U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tmprss4 transmembrane serine protease 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 367074, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Tmprss4provided by RGD
Official Full Name
transmembrane serine protease 4provided by RGD
Primary source
RGD:1305033
See related
EnsemblRapid:ENSRNOG00000026650 AllianceGenome:RGD:1305033
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable serine-type peptidase activity. Predicted to be involved in protein processing. Predicted to act upstream of or within negative regulation of growth rate; regulation of gene expression; and response to wounding. Predicted to be located in extracellular space and secretory granule. Orthologous to human TMPRSS4 (transmembrane serine protease 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 23.9), Uterus (RPKM 17.4) and 3 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tmprss4 in Genome Data Viewer
Location:
8q22
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (54372805..54405157, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (45475819..45508409, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (49469804..49503304, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene sodium voltage-gated channel beta subunit 2 Neighboring gene sodium voltage-gated channel beta subunit 4 Neighboring gene small integral membrane protein 35 Neighboring gene uncharacterized LOC120094136 Neighboring gene interleukin 10 receptor subunit alpha

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes. Zang R, et al. Sci Immunol, 2020 May 13. PMID 32404436, Free PMC Article
  2. Transmembrane protease, serine 4 (TMPRSS4) is upregulated in IPF lungs and increases the fibrotic response in bleomycin-induced lung injury. Valero-Jiménez A, et al. PLoS One, 2018. PMID 29529050, Free PMC Article
  3. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of growth rate ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of viral entry into host cell IEA
Inferred from Electronic Annotation
more info
  
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to wounding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transmembrane protease serine 4
Names
transmembrane protease, serine 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108998.1 → NP_001102468.1  transmembrane protease serine 4

    See identical proteins and their annotated locations for NP_001102468.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473975
    UniProtKB/TrEMBL
    A6J433, D3Z9X4
    Related
    ENSRNOP00000046830.3, ENSRNOT00000040313.6
    Conserved Domains (5) summary
    smart00020
    Location:202 → 427
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:56 → 90
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:203 → 430
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00530
    Location:118 → 191
    SRCR; Scavenger receptor cysteine-rich domain
    cl02509
    Location:106 → 195
    SRCR_2; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    54372805..54405157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081860.2 → XP_038937788.1  transmembrane protease serine 4 isoform X1

    Conserved Domains (3) summary
    smart00020
    Location:245 → 470
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:99 → 133
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl02509
    Location:149 → 238
    SRCR_2; Scavenger receptor cysteine-rich domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools