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Zkscan2 zinc finger with KRAB and SCAN domains 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 368120, updated on 9-Dec-2024

Summary

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Official Symbol
Zkscan2provided by RGD
Official Full Name
zinc finger with KRAB and SCAN domains 2provided by RGD
Primary source
RGD:1359568
See related
EnsemblRapid:ENSRNOG00000024245 AllianceGenome:RGD:1359568
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZKSCAN2 (zinc finger with KRAB and SCAN domains 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Brain (RPKM 25.2), Testes (RPKM 11.2) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Zkscan2 in Genome Data Viewer
Location:
1q36
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (187437095..187459300, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (178006003..178028239, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (193440749..193459755, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483809 Neighboring gene aquaporin 8 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene pyruvate kinase M1/2, pseudogene 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein with KRAB and SCAN domains 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432375.1 → NP_001419304.1  zinc finger protein with KRAB and SCAN domains 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6I905, D3ZXU0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    187437095..187459300 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230199.5 → XP_006230261.1  zinc finger protein with KRAB and SCAN domains 2 isoform X1

    See identical proteins and their annotated locations for XP_006230261.1

    UniProtKB/TrEMBL
    A6I905, D3ZXU0
    Related
    ENSRNOP00000020281.6, ENSRNOT00000020281.9
    Conserved Domains (9) summary
    smart00431
    Location:42 → 148
    SCAN; leucine rich region
    smart00349
    Location:241 → 282
    KRAB; krueppel associated box
    COG5048
    Location:766 → 915
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:770 → 790
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:768 → 790
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:42 → 129
    SCAN; SCAN domain
    pfam13465
    Location:838 → 863
    zf-H2C2_2; Zinc-finger double domain
    pfam13837
    Location:334 → 415
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
    pfam14510
    Location:466 → 505
    ABC_trans_N; ABC-transporter extracellular N-terminal

  2. XM_039101194.2 → XP_038957122.1  zinc finger protein with KRAB and SCAN domains 2 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:538 → 687
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:542 → 562
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13837
    Location:262 → 343
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
    cl02605
    Location:42 → 148
    SCAN; SCAN oligomerization domain

  3. XM_001079250.8 → XP_001079250.1  zinc finger protein with KRAB and SCAN domains 2 isoform X1

    Conserved Domains (9) summary
    smart00431
    Location:42 → 148
    SCAN; leucine rich region
    smart00349
    Location:241 → 282
    KRAB; krueppel associated box
    COG5048
    Location:766 → 915
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:770 → 790
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:768 → 790
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:42 → 129
    SCAN; SCAN domain
    pfam13465
    Location:838 → 863
    zf-H2C2_2; Zinc-finger double domain
    pfam13837
    Location:334 → 415
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
    pfam14510
    Location:466 → 505
    ABC_trans_N; ABC-transporter extracellular N-terminal
Nucleotide Protein Strain
Heading Accession and Version

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