7 and Lhx8

cd09383
Location:126 → 180

LIM2_Lhx7_Lhx8; The second LIM domain of Lhx7 and Lhx8

pfam00046
Location:219 → 272

Homeobox; Homeobox domain
NM_001415091.1 → NP_001402020.1 LIM/homeobox protein Lhx8 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6HWP9, G3V6V6, Q5FVG3

Related

ENSRNOP00000009370.6, ENSRNOT00000009370.7